GREMLIN Database
XYLG - Xylose import ATP-binding protein XylG
UniProt: P37388 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12275
Length: 513 (473)
Sequences: 8695 (5836)
Seq/√Len: 268.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
62_E69_E3.5801.00
31_E211_T3.5621.00
21_D219_Q3.3931.00
33_V213_C3.3281.00
260_R283_S3.2431.00
305_Q311_W3.2131.00
120_T137_D3.1781.00
14_F54_Y3.1781.00
389_I399_P3.0951.00
322_D425_R3.0351.00
318_K325_Q2.9491.00
34_S209_S2.9481.00
66_A162_R2.8611.00
9_N22_N2.8131.00
262_E318_K2.7861.00
304_I461_I2.7801.00
263_H279_D2.7431.00
118_L122_R2.7271.00
124_Q128_A2.6571.00
260_R320_Y2.6361.00
222_G237_M2.5901.00
186_R207_A2.5701.00
257_E260_R2.5631.00
6_E26_R2.5341.00
32_I185_I2.4641.00
72_A81_K2.4431.00
8_K62_E2.3901.00
389_I396_T2.3581.00
13_T18_K2.3351.00
138_T142_D2.3271.00
209_S226_A2.3041.00
6_E64_I2.3031.00
7_M10_I2.2981.00
122_R125_K2.2681.00
352_V363_L2.2611.00
256_D286_R2.2581.00
303_T478_M2.2041.00
460_V471_L2.1481.00
476_L486_N2.1261.00
450_Q454_Q2.1221.00
225_D228_G2.1141.00
18_K21_D2.1011.00
257_E283_S2.0771.00
387_E391_Q2.0761.00
261_I264_L2.0751.00
129_Q191_H2.0691.00
47_M198_I2.0351.00
179_S207_A2.0271.00
11_T18_K2.0251.00
388_S417_A1.9731.00
290_L476_L1.9601.00
236_T242_E1.9281.00
425_R456_I1.9251.00
86_I166_L1.9241.00
115_D118_L1.8951.00
9_N24_C1.8641.00
304_I428_I1.8581.00
261_I282_F1.8461.00
278_N482_K1.8151.00
436_I444_I1.8061.00
230_S233_D1.7971.00
47_M85_I1.7971.00
262_E320_Y1.7771.00
92_L140_V1.7751.00
324_K337_Q1.7541.00
93_V104_L1.7311.00
289_I448_I1.7281.00
284_L457_A1.7211.00
429_L448_I1.7151.00
73_S77_D1.7141.00
11_T22_N1.7081.00
65_F163_L1.6891.00
4_L194_A1.6891.00
258_I457_A1.6871.00
257_E285_K1.6841.00
321_I326_V1.6831.00
362_T381_E1.6811.00
75_I78_T1.6721.00
291_G472_S1.6551.00
293_A468_V1.6471.00
10_I49_V1.6341.00
13_T60_E1.6251.00
358_G400_D1.6061.00
7_M50_L1.6051.00
357_V396_T1.5991.00
386_L390_Q1.5981.00
284_L290_L1.5961.00
64_I69_E1.5941.00
53_I87_H1.5901.00
306_C313_G1.5871.00
8_K64_I1.5681.00
351_I403_I1.5641.00
121_L125_K1.5641.00
403_I414_A1.5621.00
284_L459_I1.5471.00
74_H77_D1.5451.00
125_K129_Q1.5341.00
321_I426_I1.5341.00
186_R189_Q1.5281.00
396_T401_L1.5161.00
162_R193_I1.5121.00
361_I394_V1.5121.00
284_L426_I1.5091.00
213_C220_H1.5011.00
224_R237_M1.4931.00
29_A194_A1.4831.00
139_R142_D1.4781.00
9_N60_E1.4771.00
247_Y470_G1.4751.00
377_D380_A1.4641.00
305_Q349_D1.4611.00
265_T279_D1.4601.00
99_L120_T1.4451.00
