GREMLIN Database
MENE - 2-succinylbenzoate--CoA ligase
UniProt: P37353 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12437
Length: 451 (432)
Sequences: 70450 (49543)
Seq/√Len: 2383.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
136_L153_V3.8641.00
374_H410_W3.0811.00
305_V338_G3.0491.00
38_D74_Q2.8941.00
97_N141_L2.8631.00
319_N322_L2.8391.00
297_E308_R2.8021.00
339_E346_T2.7271.00
155_T314_E2.7221.00
53_S101_Q2.7211.00
34_C74_Q2.6951.00
56_M100_L2.6801.00
49_V77_A2.6521.00
22_R202_R2.5321.00
356_F361_G2.5141.00
304_E333_A2.4521.00
19_I27_Q2.3891.00
177_D202_R2.3741.00
379_Q432_K2.3351.00
43_G47_Q2.3291.00
54_G80_L2.3281.00
301_V306_W2.3011.00
99_T318_R2.2541.00
15_R18_T2.2491.00
371_I396_A2.2471.00
9_R34_C2.2181.00
372_A380_V2.2141.00
36_R67_L2.1431.00
341_H346_T2.1131.00
11_W15_R2.1121.00
97_N319_N2.1051.00
306_W333_A2.0901.00
68_A104_L2.0821.00
93_E148_L2.0641.00
23_L63_P2.0441.00
353_N440_R2.0331.00
34_C38_D2.0271.00
395_V425_L2.0271.00
439_S442_A1.9871.00
72_L77_A1.9861.00
341_H344_K1.9661.00
288_D346_T1.9651.00
132_Q135_R1.9391.00
176_D241_K1.9301.00
373_A414_K1.9271.00
176_D219_T1.8941.00
40_L67_L1.8791.00
339_E348_V1.8471.00
320_G324_S1.8401.00
366_E419_Q1.8271.00
51_E135_R1.7891.00
252_V256_E1.7891.00
17_E31_R1.7791.00
299_K306_W1.7671.00
92_E96_P1.7641.00
50_V53_S1.7591.00
52_G135_R1.7521.00
340_M345_L1.7271.00
45_A75_C1.7261.00
37_V74_Q1.7221.00
22_R27_Q1.7221.00
378_L401_D1.6981.00
442_A445_E1.6731.00
372_A379_Q1.6601.00
66_L193_M1.6531.00
204_T218_C1.6511.00
155_T158_A1.6491.00
10_H14_V1.6481.00
60_W106_P1.6441.00
368_E382_I1.6361.00
38_D42_S1.6341.00
397_V443_L1.6291.00
31_R35_A1.6221.00
383_V397_V1.6181.00
56_M82_V1.5861.00
223_L228_L1.5681.00
211_L215_L1.5571.00
136_L314_E1.5501.00
73_L137_C1.5441.00
217_G239_S1.5411.00
29_N32_E1.5291.00
141_L151_A1.5251.00
400_Y426_T1.5081.00
399_E430_E1.5041.00
211_L214_M1.5021.00
11_W14_V1.5011.00
398_M426_T1.5001.00
382_I396_A1.4981.00
357_S362_I1.4901.00
19_I22_R1.4831.00
264_R282_E1.4801.00
28_L67_L1.4761.00
397_V444_K1.4731.00
54_G78_R1.4701.00
325_L328_D1.4621.00
278_V307_L1.4601.00
196_W201_A1.4571.00
167_L199_A1.4571.00
300_I338_G1.4511.00
256_E260_E1.4511.00
376_A406_D1.4511.00
134_T157_Q1.4361.00
433_N439_S1.4251.00
16_G31_R1.4211.00
338_G347_I1.4211.00
226_T248_A1.4201.00
285_G342_N1.4191.00
98_L141_L1.4071.00
228_L243_V1.4061.00
9_R74_Q1.4051.00
168_S294_P1.4031.00
271_L332_Y1.4021.00
19_I202_R1.4021.00
370_V414_K1.3971.00
55_V72_L1.3951.00
139_M317_W1.3951.00
158_A275_A1.3931.00
12_R34_C1.3931.00
18_T175_H1.3931.00
410_W414_K1.3911.00
179_L218_C1.3871.00
153_V317_W1.3731.00
212_E215_L1.3731.00
28_L63_P1.3661.00
20_A33_L1.3621.00
