GREMLIN Database
XYLF - D-xylose-binding periplasmic protein
UniProt: P37387 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG20252
Length: 330 (283)
Sequences: 38186 (28614)
Seq/√Len: 1700.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
130_E170_K3.5381.00
146_Q213_D3.2741.00
84_V278_A2.8301.00
136_Q242_S2.7251.00
246_A264_Y2.6451.00
146_Q240_A2.6101.00
165_R169_M2.6071.00
198_L232_A2.3401.00
50_K53_S2.3111.00
202_E233_Q2.2321.00
50_K276_E2.2091.00
134_E171_V2.1801.00
134_E170_K2.1431.00
138_K171_V2.1151.00
202_E229_A2.1021.00
131_K135_L2.1001.00
273_T276_E2.0981.00
51_A275_A2.0981.00
134_E178_S2.0551.00
140_L214_A2.0241.00
132_V244_Q2.0101.00
130_E166_A1.9921.00
46_I271_A1.9891.00
133_G137_A1.9781.00
280_E285_Q1.9761.00
50_K272_N1.9761.00
138_K142_D1.9541.00
141_V179_G1.9531.00
123_F281_L1.9321.00
197_A225_G1.9141.00
230_L239_V1.8851.00
206_T233_Q1.8551.00
133_G216_V1.8171.00
29_G82_V1.8121.00
49_K268_T1.7941.00
137_A168_Q1.7841.00
134_E138_K1.7791.00
150_F212_I1.7781.00
138_K179_G1.7441.00
198_L229_A1.7311.00
217_A226_A1.7281.00
151_L218_S1.7231.00
201_M226_A1.7201.00
50_K54_L1.6831.00
235_L238_K1.6801.00
266_P269_L1.6731.00
112_Y274_A1.6521.00
148_N211_K1.6511.00
46_I268_T1.6401.00
166_A170_K1.6381.00
231_S256_A1.6351.00
131_K134_E1.6181.00
229_A233_Q1.5991.00
141_V171_V1.5591.00
54_L279_V1.5591.00
139_A142_D1.5401.00
264_Y308_I1.5101.00
139_A143_I1.5091.00
169_M173_K1.5051.00
208_N211_K1.5051.00
163_L166_A1.4981.00
279_V283_N1.4971.00
229_A232_A1.4891.00
198_L228_Q1.4771.00
128_D131_K1.4661.00
191_G196_N1.4641.00
26_V83_D1.4581.00
269_L273_T1.4511.00
269_L272_N1.4481.00
50_K275_A1.4351.00
137_A141_V1.4281.00
5_N9_T1.4161.00
148_N213_D1.4051.00
148_N182_K1.3911.00
133_G167_G1.3911.00
230_L235_L1.3891.00
150_F204_A1.3891.00
202_E232_A1.3831.00
201_M215_V1.3791.00
148_N184_V1.3691.00
29_G77_M1.3541.00
198_L202_E1.3431.00
137_A167_G1.3391.00
75_E101_E1.3341.00
28_I51_A1.3321.00
137_A171_V1.3311.00
86_V274_A1.3141.00
130_E134_E1.3111.00
100_K104_Q1.3051.00
201_M230_L1.2991.00
276_E280_E1.2971.00
51_A58_V1.2961.00
184_V187_Q1.2941.00
26_V56_A1.2941.00
167_G171_V1.2881.00
135_L307_P1.2721.00
135_L138_K1.2681.00
183_V186_D1.2571.00
61_Q77_M1.2501.00
61_Q73_Q1.2471.00
202_E206_T1.2431.00
6_I9_T1.2391.00
231_S258_T1.2371.00
146_Q214_A1.2351.00
47_F275_A1.2291.00
27_K57_K1.2251.00
268_T272_N1.2091.00
30_M47_F1.2081.00
225_G229_A1.1981.00
48_V52_E1.1941.00
227_I241_I1.1931.00
208_N212_I1.1891.00
54_L276_E1.1791.00
168_Q172_L1.1751.00
195_E199_K1.1611.00
169_M183_V1.1541.00
27_K59_F1.1511.00
130_E167_G1.1511.00
152_M226_A1.1501.00
138_K178_S1.1361.00
130_E163_L1.1361.00
47_F86_V1.1301.00
151_L165_R1.1301.00
200_I203_N1.1291.00
168_Q216_V1.1281.00
220_D262_T1.1241.00
30_M58_V1.1231.00
203_N207_A1.1121.00
14_L20_A1.1111.00
308_I311_N1.1101.00
242_S260_T1.1071.00
162_K166_A1.1061.00
215_V226_A1.1041.00
141_V181_I1.0981.00
171_V178_S1.0961.00
136_Q216_V1.0961.00
220_D243_G1.0961.00
142_D179_G1.0901.00
44_R48_V1.0881.00
193_L196_N1.0821.00
