NORW - ECOLI - GREMLIN Contacts

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NORW - Nitric oxide reductase FlRd-NAD(+) reductase

UniProt:	P37596	Sequences: MSNGIVIIGSGFAARQLVKNIRKQDATIPLTLIAADSMDEYNKPDLSHVISQGQRADDLTRQTAGEFAEQFNLHLFPQTWVTDIDAEARVVKSQNNQWQYDKLVLATGASAFVPPVPGRELMLTLNSQQEYRACETQLRDARRVLIVGGGLIGSELAMDFCRAGKAVTLIDNAASILASLMPPEVSSRLQHRLTEMGVHLLLKSQLQGLEKTDSGIQATLDRQRNIEVDAVIAATGLRPETALARRAGLTINRGVCVDSYLQTSNTDIYALGDCAEINGQVLPFLQPIQLSAMVLAKNLLGNNTPLKLPAMLVKIKTPELPLHLAGETQRQDLRWQINTERQGMVARGVDDADQLRAFVVSEDRMKEAFGLLKTLPM	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG12450
Length:	377 (298)
Sequences:	47497 (33592)
Seq/√Len:	1946.0

ECOLI - NORW HCAD NIRB STHA RCLA DLDH GSHR DHNA TRXB PRET AHPF GLTD YGFT
BACSU - NASB NASD DLDH1 DLDH3 DLDH2 YJLD YUMB YUTJ FENR2 DHNA YPDA FENR1 TRXB CZCO GLTB
HALSA - Q9HP48 DLDH Q9HSN0 Q9HR27 P82854
SULSO - Q97YT2 Q97XZ3 Q97WE3 Q97VD9 Q97Z19 Q97Y24 Q97VQ4 Q97VJ3 Q97WG1 Q97W27 Q97V69 FENR Q97U72 Q97ZB4 Q97UP4 Q97Z14 Q97UV0 Q980U1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
145_L	228_V	4.186	1.00
35_A	80_W	3.950	1.00
143_R	166_A	3.405	1.00
4_G	29_P	3.291	1.00
168_T	201_L	3.253	1.00
208_G	219_T	3.023	1.00
166_A	199_H	3.014	1.00
217_Q	225_N	2.950	1.00
210_E	219_T	2.914	1.00
258_D	262_Q	2.733	1.00
4_G	101_D	2.652	1.00
90_V	97_Q	2.615	1.00
210_E	217_Q	2.597	1.00
190_Q	194_T	2.492	1.00
31_T	76_F	2.477	1.00
89_R	267_D	2.476	1.00
5_I	21_I	2.464	1.00
17_L	104_V	2.431	1.00
201_L	224_R	2.419	1.00
250_T	256_C	2.385	1.00
219_T	225_N	2.371	1.00
143_R	229_D	2.333	1.00
145_L	170_I	2.286	1.00
112_F	238_R	2.268	1.00
33_I	98_W	2.208	1.00
117_P	208_G	2.183	1.00
143_R	168_T	2.156	1.00
145_L	218_A	2.075	1.00
29_P	74_H	2.075	1.00
4_G	31_T	2.071	1.00
86_A	265_N	2.044	1.00
6_V	33_I	2.033	1.00
85_D	88_A	2.015	1.00
172_N	205_Q	1.999	1.00
207_Q	219_T	1.988	1.00
6_V	98_W	1.963	1.00
92_K	97_Q	1.938	1.00
102_K	267_D	1.923	1.00
100_Y	103_L	1.871	1.00
269_Y	298_N	1.858	1.00
217_Q	227_E	1.847	1.00
168_T	199_H	1.833	1.00
13_A	271_L	1.830	1.00
211_K	215_G	1.800	1.00
110_S	240_E	1.789	1.00
210_E	225_N	1.754	1.00
110_S	242_A	1.745	1.00
121_L	211_K	1.734	1.00
83_D	92_K	1.691	1.00
110_S	238_R	1.681	1.00
250_T	264_S	1.675	1.00
204_S	222_R	1.665	1.00
174_A	203_K	1.644	1.00
142_R	229_D	1.638	1.00
6_V	31_T	1.629	1.00
55_R	58_D	1.614	1.00
