GREMLIN Database
RPIB - Ribose-5-phosphate isomerase B
UniProt: P37351 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11827
Length: 149 (142)
Sequences: 3508 (2150)
Seq/√Len: 180.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
45_H140_A3.3911.00
135_Q139_E3.3071.00
22_H122_D2.6141.00
17_H20_V2.3351.00
26_R122_D2.2491.00
18_E114_L2.1501.00
5_A33_K2.0761.00
90_P119_M2.0731.00
84_A106_A2.0371.00
33_K53_A2.0011.00
94_Q98_Q1.9561.00
98_Q130_E1.8911.00
5_A59_V1.8821.00
7_G50_V1.8631.00
14_I38_S1.8621.00
20_V24_V1.7821.00
85_V96_S1.7711.00
88_S92_S1.7211.00
67_G110_R1.7191.00
18_E118_K1.7081.00
15_L117_A1.6941.00
3_K29_E1.6941.00
113_G116_L1.6751.00
53_A58_E1.6531.00
48_S144_I1.6441.00
12_G65_I1.6341.00
14_I109_S1.6321.00
64_L76_A1.4571.00
21_A25_E1.4401.00
31_I59_V1.4381.00
42_D136_Q1.4371.00
122_D126_G1.4311.00
21_A24_V1.4281.00
26_R126_G1.4061.00
5_A53_A1.3871.00
51_A82_I1.3851.00
98_Q127_A1.3831.00
48_S52_L1.3771.00
55_A79_F1.3761.00
89_E92_S1.3651.00
47_A72_I1.3641.00
91_Y95_L1.3491.00
64_L72_I1.3231.00
48_S79_F1.3011.00
64_L106_A1.2931.00
11_V110_R1.2871.00
52_L56_G1.2811.00
22_H118_K1.2761.00
22_H26_R1.2751.00
94_Q119_M1.2731.00
24_V30_V1.2721.00
102_T124_W1.2701.00
13_F17_H1.2651.00
16_K32_D1.2571.00
63_I121_V1.2061.00
55_A82_I1.1951.00
70_V85_V1.1781.00
139_E143_A1.1711.00
78_K142_T1.1641.00
90_P123_A1.1271.00
115_E118_K1.1211.00
50_V62_G1.1211.00
76_A84_A1.1131.00
84_A104_V1.1081.00
6_F20_V1.1071.00
95_L98_Q1.0971.00
73_S106_A1.0941.00
96_S124_W1.0791.00
19_I121_V1.0681.00
91_Y111_V1.0631.00
73_S86_V1.0571.00
123_A127_A1.0501.00
96_S102_T1.0451.00
47_A64_L1.0421.00
61_G124_W1.0361.00
5_A57_G1.0291.00
40_R136_Q1.0240.99
87_C105_L1.0210.99
61_G97_R1.0190.99
94_Q123_A1.0140.99
66_C72_I1.0050.99
120_I123_A0.9940.99
57_G60_D0.9830.99
82_I104_V0.9810.99
93_A120_I0.9730.99
15_L114_L0.9530.99
51_A104_V0.9470.99
50_V64_L0.9460.99
105_L120_I0.9440.99
15_L109_S0.9400.99
7_G33_K0.9400.99
72_I106_A0.9230.99
41_T46_Y0.9190.99
87_C120_I0.9020.99
101_D129_Y0.9000.99
79_F144_I0.8910.99
139_E142_T0.8890.99
8_C35_T0.8880.99
88_S112_V0.8790.98
131_G135_Q0.8730.98
8_C12_G0.8640.98
73_S84_A0.8500.98
13_F37_S0.8500.98
138_V142_T0.8370.98
31_I53_A0.8340.98
51_A55_A0.8320.98
5_A60_D0.8320.98
32_D36_W0.8300.98
18_E21_A0.8300.98
91_Y113_G0.8240.98
7_G46_Y0.8130.97
49_Q53_A0.8130.97
108_G111_V0.8100.97
6_F23_L0.8070.97
