GREMLIN Database
NORW - Nitric oxide reductase FlRd-NAD(+) reductase
UniProt: P37596 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12450
Length: 377 (298)
Sequences: 47497 (33592)
Seq/√Len: 1946.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
145_L228_V4.1861.00
35_A80_W3.9501.00
143_R166_A3.4051.00
4_G29_P3.2911.00
168_T201_L3.2531.00
208_G219_T3.0231.00
166_A199_H3.0141.00
217_Q225_N2.9501.00
210_E219_T2.9141.00
258_D262_Q2.7331.00
4_G101_D2.6521.00
90_V97_Q2.6151.00
210_E217_Q2.5971.00
190_Q194_T2.4921.00
31_T76_F2.4771.00
89_R267_D2.4761.00
5_I21_I2.4641.00
17_L104_V2.4311.00
201_L224_R2.4191.00
250_T256_C2.3851.00
219_T225_N2.3711.00
143_R229_D2.3331.00
145_L170_I2.2861.00
112_F238_R2.2681.00
33_I98_W2.2081.00
117_P208_G2.1831.00
143_R168_T2.1561.00
145_L218_A2.0751.00
29_P74_H2.0751.00
4_G31_T2.0711.00
86_A265_N2.0441.00
6_V33_I2.0331.00
85_D88_A2.0151.00
172_N205_Q1.9991.00
207_Q219_T1.9881.00
6_V98_W1.9631.00
92_K97_Q1.9381.00
102_K267_D1.9231.00
100_Y103_L1.8711.00
269_Y298_N1.8581.00
217_Q227_E1.8471.00
168_T199_H1.8331.00
13_A271_L1.8301.00
211_K215_G1.8001.00
110_S240_E1.7891.00
210_E225_N1.7541.00
110_S242_A1.7451.00
121_L211_K1.7341.00
83_D92_K1.6911.00
110_S238_R1.6811.00
250_T264_S1.6751.00
204_S222_R1.6651.00
174_A203_K1.6441.00
142_R229_D1.6381.00
6_V31_T1.6291.00
55_R58_D1.6141.00
90_V99_Q1.5901.00
6_V100_Y1.5801.00
143_R227_E1.5791.00
205_Q221_D1.5781.00
6_V91_V1.5581.00
107_T274_C1.5421.00
76_F96_N1.5251.00
170_I226_I1.4881.00
102_K269_Y1.4821.00
104_V299_L1.4531.00
252_N276_E1.4481.00
220_L226_I1.4151.00
262_Q266_T1.4081.00
86_A268_I1.3991.00
201_L204_S1.3851.00
175_S186_S1.3841.00
104_V271_L1.3821.00
295_L299_L1.3651.00
10_S34_A1.3621.00
211_K216_I1.3511.00
102_K299_L1.3311.00
7_I18_V1.3311.00
204_S224_R1.3301.00
66_E70_Q1.3121.00
209_L231_V1.3081.00
143_R165_K1.3061.00
192_R195_E1.3051.00
144_V160_F1.3011.00
252_N256_C1.2931.00
296_A300_L1.2841.00
212_T215_G1.2821.00
149_G171_D1.2761.00
171_D202_L1.2721.00
204_S220_L1.2641.00
31_T98_W1.2541.00
207_Q221_D1.2471.00
255_V270_A1.2381.00
5_I104_V1.2361.00
59_L62_Q1.2321.00
154_S169_L1.2321.00
93_S98_W1.2241.00
259_S305_P1.2221.00
161_C166_A1.2141.00
257_V275_A1.1931.00
82_T92_K1.1891.00
18_V32_L1.1801.00
243_L246_R1.1791.00
106_A271_L1.1761.00
294_V298_N1.1761.00
144_V230_A1.1731.00
168_T228_V1.1671.00
141_A165_K1.1651.00
