GREMLIN Database
TAUD - Alpha-ketoglutarate-dependent taurine dioxygenase
UniProt: P37610 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12423
Length: 283 (266)
Sequences: 2998 (1800)
Seq/√Len: 110.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
29_D63_R3.5661.00
61_A271_A3.4241.00
53_T56_Q3.3071.00
137_A234_F3.1201.00
136_E197_K3.0531.00
147_S198_Q2.9791.00
140_V143_R2.9751.00
185_L211_V2.9721.00
28_S31_Q2.8761.00
121_S264_Q2.8711.00
40_L194_V2.7681.00
17_Q48_R2.7611.00
132_I197_K2.6171.00
116_A119_L2.4391.00
125_D237_R2.4091.00
46_F246_A2.3681.00
238_W244_D2.3221.00
150_R185_L2.2211.00
37_H41_R2.1571.00
133_A137_A2.1061.00
46_F238_W2.0871.00
139_S142_F2.0841.00
103_T153_H2.0651.00
8_T17_Q2.0491.00
215_E219_E2.0381.00
39_V45_V2.0191.00
8_T19_S2.0131.00
140_V144_Q2.0021.00
62_Q81_E1.9731.00
43_Q132_I1.9531.00
32_F63_R1.9161.00
49_D241_Q1.9151.00
135_Y143_R1.9151.00
118_E265_R1.9151.00
152_E211_V1.9121.00
146_L225_L1.9121.00
113_I245_I1.8921.00
111_G273_I1.8801.00
36_Y110_A1.8701.00
191_T198_Q1.8581.00
151_A207_T1.8571.00
43_Q130_S1.8501.00
18_I45_V1.8371.00
36_Y194_V1.8251.00
48_R241_Q1.8081.00
135_Y147_S1.8001.00
16_A42_H1.7841.00
22_D25_R1.7711.00
152_E209_R1.7551.00
51_A243_N1.7371.00
219_E223_S1.7321.00
132_I199_A1.7021.00
223_S227_A1.7011.00
55_Q59_A1.7001.00
40_L195_S1.6871.00
116_A268_M1.6721.00
241_Q244_D1.6521.00
56_Q59_A1.6041.00
23_L50_Q1.5481.00
189_V200_L1.5481.00
6_S19_S1.5251.00
150_R211_V1.5071.00
54_P269_H1.5041.00
7_I38_A1.4601.00
16_A38_A1.4541.00
31_Q34_Q1.4471.00
134_A228_H1.4291.00
14_I130_S1.4171.00
238_W246_A1.3851.00
111_G247_I1.3821.00
135_Y198_Q1.3791.00
150_R212_D1.3771.00
192_H249_D1.3671.00
125_D239_R1.3531.00
58_R79_V1.3511.00
61_A113_I1.3331.00
6_S20_G1.3291.00
151_A188_V1.3261.00
132_I252_V1.3211.00
144_Q147_S1.3150.99
33_E37_H1.3020.99
188_V210_I1.3000.99
39_V111_G1.2920.99
127_L258_N1.2870.99
144_Q148_G1.2850.99
9_P42_H1.2830.99
49_D244_D1.2820.99
35_L47_L1.2800.99
55_Q79_V1.2720.99
145_L217_E1.2700.99
207_T226_F1.2340.99
134_A200_L1.2300.99
131_G229_I1.2270.99
152_E185_L1.2170.99
58_R81_E1.2080.99
204_E230_T1.2030.99
132_I136_E1.1970.99
47_L247_I1.1880.99
128_W253_T1.1530.99
142_F224_F1.1390.99
102_V206_F1.1350.98
127_L232_P1.1310.98
228_H234_F1.1290.98
21_A35_L1.1150.98
143_R147_S1.1090.98
7_I16_A1.1000.98
58_R62_Q1.0920.98
41_R197_K1.0890.98
146_L189_V1.0880.98
137_A233_E1.0860.98
38_A42_H1.0830.98
207_T222_L1.0800.98
97_N205_G1.0750.98
143_R198_Q1.0740.98
7_I18_I1.0690.98
59_A62_Q1.0620.98
100_T253_T1.0560.98
10_L46_F1.0520.97
46_F128_W1.0510.97
98_W129_T1.0510.97
190_R276_D1.0380.97
43_Q197_K1.0380.97
43_Q252_V1.0340.97
32_F64_F1.0330.97
141_P145_L1.0270.97
48_R244_D1.0210.97
66_E274_L1.0190.97
145_L224_F1.0100.97
55_Q78_G1.0090.97
9_P41_R1.0080.97
82_I271_A1.0070.97
110_A275_G1.0040.97
16_A45_V1.0030.97
60_L113_I1.0020.97