206_K234_I1.4441.00
27_L163_L1.4401.00
224_R229_M1.4221.00
389_I394_V1.4211.00
354_V404_G1.4161.00
187_D191_H1.4101.00
329_R333_Q1.3941.00
68_E81_K1.3871.00
95_E141_G1.3811.00
233_D236_T1.3781.00
118_L121_L1.3751.00
100_E116_Y1.3751.00
129_Q187_D1.3711.00
376_L381_E1.3701.00
124_Q136_P1.3681.00
401_L405_R1.3651.00
94_K148_Q1.3601.00
345_D348_R1.3511.00
266_A277_V1.3461.00
182_L208_I1.3461.00
282_F476_L1.3411.00
33_V223_T1.3351.00
189_Q210_D1.3291.00
286_R457_A1.3251.00
320_Y325_Q1.3231.00
386_L399_P1.3211.00
391_Q450_Q1.3211.00
102_I123_C1.3151.00
97_T100_E1.3111.00
15_G19_A1.3101.00
266_A315_W1.3041.00
15_G18_K1.3031.00
258_I322_D1.3031.00
291_G468_V1.2981.00
476_L483_L1.2951.00
383_K387_E1.2841.00
262_E283_S1.2841.00
441_K464_E1.2661.00
51_C85_I1.2641.00
380_A383_K1.2631.00
229_M233_D1.2611.00
266_A306_C1.2611.00
24_C220_H1.2571.00
282_F292_I1.2511.00
144_G147_Q1.2461.00
113_I375_Q1.2381.00
13_T59_Y1.2361.00
135_S138_T1.2351.00
357_V414_A1.2351.00
254_T285_K1.2301.00
397_S401_L1.2281.00
286_R425_R1.2251.00
72_A77_D1.2241.00
74_H78_T1.2131.00
126_L158_N1.2101.00
77_D80_R1.2071.00
292_I476_L1.1991.00
257_E286_R1.1971.00
275_K278_N1.1971.00
26_R211_T1.1961.00
99_L136_P1.1951.00
263_H281_S1.1951.00
277_V306_C1.1931.00
203_N231_E1.1901.00
11_T60_E1.1871.00
212_I226_A1.1871.00
36_C202_L1.1821.00
468_V472_S1.1761.00
342_V429_L1.1751.00
382_Q400_D1.1741.00
211_T225_D1.1731.00
415_I418_R1.1651.00
214_V237_M1.1601.00
220_H223_T1.1571.00
180_I183_D1.1571.00
213_C223_T1.1521.00
448_I460_V1.1491.00
332_Q336_A1.1471.00
185_I195_C1.1471.00
267_W315_W1.1451.00
301_T344_E1.1441.00
356_A359_K1.1441.00
288_E474_R1.1431.00
290_L459_I1.1401.00
263_H316_E1.1381.00
355_M359_K1.1351.00
102_I158_N1.1301.00
267_W275_K1.1291.00
468_V475_V1.1281.00
166_L195_C1.1221.00
185_I208_I1.1221.00
402_A405_R1.1181.00
23_V215_I1.1131.00
89_E434_R1.1041.00
282_F290_L1.1041.00
187_D190_Q1.1011.00
328_I333_Q1.1011.00
98_V134_I1.0971.00
279_D482_K1.0961.00
387_E390_Q1.0951.00
56_H59_Y1.0921.00
343_P349_D1.0911.00
206_K230_S1.0901.00
450_Q453_Q1.0861.00
388_S394_V1.0831.00
224_R233_D1.0831.00
428_I461_I1.0731.00
224_R228_G1.0721.00
29_A162_R1.0721.00
398_S401_L1.0591.00
277_V280_V1.0581.00
330_N333_Q1.0551.00
292_I303_T1.0461.00
4_L163_L1.0461.00
265_T316_E1.0451.00
130_V154_A1.0431.00
27_L194_A1.0421.00
161_V164_L1.0421.00
431_E463_S1.0381.00
136_P139_R1.0371.00
206_K231_E1.0331.00
448_I471_L1.0321.00
128_A133_S1.0261.00
384_C421_L1.0241.00
334_A339_I1.0181.00