153_V315_G1.3621.00
173_G176_D1.3601.00
176_D220_H1.3551.00
386_A392_H1.3541.00
408_S424_W1.3521.00
398_M424_W1.3511.00
308_R331_W1.3481.00
95_L100_L1.3411.00
279_C298_V1.3211.00
177_D204_T1.3171.00
55_V77_A1.3161.00
298_V307_L1.3091.00
52_G314_E1.3091.00
337_R351_L1.3051.00
23_L26_E1.3041.00
409_E413_D1.2981.00
97_N318_R1.2881.00
291_S344_K1.2841.00
397_V427_L1.2801.00
80_L98_L1.2721.00
285_G344_K1.2691.00
56_M95_L1.2651.00
54_G139_M1.2651.00
387_D393_R1.2631.00
49_V53_S1.2601.00
299_K331_W1.2561.00
133_P157_Q1.2561.00
355_F364_P1.2551.00
70_L197_L1.2531.00
54_G317_W1.2501.00
101_Q116_T1.2401.00
379_Q399_E1.2341.00
353_N365_E1.2321.00
408_S412_K1.2281.00
245_L250_I1.2281.00
292_P298_V1.2241.00
395_V423_R1.2111.00
412_K420_Q1.2061.00
385_V395_V1.2051.00
403_E406_D1.2041.00
93_E97_N1.2021.00
305_V347_I1.2011.00
71_A75_C1.1991.00
78_R136_L1.1981.00
410_W413_D1.1971.00
57_L68_A1.1961.00
49_V55_V1.1901.00
157_Q310_A1.1871.00
97_N148_L1.1831.00
304_E351_L1.1821.00
365_E369_R1.1791.00
139_M151_A1.1681.00
177_D218_C1.1621.00
281_K344_K1.1581.00
188_S222_S1.1581.00
33_L70_L1.1561.00
142_T152_A1.1511.00
221_A240_L1.1501.00
153_V314_E1.1501.00
88_Q92_E1.1481.00
36_R39_E1.1431.00
412_K417_R1.1421.00
35_A39_E1.1411.00
360_E418_F1.1361.00
393_R422_V1.1331.00
233_V257_Q1.1211.00
154_H158_A1.1211.00
384_P392_H1.1161.00
96_P148_L1.1161.00
131_W135_R1.1081.00
354_L363_Q1.1031.00
40_L71_A1.1011.00
28_L36_R1.0971.00
396_A424_W1.0941.00
220_H242_A1.0901.00
58_R91_L1.0901.00
9_R38_D1.0871.00
411_V420_Q1.0861.00
43_G46_V1.0841.00
22_R204_T1.0821.00
393_R423_R1.0771.00
90_L419_Q1.0761.00
404_S424_W1.0751.00
232_L257_Q1.0731.00
20_A30_W1.0711.00
32_E35_A1.0641.00
134_T155_T1.0631.00
65_T184_L1.0631.00
229_W254_L1.0601.00
36_R64_Q1.0601.00
404_S426_T1.0591.00
319_N323_V1.0561.00
281_K288_D1.0541.00
40_L104_L1.0541.00
26_E63_P1.0491.00
327_N333_A1.0471.00
41_A74_Q1.0451.00
358_G390_F1.0431.00
296_R311_S1.0381.00
289_V347_I1.0351.00
33_L67_L1.0321.00
306_W331_W1.0281.00
143_S435_G1.0251.00
251_P254_L1.0211.00
161_A295_G1.0121.00
405_V409_E1.0091.00
427_L430_E1.0081.00
177_D219_T1.0051.00
406_D409_E1.0011.00
385_V423_R1.0011.00
176_D201_A0.9981.00
140_T272_T0.9941.00
178_W196_W0.9941.00
82_V91_L0.9941.00
416_A419_Q0.9931.00
182_L188_S0.9901.00
378_L399_E0.9851.00
93_E141_L0.9821.00
49_V102_F0.9811.00
37_V71_A0.9811.00
18_T202_R0.9781.00
213_Q216_A0.9771.00
24_N207_D0.9761.00
355_F394_P0.9761.00
374_H407_L0.9721.00
212_E216_A0.9711.00
152_A313_A0.9711.00
430_E438_I0.9701.00
161_A310_A0.9661.00
309_A312_M0.9641.00
83_N185_F0.9641.00
308_R329_E0.9621.00
370_V373_A0.9601.00
288_D344_K0.9571.00
158_A312_M0.9571.00
368_E440_R0.9551.00
40_L68_A0.9531.00
