GREMLIN Database
IAAA - Isoaspartyl peptidase
UniProt: P37595 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12407
Length: 321 (286)
Sequences: 2106 (1288)
Seq/√Len: 76.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
42_M47_E4.6481.00
54_T108_L4.4801.00
281_D285_N4.4751.00
57_V194_A4.3241.00
147_S151_E3.8551.00
190_N222_N3.8541.00
191_L226_A3.6671.00
58_R108_L3.4711.00
62_E105_N3.3981.00
107_V194_A3.2871.00
100_V109_A3.0331.00
72_A82_L2.9691.00
245_I277_L2.9691.00
98_A123_I2.6491.00
123_I208_V2.6371.00
51_D111_R2.6351.00
111_R115_E2.6251.00
257_A261_E2.5901.00
255_S258_E2.5091.00
248_L254_L2.4591.00
31_A63_C2.3691.00
36_V298_A2.3231.00
79_T101_S2.2871.00
240_L243_Y2.2841.00
74_F145_S2.2381.00
122_M130_F2.1541.00
86_V107_V2.1461.00
74_F80_H2.1101.00
75_T79_T2.1051.00
54_T111_R2.0061.00
53_V184_A1.9961.00
96_A121_M1.9841.00
75_T81_E1.9501.00
261_E265_M1.9361.00
254_L262_R1.9201.00
150_Y154_L1.8651.00
88_D91_T1.8201.00
112_L116_Q1.7241.00
80_H145_S1.7031.00
109_A136_M1.6911.00
195_T228_S1.6841.00
26_L30_E1.6801.00
227_V279_A1.6761.00
94_A120_V1.6631.00
54_T86_V1.6621.00
185_L280_I1.6021.00
28_Y65_L1.5981.00
77_D129_N1.5880.99
244_D247_A1.5820.99
92_L219_Y1.5770.99
132_F138_R1.5590.99
248_L262_R1.5550.99
94_A214_V1.5510.99
264_V291_N1.5410.99
130_F134_R1.5380.99
102_H138_R1.5370.99
241_A263_V1.5360.99
125_E129_N1.5320.99
260_C279_A1.5280.99
47_E52_V1.5130.99
52_V56_A1.5050.99
99_G123_I1.4980.99
145_S150_Y1.4910.99
85_C218_C1.4890.99
221_N250_D1.4640.99
236_F275_G1.4580.99
256_L279_A1.4510.99
102_H141_P1.4320.99
213_L216_A1.4290.99
301_Y304_D1.4200.99
25_E29_I1.4090.99
62_E104_R1.3900.99
191_L220_A1.3680.98
90_N222_N1.3590.98
6_I36_V1.3520.98
38_T59_L1.3450.98
56_A182_A1.3330.98
57_V180_V1.3290.98
185_L191_L1.3280.98
200_M232_T1.3100.98
88_D93_K1.3070.98
54_T58_R1.3050.98
121_M213_L1.3040.98
42_M52_V1.2850.98
98_A208_V1.2840.98
35_I59_L1.2830.98
34_A63_C1.2800.98
112_L134_R1.2760.98
53_V194_A1.2740.98
103_L109_A1.2720.97
227_V242_A1.2660.97
102_H128_E1.2630.97
153_L157_R1.2620.97
244_D251_Y1.2600.97
243_Y247_A1.2550.97
213_L237_I1.2510.97
57_V107_V1.2340.97
286_V299_W1.2250.97
225_V246_A1.1810.96
117_S204_L1.1810.96
81_E101_S1.1800.96
228_S278_I1.1750.96
38_T41_K1.1620.96
108_L111_R1.1550.96
274_S292_T1.1500.95
98_A121_M1.1410.95
88_D190_N1.1330.95
41_K45_A1.1130.95
147_S150_Y1.1080.94
127_A131_A1.1060.94
49_A192_A1.0940.94
103_L131_A1.0930.94
236_F241_A1.0920.94
33_S37_E1.0740.93
40_Q44_E1.0680.93
193_A218_C1.0630.93
105_N108_L1.0600.93
112_L136_M1.0510.93
103_L128_E1.0480.93
113_V117_S1.0450.92
116_Q134_R1.0440.92
149_R152_Q1.0400.92
248_L267_K1.0400.92
74_F150_Y1.0390.92
224_S246_A1.0390.92
90_N190_N1.0380.92
38_T56_A1.0380.92
58_R105_N1.0290.92
62_E143_I1.0210.92
117_S130_F1.0140.91
39_G56_A1.0130.91
229_C277_L1.0120.91
47_E51_D1.0110.91
49_A184_A1.0030.91
247_A250_D0.9990.91
225_V249_M0.9930.90
6_I300_G0.9890.90
35_I55_E0.9880.90
183_V226_A0.9860.90
146_T149_R0.9810.90
104_R143_I0.9780.90
55_E58_R0.9730.90
70_I143_I0.9730.90
245_I279_A0.9680.89