107_F121_V0.8070.97
19_I118_K0.8060.97
107_F112_V0.8060.97
22_H25_E0.8010.97
42_D140_A0.7970.97
18_E22_H0.7970.97
63_I105_L0.7960.97
35_T46_Y0.7920.97
112_V120_I0.7810.97
6_F30_V0.7780.97
50_V104_V0.7740.97
33_K59_V0.7690.96
119_M122_D0.7650.96
51_A79_F0.7640.96
97_R124_W0.7600.96
43_Y134_H0.7580.96
17_H21_A0.7570.96
8_C17_H0.7550.96
97_R127_A0.7530.96
112_V117_A0.7470.96
31_I36_W0.7460.96
19_I65_I0.7450.96
3_K31_I0.7370.95
99_H137_R0.7310.95
3_K60_D0.7210.95
75_A141_I0.7120.94
24_V29_E0.7100.94
119_M123_A0.7030.94
52_L144_I0.6990.94
4_I28_V0.6980.94
89_E116_L0.6930.94
7_G64_L0.6880.93
112_V116_L0.6870.93
134_H137_R0.6870.93
8_C13_F0.6850.93
4_I125_L0.6830.93
5_A50_V0.6790.93
129_Y135_Q0.6760.93
132_G135_Q0.6750.93
54_V81_G0.6740.93
74_I102_T0.6720.93
35_T41_T0.6690.92
6_F65_I0.6680.92
53_A59_V0.6640.92
72_I75_A0.6610.92
70_V96_S0.6590.92
90_P120_I0.6510.91
42_D45_H0.6480.91
31_I58_E0.6470.91
99_H134_H0.6410.91
99_H133_R0.6410.91
70_V73_S0.6310.90
55_A80_A0.6280.90
136_Q139_E0.6220.89
133_R137_R0.6190.89
93_A105_L0.6170.89
90_P94_Q0.6160.89
69_G86_V0.6130.89
70_V86_V0.6120.89
35_T40_R0.6060.88
92_S108_G0.6050.88
44_P140_A0.6010.88
95_L99_H0.5990.88
45_H49_Q0.5970.87
7_G16_K0.5970.87
114_L118_K0.5970.87
101_D142_T0.5940.87
61_G101_D0.5920.87
92_S111_V0.5900.87
88_S107_F0.5850.86
66_C73_S0.5800.86
78_K141_I0.5790.86
135_Q138_V0.5780.86
57_G61_G0.5730.85
62_G104_V0.5710.85
52_L55_A0.5690.85
23_L26_R0.5620.84
11_V67_G0.5590.84
48_S142_T0.5590.84
47_A51_A0.5560.84
116_L120_I0.5550.83
8_C32_D0.5510.83
101_D135_Q0.5440.82
47_A66_C0.5430.82
83_R142_T0.5370.81
13_F16_K0.5340.81
23_L121_V0.5300.81
14_I18_E0.5280.80
75_A79_F0.5250.80
10_H42_D0.5230.80
40_R46_Y0.5140.78
25_E118_K0.5130.78
129_Y138_V0.5100.78
70_V92_S0.5080.78
70_V74_I0.5070.78
26_R118_K0.5060.77
6_F63_I0.5000.77
65_I109_S0.5000.77
101_D131_G0.5000.77
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2vvrA 2 0.9866 100 0.022 Contact Map
3s5pA 4 0.8926 100 0.033 Contact Map
3he8A 2 0.9933 100 0.037 Contact Map
3k7pA 4 1 100 0.038 Contact Map
4lflB 3 0.9933 100 0.039 Contact Map
3ph3A 2 0.9866 100 0.039 Contact Map
2vvpA 2 1 100 0.047 Contact Map
3sgwA 4 1 100 0.056 Contact Map
1o1xA 3 0.9664 100 0.06 Contact Map
4lflA 2 0.9396 100 0.067 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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