53_S77_A0.9501.00
28_L33_L0.9501.00
230_R389_E0.9481.00
89_P414_K0.9471.00
441_Q445_E0.9471.00
279_C345_L0.9431.00
44_F72_L0.9421.00
298_V345_L0.9411.00
179_L206_R0.9341.00
307_L334_T0.9341.00
370_V411_V0.9331.00
59_A62_T0.9291.00
285_G341_H0.9251.00
253_E257_Q0.9241.00
162_S276_S0.9211.00
337_R349_G0.9201.00
381_F430_E0.9191.00
54_G99_T0.9191.00
404_S408_S0.9181.00
26_E36_R0.9161.00
229_W251_P0.9131.00
86_L94_L0.9121.00
33_L37_V0.9121.00
21_L66_L0.9051.00
250_I255_T0.9041.00
373_A410_W0.9031.00
93_E96_P0.9031.00
56_M103_A0.9031.00
357_S422_V0.9021.00
8_W12_R0.9001.00
42_S45_A0.8961.00
228_L258_A0.8931.00
89_P93_E0.8901.00
63_P67_L0.8811.00
163_A198_Y0.8791.00
409_E412_K0.8781.00
374_H406_D0.8761.00
69_W190_Q0.8741.00
242_A266_F0.8731.00
57_L79_V0.8711.00
69_W79_V0.8701.00
406_D410_W0.8701.00
89_P92_E0.8691.00
137_C156_Y0.8691.00
222_S277_T0.8681.00
244_L268_G0.8681.00
300_I345_L0.8681.00
298_V305_V0.8681.00
93_E319_N0.8671.00
34_C37_V0.8671.00
357_S384_P0.8671.00
22_R177_D0.8601.00
240_L243_V0.8571.00
154_H275_A0.8571.00
187_V271_L0.8551.00
407_L424_W0.8511.00
72_L79_V0.8501.00
64_Q67_L0.8491.00
196_W203_M0.8471.00
154_H313_A0.8461.00
376_A401_D0.8451.00
187_V276_S0.8441.00
209_Q227_Q0.8381.00
41_A75_C0.8371.00
60_W108_G0.8281.00
32_E36_R0.8251.00
257_Q260_E0.8241.00
386_A389_E0.8241.00
45_A50_V0.8231.00
36_R63_P0.8231.00
49_V75_C0.8221.00
322_L325_L0.8151.00
175_H219_T0.8131.00
44_F104_L0.8121.00
21_L63_P0.8111.00
39_E43_G0.8101.00
56_M80_L0.8091.00
10_H13_Q0.8091.00
181_S227_Q0.8061.00
224_V227_Q0.8021.00
19_I29_N0.8011.00
228_L245_L0.7991.00
308_R330_G0.7981.00
206_R214_M0.7961.00
7_P164_Q0.7951.00
216_A235_R0.7951.00
381_F443_L0.7921.00
66_L205_V0.7911.00
305_V345_L0.7881.00
378_L400_Y0.7871.00
136_L155_T0.7861.00
327_N330_G0.7861.00
376_A400_Y0.7841.00
274_F332_Y0.7831.00
328_D333_A0.7821.00
7_P11_W0.7801.00
8_W70_L0.7801.00
242_A264_R0.7791.00
326_V331_W0.7791.00
177_D217_G0.7771.00
274_F312_M0.7761.00
33_L66_L0.7751.00
321_Q324_S0.7741.00
235_R238_V0.7731.00
19_I23_L0.7681.00
9_R13_Q0.7671.00
18_T174_D0.7641.00
353_N368_E0.7621.00
6_W9_R0.7611.00
320_G323_V0.7541.00
219_T241_K0.7531.00
72_L75_C0.7521.00
274_F307_L0.7521.00
131_W156_Y0.7521.00
94_L151_A0.7521.00
229_W257_Q0.7521.00
297_E331_W0.7511.00
80_L100_L0.7501.00
6_W10_H0.7501.00
26_E64_Q0.7481.00
67_L71_A0.7481.00
408_S420_Q0.7481.00
333_A351_L0.7451.00
188_S246_G0.7451.00
399_E429_P0.7451.00
162_S275_A0.7431.00
115_L118_L0.7421.00
69_W73_L0.7411.00
253_E256_E0.7361.00
15_R31_R0.7361.00
191_G222_S0.7351.00
298_V338_G0.7331.00
386_A390_F0.7281.00
47_Q102_F0.7281.00
299_K308_R0.7251.00
58_R103_A0.7231.00
338_G345_L0.7211.00
59_A65_T0.7211.00
381_F438_I0.7191.00
