GREMLIN Database
YHHQ - Inner membrane protein YhhQ
UniProt: P37619 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12217
Length: 221 (195)
Sequences: 1755 (1078)
Seq/√Len: 77.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
125_L153_S4.7061.00
117_M161_I4.3731.00
110_R165_R3.4441.00
140_W199_G3.0891.00
132_R135_Q2.8241.00
114_A161_I2.8061.00
59_T71_I2.6991.00
157_A161_I2.6871.00
100_A103_H2.5691.00
92_M95_W2.5491.00
117_M157_A2.3561.00
171_M174_H2.2801.00
23_V52_I2.2801.00
152_V183_Y2.2291.00
73_F124_I2.2021.00
99_G102_A2.1471.00
57_D146_S2.1101.00
155_T186_K2.0931.00
17_S71_I2.0931.00
49_F122_G2.0851.00
66_P69_R1.9271.00
73_F77_I1.8781.00
98_F102_A1.8671.00
156_L179_A1.8551.00
125_L149_F1.8311.00
75_V119_Y1.8271.00
129_V133_L1.7411.00
60_V131_N1.7411.00
121_L157_A1.7391.00
144_T194_F1.6961.00
158_F162_A1.6951.00
31_V43_T1.6731.00
28_N115_S1.6521.00
152_V156_L1.6501.00
138_R141_L1.6441.00
122_G150_G1.6271.00
90_F102_A1.6271.00
133_L136_S1.6241.00
194_F199_G1.6221.00
25_T82_I1.6071.00
148_L183_Y1.6051.00
110_R163_F1.6001.00
123_Q127_V1.5971.00
125_L129_V1.5840.99
43_T182_D1.5770.99
204_M208_R1.5000.99
121_L153_S1.4820.99
174_H177_E1.4620.99
143_P194_F1.4510.99
126_D150_G1.4090.99
148_L187_V1.4060.99
21_L25_T1.3670.99
18_L74_A1.3580.98
56_T126_D1.3480.98
175_W179_A1.3420.98
155_T183_Y1.3170.98
203_N207_K1.3020.98
43_T159_F1.2960.98
143_P193_F1.2960.98
110_R166_S1.2600.97
83_S112_A1.2560.97
128_H132_R1.2500.97
139_W198_Y1.2410.97
140_W194_F1.2350.97
115_S154_D1.2300.97
46_A182_D1.2280.97
31_V46_A1.2230.97
54_L198_Y1.2200.97
126_D130_F1.2040.97
172_A176_M1.1910.96
66_P70_R1.1900.96
79_A83_S1.1690.96
203_N206_L1.1600.96
111_I162_A1.1590.96
123_Q130_F1.1500.96
31_V182_D1.1370.95
22_L78_P1.1330.95
91_Y106_L1.1320.95
58_L201_L1.1200.95
183_Y187_V1.1160.95
61_R142_A1.1150.95
76_M116_F1.1130.95
80_L116_F1.0940.94
177_E181_V1.0930.94
146_S190_S1.0740.94
193_F196_P1.0720.94
151_N190_S1.0710.94
154_D158_F1.0630.93
65_A127_V1.0620.93
65_A69_R1.0540.93
16_L55_A1.0470.93
89_L101_L1.0450.93
170_F178_I1.0420.93
33_L98_F1.0310.92
117_M121_L1.0220.92
184_C188_L1.0060.91
57_D147_T0.9960.91
36_S39_G0.9890.91
160_F175_W0.9840.90
76_M120_A0.9730.90
129_V132_R0.9720.90
37_I42_T0.9700.90
164_W172_A0.9630.89
111_I115_S0.9610.89
42_T185_F0.9490.89
129_V149_F0.9470.89
72_I127_V0.9420.88
19_F81_L0.9420.88
170_F174_H0.9420.88
139_W143_P0.9420.88
56_T190_S0.9370.88
86_I105_N0.9320.88
174_H178_I0.9320.88
90_F105_N0.9310.88
15_W19_F0.9160.87
82_I86_I0.9160.87
67_L70_R0.9150.87
111_I114_A0.9030.86
69_R73_F0.8970.86
87_S91_Y0.8870.85
134_R142_A0.8870.85
11_K15_W0.8770.84
173_E176_M0.8740.84
201_L205_L0.8700.84
147_T190_S0.8660.84
156_L160_F0.8610.83
26_S82_I0.8610.83
160_F164_W0.8590.83
20_H75_V0.8580.83
28_N154_D0.8550.83
76_M161_I0.8510.83
30_L45_G0.8500.83
16_L59_T0.8470.82
22_L25_T0.8470.82
96_Q99_G0.8450.82
49_F193_F0.8380.82
29_Y105_N0.8350.81
20_H24_I0.8320.81
62_I205_L0.8280.81
95_W98_F0.8170.80
123_Q126_D0.8150.80
152_V179_A0.8120.80
29_Y33_L0.8000.79
49_F186_K0.7970.78
57_D162_A0.7940.78
61_R134_R0.7910.78
189_I193_F0.7910.78
30_L86_I0.7850.77
180_L184_C0.7800.77
13_L67_L0.7790.77
66_P135_Q0.7780.77
190_S193_F0.7770.76
