GREMLIN Database
MENH - 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase
UniProt: P37355 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12438
Length: 252 (236)
Sequences: 57503 (47231)
Seq/√Len: 3074.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
81_W105_G4.7541.00
48_P67_L4.7111.00
33_V243_I3.5731.00
208_E228_P2.9561.00
110_G210_D2.9431.00
69_R95_A2.9011.00
238_N241_G2.8341.00
81_W104_C2.6641.00
109_E242_V2.5821.00
225_H245_S2.5561.00
79_D104_C2.5381.00
203_Y249_I2.4331.00
89_G111_G2.3851.00
72_L80_F2.3811.00
227_I245_S2.2341.00
73_V102_G2.2251.00
95_A99_G2.2221.00
39_D247_A2.1011.00
69_R99_G2.0831.00
66_D98_Q2.0451.00
81_W107_I2.0271.00
82_L92_A2.0121.00
208_E226_V2.0031.00
230_A238_N1.9991.00
69_R102_G1.9621.00
10_G41_S1.9221.00
16_W43_L1.8711.00
69_R73_V1.8691.00
92_A106_V1.8441.00
21_H50_H1.8041.00
36_A243_I1.7821.00
45_V68_L1.7811.00
40_Y81_W1.7591.00
15_P81_W1.7481.00
96_A106_V1.7371.00
107_I246_L1.7251.00
94_M98_Q1.6961.00
68_L95_A1.6781.00
21_H47_L1.6631.00
16_W77_I1.6431.00
203_Y225_H1.6331.00
62_D98_Q1.5831.00
16_W41_S1.5801.00
47_L91_V1.5751.00
20_L92_A1.5731.00
244_A248_Q1.5631.00
99_G102_G1.5601.00
245_S248_Q1.5281.00
15_P104_C1.5261.00
43_L71_T1.4991.00
20_L47_L1.4921.00
95_A103_L1.4921.00
25_G29_E1.4821.00
194_N197_A1.4681.00
34_G44_Y1.4391.00
19_F83_V1.4361.00
60_G63_D1.4221.00
19_F42_R1.4151.00
27_C52_G1.4081.00
65_T94_M1.3991.00
108_V111_G1.3951.00
27_C46_D1.3501.00
24_S50_H1.3381.00
77_I80_F1.3281.00
157_N160_Q1.3221.00
45_V71_T1.3211.00
46_D51_G1.3201.00
36_A247_A1.3181.00
95_A102_G1.3121.00
20_L68_L1.3031.00
208_E229_R1.3001.00
73_V99_G1.2991.00
85_Y235_H1.2971.00
11_K14_L1.2951.00
24_S86_S1.2911.00
18_V72_L1.2851.00
227_I230_A1.2821.00
241_G245_S1.2791.00
72_L77_I1.2631.00
206_C217_A1.2501.00
71_T75_Y1.2291.00
94_M97_C1.2211.00
107_I203_Y1.2181.00
93_M108_V1.1901.00
242_V246_L1.1851.00
180_L183_T1.1761.00
72_L95_A1.1671.00
80_F103_L1.1591.00
14_L41_S1.1571.00
36_A240_A1.1471.00
97_C194_N1.1231.00
83_V109_E1.1231.00
241_G244_A1.1191.00
15_P40_Y1.1091.00
205_L245_S1.1071.00
205_L227_I1.1021.00
38_A42_R1.0911.00
10_G14_L1.0911.00
177_A181_E1.0861.00
230_A237_E1.0841.00
16_W40_Y1.0781.00
27_C44_Y1.0761.00
230_A234_A1.0671.00
43_L75_Y1.0541.00
85_Y233_N1.0461.00
29_E235_H1.0441.00
80_F102_G1.0431.00
179_M182_A1.0381.00
17_L40_Y1.0361.00
158_D162_R1.0341.00
86_S232_H1.0301.00
65_T91_V1.0131.00
106_V202_F1.0041.00
223_D245_S1.0031.00
206_C224_C1.0021.00
240_A244_A0.9991.00
18_V68_L0.9981.00
20_L82_L0.9981.00
227_I241_G0.9961.00