300_R430_D1.0111.00
308_F419_C1.0101.00
250_E453_Q1.0051.00
328_I334_A1.0021.00
423_N454_Q1.0011.00
248_P470_G1.0001.00
77_D81_K0.9961.00
117_D121_L0.9931.00
110_H113_I0.9931.00
335_I419_C0.9901.00
447_L450_Q0.9851.00
361_I385_I0.9841.00
397_S405_R0.9831.00
292_I459_I0.9831.00
5_L50_L0.9821.00
423_N456_I0.9821.00
89_E347_K0.9791.00
186_R190_Q0.9781.00
11_T21_D0.9771.00
98_V138_T0.9751.00
206_K226_A0.9741.00
5_L65_F0.9711.00
22_N219_Q0.9701.00
353_P403_I0.9691.00
266_A276_R0.9661.00
108_I119_M0.9661.00
257_E262_E0.9661.00
48_K54_Y0.9641.00
479_H484_K0.9611.00
120_T124_Q0.9591.00
4_L65_F0.9581.00
233_D237_M0.9581.00
385_I399_P0.9571.00
125_K128_A0.9561.00
358_G399_P0.9551.00
290_L486_N0.9531.00
369_F384_C0.9501.00
70_I81_K0.9461.00
84_A161_V0.9431.00
358_G381_E0.9391.00
185_I197_Y0.9381.00
127_L154_A0.9361.00
448_I458_V0.9331.00
393_K443_E0.9321.00
28_N31_E0.9311.00
427_L456_I0.9311.00
474_R486_N0.9311.00
50_L63_I0.9291.00
183_D187_D0.9291.00
20_I49_V0.9281.00
255_G286_R0.9281.00
462_S468_V0.9261.00
261_I307_L0.9261.00
98_V143_L0.9241.00
338_G425_R0.9241.00
352_V355_M0.9241.00
109_T115_D0.9201.00
256_D322_D0.9201.00
449_N453_Q0.9191.00
56_H71_Q0.9181.00
72_A78_T0.9151.00
339_I426_I0.9131.00
258_I286_R0.9051.00
108_I122_R0.9021.00
340_A427_L0.8981.00
277_V303_T0.8981.00
451_L456_I0.8971.00
342_V415_I0.8961.00
264_L306_C0.8941.00
84_A156_A0.8941.00
262_E281_S0.8941.00
8_K24_C0.8931.00
343_P415_I0.8911.00
446_K450_Q0.8891.00
371_G374_S0.8891.00
63_I72_A0.8861.00
4_L66_A0.8761.00
358_G382_Q0.8761.00
361_I414_A0.8741.00
357_V406_L0.8671.00
347_K353_P0.8661.00
340_A419_C0.8581.00
48_K87_H0.8541.00
122_R160_Q0.8531.00
28_N211_T0.8491.00
301_T430_D0.8471.00
164_L195_C0.8461.00
179_S183_D0.8461.00
49_V56_H0.8461.00
79_E159_K0.8441.00
99_L108_I0.8431.00
261_I319_I0.8340.99
340_A424_P0.8340.99
205_V226_A0.8310.99
396_T406_L0.8300.99
264_L313_G0.8260.99
296_V463_S0.8260.99
331_C334_A0.8250.99
379_A383_K0.8250.99
123_C136_P0.8240.99
386_L389_I0.8200.99
364_A419_C0.8190.99
22_N60_E0.8190.99
32_I189_Q0.8180.99
172_S296_V0.8170.99
51_C87_H0.8160.99
300_R344_E0.8140.99
121_L124_Q0.8130.99
328_I339_I0.8130.99
108_I114_M0.8130.99
234_I240_G0.8130.99
469_L475_V0.8120.99
29_A66_A0.8100.99
212_I224_R0.8090.99
27_L196_I0.8060.99
361_I417_A0.8050.99
358_G385_I0.8050.99
428_I459_I0.8040.99
99_L119_M0.7990.99
289_I449_N0.7980.99
362_T366_L0.7970.99
238_M241_R0.7960.99
103_F119_M0.7960.99
368_K423_N0.7950.99
236_T240_G0.7940.99