161_C198_V1.1651.00
5_I28_I1.1591.00
85_D90_V1.1571.00
115_P119_R1.1501.00
144_V165_K1.1501.00
33_I76_F1.1461.00
7_I14_A1.1461.00
20_N297_K1.1421.00
191_H195_E1.1361.00
8_I81_V1.1361.00
292_A296_A1.1341.00
212_T217_Q1.1281.00
83_D246_R1.1251.00
211_K214_S1.1191.00
124_T127_S1.1181.00
191_H194_T1.1111.00
242_A245_R1.1061.00
170_I220_L1.1061.00
93_S96_N1.1051.00
67_F71_F1.1021.00
192_R196_M1.0971.00
187_S190_Q1.0921.00
56_A60_T1.0881.00
257_V261_L1.0871.00
118_G121_L1.0821.00
8_I105_L1.0731.00
76_F98_W1.0671.00
20_N23_K1.0641.00
190_Q202_L1.0541.00
265_N268_I1.0521.00
66_E69_E1.0471.00
255_V274_C1.0421.00
22_R73_L1.0381.00
162_R196_M1.0321.00
188_R192_R1.0311.00
8_I107_T1.0301.00
257_V270_A1.0241.00
13_A288_I1.0211.00
183_P187_S1.0151.00
145_L226_I1.0111.00
24_Q297_K1.0071.00
55_R62_Q1.0061.00
204_S221_D1.0041.00
271_L295_L1.0001.00
262_Q298_N0.9961.00
20_N293_M0.9921.00
85_D92_K0.9901.00
147_V231_V0.9891.00
187_S191_H0.9881.00
61_R66_E0.9841.00
4_G99_Q0.9821.00
261_L275_A0.9791.00
157_A169_L0.9671.00
262_Q267_D0.9641.00
125_L129_Q0.9621.00
123_L137_Q0.9611.00
31_T74_H0.9581.00
220_L224_R0.9531.00
20_N24_Q0.9501.00
33_I81_V0.9491.00
83_D89_R0.9481.00
270_A274_C0.9431.00
123_L127_S0.9421.00
126_N129_Q0.9391.00
17_L271_L0.9301.00
122_M209_L0.9271.00
78_Q94_Q0.9161.00
111_A114_P0.9131.00
85_D89_R0.9121.00
56_A63_T0.9121.00
55_R59_L0.9111.00
61_R64_A0.8991.00
175_S183_P0.8951.00
37_S78_Q0.8871.00
17_L295_L0.8851.00
149_G176_I0.8841.00
260_Y305_P0.8841.00
24_Q300_L0.8831.00
18_V73_L0.8711.00
58_D62_Q0.8671.00
68_A71_F0.8671.00
5_I102_K0.8651.00
295_L298_N0.8611.00
118_G208_G0.8591.00
104_V295_L0.8571.00
190_Q200_L0.8531.00
201_L226_I0.8531.00
188_R191_H0.8511.00
86_A89_R0.8491.00
251_I256_C0.8491.00
176_I202_L0.8441.00
212_T227_E0.8441.00
21_I28_I0.8431.00
168_T226_I0.8401.00
64_A69_E0.8371.00
127_S130_E0.8351.00
103_L268_I0.8351.00
212_T216_I0.8351.00
261_L295_L0.8351.00
84_I103_L0.8321.00
109_A237_L0.8301.00
287_P291_S0.8291.00
81_V91_V0.8241.00
209_L218_A0.8171.00
124_T130_E0.8151.00
56_A62_Q0.8141.00
57_D61_R0.8131.00
293_M297_K0.8111.00
170_I201_L0.8101.00
88_A97_Q0.8081.00
50_I53_G0.8071.00
105_L274_C0.8061.00
4_G28_I0.8041.00
146_I157_A0.8031.00
263_T270_A0.7981.00
49_V53_G0.7961.00
170_I204_S0.7951.00
47_S50_I0.7941.00
161_C196_M0.7941.00
153_G171_D0.7931.00
284_F288_I0.7931.00
68_A73_L0.7921.00
