ATZN - ECOLI - GREMLIN Contacts

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ATZN - Lead, cadmium, zinc and mercury-transporting ATPase

UniProt:	P37617	Sequences: MSTPDNHGKKAPQFAAFKPLTTVQNANDCCCDGACSSTPTLSENVSGTRYSWKVSGMDCAACARKVENAVRQLAGVNQVQVLFATEKLVVDADNDIRAQVESALQKAGYSLRDEQAAEEPQASRLKENLPLITLIVMMAISWGLEQFNHPFGQLAFIATTLVGLYPIARQALRLIKSGSYFAIETLMSVAAIGALFIGATAEAAMVLLLFLIGERLEGWAASRARQGVSALMALKPETATRLRKGEREEVAINSLRPGDVIEVAAGGRLPADGKLLSPFASFDESALTGESIPVERATGDKVPAGATSVDRLVTLEVLSEPGASAIDRILKLIEEAEERRAPIERFIDRFSRIYTPAIMAVALLVTLVPPLLFAASWQEWIYKGLTLLLIGCPCALVISTPAAITSGLAAAARRGALIKGGAALEQLGRVTQVAFDKTGTLTVGKPRVTAIHPATGISESELLTLAAAVEQGATHPLAQAIVREAQVAELAIPTAESQRALVGSGIEAQVNGERVLICAAGKHPADAFTGLINELESAGQTVVLVVRNDDVLGVIALQDTLRADAATAISELNALGVKGVILTGDNPRAAAAIAGELGLEFKAGLLPEDKVKAVTELNQHAPLAMVGDGINDAPAMKAAAIGIAMGSGTDVALETADAALTHNHLRGLVQMIELARATHANIRQNITIALGLKGIFLVTTLLGMTGLWLAVLADTGATVLVTANALRLLRRR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG12215
Length:	732 (597)
Sequences:	18234 (11404)
Seq/√Len:	466.7

ECOLI - ATZN COPA ATKB ATMA
BACSU - COPA CADA ZOSA ATCL
HALSA - Q9HRH2 Q9HN90 Q9HSN5 ATKB
SULSO - Q97UU7 Q97VH4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
587_P	591_A	4.426	1.00
515_V	518_C	3.963	1.00
274_K	316_E	3.608	1.00
238_T	249_E	3.446	1.00
273_G	315_L	3.397	1.00
613_A	616_E	3.359	1.00
430_V	624_A	3.331	1.00
280_A	313_V	3.291	1.00
547_R	552_L	3.262	1.00
469_V	508_A	3.238	1.00
277_S	314_T	3.196	1.00
564_D	664_H	3.172	1.00
615_T	638_A	3.141	1.00
243_R	248_E	3.136	1.00
158_A	195_L	3.085	1.00
618_N	638_A	3.020	1.00
499_R	507_E	3.003	1.00
587_P	604_G	2.916	1.00
242_L	314_T	2.863	1.00
609_D	612_K	2.846	1.00
240_T	249_E	2.820	1.00
583_T	590_A	2.819	1.00
260_V	314_T	2.787	1.00
497_S	509_Q	2.762	1.00
594_A	601_F	2.750	1.00
260_V	276_L	2.729	1.00
602_K	613_A	2.690	1.00
241_R	248_E	2.650	1.00
450_A	540_Q	2.571	1.00
443_V	560_T	2.567	1.00
243_R	246_E	2.540	1.00
591_A	595_G	2.515	1.00
566_A	570_S	2.495	1.00
513_E	548_N	2.489	1.00
443_V	563_A	2.468	1.00
280_A	308_S	2.416	1.00
448_V	484_E	2.412	1.00
624_A	643_I	2.409	1.00
302_V	315_L	2.406	1.00
276_L	316_E	2.396	1.00
468_A	493_P	2.392	1.00
271_A	317_V	2.336	1.00
260_V	316_E	2.279	1.00
515_V	519_A	2.251	1.00
618_N	640_A	2.238	1.00
531_L	534_E	2.205	1.00
573_N	600_E	2.196	1.00
513_E	518_C	2.190	1.00
240_T	267_G	2.188	1.00
366_T	384_G	2.183	1.00
414_R	670_Q	2.177	1.00
570_S	574_A	2.169	1.00
458_S	461_E	2.164	1.00
247_R	262_E	2.117	1.00
459_E	488_A	2.074	1.00
169_R	173_R	2.073	1.00
484_E	488_A	2.037	1.00
571_E	673_E	2.032	1.00
431_T	622_P	2.004	1.00
575_L	673_E	2.003	1.00
242_L	247_R	1.987	1.00
269_L	282_F	1.981	1.00
484_E	487_V	1.956	1.00
240_T	247_R	1.953	1.00
462_L	553_G	1.940	1.00
448_V	555_I	1.894	1.00
544_L	551_V	1.893	1.00
441_L	597_L	1.877	1.00
582_L	613_A	1.875	1.00
243_R	259_D	1.869	1.00