83_V246_L0.9961.00
32_E35_E0.9841.00
227_I238_N0.9811.00
136_L139_P0.9801.00
31_Q44_Y0.9781.00
172_N175_T0.9761.00
18_V80_F0.9751.00
69_R98_Q0.9651.00
17_L83_V0.9641.00
206_C226_V0.9621.00
15_P105_G0.9601.00
179_M183_T0.9501.00
62_D94_M0.9411.00
96_A103_L0.9341.00
203_Y223_D0.9291.00
15_P79_D0.9231.00
162_R166_A0.9221.00
231_G237_E0.9181.00
174_A178_A0.9171.00
94_M194_N0.9161.00
218_A221_A0.9141.00
22_G86_S0.9111.00
109_E235_H0.9111.00
204_Y222_A0.9071.00
139_P142_A0.9041.00
27_C45_V0.9021.00
65_T98_Q0.8991.00
20_L45_V0.8981.00
17_L42_R0.8961.00
178_A181_E0.8961.00
69_R72_L0.8951.00
82_L95_A0.8881.00
84_G92_A0.8881.00
225_H248_Q0.8881.00
176_L179_M0.8861.00
34_G42_R0.8741.00
12_P41_S0.8731.00
162_R165_V0.8721.00
84_G89_G0.8681.00
47_L87_L0.8651.00
76_N79_D0.8611.00
21_H45_V0.8581.00
35_E38_A0.8521.00
218_A226_V0.8451.00
175_T178_A0.8381.00
163_E167_L0.8321.00
129_R133_Q0.8301.00
225_H241_G0.8241.00
105_G201_A0.8231.00
16_W80_F0.8221.00
141_T145_A0.8191.00
70_K74_S0.8161.00
218_A224_C0.8141.00
178_A182_A0.8131.00
24_S87_L0.8131.00
229_R238_N0.8121.00
64_V87_L0.8111.00
215_A218_A0.8101.00
41_S77_I0.8091.00
209_R229_R0.8071.00
217_A224_C0.8071.00
70_K73_V0.8041.00
83_V107_I0.8041.00
66_D70_K0.8011.00
103_L200_F0.7981.00
28_H31_Q0.7901.00
205_L242_V0.7901.00
47_L50_H0.7901.00
110_G234_A0.7891.00
43_L77_I0.7881.00
63_D66_D0.7811.00
109_E234_A0.7801.00
239_P243_I0.7791.00
110_G206_C0.7771.00
47_L64_V0.7701.00
46_D52_G0.7681.00
176_L180_L0.7681.00
66_D69_R0.7641.00
18_V82_L0.7581.00
48_P64_V0.7561.00
47_L68_L0.7511.00
221_A224_C0.7511.00
93_M111_G0.7481.00
40_Y247_A0.7471.00
174_A179_M0.7451.00
207_G234_A0.7441.00
66_D99_G0.7441.00
23_F87_L0.7401.00
82_L103_L0.7381.00
34_G38_A0.7371.00
175_T179_M0.7361.00
223_D248_Q0.7281.00
96_A200_F0.7281.00
10_G13_G0.7261.00
108_V204_Y0.7231.00
105_G249_I0.7211.00
198_R202_F0.7211.00
13_G41_S0.7201.00
142_A145_A0.7181.00
17_L37_F0.7161.00
39_D42_R0.7141.00
174_A177_A0.7141.00
204_Y224_C0.7121.00
126_R129_R0.7091.00
65_T95_A0.7091.00
85_Y110_G0.7061.00
84_G88_G0.7061.00
33_V36_A0.7051.00
30_W34_G0.7041.00
11_K41_S0.7021.00
71_T74_S0.6991.00
17_L81_W0.6991.00
243_I247_A0.6951.00
19_F30_W0.6941.00
78_L102_G0.6921.00
72_L102_G0.6851.00
30_W33_V0.6831.00
93_M113_P0.6701.00
96_A198_R0.6691.00
19_F37_F0.6681.00
80_F104_C0.6661.00
89_G108_V0.6641.00
86_S233_N0.6631.00
110_G207_G0.6621.00
19_F44_Y0.6581.00
33_V242_V0.6561.00
172_N176_L0.6531.00
204_Y221_A0.6511.00
46_D53_S0.6511.00
177_A180_L0.6491.00
97_C197_A0.6481.00
80_F95_A0.6481.00