123_L230_A0.7891.00
305_P308_L0.7891.00
47_S51_S0.7881.00
145_L231_V0.7881.00
10_S32_L0.7861.00
112_F115_P0.7781.00
7_I17_L0.7761.00
19_K23_K0.7761.00
33_I93_S0.7721.00
147_V233_A0.7711.00
147_V235_T0.7681.00
260_Y298_N0.7621.00
125_L131_Y0.7601.00
31_T100_Y0.7601.00
129_Q132_R0.7591.00
199_H224_R0.7591.00
228_V231_V0.7591.00
45_D48_H0.7561.00
14_A18_V0.7541.00
45_D49_V0.7491.00
14_A106_A0.7451.00
248_G251_I0.7431.00
60_T63_T0.7421.00
269_Y295_L0.7391.00
127_S131_Y0.7371.00
21_I30_L0.7321.00
19_K71_F0.7261.00
175_S190_Q0.7261.00
90_V93_S0.7231.00
21_I296_A0.7221.00
129_Q133_A0.7201.00
256_C264_S0.7151.00
60_T64_A0.7141.00
22_R30_L0.7141.00
49_V54_Q0.7131.00
206_L218_A0.7121.00
171_D178_A0.7081.00
201_L220_L0.7061.00
262_Q269_Y0.7031.00
270_A275_A0.7031.00
38_M64_A0.7001.00
107_T243_L0.6981.00
217_Q220_L0.6971.00
158_M162_R0.6971.00
83_D86_A0.6951.00
157_A198_V0.6951.00
177_L180_L0.6941.00
113_V124_T0.6931.00
117_P121_L0.6921.00
269_Y299_L0.6921.00
261_L294_V0.6901.00
216_I219_T0.6871.00
123_L128_Q0.6841.00
297_K302_N0.6811.00
46_L49_V0.6801.00
147_V206_L0.6791.00
297_K301_G0.6741.00
114_P233_A0.6741.00
17_L292_A0.6741.00
125_L130_E0.6721.00
123_L131_Y0.6711.00
189_L193_L0.6701.00
193_L200_L0.6701.00
142_R166_A0.6701.00
55_R63_T0.6681.00
113_V120_E0.6671.00
247_A251_I0.6661.00
143_R228_V0.6651.00
92_K95_N0.6621.00
164_G167_V0.6611.00
284_F291_S0.6591.00
116_V119_R0.6591.00
58_D61_R0.6581.00
169_L200_L0.6581.00
29_P101_D0.6571.00
209_L216_I0.6571.00
48_H53_G0.6571.00
124_T129_Q0.6561.00
130_E133_A0.6501.00
56_A59_L0.6491.00
48_H51_S0.6471.00
28_I101_D0.6401.00
47_S52_Q0.6401.00
55_R60_T0.6381.00
215_G227_E0.6381.00
146_I153_G0.6371.00
4_G98_W0.6371.00
242_A246_R0.6361.00
25_D28_I0.6361.00
290_L293_M0.6341.00
194_T199_H0.6341.00
59_L63_T0.6341.00
301_G304_T0.6311.00
140_D165_K0.6301.00
241_T251_I0.6291.00
154_S193_L0.6261.00
10_S39_D0.6251.00
241_T274_C0.6241.00
245_R251_I0.6221.00
49_V52_Q0.6201.00
18_V30_L0.6201.00
133_A136_T0.6181.00
34_A75_L0.6171.00
21_I299_L0.6151.00
253_R276_E0.6141.00
174_A183_P0.6131.00
298_N302_N0.6121.00
175_S178_A0.6111.00
158_M196_M0.6101.00
62_Q66_E0.6101.00
249_L255_V0.6091.00
16_Q20_N0.6091.00
156_L159_D0.6071.00
186_S190_Q0.6031.00
173_A178_A0.6031.00
16_Q289_Q0.6031.00
243_L247_A0.6031.00
119_R233_A0.6021.00
131_Y134_C0.6011.00
284_F287_P0.5991.00
7_I106_A0.5981.00
89_R93_S0.5971.00