274_K	318_L	1.850	1.00
573_N	579_G	1.844	1.00
535_L	556_A	1.832	1.00
411_A	674_L	1.827	1.00
331_K	335_E	1.820	1.00
255_L	271_A	1.819	1.00
542_V	554_V	1.817	1.00
616_E	620_H	1.809	1.00
262_E	314_T	1.797	1.00
433_V	624_A	1.786	1.00
275_L	313_V	1.785	1.00
518_C	521_G	1.784	1.00
615_T	619_Q	1.771	1.00
434_A	617_L	1.761	1.00
681_N	727_R	1.748	1.00
261_I	315_L	1.733	1.00
578_K	600_E	1.714	1.00
591_A	601_F	1.695	1.00
612_K	615_T	1.694	1.00
507_E	514_R	1.692	1.00
567_T	571_E	1.689	1.00
297_A	300_D	1.683	1.00
568_A	669_V	1.671	1.00
611_V	638_A	1.667	1.00
136_V	208_L	1.666	1.00
255_L	261_I	1.664	1.00
513_E	519_A	1.663	1.00
432_Q	580_V	1.654	1.00
241_R	259_D	1.652	1.00
561_L	597_L	1.642	1.00
567_T	666_R	1.635	1.00
532_I	544_L	1.634	1.00
434_A	582_L	1.633	1.00
284_E	296_R	1.631	1.00
466_A	545_V	1.630	1.00
301_K	318_L	1.623	1.00
566_A	596_E	1.619	1.00
360_A	364_L	1.612	1.00
522_K	525_A	1.608	1.00
410_A	414_R	1.607	1.00
281_S	295_E	1.602	1.00
429_R	622_P	1.598	1.00
581_I	590_A	1.588	1.00
241_R	250_V	1.576	1.00
165_Y	169_R	1.563	1.00
479_Q	483_R	1.561	1.00
283_D	309_V	1.557	1.00
156_F	160_T	1.549	1.00
261_I	273_G	1.548	1.00
513_E	547_R	1.548	1.00
537_S	588_R	1.545	1.00
449_T	558_Q	1.545	1.00
564_D	666_R	1.536	1.00
258_G	316_E	1.528	1.00
192_I	196_F	1.525	1.00
434_A	614_V	1.521	1.00
457_I	552_L	1.518	1.00
349_R	353_I	1.517	1.00
450_A	538_A	1.517	1.00
157_I	160_T	1.493	1.00
282_F	313_V	1.482	1.00
240_T	264_A	1.481	1.00
687_T	691_G	1.480	1.00
602_K	616_E	1.476	1.00
513_E	516_L	1.476	1.00
447_R	483_R	1.475	1.00
279_F	295_E	1.474	1.00
582_L	605_L	1.468	1.00
287_L	303_P	1.468	1.00
467_A	485_A	1.461	1.00
273_G	302_V	1.460	1.00
279_F	297_A	1.451	1.00
301_K	319_S	1.447	1.00
407_G	678_T	1.445	1.00
443_V	447_R	1.439	1.00
534_E	538_A	1.434	1.00
612_K	616_E	1.433	1.00
540_Q	556_A	1.417	1.00
647_S	663_N	1.416	1.00
583_T	603_A	1.416	1.00
365_V	383_K	1.415	1.00
447_R	560_T	1.412	1.00
481_I	555_I	1.411	1.00
543_V	557_L	1.411	1.00
157_I	161_L	1.393	1.00
250_V	254_S	1.389	1.00
529_T	533_N	1.388	1.00
493_P	511_N	1.383	1.00
461_E	464_T	1.383	1.00
547_R	550_D	1.381	1.00
662_H	667_G	1.381	1.00
449_T	540_Q	1.374	1.00
524_P	527_A	1.374	1.00
255_L	317_V	1.366	1.00
132_I	163_G	1.362	1.00
468_A	492_I	1.359	1.00
188_S	192_I	1.354	1.00
274_K	301_K	1.343	1.00
515_V	521_G	1.342	1.00
513_E	517_I	1.341	1.00
483_R	487_V	1.334	1.00
257_P	320_E	1.332	1.00
679_H	683_R	1.319	1.00
168_A	188_S	1.317	1.00
643_I	668_L	1.317	1.00
251_A	254_S	1.316	1.00
426_Q	622_P	1.312	1.00
457_I	462_L	1.308	1.00
533_N	537_S	1.293	1.00
515_V	547_R	1.286	1.00
644_A	656_A	1.285	1.00
242_L	262_E	1.285	1.00
452_H	531_L	1.280	1.00
567_T	570_S	1.274	1.00
464_T	493_P	1.269	1.00
466_A	555_I	1.268	1.00
261_I	317_V	1.264	1.00
464_T	511_N	1.263	1.00
370_P	377_W	1.254	1.00
133_T	208_L	1.245	1.00
571_E	574_A	1.244	1.00
376_S	379_E	1.241	1.00