13_T19_A0.7940.99
124_Q135_S0.7910.99
249_N449_N0.7890.99
211_T223_T0.7890.99
292_I478_M0.7880.99
280_V483_L0.7840.99
292_I304_I0.7830.99
286_R322_D0.7830.99
212_I234_I0.7830.99
15_G21_D0.7820.99
103_F122_R0.7790.99
124_Q137_D0.7790.99
234_I238_M0.7750.99
106_N159_K0.7720.99
152_E155_K0.7710.99
65_F70_I0.7690.99
206_K229_M0.7670.99
359_K381_E0.7670.99
164_L193_I0.7660.99
350_G415_I0.7640.99
333_Q336_A0.7620.99
106_N158_N0.7620.99
55_P71_Q0.7600.99
388_S421_L0.7570.99
90_L145_L0.7560.99
100_E107_E0.7560.99
347_K411_Q0.7540.99
156_A164_L0.7540.99
15_G397_S0.7520.99
240_G243_L0.7520.99
76_R80_R0.7510.99
49_V54_Y0.7510.99
166_L185_I0.7500.99
46_L215_I0.7480.99
225_D229_M0.7480.99
7_M25_L0.7450.99
266_A275_K0.7440.99
365_A368_K0.7430.99
132_L150_L0.7350.99
32_I186_R0.7340.99
126_L154_A0.7310.99
260_R318_K0.7300.99
308_F428_I0.7300.99
26_R223_T0.7270.99
351_I411_Q0.7260.99
333_Q337_Q0.7170.98
282_F303_T0.7170.98
259_L284_L0.7160.98
442_Y446_K0.7150.98
12_K59_Y0.7140.98
282_F459_I0.7140.98
239_V243_L0.7130.98
365_A421_L0.7090.98
8_K26_R0.7090.98
214_V234_I0.7090.98
102_I151_V0.7070.98
321_I339_I0.7070.98
396_T399_P0.7070.98
140_V151_V0.7060.98
15_G401_L0.7060.98
384_C387_E0.7050.98
445_Y470_G0.7040.98
23_V220_H0.7030.98
160_Q191_H0.7020.98
340_A422_L0.7020.98
20_I215_I0.7020.98
296_V300_R0.7010.98
131_S187_D0.7000.98
65_F83_I0.6950.98
7_M63_I0.6940.98
33_V211_T0.6940.98
283_S486_N0.6930.98
308_F331_C0.6920.98
426_I459_I0.6920.98
260_R323_G0.6910.98
424_P429_L0.6900.98
416_L436_I0.6890.98
237_M240_G0.6890.98
107_E119_M0.6890.98
25_L35_L0.6880.98
90_L172_S0.6870.98
19_A397_S0.6850.98
120_T136_P0.6850.98
403_I418_R0.6850.98
356_A400_D0.6840.98
91_A152_E0.6830.98
250_E473_D0.6820.98
280_V303_T0.6820.98
256_D285_K0.6810.98
127_L136_P0.6810.98
392_L420_L0.6810.98
357_V389_I0.6800.98
55_P59_Y0.6800.98
328_I337_Q0.6790.98
99_L123_C0.6780.98
92_L148_Q0.6770.98
241_R247_Y0.6770.98
382_Q399_P0.6750.98
353_P404_G0.6750.98
353_P418_R0.6740.98
75_I79_E0.6730.98
109_T112_G0.6730.98
306_C311_W0.6730.98
319_I328_I0.6720.98
38_E241_R0.6720.98
97_T139_R0.6720.98
84_A159_K0.6710.98
87_H91_A0.6700.98
28_N225_D0.6690.98
313_G327_D0.6680.98
266_A311_W0.6680.98
126_L130_V0.6660.97
92_L151_V0.6660.97
110_H115_D0.6620.97
449_N473_D0.6610.97
95_E139_R0.6600.97
304_I341_M0.6590.97
382_Q386_L0.6550.97
197_Y208_I0.6550.97
424_P456_I0.6550.97
265_T277_V0.6540.97
202_L205_V0.6540.97
7_M165_I0.6540.97
127_L132_L0.6540.97
90_L152_E0.6530.97