90_V	99_Q	1.590	1.00
6_V	100_Y	1.580	1.00
143_R	227_E	1.579	1.00
205_Q	221_D	1.578	1.00
6_V	91_V	1.558	1.00
107_T	274_C	1.542	1.00
76_F	96_N	1.525	1.00
170_I	226_I	1.488	1.00
102_K	269_Y	1.482	1.00
104_V	299_L	1.453	1.00
252_N	276_E	1.448	1.00
220_L	226_I	1.415	1.00
262_Q	266_T	1.408	1.00
86_A	268_I	1.399	1.00
201_L	204_S	1.385	1.00
175_S	186_S	1.384	1.00
104_V	271_L	1.382	1.00
295_L	299_L	1.365	1.00
10_S	34_A	1.362	1.00
211_K	216_I	1.351	1.00
102_K	299_L	1.331	1.00
7_I	18_V	1.331	1.00
204_S	224_R	1.330	1.00
66_E	70_Q	1.312	1.00
209_L	231_V	1.308	1.00
143_R	165_K	1.306	1.00
192_R	195_E	1.305	1.00
144_V	160_F	1.301	1.00
252_N	256_C	1.293	1.00
296_A	300_L	1.284	1.00
212_T	215_G	1.282	1.00
149_G	171_D	1.276	1.00
171_D	202_L	1.272	1.00
204_S	220_L	1.264	1.00
31_T	98_W	1.254	1.00
207_Q	221_D	1.247	1.00
255_V	270_A	1.238	1.00
5_I	104_V	1.236	1.00
59_L	62_Q	1.232	1.00
154_S	169_L	1.232	1.00
93_S	98_W	1.224	1.00
259_S	305_P	1.222	1.00
161_C	166_A	1.214	1.00
257_V	275_A	1.193	1.00
82_T	92_K	1.189	1.00
18_V	32_L	1.180	1.00
243_L	246_R	1.179	1.00
106_A	271_L	1.176	1.00
294_V	298_N	1.176	1.00
144_V	230_A	1.173	1.00
168_T	228_V	1.167	1.00
141_A	165_K	1.165	1.00
161_C	198_V	1.165	1.00
5_I	28_I	1.159	1.00
85_D	90_V	1.157	1.00
115_P	119_R	1.150	1.00
144_V	165_K	1.150	1.00
33_I	76_F	1.146	1.00
7_I	14_A	1.146	1.00
20_N	297_K	1.142	1.00
191_H	195_E	1.136	1.00
8_I	81_V	1.136	1.00
292_A	296_A	1.134	1.00
212_T	217_Q	1.128	1.00
83_D	246_R	1.125	1.00
211_K	214_S	1.119	1.00
124_T	127_S	1.118	1.00
191_H	194_T	1.111	1.00
242_A	245_R	1.106	1.00
170_I	220_L	1.106	1.00
93_S	96_N	1.105	1.00
67_F	71_F	1.102	1.00
192_R	196_M	1.097	1.00
187_S	190_Q	1.092	1.00
56_A	60_T	1.088	1.00
257_V	261_L	1.087	1.00
118_G	121_L	1.082	1.00
8_I	105_L	1.073	1.00
76_F	98_W	1.067	1.00
20_N	23_K	1.064	1.00
190_Q	202_L	1.054	1.00
265_N	268_I	1.052	1.00
66_E	69_E	1.047	1.00
255_V	274_C	1.042	1.00
22_R	73_L	1.038	1.00
162_R	196_M	1.032	1.00
188_R	192_R	1.031	1.00
8_I	107_T	1.030	1.00
257_V	270_A	1.024	1.00
13_A	288_I	1.021	1.00
183_P	187_S	1.015	1.00
145_L	226_I	1.011	1.00
24_Q	297_K	1.007	1.00
55_R	62_Q	1.006	1.00
204_S	221_D	1.004	1.00
271_L	295_L	1.000	1.00
262_Q	298_N	0.996	1.00
20_N	293_M	0.992	1.00
85_D	92_K	0.990	1.00
147_V	231_V	0.989	1.00
187_S	191_H	0.988	1.00
61_R	66_E	0.984	1.00
4_G	99_Q	0.982	1.00
261_L	275_A	0.979	1.00