545_V	553_G	1.235	1.00
444_G	559_D	1.233	1.00
622_P	640_A	1.233	1.00
460_S	488_A	1.232	1.00
238_T	251_A	1.230	1.00
435_F	579_G	1.230	1.00
616_E	619_Q	1.230	1.00
263_V	315_L	1.229	1.00
418_I	658_A	1.229	1.00
134_L	138_M	1.228	1.00
501_L	507_E	1.228	1.00
470_E	478_A	1.226	1.00
615_T	618_N	1.223	1.00
474_T	500_A	1.217	1.00
608_E	612_K	1.217	1.00
428_G	679_H	1.209	1.00
569_I	579_G	1.208	1.00
558_Q	596_E	1.205	1.00
168_A	192_I	1.204	1.00
587_P	603_A	1.201	1.00
507_E	516_L	1.198	1.00
564_D	568_A	1.195	1.00
274_K	299_G	1.191	1.00
636_M	652_A	1.191	1.00
262_E	312_L	1.190	1.00
189_V	359_M	1.189	1.00
364_L	368_V	1.188	1.00
435_F	441_L	1.183	1.00
263_V	269_L	1.183	1.00
564_D	567_T	1.182	1.00
453_P	553_G	1.180	1.00
140_I	205_M	1.174	1.00
672_I	676_R	1.169	1.00
273_G	318_L	1.168	1.00
369_P	380_W	1.166	1.00
516_L	519_A	1.165	1.00
256_R	259_D	1.165	1.00
455_T	550_D	1.163	1.00
575_L	676_R	1.161	1.00
535_L	540_Q	1.160	1.00
464_T	468_A	1.157	1.00
420_G	657_D	1.156	1.00
590_A	601_F	1.151	1.00
445_K	483_R	1.147	1.00
453_P	459_E	1.141	1.00
471_Q	486_Q	1.137	1.00
275_L	282_F	1.136	1.00
359_M	363_L	1.135	1.00
592_A	596_E	1.132	1.00
526_D	530_G	1.131	1.00
172_L	176_K	1.131	1.00
483_R	486_Q	1.131	1.00
410_A	413_R	1.125	1.00
317_V	320_E	1.125	1.00
158_A	162_V	1.124	1.00
590_A	603_A	1.121	1.00
403_A	681_N	1.119	1.00
496_E	509_Q	1.117	1.00
684_Q	724_N	1.114	1.00
319_S	323_A	1.113	1.00
605_L	609_D	1.111	1.00
503_G	507_E	1.109	1.00
509_Q	514_R	1.108	1.00
514_R	518_C	1.106	1.00
465_L	515_V	1.105	1.00
426_Q	640_A	1.105	1.00
282_F	308_S	1.103	1.00
517_I	521_G	1.103	1.00
462_L	552_L	1.098	1.00
602_K	605_L	1.098	1.00
328_R	331_K	1.094	1.00
501_L	504_S	1.093	1.00
243_R	250_V	1.093	1.00
448_V	557_L	1.092	1.00
561_L	593_I	1.091	1.00
530_G	533_N	1.087	1.00
450_A	459_E	1.087	1.00
242_L	260_V	1.086	1.00
173_R	176_K	1.082	1.00
320_E	323_A	1.082	1.00
517_I	520_A	1.082	1.00
571_E	575_L	1.080	1.00
277_S	298_T	1.078	1.00
452_H	535_L	1.070	1.00
526_D	529_T	1.069	1.00
366_T	370_P	1.067	1.00
450_A	556_A	1.065	1.00
441_L	561_L	1.059	1.00
468_A	495_A	1.056	1.00
132_I	136_V	1.056	1.00
446_P	477_L	1.047	1.00
328_R	608_E	1.046	1.00
139_A	143_G	1.040	1.00
528_F	551_V	1.040	1.00
432_Q	578_K	1.039	1.00
427_L	671_M	1.037	1.00
312_L	472_G	1.034	1.00
525_A	529_T	1.032	1.00
577_V	672_I	1.031	1.00
677_A	680_A	1.030	1.00
427_L	641_I	1.025	1.00
403_A	725_A	1.024	1.00
477_L	557_L	1.023	1.00
264_A	267_G	1.019	1.00
281_S	310_D	1.019	1.00
498_Q	506_I	1.017	1.00
431_T	621_A	1.015	1.00
454_A	528_F	1.013	1.00
219_W	223_R	1.011	1.00
469_V	506_I	1.008	1.00
530_G	534_E	1.007	1.00
161_L	168_A	1.006	1.00
587_P	601_F	1.004	1.00
503_G	508_A	1.000	1.00
215_R	219_W	0.999	1.00
681_N	725_A	0.996	1.00
525_A	528_F	0.995	1.00
570_S	573_N	0.986	1.00
637_K	655_T	0.985	1.00
492_I	495_A	0.982	1.00
724_N	727_R	0.980	1.00
433_V	577_V	0.979	1.00