229_W233_V0.7161.00
364_P382_I0.7141.00
137_C159_H0.7131.00
162_S191_G0.7071.00
186_H360_E0.7061.00
267_C287_A0.7061.00
138_S154_H0.7061.00
79_V190_Q0.7041.00
172_F176_D0.7041.00
62_T106_P0.7031.00
212_E234_N0.7021.00
274_F278_V0.7011.00
169_L294_P0.7011.00
411_V415_L0.7011.00
50_V77_A0.7001.00
386_A391_G0.6991.00
167_L195_R0.6961.00
338_G348_V0.6951.00
222_S268_G0.6941.00
8_W34_C0.6931.00
68_A72_L0.6921.00
268_G277_T0.6911.00
87_P90_L0.6891.00
172_F220_H0.6891.00
40_L44_F0.6881.00
370_V410_W0.6871.00
42_S127_H0.6861.00
266_F282_E0.6841.00
41_A71_A0.6821.00
89_P148_L0.6801.00
45_A129_A0.6791.00
181_S224_V0.6791.00
385_V393_R0.6771.00
243_V258_A0.6751.00
250_I265_C0.6751.00
306_W327_N0.6751.00
69_W194_W0.6751.00
383_V444_K0.6741.00
178_W220_H0.6731.00
300_I340_M0.6731.00
17_E29_N0.6721.00
113_P116_T0.6721.00
293_L296_R0.6721.00
40_L43_G0.6721.00
56_M98_L0.6711.00
269_Y278_V0.6691.00
357_S390_F0.6691.00
417_R420_Q0.6671.00
328_D331_W0.6671.00
364_P440_R0.6661.00
59_A68_A0.6661.00
59_A104_L0.6661.00
371_I380_V0.6641.00
387_D390_F0.6621.00
173_G241_K0.6611.00
326_V332_Y0.6611.00
381_F440_R0.6601.00
431_L443_L0.6601.00
210_P213_Q0.6591.00
45_A128_A0.6581.00
48_G77_A0.6581.00
27_Q202_R0.6571.00
397_V425_L0.6571.00
55_V102_F0.6551.00
46_V121_Q0.6481.00
312_M332_Y0.6481.00
11_W200_G0.6471.00
12_R16_G0.6471.00
162_S277_T0.6451.00
357_S394_P0.6451.00
229_W253_E0.6441.00
99_T317_W0.6431.00
365_E368_E0.6431.00
39_E42_S0.6401.00
377_V398_M0.6401.00
158_A314_E0.6361.00
37_V41_A0.6351.00
364_P384_P0.6341.00
301_V331_W0.6341.00
38_D45_A0.6331.00
249_A347_I0.6331.00
183_P186_H0.6311.00
378_L402_H0.6311.00
134_T314_E0.6301.00
23_L207_D0.6291.00
50_V101_Q0.6281.00
30_W201_A0.6281.00
271_L334_T0.6261.00
243_V263_I0.6261.00
191_G277_T0.6251.00
300_I305_V0.6251.00
70_L194_W0.6251.00
37_V40_L0.6241.00
51_E129_A0.6241.00
97_N317_W0.6241.00
377_V380_V0.6231.00
191_G276_S0.6221.00
182_L222_S0.6211.00
185_F360_E0.6161.00
172_F201_A0.6161.00
299_K328_D0.6161.00
352_D392_H0.6141.00
13_Q34_C0.6131.00
64_Q106_P0.6131.00
115_L119_H0.6121.00
221_A243_V0.6111.00
21_L203_M0.6101.00
28_L32_E0.6091.00
297_E328_D0.6081.00
114_A117_S0.6071.00
138_S159_H0.6061.00
271_L274_F0.6061.00
392_H444_K0.6051.00
163_A194_W0.6031.00
19_I177_D0.6011.00
59_A106_P0.6011.00
51_E131_W0.6011.00
80_L141_L0.6001.00
192_I222_S0.5981.00
138_S190_Q0.5981.00
408_S411_V0.5981.00
59_A105_V0.5971.00
54_G318_R0.5971.00
398_M407_L0.5951.00
325_L332_Y0.5951.00
164_Q198_Y0.5951.00
44_F102_F0.5941.00
356_F363_Q0.5911.00
297_E329_E0.5911.00
257_Q261_Q0.5891.00
78_R139_M0.5851.00
250_I267_C0.5841.00
404_S423_R0.5841.00
289_V338_G0.5831.00
15_R200_G0.5821.00
78_R317_W0.5781.00