157_A	169_L	0.967	1.00
262_Q	267_D	0.964	1.00
125_L	129_Q	0.962	1.00
123_L	137_Q	0.961	1.00
31_T	74_H	0.958	1.00
220_L	224_R	0.953	1.00
20_N	24_Q	0.950	1.00
33_I	81_V	0.949	1.00
83_D	89_R	0.948	1.00
270_A	274_C	0.943	1.00
123_L	127_S	0.942	1.00
126_N	129_Q	0.939	1.00
17_L	271_L	0.930	1.00
122_M	209_L	0.927	1.00
78_Q	94_Q	0.916	1.00
111_A	114_P	0.913	1.00
85_D	89_R	0.912	1.00
56_A	63_T	0.912	1.00
55_R	59_L	0.911	1.00
61_R	64_A	0.899	1.00
175_S	183_P	0.895	1.00
37_S	78_Q	0.887	1.00
17_L	295_L	0.885	1.00
149_G	176_I	0.884	1.00
260_Y	305_P	0.884	1.00
24_Q	300_L	0.883	1.00
18_V	73_L	0.871	1.00
58_D	62_Q	0.867	1.00
68_A	71_F	0.867	1.00
5_I	102_K	0.865	1.00
295_L	298_N	0.861	1.00
118_G	208_G	0.859	1.00
104_V	295_L	0.857	1.00
190_Q	200_L	0.853	1.00
201_L	226_I	0.853	1.00
188_R	191_H	0.851	1.00
86_A	89_R	0.849	1.00
251_I	256_C	0.849	1.00
176_I	202_L	0.844	1.00
212_T	227_E	0.844	1.00
21_I	28_I	0.843	1.00
168_T	226_I	0.840	1.00
64_A	69_E	0.837	1.00
127_S	130_E	0.835	1.00
103_L	268_I	0.835	1.00
212_T	216_I	0.835	1.00
261_L	295_L	0.835	1.00
84_I	103_L	0.832	1.00
109_A	237_L	0.830	1.00
287_P	291_S	0.829	1.00
81_V	91_V	0.824	1.00
209_L	218_A	0.817	1.00
124_T	130_E	0.815	1.00
56_A	62_Q	0.814	1.00
57_D	61_R	0.813	1.00
293_M	297_K	0.811	1.00
170_I	201_L	0.810	1.00
88_A	97_Q	0.808	1.00
50_I	53_G	0.807	1.00
105_L	274_C	0.806	1.00
4_G	28_I	0.804	1.00
146_I	157_A	0.803	1.00
263_T	270_A	0.798	1.00
49_V	53_G	0.796	1.00
170_I	204_S	0.795	1.00
47_S	50_I	0.794	1.00
161_C	196_M	0.794	1.00
153_G	171_D	0.793	1.00
284_F	288_I	0.793	1.00
68_A	73_L	0.792	1.00
123_L	230_A	0.789	1.00
305_P	308_L	0.789	1.00
47_S	51_S	0.788	1.00
145_L	231_V	0.788	1.00
10_S	32_L	0.786	1.00
112_F	115_P	0.778	1.00
7_I	17_L	0.776	1.00
19_K	23_K	0.776	1.00
33_I	93_S	0.772	1.00
147_V	233_A	0.771	1.00
147_V	235_T	0.768	1.00
260_Y	298_N	0.762	1.00
125_L	131_Y	0.760	1.00
31_T	100_Y	0.760	1.00
129_Q	132_R	0.759	1.00
199_H	224_R	0.759	1.00
228_V	231_V	0.759	1.00
45_D	48_H	0.756	1.00
14_A	18_V	0.754	1.00
45_D	49_V	0.749	1.00
14_A	106_A	0.745	1.00
248_G	251_I	0.743	1.00
60_T	63_T	0.742	1.00
269_Y	295_L	0.739	1.00
127_S	131_Y	0.737	1.00
21_I	30_L	0.732	1.00
19_K	71_F	0.726	1.00
175_S	190_Q	0.726	1.00
90_V	93_S	0.723	1.00
21_I	296_A	0.722	1.00
129_Q	133_A	0.720	1.00
256_C	264_S	0.715	1.00
60_T	64_A	0.714	1.00