188_V202_V1.0000.97
128_W246_A0.9990.97
137_A228_H0.9970.97
29_D33_E0.9930.96
149_L221_L0.9920.96
131_G254_Q0.9900.96
136_E143_R0.9830.96
142_F221_L0.9830.96
222_L226_F0.9770.96
145_L213_V0.9700.96
145_L221_L0.9690.96
27_L32_F0.9560.96
48_R238_W0.9520.95
118_E242_P0.9490.95
210_I213_V0.9430.95
82_I269_H0.9420.95
133_A136_E0.9410.95
18_I47_L0.9410.95
64_F111_G0.9370.95
188_V207_T0.9310.95
209_R218_S0.9290.95
130_S133_A0.9290.95
59_A63_R0.9240.95
46_F236_V0.9170.94
57_Q113_I0.9160.94
43_Q253_T0.9100.94
210_I222_L0.9100.94
88_H265_R0.8980.94
36_Y40_L0.8940.94
54_P115_A0.8920.94
49_D243_N0.8800.93
13_Y133_A0.8790.93
85_L268_M0.8760.93
183_P209_R0.8690.93
127_L237_R0.8680.93
142_F145_L0.8670.93
30_N33_E0.8640.93
152_E183_P0.8640.93
106_E277_K0.8610.92
84_V269_H0.8570.92
131_G199_A0.8540.92
114_L240_W0.8490.92
23_L47_L0.8490.92
214_S218_S0.8430.92
13_Y130_S0.8430.92
189_V198_Q0.8370.91
129_T254_Q0.8330.91
44_V253_T0.8310.91
192_H195_S0.8290.91
8_T241_Q0.8260.91
125_D258_N0.8240.91
119_L242_P0.8240.91
135_Y189_V0.8230.91
209_R215_E0.8140.90
60_L247_I0.8130.90
136_E198_Q0.8110.90
202_V207_T0.8080.90
102_V109_P0.8070.90
141_P213_V0.8050.90
7_I45_V0.8040.90
57_Q61_A0.8010.89
60_L63_R0.7990.89
70_H102_V0.7990.89
9_P16_A0.7920.89
203_N207_T0.7910.89
127_L256_Y0.7860.88
153_H206_F0.7850.88
10_L17_Q0.7760.88
103_T201_F0.7740.88
203_N226_F0.7740.88
257_A261_Y0.7730.88
58_R67_L0.7710.88
57_Q115_A0.7690.87
227_A231_K0.7670.87
142_F146_L0.7660.87
202_V222_L0.7660.87
32_F36_Y0.7590.87
175_R179_A0.7530.86
154_D183_P0.7530.86
100_T103_T0.7520.86
134_A225_L0.7480.86
224_F228_H0.7460.86
96_D256_Y0.7460.86
57_Q271_A0.7400.85
86_D267_I0.7390.85
64_F247_I0.7350.85
67_L273_I0.7310.85
44_V128_W0.7300.85
37_H40_L0.7300.85
8_T239_R0.7290.84
39_V252_V0.7280.84
194_V251_R0.7240.84
145_L148_G0.7230.84
9_P122_T0.7200.84
70_H206_F0.7180.84
228_H231_K0.7130.83
139_S217_E0.7120.83
139_S224_F0.7110.83
129_T134_A0.7100.83
231_K234_F0.7100.83
40_L111_G0.7090.83
45_V246_A0.7040.82
220_A223_S0.7010.82
67_L271_A0.7000.82
190_R278_P0.6960.82
190_R251_R0.6950.82
33_E36_Y0.6940.81
100_T190_R0.6890.81
130_S197_K0.6880.81
115_A245_I0.6870.81
52_I243_N0.6840.80
192_H252_V0.6840.80
19_S49_D0.6840.80
19_S48_R0.6840.80
138_L143_R0.6800.80
68_H102_V0.6790.80
213_V217_E0.6780.80
29_D32_F0.6760.80
35_L45_V0.6720.79
13_Y137_A0.6690.79
22_D51_A0.6690.79
68_H105_I0.6680.79
145_L214_S0.6660.79
46_F244_D0.6660.79
109_P112_A0.6620.78
117_K269_H0.6610.78
190_R201_F0.6600.78
32_F247_I0.6540.77
10_L238_W0.6530.77
53_T59_A0.6500.77
118_E267_I0.6460.77
104_F109_P0.6460.77
275_G278_P0.6450.76
160_P163_K0.6440.76
73_Y83_I0.6430.76
216_K220_A0.6370.76
44_V236_V0.6370.76
221_L225_L0.6370.76
11_G236_V0.6370.76
129_T235_Q0.6360.75
39_V110_A0.6360.75
117_K267_I0.6350.75
108_P190_R0.6340.75
21_A31_Q0.6340.75
154_D208_T0.6340.75