565_A	569_I	0.979	1.00
452_H	554_V	0.978	1.00
156_F	159_T	0.976	1.00
340_R	348_D	0.969	1.00
453_P	462_L	0.966	1.00
571_E	666_R	0.965	1.00
618_N	623_L	0.963	1.00
516_L	546_V	0.962	1.00
586_N	604_G	0.961	1.00
175_I	178_G	0.959	1.00
430_V	622_P	0.958	1.00
269_L	302_V	0.957	1.00
495_A	498_Q	0.955	1.00
569_I	573_N	0.954	1.00
132_I	135_I	0.951	1.00
454_A	551_V	0.949	1.00
136_V	139_A	0.946	1.00
504_S	606_L	0.943	1.00
491_A	511_N	0.942	1.00
135_I	139_A	0.941	1.00
426_Q	429_R	0.938	1.00
149_H	153_Q	0.938	1.00
531_L	535_L	0.937	1.00
154_L	199_A	0.936	1.00
533_N	588_R	0.936	1.00
432_Q	617_L	0.933	1.00
503_G	506_I	0.933	1.00
390_I	696_F	0.930	1.00
586_N	589_A	0.927	1.00
135_I	138_M	0.925	1.00
580_V	617_L	0.922	1.00
451_I	484_E	0.922	1.00
462_L	466_A	0.921	1.00
575_L	669_V	0.920	1.00
447_R	487_V	0.919	1.00
361_V	701_L	0.919	1.00
133_T	136_V	0.917	1.00
275_L	278_P	0.913	1.00
158_A	161_L	0.910	1.00
495_A	508_A	0.909	1.00
239_A	270_P	0.909	1.00
154_L	158_A	0.906	1.00
681_N	684_Q	0.906	1.00
614_V	625_M	0.906	1.00
174_L	178_G	0.905	1.00
495_A	510_V	0.904	1.00
321_P	324_S	0.903	1.00
515_V	520_A	0.903	1.00
287_L	325_A	0.902	1.00
536_E	588_R	0.900	1.00
303_P	306_A	0.900	1.00
467_A	492_I	0.898	1.00
582_L	602_K	0.897	1.00
181_F	185_T	0.896	1.00
428_G	675_A	0.895	1.00
302_V	313_V	0.895	1.00
544_L	554_V	0.893	1.00
457_I	461_E	0.893	1.00
575_L	672_I	0.893	1.00
451_I	555_I	0.891	1.00
191_A	207_L	0.890	1.00
345_R	349_R	0.890	1.00
241_R	261_I	0.890	1.00
275_L	300_D	0.889	1.00
241_R	255_L	0.887	1.00
282_F	302_V	0.887	1.00
532_I	536_E	0.885	1.00
136_V	140_I	0.884	1.00
427_L	672_I	0.879	1.00
284_E	294_V	0.875	1.00
239_A	255_L	0.875	1.00
667_G	670_Q	0.872	1.00
580_V	602_K	0.867	1.00
310_D	499_R	0.866	1.00
226_Q	229_S	0.866	1.00
463_L	484_E	0.866	1.00
571_E	669_V	0.866	1.00
377_W	381_I	0.865	1.00
223_R	226_Q	0.865	1.00
467_A	482_V	0.864	1.00
261_I	270_P	0.863	1.00
284_E	306_A	0.862	1.00
156_F	161_L	0.860	1.00
645_M	648_G	0.858	1.00
249_E	267_G	0.854	1.00
611_V	615_T	0.853	1.00
696_F	713_A	0.853	1.00
463_L	466_A	0.851	1.00
515_V	552_L	0.849	1.00
465_L	547_R	0.848	1.00
226_Q	230_A	0.847	1.00
522_K	526_D	0.847	1.00
580_V	613_A	0.846	1.00
268_R	307_T	0.844	1.00
714_D	717_A	0.843	1.00
265_A	280_A	0.842	1.00
160_T	204_A	0.839	1.00
606_L	609_D	0.837	1.00
291_S	589_A	0.836	1.00
325_A	608_E	0.833	1.00
296_R	300_D	0.831	1.00
367_L	371_L	0.829	1.00
366_T	380_W	0.826	1.00
626_V	668_L	0.825	1.00
259_D	317_V	0.824	1.00
420_G	423_A	0.821	1.00
583_T	601_F	0.821	1.00
261_I	271_A	0.821	1.00
275_L	280_A	0.820	1.00
581_I	599_L	0.816	1.00
589_A	593_I	0.814	1.00
153_Q	156_F	0.813	1.00
427_L	430_V	0.813	1.00
282_F	296_R	0.813	1.00
270_P	315_L	0.813	1.00
370_P	380_W	0.811	1.00
353_I	357_A	0.809	1.00
243_R	256_R	0.808	1.00
433_V	626_V	0.807	1.00
174_L	182_A	0.806	1.00
435_F	572_L	0.802	1.00
516_L	520_A	0.800	1.00