101_L104_F0.7740.76
118_A154_D0.7730.76
44_W182_D0.7710.76
139_W194_F0.7580.75
111_I158_F0.7570.75
139_W202_L0.7550.74
125_L133_L0.7550.74
54_L193_F0.7540.74
49_F53_F0.7530.74
148_L191_I0.7510.74
206_L209_L0.7510.74
154_D186_K0.7470.74
90_F101_L0.7390.73
65_A135_Q0.7370.73
80_L84_Y0.7340.72
178_I182_D0.7340.72
159_F182_D0.7340.72
126_D140_W0.7270.72
54_L122_G0.7250.71
65_A131_N0.7240.71
49_F143_P0.7100.70
83_S108_V0.7090.70
94_S187_V0.7090.70
188_L192_V0.7050.69
123_Q155_T0.7030.69
121_L180_L0.7030.69
44_W89_L0.7030.69
119_Y154_D0.7010.69
87_S90_F0.6960.68
56_T127_V0.6890.68
131_N135_Q0.6880.67
19_F85_V0.6870.67
84_Y88_S0.6840.67
97_G103_H0.6790.66
118_A157_A0.6670.65
24_I52_I0.6660.65
126_D190_S0.6620.64
34_P163_F0.6620.64
76_M119_Y0.6560.64
114_A158_F0.6530.63
125_L128_H0.6520.63
21_L127_V0.6500.63
89_L153_S0.6490.63
45_G124_I0.6480.63
27_S49_F0.6470.63
46_A181_V0.6410.62
91_Y102_A0.6410.62
23_V27_S0.6410.62
130_F143_P0.6390.62
119_Y185_F0.6370.61
26_S86_I0.6290.60
69_R134_R0.6260.60
54_L201_L0.6250.60
159_F178_I0.6240.60
45_G79_A0.6240.60
61_R139_W0.6230.60
68_A123_Q0.6220.60
88_S121_L0.6190.59
144_T148_L0.6190.59
158_F163_F0.6180.59
173_E177_E0.6150.59
22_L26_S0.6100.58
51_F85_V0.6090.58
39_G177_E0.6080.58
24_I119_Y0.6070.58
144_T193_F0.6040.57
75_V151_N0.6040.57
65_A128_H0.6030.57
114_A172_A0.6010.57
126_D144_T0.5990.57
127_V130_F0.5970.57
139_W199_G0.5960.56
34_P178_I0.5950.56
38_L113_T0.5940.56
62_I202_L0.5920.56
20_H30_L0.5920.56
31_V37_I0.5890.56
109_A112_A0.5870.55
32_Q86_I0.5850.55
130_F134_R0.5850.55
48_S85_V0.5850.55
196_P201_L0.5830.55
90_F98_F0.5820.55
49_F187_V0.5780.54
104_F113_T0.5770.54
20_H147_T0.5720.53
147_T199_G0.5720.53
93_G98_F0.5700.53
46_A159_F0.5700.53
37_I41_H0.5630.52
57_D126_D0.5610.52
15_W74_A0.5580.52
133_L145_A0.5580.52
14_F74_A0.5560.51
54_L196_P0.5550.51
59_T62_I0.5530.51
59_T142_A0.5520.51
155_T189_I0.5510.51
150_G195_L0.5490.50
170_F175_W0.5420.50
107_F157_A0.5410.49
30_L44_W0.5400.49
19_F51_F0.5370.49
58_L198_Y0.5360.49
81_L85_V0.5340.49
49_F115_S0.5340.49
49_F154_D0.5330.48
144_T191_I0.5300.48
59_T68_A0.5290.48
94_S174_H0.5280.48
113_T138_R0.5220.47
176_M180_L0.5220.47
84_Y135_Q0.5220.47
16_L205_L0.5200.47
134_R186_K0.5200.47
133_L141_L0.5190.47
80_L112_A0.5190.47
32_Q104_F0.5180.47
109_A113_T0.5180.47
22_L74_A0.5170.46
21_L161_I0.5170.46
97_G173_E0.5170.46
39_G178_I0.5160.46
27_S45_G0.5150.46
18_L173_E0.5150.46
48_S127_V0.5150.46
126_D146_S0.5140.46
66_P204_M0.5130.46
146_S149_F0.5110.46
136_S206_L0.5100.45
108_V112_A0.5080.45
155_T182_D0.5080.45
43_T86_I0.5080.45
57_D199_G0.5060.45
45_G149_F0.5060.45
36_S93_G0.5060.45
56_T130_F0.5060.45
156_L203_N0.5000.44
131_N193_F0.5000.44
93_G96_Q0.5000.44
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4rfsS 1 0.7919 73.3 0.929 Contact Map
4huqS 1 0.7376 61.7 0.935 Contact Map
4z7fA 2 0.7466 38 0.943 Contact Map
4dveA 3 0.8281 31.2 0.946 Contact Map
4tkrA 2 0.7873 22.7 0.949 Contact Map
2cfqA 1 0.8914 19.1 0.951 Contact Map
3aqpA 1 0.7602 15.1 0.953 Contact Map
3p5nA 2 0.7014 13.1 0.954 Contact Map
3rlbA 1 0.7647 11.8 0.955 Contact Map
4lz6A 1 0.9457 8.9 0.958 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0083 seconds.