341_M349_D0.6520.97
356_A402_A0.6520.97
394_V417_A0.6520.97
372_G377_D0.6510.97
264_L319_I0.6480.97
416_L444_I0.6470.97
108_I115_D0.6440.97
5_L163_L0.6440.97
203_N207_A0.6400.97
47_M165_I0.6390.97
123_C127_L0.6390.97
143_L151_V0.6390.97
27_L33_V0.6390.97
401_L404_G0.6380.97
48_K53_I0.6370.97
25_L33_V0.6370.97
258_I426_I0.6360.97
424_P427_L0.6350.97
90_L171_A0.6350.97
17_V397_S0.6340.97
380_A384_C0.6330.97
189_Q195_C0.6310.97
120_T123_C0.6300.96
6_E67_G0.6290.96
199_S205_V0.6270.96
289_I471_L0.6270.96
308_F335_I0.6270.96
124_Q133_S0.6250.96
326_V337_Q0.6240.96
259_L264_L0.6220.96
321_I337_Q0.6210.96
34_S226_A0.6210.96
477_V484_K0.6200.96
25_L196_I0.6190.96
99_L137_D0.6190.96
357_V403_I0.6180.96
28_N194_A0.6180.96
174_T178_T0.6170.96
286_R290_L0.6170.96
258_I284_L0.6170.96
102_I126_L0.6170.96
108_I118_L0.6160.96
255_G285_K0.6130.96
35_L196_I0.6130.96
390_Q393_K0.6120.96
293_A465_L0.6110.96
436_I447_L0.6110.96
197_Y201_K0.6100.96
416_L429_L0.6100.96
342_V416_L0.6070.96
72_A83_I0.6070.96
184_I187_D0.6050.96
371_G377_D0.6050.96
178_T208_I0.6050.96
292_I483_L0.6040.96
283_S320_Y0.6040.96
13_T21_D0.6030.95
478_M483_L0.6010.95
451_L458_V0.6000.95
89_E152_E0.5990.95
44_S48_K0.5990.95
174_T177_E0.5990.95
303_T307_L0.5980.95
252_H255_G0.5980.95
452_V458_V0.5960.95
98_V136_P0.5950.95
252_H453_Q0.5930.95
76_R79_E0.5920.95
7_M24_C0.5910.95
197_Y205_V0.5910.95
163_L194_A0.5910.95
362_T384_C0.5900.95
259_L263_H0.5900.95
206_K209_S0.5880.95
411_Q463_S0.5880.95
113_I116_Y0.5860.95
188_L195_C0.5860.95
209_S212_I0.5860.95
329_R334_A0.5860.95
129_Q160_Q0.5850.95
4_L29_A0.5850.95
280_V478_M0.5840.95
241_R466_P0.5830.95
392_L417_A0.5830.95
215_I220_H0.5830.95
383_K386_L0.5820.95
25_L194_A0.5810.94
186_R208_I0.5800.94
122_R126_L0.5780.94
145_L171_A0.5780.94
149_Q152_E0.5770.94
249_N473_D0.5760.94
403_I415_I0.5760.94
300_R463_S0.5760.94
31_E194_A0.5740.94
451_L454_Q0.5730.94
202_L234_I0.5730.94
391_Q447_L0.5720.94
305_Q310_V0.5720.94
123_C126_L0.5710.94
452_V457_A0.5710.94
445_Y449_N0.5690.94
364_A422_L0.5690.94
126_L129_Q0.5680.94
217_D395_K0.5680.94
245_A248_P0.5670.94
306_C312_P0.5660.94
145_L434_R0.5660.94
171_A434_R0.5650.94
254_T257_E0.5650.94
235_I240_G0.5640.94
350_G418_R0.5640.94
146_G296_V0.5640.94
304_I430_D0.5630.94
65_F81_K0.5620.93
385_I389_I0.5610.93
174_T296_V0.5610.93
290_L457_A0.5600.93
257_E320_Y0.5600.93
266_A313_G0.5590.93
460_V472_S0.5570.93
335_I364_A0.5560.93
141_G148_Q0.5560.93
259_L426_I0.5550.93