117_P120_E0.5971.00
7_I30_L0.5961.00
113_V233_A0.5961.00
176_I200_L0.5951.00
258_D261_L0.5941.00
262_Q265_N0.5941.00
67_F72_N0.5931.00
150_G236_G0.5931.00
13_A106_A0.5921.00
157_A167_V0.5911.00
244_A247_A0.5901.00
16_Q292_A0.5901.00
288_I292_A0.5881.00
34_A77_P0.5881.00
171_D174_A0.5861.00
112_F235_T0.5831.00
286_Q290_L0.5791.00
131_Y135_E0.5741.00
285_L288_I0.5721.00
142_R165_K0.5721.00
171_D200_L0.5721.00
249_L265_N0.5721.00
83_D87_E0.5701.00
28_I299_L0.5701.00
247_A265_N0.5691.00
105_L268_I0.5681.00
145_L168_T0.5681.00
28_I300_L0.5661.00
37_S77_P0.5651.00
51_S54_Q0.5651.00
45_D50_I0.5631.00
126_N130_E0.5621.00
306_L309_P0.5621.00
32_L75_L0.5621.00
33_I100_Y0.5601.00
74_H77_P0.5581.00
251_I255_V0.5571.00
294_V306_L0.5571.00
105_L243_L0.5551.00
22_R72_N0.5541.00
189_L192_R0.5521.00
100_Y267_D0.5501.00
39_D75_L0.5481.00
6_V103_L0.5481.00
47_S54_Q0.5481.00
45_D53_G0.5471.00
273_D288_I0.5461.00
207_Q223_Q0.5451.00
144_V232_I0.5451.00
161_C197_G0.5441.00
5_I299_L0.5431.00
86_A100_Y0.5411.00
57_D60_T0.5401.00
116_V209_L0.5401.00
176_I186_S0.5371.00
154_S200_L0.5361.00
111_A115_P0.5351.00
175_S187_S0.5321.00
87_E90_V0.5311.00
156_L232_I0.5291.00
122_M129_Q0.5271.00
103_L267_D0.5271.00
4_G100_Y0.5261.00
113_V119_R0.5251.00
122_M231_V0.5241.00
32_L73_L0.5231.00
16_Q19_K0.5231.00
289_Q293_M0.5231.00
41_Y44_P0.5221.00
215_G231_V0.5221.00
139_R142_R0.5211.00
199_H202_L0.5211.00
132_R135_E0.5211.00
114_P119_R0.5201.00
290_L294_V0.5191.00
68_A75_L0.5191.00
283_P287_P0.5181.00
82_T85_D0.5181.00
125_L128_Q0.5181.00
176_I190_Q0.5161.00
7_I32_L0.5151.00
85_D97_Q0.5151.00
50_I54_Q0.5151.00
193_L198_V0.5141.00
81_V93_S0.5121.00
84_I243_L0.5101.00
125_L134_C0.5071.00
248_G265_N0.5061.00
48_H52_Q0.5061.00
288_I291_S0.5041.00
153_G234_A0.5041.00
83_D88_A0.5031.00
102_K303_N0.5021.00
175_S179_S0.5021.00
220_L225_N0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3kljA 1 0.9496 100 0.257 Contact Map
1q1rA 1 0.9947 100 0.261 Contact Map
2v3aA 1 0.9947 100 0.267 Contact Map
3iwaA 2 0.8912 100 0.273 Contact Map
1xhcA 1 0.9151 100 0.276 Contact Map
3icsA 2 0.9894 100 0.276 Contact Map
3lxdA 1 0.9947 100 0.278 Contact Map
3ntdA 2 0.992 100 0.279 Contact Map
3fg2P 1 0.9894 100 0.279 Contact Map
3oc4A 2 0.9363 100 0.28 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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