136_V	143_G	0.800	1.00
523_H	526_D	0.799	1.00
461_E	465_L	0.799	1.00
469_V	545_V	0.798	1.00
422_A	426_Q	0.796	1.00
677_A	681_N	0.794	1.00
132_I	140_I	0.793	1.00
151_F	155_A	0.792	1.00
513_E	521_G	0.791	1.00
545_V	555_I	0.791	1.00
265_A	308_S	0.790	1.00
252_I	255_L	0.789	1.00
418_I	671_M	0.789	1.00
450_A	535_L	0.786	1.00
230_A	233_A	0.785	1.00
247_R	314_T	0.782	1.00
156_F	162_V	0.782	1.00
153_Q	157_I	0.780	1.00
453_P	456_G	0.778	1.00
164_L	207_L	0.776	1.00
247_R	264_A	0.775	1.00
427_L	658_A	0.773	1.00
568_A	666_R	0.772	1.00
140_I	144_L	0.772	1.00
441_L	569_I	0.771	1.00
286_A	306_A	0.771	1.00
523_H	527_A	0.769	1.00
275_L	315_L	0.764	1.00
230_A	651_V	0.762	1.00
233_A	237_E	0.761	1.00
434_A	580_V	0.759	1.00
561_L	566_A	0.759	1.00
256_R	320_E	0.759	1.00
171_A	176_K	0.759	1.00
675_A	679_H	0.758	1.00
614_V	623_L	0.757	1.00
379_E	383_K	0.756	1.00
538_A	596_E	0.755	1.00
365_V	701_L	0.755	1.00
325_A	328_R	0.754	1.00
263_V	308_S	0.753	1.00
706_G	709_L	0.751	1.00
163_G	211_L	0.751	1.00
138_M	142_W	0.750	1.00
494_T	511_N	0.750	1.00
644_A	648_G	0.750	1.00
411_A	418_I	0.749	1.00
464_T	490_L	0.744	1.00
471_Q	492_I	0.743	1.00
237_E	268_R	0.739	1.00
380_W	384_G	0.738	1.00
155_A	159_T	0.738	1.00
310_D	500_A	0.738	1.00
589_A	592_A	0.737	1.00
131_L	163_G	0.737	1.00
362_A	388_L	0.736	1.00
404_I	425_E	0.736	1.00
517_I	545_V	0.736	1.00
230_A	413_R	0.736	1.00
147_F	150_P	0.735	1.00
549_D	552_L	0.734	1.00
684_Q	727_R	0.734	1.00
279_F	298_T	0.733	1.00
680_A	684_Q	0.733	1.00
462_L	545_V	0.732	1.00
137_M	141_S	0.732	1.00
534_E	537_S	0.732	1.00
711_V	715_T	0.731	1.00
159_T	162_V	0.730	1.00
222_S	226_Q	0.730	1.00
568_A	665_L	0.728	1.00
430_V	577_V	0.726	1.00
463_L	467_A	0.725	1.00
669_V	672_I	0.724	1.00
185_T	189_V	0.722	1.00
467_A	471_Q	0.720	1.00
161_L	192_I	0.720	1.00
516_L	521_G	0.719	1.00
504_S	519_A	0.718	1.00
265_A	500_A	0.717	1.00
696_F	709_L	0.716	1.00
479_Q	482_V	0.715	1.00
490_L	493_P	0.713	1.00
240_T	262_E	0.712	1.00
182_A	185_T	0.712	1.00
275_L	296_R	0.712	1.00
368_V	372_L	0.711	1.00
248_E	254_S	0.711	1.00
146_Q	149_H	0.709	1.00
459_E	466_A	0.709	1.00
416_A	667_G	0.707	1.00
716_G	720_L	0.706	1.00
523_H	528_F	0.704	1.00
433_V	579_G	0.704	1.00
195_L	199_A	0.703	1.00
588_R	591_A	0.703	1.00
581_I	594_A	0.702	1.00
593_I	597_L	0.702	1.00
229_S	233_A	0.701	1.00
150_P	153_Q	0.700	1.00
161_L	203_A	0.700	1.00
569_I	597_L	0.700	1.00
533_N	536_E	0.698	1.00
331_K	334_E	0.697	1.00
707_L	714_D	0.697	1.00
305_G	326_I	0.697	1.00
469_V	515_V	0.696	1.00
176_K	179_S	0.693	1.00
242_L	245_G	0.693	1.00
132_I	143_G	0.692	1.00
565_A	597_L	0.691	1.00
133_T	138_M	0.691	1.00
282_F	306_A	0.691	1.00
170_Q	173_R	0.691	1.00
535_L	538_A	0.690	1.00
368_V	373_F	0.689	1.00
352_R	356_P	0.688	1.00
347_I	400_T	0.688	1.00
224_A	409_A	0.688	1.00
536_E	542_V	0.688	1.00
535_L	554_V	0.687	1.00