265_T278_N0.5540.93
26_R64_I0.5540.93
143_L147_Q0.5540.93
19_A215_I0.5530.93
308_F340_A0.5530.93
189_Q208_I0.5530.93
103_F123_C0.5510.93
357_V401_L0.5510.93
178_T201_K0.5510.93
98_V151_V0.5500.93
226_A229_M0.5500.93
116_Y119_M0.5490.93
365_A422_L0.5490.93
370_T375_Q0.5480.93
235_I238_M0.5470.93
416_L420_L0.5470.93
199_S463_S0.5460.92
120_T135_S0.5450.92
130_V150_L0.5440.92
171_A201_K0.5430.92
232_D242_E0.5430.92
131_S183_D0.5430.92
183_D207_A0.5420.92
265_T275_K0.5410.92
388_S392_L0.5410.92
321_I328_I0.5400.92
152_E434_R0.5400.92
360_N363_L0.5400.92
304_I459_I0.5390.92
182_L189_Q0.5390.92
145_L148_Q0.5390.92
241_R439_G0.5350.92
205_V209_S0.5350.92
38_E238_M0.5350.92
101_N140_V0.5350.92
169_P177_E0.5350.92
49_V59_Y0.5340.92
378_D381_E0.5330.92
319_I326_V0.5330.92
216_R221_I0.5320.92
395_K401_L0.5320.92
264_L303_T0.5320.92
106_N122_R0.5310.91
357_V405_R0.5280.91
138_T143_L0.5280.91
127_L130_V0.5270.91
259_L262_E0.5270.91
445_Y471_L0.5260.91
135_S139_R0.5250.91
33_V196_I0.5250.91
357_V397_S0.5250.91
50_L165_I0.5240.91
203_N464_E0.5240.91
33_V194_A0.5240.91
116_Y120_T0.5240.91
293_A462_S0.5230.91
134_I138_T0.5230.91
379_A382_Q0.5220.91
13_T16_S0.5200.91
449_N471_L0.5190.90
231_E234_I0.5190.90
300_R431_E0.5190.90
343_P348_R0.5190.90
181_L185_I0.5190.90
7_M49_V0.5180.90
308_F341_M0.5170.90
448_I452_V0.5170.90
138_T147_Q0.5160.90
133_S147_Q0.5160.90
4_L28_N0.5160.90
85_I90_L0.5150.90
388_S391_Q0.5150.90
117_D379_A0.5140.90
396_T405_R0.5140.90
36_C212_I0.5130.90
255_G259_L0.5130.90
165_I198_I0.5130.90
47_M50_L0.5120.90
32_I208_I0.5110.90
94_K141_G0.5100.90
392_L447_L0.5090.90
131_S180_I0.5080.90
263_H318_K0.5080.90
365_A369_F0.5070.89
36_C205_V0.5070.89
109_T113_I0.5050.89
90_L140_V0.5050.89
483_L486_N0.5050.89
70_I73_S0.5050.89
35_L47_M0.5040.89
290_L483_L0.5040.89
343_P350_G0.5040.89
351_I414_A0.5020.89
442_Y470_G0.5020.89
232_D236_T0.5010.89
214_V222_G0.5010.89
261_I313_G0.5000.89
20_I23_V0.5000.89
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4q9hA 1 0.9532 100 0.374 Contact Map
4finA 2 0.8986 100 0.394 Contact Map
4f4cA 1 0.9279 100 0.399 Contact Map
1yqtA 1 0.8967 100 0.429 Contact Map
3ux8A 2 0.8382 100 0.433 Contact Map
3bk7A 1 0.9103 100 0.441 Contact Map
3ozxA 1 0.883 100 0.442 Contact Map
2iw3A 2 0.883 100 0.446 Contact Map
3j16B 1 0.9123 100 0.455 Contact Map
2vf7A 2 0.9376 100 0.529 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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