151_P154_A0.6441.00
85_Y109_E0.6431.00
62_D66_D0.6421.00
48_P55_A0.6401.00
61_F94_M0.6331.00
167_L170_N0.6311.00
205_L225_H0.6311.00
216_L219_E0.6311.00
29_E85_Y0.6251.00
228_P241_G0.6251.00
172_N180_L0.6221.00
90_R112_H0.6191.00
172_N178_A0.6181.00
244_A247_A0.6181.00
130_Q134_R0.6171.00
190_D194_N0.6141.00
159_D162_R0.6141.00
143_V147_W0.6121.00
48_P56_I0.6121.00
98_Q194_N0.6111.00
191_L194_N0.6071.00
61_F91_V0.6011.00
204_Y217_A0.6011.00
136_L140_L0.6001.00
65_T69_R0.5991.00
33_V235_H0.5971.00
164_L167_L0.5951.00
163_E166_A0.5951.00
23_F50_H0.5941.00
161_R165_V0.5941.00
128_D131_W0.5941.00
64_V91_V0.5891.00
79_D102_G0.5891.00
26_D50_H0.5881.00
131_W135_F0.5861.00
140_L144_F0.5861.00
147_W150_Q0.5861.00
209_R230_A0.5851.00
234_A242_V0.5851.00
20_L91_V0.5851.00
128_D132_V0.5841.00
140_L143_V0.5821.00
87_L91_V0.5801.00
217_A221_A0.5801.00
136_L141_T0.5771.00
105_G203_Y0.5721.00
25_G233_N0.5701.00
37_F42_R0.5701.00
129_R135_F0.5701.00
138_E142_A0.5691.00
215_A219_E0.5671.00
31_Q35_E0.5671.00
109_E205_L0.5651.00
30_W83_V0.5631.00
190_D193_A0.5611.00
151_P155_S0.5581.00
144_F148_Y0.5551.00
104_C107_I0.5551.00
235_H242_V0.5551.00
128_D135_F0.5531.00
173_G180_L0.5501.00
107_I205_L0.5501.00
176_L183_T0.5491.00
28_H52_G0.5471.00
125_Q131_W0.5421.00
125_Q128_D0.5401.00
85_Y234_A0.5391.00
148_Y151_P0.5391.00
79_D101_A0.5381.00
176_L181_E0.5371.00
165_V169_S0.5361.00
29_E236_R0.5361.00
166_A169_S0.5351.00
14_L40_Y0.5331.00
21_H30_W0.5311.00
25_G85_Y0.5301.00
160_Q163_E0.5251.00
161_R164_L0.5211.00
68_L91_V0.5201.00
209_R228_P0.5201.00
123_E126_R0.5171.00
130_Q133_Q0.5171.00
143_V146_D0.5161.00
159_D163_E0.5141.00
173_G178_A0.5131.00
149_Q152_V0.5121.00
139_P148_Y0.5121.00
150_Q153_F0.5121.00
89_G110_G0.5111.00
23_F86_S0.5111.00
175_T181_E0.5101.00
125_Q129_R0.5091.00
142_A146_D0.5081.00
124_R128_D0.5071.00
243_I248_Q0.5071.00
193_A196_S0.5071.00
173_G176_L0.5041.00
202_F222_A0.5031.00
63_D67_L0.5021.00
108_V202_F0.5021.00
152_V155_S0.5011.00
130_Q135_F0.5001.00
176_L182_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4mydA 1 1 100 0.15 Contact Map
1ehyA 1 0.9484 100 0.206 Contact Map
1r3dA 1 0.9722 100 0.216 Contact Map
2xmzA 1 0.996 100 0.218 Contact Map
4inzA 1 0.9881 100 0.227 Contact Map
3bf7A 1 0.9444 100 0.234 Contact Map
3om8A 4 0.9683 100 0.239 Contact Map
3oosA 1 0.9603 100 0.244 Contact Map
5bovA 2 0.996 100 0.248 Contact Map
2xuaA 2 0.9683 100 0.25 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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