7_P160_L0.5761.00
371_I411_V0.5741.00
178_W201_A0.5731.00
355_F384_P0.5711.00
211_L216_A0.5711.00
245_L265_C0.5711.00
78_R81_P0.5701.00
256_E259_R0.5701.00
254_L257_Q0.5691.00
69_W193_M0.5691.00
148_L319_N0.5671.00
306_W351_L0.5671.00
7_P198_Y0.5661.00
354_L361_G0.5641.00
188_S244_L0.5641.00
97_N151_A0.5631.00
181_S223_L0.5621.00
349_G364_P0.5621.00
379_Q430_E0.5611.00
57_L72_L0.5601.00
147_G363_Q0.5601.00
180_L203_M0.5601.00
22_R25_D0.5591.00
370_V415_L0.5591.00
54_G100_L0.5581.00
376_A410_W0.5581.00
109_E113_P0.5571.00
368_E396_A0.5551.00
177_D180_L0.5541.00
15_R174_D0.5531.00
139_M153_V0.5531.00
113_P117_S0.5521.00
113_P119_H0.5521.00
420_Q424_W0.5501.00
374_H377_V0.5491.00
135_R156_Y0.5481.00
385_V397_V0.5471.00
164_Q167_L0.5471.00
8_W11_W0.5451.00
81_P140_T0.5431.00
349_G365_E0.5431.00
36_R40_L0.5431.00
222_S246_G0.5421.00
42_S46_V0.5421.00
367_V394_P0.5421.00
86_L91_L0.5421.00
225_P248_A0.5421.00
369_R373_A0.5421.00
165_G169_L0.5411.00
279_C289_V0.5401.00
96_P114_A0.5391.00
57_L65_T0.5391.00
326_V333_A0.5381.00
82_V95_L0.5371.00
179_L214_M0.5371.00
180_L189_G0.5351.00
162_S166_V0.5341.00
216_A236_S0.5341.00
259_R264_R0.5341.00
258_A265_C0.5341.00
86_L185_F0.5321.00
268_G280_A0.5321.00
144_G150_K0.5291.00
49_V101_Q0.5291.00
246_G268_G0.5281.00
245_L267_C0.5261.00
353_N364_P0.5261.00
180_L205_V0.5261.00
98_L151_A0.5261.00
6_W130_T0.5241.00
98_L139_M0.5231.00
163_A195_R0.5231.00
307_L312_M0.5221.00
246_G277_T0.5221.00
58_R105_V0.5221.00
152_A272_T0.5201.00
30_W197_L0.5201.00
8_W37_V0.5201.00
282_E291_S0.5201.00
255_T267_C0.5191.00
162_S278_V0.5191.00
188_S268_G0.5191.00
219_T239_S0.5191.00
369_R372_A0.5181.00
371_I382_I0.5171.00
357_S392_H0.5171.00
300_I303_N0.5161.00
313_A332_Y0.5151.00
164_Q168_S0.5151.00
367_V421_P0.5151.00
21_L33_L0.5131.00
146_T150_K0.5131.00
335_R352_D0.5121.00
232_L254_L0.5111.00
315_G320_G0.5101.00
60_W208_K0.5091.00
165_G293_L0.5091.00
143_S149_P0.5071.00
143_S150_K0.5061.00
37_V70_L0.5051.00
172_F195_R0.5041.00
90_L366_E0.5041.00
77_A102_F0.5031.00
245_L258_A0.5031.00
35_A38_D0.5031.00
47_Q117_S0.5031.00
21_L28_L0.5021.00
73_L79_V0.5021.00
31_R34_C0.5021.00
412_K421_P0.5001.00
403_E426_T0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3tsyA 2 0.7827 100 0.133 Contact Map
3g7sA 2 0.9091 100 0.139 Contact Map
1mdbA 1 1 100 0.14 Contact Map
3etcA 2 0.9579 100 0.146 Contact Map
1v25A 2 0.949 100 0.148 Contact Map
1pg4A 1 0.9978 100 0.149 Contact Map
3wvnA 1 0.7561 100 0.151 Contact Map
4lgcA 1 0.7583 100 0.152 Contact Map
2vsqA 1 0.9978 100 0.153 Contact Map
3ni2A 1 0.9889 100 0.155 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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