174_W178_V0.6340.75
79_V82_I0.6340.75
225_L229_I0.6320.75
24_T245_I0.6300.75
191_T196_G0.6300.75
45_V111_G0.6300.75
141_P224_F0.6290.75
128_W248_W0.6270.74
61_A67_L0.6230.74
251_R276_D0.6220.74
55_Q58_R0.6210.74
146_L224_F0.6200.74
50_Q245_I0.6180.73
149_L188_V0.6130.73
86_D244_D0.6130.73
133_A234_F0.6120.73
176_E180_K0.6120.73
17_Q241_Q0.6110.73
202_V226_F0.6090.72
221_L224_F0.6080.72
52_I115_A0.6080.72
23_L245_I0.6060.72
210_I218_S0.6030.72
132_I195_S0.6020.71
149_L210_I0.6020.71
160_P164_Y0.6020.71
67_L81_E0.6010.71
83_I272_T0.6010.71
93_P259_A0.5990.71
11_G125_D0.5990.71
52_I56_Q0.5980.71
176_E179_A0.5970.71
210_I221_L0.5960.71
153_H203_N0.5940.70
62_Q66_E0.5930.70
109_P272_T0.5920.70
157_K208_T0.5920.70
65_G270_R0.5910.70
204_E254_Q0.5900.70
40_L43_Q0.5860.69
109_P251_R0.5850.69
144_Q223_S0.5840.69
12_P235_Q0.5820.69
28_S32_F0.5820.69
115_A243_N0.5820.69
96_D257_A0.5780.68
229_I254_Q0.5750.68
61_A272_T0.5740.68
22_D56_Q0.5730.68
68_H109_P0.5730.68
7_I34_Q0.5710.67
23_L49_D0.5700.67
134_A138_L0.5690.67
100_T201_F0.5670.67
84_V267_I0.5670.67
213_V221_L0.5650.67
52_I209_R0.5650.67
190_R199_A0.5650.67
54_P79_V0.5640.67
96_D259_A0.5620.66
173_R177_A0.5580.66
87_T92_P0.5570.66
34_Q37_H0.5520.65
95_N257_A0.5520.65
113_I273_I0.5500.65
113_I247_I0.5480.64
162_Y219_E0.5470.64
112_A272_T0.5460.64
149_L189_V0.5460.64
44_V246_A0.5460.64
98_W195_S0.5450.64
91_N263_P0.5440.64
174_W177_A0.5430.64
216_K227_A0.5420.63
57_Q245_I0.5410.63
154_D157_K0.5390.63
128_W238_W0.5380.63
84_V87_T0.5360.63
62_Q67_L0.5340.62
172_Q175_R0.5340.62
87_T91_N0.5330.62
24_T52_I0.5310.62
172_Q176_E0.5310.62
127_L235_Q0.5310.62
148_G210_I0.5300.62
24_T56_Q0.5300.62
110_A251_R0.5290.62
193_P251_R0.5290.62
14_I253_T0.5280.61
22_D28_S0.5280.61
87_T94_D0.5270.61
88_H91_N0.5260.61
12_P122_T0.5250.61
119_L268_M0.5250.61
147_S150_R0.5220.61
40_L251_R0.5220.61
40_L252_V0.5190.60
130_S252_V0.5180.60
9_P38_A0.5180.60
147_S189_V0.5180.60
54_P82_I0.5170.60
43_Q249_D0.5160.60
191_T224_F0.5160.60
58_R271_A0.5150.60
30_N34_Q0.5130.59
89_N92_P0.5100.59
94_D259_A0.5090.59
255_H266_R0.5090.59
28_S63_R0.5070.58
29_D140_V0.5060.58
217_E220_A0.5050.58
257_A260_D0.5040.58
142_F228_H0.5040.58
95_N203_N0.5040.58
94_D102_V0.5030.58
67_L83_I0.5020.58
227_A230_T0.5010.57
49_D242_P0.5010.57
206_F257_A0.5000.57
76_A80_D0.5000.57
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1otjA 2 0.9929 100 0.254 Contact Map
3pvjA 3 0.9753 100 0.27 Contact Map
1oihA 3 0.8693 100 0.287 Contact Map
4cvyA 2 0.8127 100 0.297 Contact Map
4j5iA 3 0.9399 100 0.3 Contact Map
4ylmX 5 0.8869 100 0.32 Contact Map
4oj8A 4 0.894 100 0.378 Contact Map
4c5wA 2 0.9258 100 0.448 Contact Map
2q4aA 2 0.9399 100 0.45 Contact Map
1ds1A 1 0.9152 100 0.472 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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