263_V	270_P	0.687	1.00
174_L	185_T	0.686	1.00
714_D	718_T	0.686	1.00
633_A	655_T	0.684	1.00
594_A	599_L	0.684	1.00
417_L	661_T	0.684	1.00
139_A	142_W	0.683	1.00
365_V	384_G	0.682	1.00
309_V	479_Q	0.682	1.00
193_G	385_L	0.681	1.00
441_L	581_I	0.678	1.00
465_L	552_L	0.677	1.00
367_L	370_P	0.674	1.00
693_K	714_D	0.673	1.00
690_L	694_G	0.672	1.00
269_L	308_S	0.671	1.00
528_F	531_L	0.671	1.00
206_V	711_V	0.670	1.00
510_V	515_V	0.668	1.00
484_E	555_I	0.667	1.00
360_A	363_L	0.665	1.00
304_A	324_S	0.665	1.00
276_L	298_T	0.665	1.00
551_V	554_V	0.665	1.00
375_A	379_E	0.664	1.00
275_L	302_V	0.664	1.00
148_N	151_F	0.664	1.00
169_R	172_L	0.663	1.00
457_I	547_R	0.663	1.00
524_P	528_F	0.663	1.00
435_F	668_L	0.663	1.00
259_D	271_A	0.662	1.00
278_P	298_T	0.662	1.00
658_A	671_M	0.662	1.00
319_S	328_R	0.661	1.00
723_A	727_R	0.659	1.00
441_L	565_A	0.658	1.00
310_D	502_V	0.657	1.00
430_V	672_I	0.657	1.00
592_A	595_G	0.656	1.00
669_V	673_E	0.655	1.00
321_P	327_D	0.654	1.00
269_L	313_V	0.653	1.00
449_T	556_A	0.652	1.00
288_T	294_V	0.651	1.00
719_V	723_A	0.650	1.00
320_E	324_S	0.650	1.00
281_S	309_V	0.647	1.00
579_G	599_L	0.646	1.00
433_V	672_I	0.646	1.00
593_I	596_E	0.645	1.00
491_A	510_V	0.645	1.00
434_A	605_L	0.645	1.00
322_G	327_D	0.645	1.00
418_I	424_L	0.644	1.00
362_A	366_T	0.644	1.00
432_Q	621_A	0.644	1.00
515_V	545_V	0.642	1.00
136_V	142_W	0.641	1.00
532_I	542_V	0.641	1.00
139_A	157_I	0.640	1.00
138_M	141_S	0.640	1.00
564_D	665_L	0.640	1.00
152_G	155_A	0.638	1.00
636_M	642_G	0.638	1.00
571_E	670_Q	0.637	1.00
237_E	253_N	0.637	1.00
368_V	703_G	0.636	1.00
187_M	194_A	0.636	1.00
430_V	433_V	0.636	1.00
143_G	153_Q	0.636	1.00
427_L	675_A	0.636	1.00
471_Q	494_T	0.635	1.00
505_G	520_A	0.634	1.00
174_L	179_S	0.634	1.00
528_F	532_I	0.633	1.00
513_E	520_A	0.633	1.00
507_E	510_V	0.632	0.99
146_Q	150_P	0.632	0.99
171_A	181_F	0.631	0.99
527_A	530_G	0.630	0.99
263_V	267_G	0.628	0.99
649_T	653_L	0.627	0.99
366_T	377_W	0.625	0.99
514_R	548_N	0.624	0.99
472_G	498_Q	0.623	0.99
383_K	386_T	0.623	0.99
572_L	669_V	0.623	0.99
566_A	597_L	0.623	0.99
451_I	463_L	0.622	0.99
232_M	653_L	0.621	0.99
535_L	542_V	0.621	0.99
514_R	520_A	0.621	0.99
512_G	517_I	0.620	0.99
572_L	577_V	0.620	0.99
443_V	564_D	0.620	0.99
532_I	554_V	0.619	0.99
718_T	722_T	0.618	0.99
207_L	211_L	0.617	0.99
252_I	271_A	0.617	0.99
474_T	498_Q	0.616	0.99
522_K	529_T	0.616	0.99
275_L	297_A	0.615	0.99
664_H	667_G	0.615	0.99
363_L	367_L	0.615	0.99
212_I	216_L	0.614	0.99
453_P	457_I	0.613	0.99
649_T	652_A	0.613	0.99
279_F	497_S	0.613	0.99
139_A	204_A	0.613	0.99
529_T	532_I	0.613	0.99
489_E	492_I	0.613	0.99
194_A	203_A	0.613	0.99
514_R	519_A	0.613	0.99
373_F	376_S	0.612	0.99
195_L	203_A	0.612	0.99
403_A	678_T	0.612	0.99
514_R	517_I	0.611	0.99
504_S	521_G	0.611	0.99
154_L	157_I	0.610	0.99
136_V	160_T	0.609	0.99
271_A	321_P	0.609	0.99