71_M75_E1.0781.00
199_K203_N1.0701.00
273_T277_I1.0701.00
52_E69_T1.0631.00
149_Y172_L1.0611.00
69_T72_S1.0581.00
217_A222_T1.0571.00
197_A201_M1.0561.00
5_N8_L1.0451.00
194_P228_Q1.0441.00
196_N199_K1.0421.00
166_A169_M1.0351.00
16_L19_V1.0351.00
271_A275_A1.0331.00
139_A311_N1.0291.00
272_N276_E1.0271.00
17_T20_A1.0241.00
148_N210_N1.0201.00
132_V307_P1.0141.00
147_G213_D1.0131.00
154_G192_W1.0091.00
278_A282_G1.0041.00
56_A279_V0.9931.00
75_E79_N0.9911.00
66_N69_T0.9831.00
54_L283_N0.9811.00
53_S272_N0.9801.00
201_M205_L0.9791.00
139_A260_T0.9791.00
227_I255_A0.9791.00
96_S100_K0.9781.00
217_A223_A0.9761.00
45_D49_K0.9731.00
136_Q263_V0.9731.00
149_Y214_A0.9651.00
156_P189_V0.9611.00
137_A172_L0.9541.00
14_L17_T0.9521.00
13_S18_N0.9481.00
39_R267_I0.9341.00
159_N163_L0.9331.00
190_D222_T0.9181.00
199_K202_E0.9141.00
86_V278_A0.9131.00
141_V147_G0.9071.00
196_N200_I0.9021.00
235_L239_V0.9011.00
30_M44_R0.8951.00
84_V282_G0.8941.00
157_V162_K0.8931.00
49_K272_N0.8911.00
47_F271_A0.8891.00
28_I86_V0.8881.00
127_F266_P0.8831.00
220_D246_A0.8791.00
49_K53_S0.8751.00
150_F215_V0.8751.00
129_N164_F0.8731.00
127_F265_K0.8721.00
230_L241_I0.8711.00
215_V239_V0.8691.00
243_G262_T0.8651.00
223_A243_G0.8531.00
72_S75_E0.8521.00
205_L229_A0.8511.00
27_K80_R0.8461.00
43_D112_Y0.8451.00
273_T303_R0.8451.00
47_F58_V0.8441.00
170_K178_S0.8441.00
143_I311_N0.8421.00
125_I277_I0.8321.00
153_G165_R0.8311.00
44_R60_V0.8291.00
228_Q231_S0.8281.00
277_I280_E0.8251.00
275_A279_V0.8221.00
277_I303_R0.8201.00
12_T79_N0.8181.00
170_K173_K0.8151.00
140_L242_S0.8121.00
15_L18_N0.8101.00
31_A73_Q0.8091.00
59_F82_V0.8091.00
46_I272_N0.8021.00
59_F80_R0.8001.00
151_L216_V0.7981.00
128_D304_L0.7971.00
69_T73_Q0.7951.00
147_G181_I0.7941.00
245_D265_K0.7931.00
84_V110_L0.7911.00
123_F277_I0.7901.00
201_M229_A0.7891.00
101_E104_Q0.7881.00
64_N69_T0.7881.00
163_L167_G0.7871.00
33_D40_W0.7861.00
171_V179_G0.7841.00
172_L181_I0.7841.00
172_L183_V0.7791.00
25_E83_D0.7791.00
205_L233_Q0.7781.00
45_D48_V0.7761.00
152_M217_A0.7751.00
220_D223_A0.7741.00
201_M204_A0.7711.00
98_V101_E0.7671.00
211_K235_L0.7661.00
42_K268_T0.7551.00
253_R258_T0.7531.00
134_E167_G0.7421.00
203_N206_T0.7401.00
252_K256_A0.7371.00
29_G85_L0.7361.00
190_D196_N0.7341.00
78_I107_I0.7331.00
46_I50_K0.7301.00
7_L10_L0.7221.00
24_K283_N0.7211.00
68_E72_S0.7201.00
102_A109_V0.7181.00
207_A210_N0.7171.00
24_K83_D0.7171.00
131_K306_T0.7161.00
86_V112_Y0.7121.00
48_V58_V0.7091.00
74_I85_L0.7071.00
273_T305_L0.7051.00
266_P305_L0.7041.00
219_N245_D0.7011.00
110_L281_L0.7011.00
28_I275_A0.6991.00
266_P308_I0.6981.00
25_E57_K0.6971.00
183_V187_Q0.6971.00
37_L221_A0.6971.00
207_A211_K0.6961.00
197_A200_I0.6941.00
213_D240_A0.6931.00
12_T75_E0.6911.00
143_I240_A0.6911.00
192_W218_S0.6901.00
111_A116_I0.6901.00
228_Q258_T0.6891.00
141_V178_S0.6881.00
100_K103_K0.6881.00
71_M98_V0.6861.00
135_L263_V0.6851.00
78_I105_E0.6821.00
161_A192_W0.6781.00
207_A212_I0.6781.00
230_L233_Q0.6771.00
216_V242_S0.6771.00
201_M225_G0.6771.00