103_L138_R0.9610.89
31_A34_A0.9600.89
54_T115_E0.9470.88
41_K44_E0.9440.88
35_I39_G0.9440.88
249_M279_A0.9400.88
154_L157_R0.9400.88
230_T295_M0.9320.87
37_E300_G0.9310.87
181_G228_S0.9270.87
40_Q300_G0.9270.87
7_A226_A0.9220.87
183_V228_S0.9200.87
5_V185_L0.9180.87
244_D248_L0.9170.87
76_R157_R0.9140.86
262_R266_E0.9100.86
31_A35_I0.9050.86
76_R205_P0.9050.86
254_L258_E0.9030.86
50_L86_V0.8980.85
82_L100_V0.8970.85
38_T55_E0.8970.85
67_N73_V0.8940.85
209_G212_P0.8830.84
82_L139_V0.8830.84
229_C242_A0.8820.84
60_L68_A0.8810.84
114_M117_S0.8610.83
95_G113_V0.8610.83
42_M45_A0.8500.82
64_P146_T0.8490.82
239_A271_L0.8450.82
144_F147_S0.8390.81
186_D190_N0.8380.81
290_F297_R0.8300.81
53_V192_A0.8300.81
197_T210_D0.8290.80
120_V234_E0.8270.80
214_V218_C0.8260.80
50_L192_A0.8210.80
70_I139_V0.8200.80
144_F149_R0.8180.80
55_E59_L0.8130.79
120_V237_I0.8120.79
144_F150_Y0.8090.79
247_A251_Y0.8060.79
43_L52_V0.8040.78
8_I35_I0.8020.78
197_T211_S0.8000.78
249_M281_D0.7900.77
85_C214_V0.7900.77
80_H141_P0.7880.77
57_V182_A0.7790.76
13_G67_N0.7780.76
178_G228_S0.7780.76
89_G220_A0.7770.76
85_C240_L0.7750.76
8_I298_A0.7750.76
49_A186_D0.7740.76
6_I39_G0.7730.76
42_M55_E0.7730.76
128_E132_F0.7720.76
73_V203_K0.7710.75
72_A80_H0.7700.75
195_T278_I0.7700.75
142_E146_T0.7690.75
58_R62_E0.7660.75
8_I32_L0.7660.75
78_E150_Y0.7630.75
35_I52_V0.7560.74
94_A121_M0.7540.74
113_V130_F0.7540.74
83_D211_S0.7530.74
50_L54_T0.7520.74
65_L236_F0.7490.73
261_E289_P0.7480.73
72_A198_G0.7450.73
155_A158_K0.7450.73
89_G192_A0.7450.73
43_L46_G0.7440.73
182_A194_A0.7410.73
193_A220_A0.7400.72
247_A266_E0.7390.72
48_S188_D0.7360.72
156_A202_N0.7350.72
216_A240_L0.7350.72
128_E138_R0.7300.71
26_L33_S0.7260.71
260_C277_L0.7250.71
221_N282_H0.7250.71
301_Y305_T0.7230.71
235_V271_L0.7230.71
290_F295_M0.7200.70
14_A296_Y0.7200.70
151_E155_A0.7180.70
77_D205_P0.7160.70
48_S51_D0.7150.70
241_A268_L0.7150.70
120_V214_V0.7140.70
7_A286_V0.7130.70
52_V55_E0.7120.69
124_G131_A0.7100.69
195_T218_C0.7090.69
50_L115_E0.7030.69
70_I146_T0.7000.68
74_F200_M0.7000.68
13_G28_Y0.6970.68
170_P173_E0.6950.68
5_V286_V0.6910.67
82_L128_E0.6910.67
67_N198_G0.6890.67
46_G186_D0.6880.67
150_Y153_L0.6860.67
227_V246_A0.6850.67
68_A180_V0.6830.66
97_V113_V0.6830.66
232_T268_L0.6820.66
256_L287_A0.6810.66
253_G259_A0.6790.66
112_L115_E0.6750.65
174_K177_M0.6740.65
59_L63_C0.6720.65
64_P70_I0.6690.65
94_A218_C0.6670.64
129_N133_A0.6650.64
105_N137_E0.6600.64
181_G276_G0.6590.64
113_V119_H0.6580.63
113_V121_M0.6570.63
276_G295_M0.6560.63
81_E203_K0.6540.63
6_I184_A0.6530.63
243_Y250_D0.6510.63
92_L221_N0.6500.62
191_L281_D0.6480.62
178_G218_C0.6450.62
239_A268_L0.6420.62
60_L198_G0.6410.61
95_G110_A0.6400.61
148_L151_E0.6390.61
15_I294_G0.6380.61
8_I56_A0.6350.61
63_C70_I0.6310.60
10_G66_F0.6290.60
103_L136_M0.6290.60
8_I31_A0.6280.60
28_Y32_L0.6280.60
220_A226_A0.6270.60
126_G130_F0.6260.60
191_L216_A0.6260.60
292_T295_M0.6250.59
83_D208_V0.6240.59
44_E187_L0.6240.59
50_L111_R0.6210.59
31_A66_F0.6200.59