239_A	252_I	0.609	0.99
527_A	531_L	0.608	0.99
343_I	679_H	0.608	0.99
609_D	613_A	0.607	0.99
463_L	485_A	0.606	0.99
131_L	134_L	0.606	0.99
322_G	331_K	0.605	0.99
153_Q	160_T	0.602	0.99
157_I	204_A	0.602	0.99
461_E	547_R	0.601	0.99
267_G	474_T	0.601	0.99
562_R	663_N	0.601	0.99
171_A	185_T	0.601	0.99
400_T	682_I	0.601	0.99
433_V	569_I	0.599	0.99
458_S	547_R	0.599	0.99
468_A	510_V	0.599	0.99
514_R	549_D	0.598	0.99
428_G	676_R	0.598	0.99
525_A	530_G	0.598	0.99
454_A	531_L	0.597	0.99
641_I	658_A	0.597	0.99
171_A	175_I	0.596	0.99
522_K	528_F	0.596	0.99
445_K	479_Q	0.596	0.99
468_A	494_T	0.595	0.99
461_E	513_E	0.595	0.99
617_L	620_H	0.595	0.99
241_R	256_R	0.595	0.99
467_A	490_L	0.594	0.99
501_L	516_L	0.594	0.99
315_L	318_L	0.593	0.99
447_R	484_E	0.592	0.99
137_M	140_I	0.592	0.99
484_E	490_L	0.592	0.99
712_L	715_T	0.591	0.99
681_N	724_N	0.591	0.99
454_A	554_V	0.591	0.99
707_L	710_A	0.591	0.99
339_R	615_T	0.591	0.99
132_I	138_M	0.590	0.99
132_I	139_A	0.589	0.99
353_I	356_P	0.589	0.99
565_A	568_A	0.588	0.99
431_T	434_A	0.587	0.99
433_V	572_L	0.587	0.99
512_G	515_V	0.587	0.99
407_G	674_L	0.587	0.99
135_I	159_T	0.586	0.99
539_G	556_A	0.585	0.99
182_A	187_M	0.584	0.99
154_L	195_L	0.583	0.99
257_P	319_S	0.583	0.99
324_S	327_D	0.580	0.99
140_I	143_G	0.580	0.99
691_G	695_I	0.579	0.99
164_L	191_A	0.579	0.99
459_E	463_L	0.578	0.99
278_P	313_V	0.577	0.99
572_L	579_G	0.576	0.99
269_L	315_L	0.575	0.99
464_T	491_A	0.575	0.99
185_T	359_M	0.575	0.99
157_I	195_L	0.575	0.99
538_A	595_G	0.575	0.99
173_R	177_S	0.574	0.99
577_V	624_A	0.574	0.99
568_A	571_E	0.573	0.99
711_V	714_D	0.572	0.99
152_G	156_F	0.572	0.99
390_I	713_A	0.572	0.99
390_I	700_T	0.571	0.99
386_T	710_A	0.571	0.99
485_A	490_L	0.570	0.99
138_M	143_G	0.569	0.99
460_S	490_L	0.569	0.99
653_L	659_A	0.568	0.99
163_G	166_P	0.567	0.99
565_A	665_L	0.566	0.99
362_A	384_G	0.565	0.99
427_L	624_A	0.565	0.99
154_L	159_T	0.565	0.99
257_P	323_A	0.564	0.99
705_T	710_A	0.564	0.99
531_L	554_V	0.563	0.99
481_I	543_V	0.563	0.99
133_T	140_I	0.563	0.99
453_P	458_S	0.562	0.99
135_I	160_T	0.562	0.99
136_V	144_L	0.562	0.99
250_V	259_D	0.561	0.99
138_M	144_L	0.561	0.99
157_I	162_V	0.561	0.99
154_L	161_L	0.561	0.99
414_R	673_E	0.560	0.99
471_Q	482_V	0.560	0.99
546_V	551_V	0.559	0.99
469_V	495_A	0.559	0.99
222_S	225_R	0.558	0.99
521_G	546_V	0.558	0.99
350_F	686_I	0.558	0.99
356_P	360_A	0.558	0.99
572_L	668_L	0.558	0.99
152_G	157_I	0.557	0.99
548_N	552_L	0.557	0.99
604_G	609_D	0.557	0.99
628_D	631_N	0.557	0.99
218_G	222_S	0.557	0.99
137_M	143_G	0.556	0.99
271_A	324_S	0.556	0.99
329_I	634_P	0.556	0.99
453_P	466_A	0.555	0.99
696_F	699_T	0.554	0.99
154_L	160_T	0.553	0.99
265_A	474_T	0.553	0.99
465_L	469_V	0.553	0.99
459_E	467_A	0.553	0.99
268_R	283_D	0.552	0.99
263_V	313_V	0.552	0.99
184_E	187_M	0.550	0.99
349_R	352_R	0.548	0.99
198_G	201_A	0.547	0.99