22_R	30_L	0.714	1.00
49_V	54_Q	0.713	1.00
206_L	218_A	0.712	1.00
171_D	178_A	0.708	1.00
201_L	220_L	0.706	1.00
262_Q	269_Y	0.703	1.00
270_A	275_A	0.703	1.00
38_M	64_A	0.700	1.00
107_T	243_L	0.698	1.00
217_Q	220_L	0.697	1.00
158_M	162_R	0.697	1.00
83_D	86_A	0.695	1.00
157_A	198_V	0.695	1.00
177_L	180_L	0.694	1.00
113_V	124_T	0.693	1.00
117_P	121_L	0.692	1.00
269_Y	299_L	0.692	1.00
261_L	294_V	0.690	1.00
216_I	219_T	0.687	1.00
123_L	128_Q	0.684	1.00
297_K	302_N	0.681	1.00
46_L	49_V	0.680	1.00
147_V	206_L	0.679	1.00
297_K	301_G	0.674	1.00
114_P	233_A	0.674	1.00
17_L	292_A	0.674	1.00
125_L	130_E	0.672	1.00
123_L	131_Y	0.671	1.00
189_L	193_L	0.670	1.00
193_L	200_L	0.670	1.00
142_R	166_A	0.670	1.00
55_R	63_T	0.668	1.00
113_V	120_E	0.667	1.00
247_A	251_I	0.666	1.00
143_R	228_V	0.665	1.00
92_K	95_N	0.662	1.00
164_G	167_V	0.661	1.00
284_F	291_S	0.659	1.00
116_V	119_R	0.659	1.00
58_D	61_R	0.658	1.00
169_L	200_L	0.658	1.00
29_P	101_D	0.657	1.00
209_L	216_I	0.657	1.00
48_H	53_G	0.657	1.00
124_T	129_Q	0.656	1.00
130_E	133_A	0.650	1.00
56_A	59_L	0.649	1.00
48_H	51_S	0.647	1.00
28_I	101_D	0.640	1.00
47_S	52_Q	0.640	1.00
55_R	60_T	0.638	1.00
215_G	227_E	0.638	1.00
146_I	153_G	0.637	1.00
4_G	98_W	0.637	1.00
242_A	246_R	0.636	1.00
25_D	28_I	0.636	1.00
290_L	293_M	0.634	1.00
194_T	199_H	0.634	1.00
59_L	63_T	0.634	1.00
301_G	304_T	0.631	1.00
140_D	165_K	0.630	1.00
241_T	251_I	0.629	1.00
154_S	193_L	0.626	1.00
10_S	39_D	0.625	1.00
241_T	274_C	0.624	1.00
245_R	251_I	0.622	1.00
49_V	52_Q	0.620	1.00
18_V	30_L	0.620	1.00
133_A	136_T	0.618	1.00
34_A	75_L	0.617	1.00
21_I	299_L	0.615	1.00
253_R	276_E	0.614	1.00
174_A	183_P	0.613	1.00
298_N	302_N	0.612	1.00
175_S	178_A	0.611	1.00
158_M	196_M	0.610	1.00
62_Q	66_E	0.610	1.00
249_L	255_V	0.609	1.00
16_Q	20_N	0.609	1.00
156_L	159_D	0.607	1.00
186_S	190_Q	0.603	1.00
173_A	178_A	0.603	1.00
16_Q	289_Q	0.603	1.00
243_L	247_A	0.603	1.00
119_R	233_A	0.602	1.00
131_Y	134_C	0.601	1.00
284_F	287_P	0.599	1.00
7_I	106_A	0.598	1.00
89_R	93_S	0.597	1.00
117_P	120_E	0.597	1.00
7_I	30_L	0.596	1.00
113_V	233_A	0.596	1.00
176_I	200_L	0.595	1.00
258_D	261_L	0.594	1.00
262_Q	265_N	0.594	1.00
67_F	72_N	0.593	1.00
150_G	236_G	0.593	1.00
13_A	106_A	0.592	1.00
157_A	167_V	0.591	1.00
244_A	247_A	0.590	1.00
16_Q	292_A	0.590	1.00
288_I	292_A	0.588	1.00
34_A	77_P	0.588	1.00