264_V268_L0.6170.58
70_I105_N0.6170.58
17_R25_E0.6150.58
111_R114_M0.6140.58
37_E305_T0.6140.58
235_V239_A0.6130.58
223_A282_H0.6120.58
275_G295_M0.6110.58
182_A295_M0.6100.58
49_A189_G0.6090.57
52_V184_A0.6090.57
248_L251_Y0.6080.57
258_E262_R0.6070.57
39_G184_A0.6050.57
149_R201_T0.6040.57
277_L289_P0.6040.57
48_S190_N0.6030.57
241_A277_L0.6030.57
78_E154_L0.6010.57
195_T230_T0.6000.56
300_G304_D0.5990.56
85_C94_A0.5990.56
145_S149_R0.5990.56
295_M298_A0.5960.56
102_H142_E0.5940.56
245_I260_C0.5940.56
298_A302_A0.5940.56
101_S125_E0.5920.55
90_N188_D0.5920.55
243_Y248_L0.5910.55
16_S293_E0.5890.55
126_G234_E0.5880.55
16_S28_Y0.5840.54
44_E91_T0.5830.54
260_C289_P0.5820.54
127_A130_F0.5820.54
150_Y157_R0.5820.54
212_P229_C0.5810.54
239_A243_Y0.5810.54
109_A130_F0.5790.54
121_M208_V0.5780.54
146_T153_L0.5770.53
83_D126_G0.5770.53
207_R233_G0.5770.53
13_G294_G0.5740.53
125_E128_E0.5720.53
229_C245_I0.5710.53
41_K55_E0.5710.53
14_A294_G0.5710.53
13_G203_K0.5700.53
148_L152_Q0.5690.52
183_V195_T0.5690.52
288_L297_R0.5690.52
82_L101_S0.5680.52
67_N74_F0.5680.52
151_E154_L0.5680.52
15_I18_A0.5660.52
86_V114_M0.5650.52
226_A280_I0.5640.52
244_D267_K0.5620.52
85_C193_A0.5610.51
73_V201_T0.5580.51
171_L174_K0.5580.51
227_V277_L0.5580.51
48_S192_A0.5580.51
264_V269_P0.5570.51
260_C264_V0.5550.51
142_E150_Y0.5550.51
75_T203_K0.5540.51
149_R296_Y0.5510.50
99_G126_G0.5490.50
141_P150_Y0.5480.50
260_C287_A0.5470.50
235_V272_G0.5470.50
249_M253_G0.5460.50
33_S45_A0.5450.49
180_V196_S0.5450.49
294_G297_R0.5440.49
50_L114_M0.5440.49
52_V59_L0.5430.49
87_M94_A0.5430.49
141_P145_S0.5430.49
224_S249_M0.5420.49
143_I149_R0.5410.49
67_N149_R0.5400.49
225_V245_I0.5390.49
83_D99_G0.5380.49
10_G197_T0.5380.49
129_N132_F0.5380.49
299_W302_A0.5360.48
276_G290_F0.5350.48
62_E70_I0.5340.48
59_L62_E0.5330.48
221_N224_S0.5320.48
122_M134_R0.5310.48
37_E41_K0.5290.47
13_G16_S0.5290.47
183_V280_I0.5270.47
68_A198_G0.5270.47
157_R202_N0.5270.47
58_R194_A0.5270.47
179_T233_G0.5250.47
257_A287_A0.5240.47
14_A293_E0.5240.47
189_G192_A0.5230.47
10_G210_D0.5220.47
219_Y228_S0.5210.46
97_V100_V0.5210.46
146_T150_Y0.5200.46
139_V143_I0.5160.46
80_H150_Y0.5160.46
143_I146_T0.5150.46
34_A38_T0.5140.46
253_G256_L0.5130.45
109_A226_A0.5110.45
7_A288_L0.5110.45
104_R137_E0.5100.45
210_D219_Y0.5090.45
31_A59_L0.5080.45
94_A237_I0.5070.45
66_F198_G0.5070.45
73_V198_G0.5050.44
114_M214_V0.5050.44
87_M197_T0.5050.44
96_A209_G0.5030.44
83_D121_M0.5010.44
195_T211_S0.5000.44
38_T42_M0.5000.44
46_G49_A0.5000.44
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3c17A 2 0.9564 100 0.052 Contact Map
4o0cA 2 0.919 100 0.099 Contact Map
2a8jA 2 0.8536 100 0.121 Contact Map
1p4kA 2 0.891 100 0.212 Contact Map
4pv2A 1 0.4798 100 0.409 Contact Map
1k2xA 1 0.486 100 0.5 Contact Map
2gezA 2 0.514 100 0.506 Contact Map
1k2xB 2 0.4206 100 0.584 Contact Map
2gezB 2 0.4143 100 0.607 Contact Map
4pv2B 2 0.4081 100 0.607 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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