496_E	511_N	0.547	0.99
680_A	683_R	0.546	0.99
239_A	261_I	0.546	0.99
481_I	557_L	0.546	0.99
419_K	654_E	0.545	0.99
183_I	187_M	0.545	0.99
524_P	530_G	0.544	0.98
202_E	708_W	0.544	0.98
660_L	667_G	0.543	0.98
699_T	704_M	0.542	0.98
435_F	568_A	0.541	0.98
503_G	510_V	0.541	0.98
149_H	152_G	0.541	0.98
633_A	651_V	0.540	0.98
425_E	429_R	0.540	0.98
286_A	630_I	0.539	0.98
432_Q	623_L	0.539	0.98
416_A	671_M	0.539	0.98
134_L	137_M	0.539	0.98
151_F	159_T	0.538	0.98
133_T	212_I	0.538	0.98
150_P	154_L	0.538	0.98
339_R	422_A	0.537	0.98
558_Q	561_L	0.536	0.98
381_I	385_L	0.535	0.98
131_L	138_M	0.535	0.98
293_P	309_V	0.535	0.98
363_L	366_T	0.535	0.98
451_I	459_E	0.534	0.98
168_A	191_A	0.534	0.98
448_V	481_I	0.534	0.98
205_M	209_L	0.534	0.98
380_W	383_K	0.534	0.98
650_D	653_L	0.534	0.98
250_V	271_A	0.533	0.98
670_Q	673_E	0.533	0.98
170_Q	174_L	0.533	0.98
537_S	591_A	0.532	0.98
249_E	264_A	0.531	0.98
605_L	611_V	0.531	0.98
248_E	259_D	0.530	0.98
276_L	314_T	0.530	0.98
712_L	716_G	0.530	0.98
136_V	205_M	0.530	0.98
255_L	259_D	0.528	0.98
357_A	361_V	0.528	0.98
448_V	451_I	0.527	0.98
175_I	179_S	0.527	0.98
426_Q	641_I	0.526	0.98
319_S	325_A	0.525	0.98
195_L	198_G	0.525	0.98
451_I	553_G	0.525	0.98
464_T	467_A	0.525	0.98
681_N	728_L	0.524	0.98
522_K	527_A	0.523	0.98
374_A	379_E	0.523	0.98
202_E	206_V	0.521	0.98
312_L	498_Q	0.521	0.98
135_I	140_I	0.521	0.98
250_V	255_L	0.520	0.98
155_A	161_L	0.519	0.98
465_L	468_A	0.519	0.98
707_L	711_V	0.518	0.98
708_W	712_L	0.518	0.98
271_A	304_A	0.517	0.98
281_S	292_I	0.517	0.98
329_I	630_I	0.516	0.98
209_L	715_T	0.516	0.98
234_L	326_I	0.516	0.98
141_S	144_L	0.515	0.98
145_E	149_H	0.515	0.98
304_A	325_A	0.514	0.98
468_A	471_Q	0.513	0.98
205_M	708_W	0.513	0.98
402_A	722_T	0.512	0.98
196_F	200_T	0.512	0.98
446_P	557_L	0.512	0.98
456_G	550_D	0.512	0.98
357_A	360_A	0.511	0.98
558_Q	592_A	0.511	0.98
175_I	185_T	0.510	0.98
404_I	682_I	0.510	0.98
431_T	623_L	0.508	0.98
345_R	348_D	0.508	0.98
466_A	481_I	0.507	0.98
454_A	457_I	0.507	0.98
133_T	137_M	0.506	0.98
465_L	510_V	0.503	0.98
540_Q	558_Q	0.503	0.98
187_M	711_V	0.503	0.98
178_G	181_F	0.502	0.97
274_K	298_T	0.501	0.97
410_A	674_L	0.501	0.97
460_S	464_T	0.501	0.97
258_G	274_K	0.500	0.97

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
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HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4umwA	1	0.821	100	0.16	Contact Map
3j09A	2	0.9344	100	0.185	Contact Map
4bbjA	1	0.8374	100	0.199	Contact Map
3j08A	2	0.8347	100	0.261	Contact Map
1mhsA	2	0.9098	100	0.377	Contact Map
3b8cA	1	0.821	100	0.38	Contact Map
3ixzA	1	0.8429	100	0.402	Contact Map
2zxeA	1	0.8415	100	0.403	Contact Map
3ar4A	1	0.8279	100	0.414	Contact Map
3skxA	1	0.3525	100	0.762	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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