171_D	174_A	0.586	1.00
112_F	235_T	0.583	1.00
286_Q	290_L	0.579	1.00
131_Y	135_E	0.574	1.00
285_L	288_I	0.572	1.00
142_R	165_K	0.572	1.00
171_D	200_L	0.572	1.00
249_L	265_N	0.572	1.00
83_D	87_E	0.570	1.00
28_I	299_L	0.570	1.00
247_A	265_N	0.569	1.00
105_L	268_I	0.568	1.00
145_L	168_T	0.568	1.00
28_I	300_L	0.566	1.00
37_S	77_P	0.565	1.00
51_S	54_Q	0.565	1.00
45_D	50_I	0.563	1.00
126_N	130_E	0.562	1.00
306_L	309_P	0.562	1.00
32_L	75_L	0.562	1.00
33_I	100_Y	0.560	1.00
74_H	77_P	0.558	1.00
251_I	255_V	0.557	1.00
294_V	306_L	0.557	1.00
105_L	243_L	0.555	1.00
22_R	72_N	0.554	1.00
189_L	192_R	0.552	1.00
100_Y	267_D	0.550	1.00
39_D	75_L	0.548	1.00
6_V	103_L	0.548	1.00
47_S	54_Q	0.548	1.00
45_D	53_G	0.547	1.00
273_D	288_I	0.546	1.00
207_Q	223_Q	0.545	1.00
144_V	232_I	0.545	1.00
161_C	197_G	0.544	1.00
5_I	299_L	0.543	1.00
86_A	100_Y	0.541	1.00
57_D	60_T	0.540	1.00
116_V	209_L	0.540	1.00
176_I	186_S	0.537	1.00
154_S	200_L	0.536	1.00
111_A	115_P	0.535	1.00
175_S	187_S	0.532	1.00
87_E	90_V	0.531	1.00
156_L	232_I	0.529	1.00
122_M	129_Q	0.527	1.00
103_L	267_D	0.527	1.00
4_G	100_Y	0.526	1.00
113_V	119_R	0.525	1.00
122_M	231_V	0.524	1.00
32_L	73_L	0.523	1.00
16_Q	19_K	0.523	1.00
289_Q	293_M	0.523	1.00
41_Y	44_P	0.522	1.00
215_G	231_V	0.522	1.00
139_R	142_R	0.521	1.00
199_H	202_L	0.521	1.00
132_R	135_E	0.521	1.00
114_P	119_R	0.520	1.00
290_L	294_V	0.519	1.00
68_A	75_L	0.519	1.00
283_P	287_P	0.518	1.00
82_T	85_D	0.518	1.00
125_L	128_Q	0.518	1.00
176_I	190_Q	0.516	1.00
7_I	32_L	0.515	1.00
85_D	97_Q	0.515	1.00
50_I	54_Q	0.515	1.00
193_L	198_V	0.514	1.00
81_V	93_S	0.512	1.00
84_I	243_L	0.510	1.00
125_L	134_C	0.507	1.00
248_G	265_N	0.506	1.00
48_H	52_Q	0.506	1.00
288_I	291_S	0.504	1.00
153_G	234_A	0.504	1.00
83_D	88_A	0.503	1.00
102_K	303_N	0.502	1.00
175_S	179_S	0.502	1.00
220_L	225_N	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3kljA	1	0.9496	100	0.257	Contact Map
1q1rA	1	0.9947	100	0.261	Contact Map
2v3aA	1	0.9947	100	0.267	Contact Map
3iwaA	2	0.8912	100	0.273	Contact Map
1xhcA	1	0.9151	100	0.276	Contact Map
3icsA	2	0.9894	100	0.276	Contact Map
3lxdA	1	0.9947	100	0.278	Contact Map
3ntdA	2	0.992	100	0.279	Contact Map
3fg2P	1	0.9894	100	0.279	Contact Map
3oc4A	2	0.9363	100	0.28	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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