154_G161_A0.6731.00
141_V172_L0.6691.00
111_A121_I0.6671.00
151_L168_Q0.6661.00
224_G255_A0.6601.00
72_S76_N0.6551.00
284_G287_P0.6551.00
227_I231_S0.6541.00
84_V274_A0.6501.00
250_G259_Q0.6501.00
220_D247_D0.6501.00
113_D160_N0.6501.00
228_Q232_A0.6491.00
280_E284_G0.6471.00
168_Q183_V0.6461.00
111_A124_Y0.6461.00
28_I282_G0.6441.00
11_C14_L0.6441.00
139_A309_D0.6411.00
42_K267_I0.6361.00
146_Q180_K0.6331.00
219_N222_T0.6331.00
113_D129_N0.6301.00
126_S304_L0.6271.00
67_E71_M0.6261.00
51_A56_A0.6231.00
140_L216_V0.6211.00
127_F307_P0.6201.00
149_Y213_D0.6201.00
40_W88_I0.6191.00
135_L139_A0.6181.00
39_R43_D0.6151.00
240_A260_T0.6151.00
252_K255_A0.6121.00
223_A259_Q0.6111.00
228_Q256_A0.6071.00
110_L278_A0.6071.00
187_Q207_A0.6061.00
200_I204_A0.6061.00
195_E198_L0.6051.00
103_K109_V0.6031.00
268_T271_A0.6031.00
216_V244_Q0.6021.00
12_T16_L0.6001.00
43_D267_I0.6001.00
115_M124_Y0.5971.00
194_P225_G0.5941.00
192_W222_T0.5931.00
148_N208_N0.5921.00
73_Q76_N0.5921.00
244_Q265_K0.5911.00
161_A218_S0.5901.00
45_D268_T0.5891.00
113_D270_L0.5891.00
139_A242_S0.5881.00
128_D306_T0.5881.00
148_N187_Q0.5871.00
85_L107_I0.5871.00
164_F265_K0.5851.00
110_L125_I0.5851.00
28_I84_V0.5851.00
224_G247_D0.5851.00
148_N212_I0.5841.00
61_Q76_N0.5841.00
149_Y168_Q0.5841.00
110_L277_I0.5811.00
231_S236_S0.5811.00
46_I267_I0.5781.00
136_Q214_A0.5781.00
129_N163_L0.5771.00
56_A83_D0.5741.00
97_N100_K0.5721.00
77_M82_V0.5711.00
18_N22_H0.5711.00
28_I56_A0.5701.00
217_A243_G0.5701.00
129_N160_N0.5681.00
48_V62_S0.5671.00
212_I235_L0.5641.00
304_L307_P0.5641.00
246_A252_K0.5601.00
214_A240_A0.5591.00
101_E105_E0.5591.00
277_I281_L0.5591.00
27_K83_D0.5591.00
76_N79_N0.5591.00
126_S129_N0.5581.00
255_A258_T0.5561.00
198_L201_M0.5561.00
232_A256_A0.5491.00
134_E137_A0.5471.00
51_A279_V0.5451.00
281_L287_P0.5431.00
82_V85_L0.5421.00
228_Q253_R0.5411.00
6_I13_S0.5411.00
27_K82_V0.5371.00
198_L225_G0.5371.00
56_A282_G0.5371.00
143_I146_Q0.5371.00
110_L274_A0.5351.00
45_D64_N0.5351.00
131_K307_P0.5351.00
205_L230_L0.5341.00
10_L13_S0.5331.00
223_A241_I0.5311.00
97_N101_E0.5281.00
190_D197_A0.5271.00
19_V22_H0.5241.00
26_V283_N0.5241.00
71_M101_E0.5211.00
26_V282_G0.5201.00
173_K178_S0.5191.00
226_A230_L0.5151.00
212_I215_V0.5141.00
63_A70_Q0.5111.00
152_M200_I0.5111.00
127_F270_L0.5091.00
273_T280_E0.5081.00
127_F132_V0.5071.00
103_K120_D0.5071.00
38_E221_A0.5071.00
37_L40_W0.5071.00
179_G182_K0.5071.00
43_D271_A0.5051.00
42_K45_D0.5031.00
50_K279_V0.5021.00
78_I81_G0.5011.00
76_N80_R0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2hsgA 1 0.8788 100 0.212 Contact Map
3huuA 2 0.8 100 0.219 Contact Map
2iksA 2 0.8303 100 0.225 Contact Map
3dbiA 2 0.8303 100 0.227 Contact Map
1qpzA 2 0.9152 100 0.227 Contact Map
4o5aA 2 0.8091 100 0.229 Contact Map
2o20A 2 0.8242 100 0.23 Contact Map
3h5oA 2 0.8091 100 0.23 Contact Map
3bilA 2 0.7697 100 0.23 Contact Map
3e3mA 2 0.803 100 0.231 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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