GREMLIN Database
DHAM - PTS-dependent dihydroxyacetone kinase, phosphotransferase subunit DhaM
UniProt: P37349 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12399
Length: 472 (405)
Sequences: 406 (322)
Seq/√Len: 16.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
419_G461_L5.2831.00
135_L140_S4.1891.00
184_N223_E3.9851.00
234_L239_F3.5461.00
398_I461_L3.3970.99
374_D407_S3.2760.99
183_F227_A3.2610.99
117_I124_A2.9070.98
70_D74_A2.8310.97
398_I419_G2.7970.97
264_Q459_L2.7830.97
183_F230_A2.7630.97
185_A223_E2.7440.97
284_R343_E2.7330.97
350_L376_L2.6550.96
217_L235_A2.6100.96
87_P90_A2.5890.96
209_V215_L2.5800.96
156_R225_E2.5640.95
443_I468_F2.5450.95
103_G106_A2.5270.95
106_A110_S2.5240.95
443_I463_V2.5240.95
410_L442_W2.5180.95
70_D73_S2.5090.95
164_N240_G2.5070.95
346_W380_L2.4490.94
69_M95_L2.4340.94
101_V106_A2.4150.94
225_E229_I2.3560.93
158_L232_R2.3070.92
281_E342_A2.2790.92
161_V214_T2.2420.91
446_Q450_L2.2340.91
137_L140_S2.2240.90
162_I209_V2.2180.90
117_I121_I2.2110.90
463_V466_Q2.1880.90
317_G404_I2.1850.90
264_Q453_I2.1600.89
208_Q444_C2.1590.89
364_Y367_A2.1510.89
436_R442_W2.1140.88
223_E226_E2.0940.88
59_V62_A2.0930.87
112_A403_N2.0790.87
164_N241_E1.9890.85
296_L319_H1.9820.84
70_D75_L1.9800.84
232_R236_E1.9620.84
162_I215_L1.8940.82
187_M198_P1.8770.81
134_Q137_L1.8360.79
107_A111_A1.7970.78
166_N201_I1.7700.77
134_Q138_P1.7700.77
423_S447_G1.7650.77
292_T378_R1.7580.76
340_C344_Y1.7580.76
180_L187_M1.7180.75
189_L235_A1.6960.74
112_A117_I1.6920.73
292_T382_H1.6910.73
159_A214_T1.6800.73
73_S103_G1.6670.72
65_V72_G1.6660.72
101_V105_L1.6480.71
186_D197_T1.6220.70
180_L231_F1.6070.69
182_T363_E1.6050.69
299_L445_Q1.5740.68
423_S451_Y1.5710.68
135_L138_P1.5560.67
420_I435_A1.5260.65
183_F231_F1.5180.65
106_A109_V1.5160.65
185_A221_G1.5080.64
64_H68_M1.5070.64
370_I399_L1.5010.64
74_A81_A1.4960.64
191_K213_D1.4950.64
123_D127_A1.4920.63
184_N222_P1.4900.63
92_K95_L1.4690.62
159_A216_R1.4410.61
410_L436_R1.4230.60
285_L331_A1.4150.59
103_G107_A1.4110.59
258_G463_V1.3930.58
196_V409_V1.3910.58
121_I124_A1.3880.58
103_G114_G1.3820.57
261_F460_T1.3820.57
64_H67_V1.3720.57
86_A95_L1.3710.57
214_T237_D1.3660.56
400_L459_L1.3630.56
408_T429_S1.3600.56
285_L412_L1.3540.56
358_Q373_D1.3500.55
90_A95_L1.3460.55
346_W376_L1.3450.55
299_L378_R1.3440.55
236_E399_L1.3410.55
374_D378_R1.3060.53
422_L426_S1.3020.53
102_E124_A1.3000.53
453_I459_L1.2780.51
202_N357_Y1.2730.51
177_V403_N1.2710.51
121_I125_M1.2660.51
190_E193_G1.2650.51
255_P369_Y1.2610.50
164_N238_N1.2600.50
168_L436_R1.2560.50
77_S131_K1.2520.50
114_G126_H1.2520.50
67_V70_D1.2480.50
293_L319_H1.2480.50
176_L198_P1.2460.49
162_I364_Y1.2460.49
99_P102_E1.2450.49
283_D287_Q1.2440.49
198_P231_F1.2390.49
114_G131_K1.2360.49
303_A311_I1.2300.49
166_N264_Q1.2180.48
72_G75_L1.2150.48
124_A130_A1.2150.48
105_L108_T1.2100.47
403_N463_V1.2030.47
146_D233_Q1.2000.47
78_A95_L1.1970.47
74_A102_E1.1950.47
275_T341_T1.1940.46
156_R228_L1.1860.46
240_G318_H1.1860.46
395_S455_P1.1810.46
164_N239_F1.1790.46
227_A230_A1.1760.45
258_G466_Q1.1760.45
244_E247_P1.1710.45
70_D103_G1.1700.45
210_R213_D1.1700.45
315_F380_L1.1680.45
221_G227_A1.1650.45
429_S433_L1.1630.45
436_R463_V1.1600.44
62_A65_V1.1560.44
160_V278_V1.1540.44
196_V431_S1.1510.44
96_C99_P1.1510.44
298_T326_E1.1500.44
80_T116_D1.1430.44
157_S386_T1.1420.43
346_W379_T1.1350.43
142_T293_L1.1340.43
93_V120_V1.1290.43
346_W413_D1.1270.43
396_P418_K1.1050.41
161_V389_E1.1050.41
72_G102_E1.1020.41
123_D131_K1.0970.41
240_G434_I1.0890.40
227_A435_A1.0890.40
189_L217_L1.0860.40
59_V67_V1.0830.40
115_A125_M1.0820.40
70_D81_A1.0790.40
152_D279_E1.0760.40
408_T442_W1.0740.40
376_L463_V1.0700.39
105_L375_L1.0680.39
421_C446_Q1.0660.39
62_A67_V1.0620.39
249_T298_T1.0610.39
277_T280_E1.0540.39
343_E459_L1.0510.38
267_L434_I1.0450.38
60_A92_K1.0360.38
70_D98_A1.0350.37
433_L436_R1.0350.37
81_A114_G1.0270.37
263_Y395_S1.0270.37
243_E383_L1.0240.37
105_L110_S1.0220.37
201_I396_P1.0130.36
374_D429_S1.0120.36
319_H460_T1.0110.36
62_A68_M1.0100.36
408_T466_Q1.0100.36
378_R422_L1.0080.36
353_L372_V1.0080.36
265_P393_F1.0030.36
176_L231_F0.9960.35
199_E223_E0.9940.35
134_Q289_I0.9930.35
197_T367_A0.9900.35
374_D432_A0.9890.35
70_D77_S0.9870.35
74_A98_A0.9850.35
118_D124_A0.9850.35
260_A376_L0.9850.35
328_L331_A0.9840.35
109_V127_A0.9820.35
250_L446_Q0.9800.35
59_V69_M0.9790.34
98_A102_E0.9770.34
61_D67_V0.9750.34
183_F199_E0.9740.34
189_L195_C0.9740.34
253_V466_Q0.9720.34
176_L239_F0.9710.34
176_L362_D0.9640.34
343_E384_T0.9640.34
183_F223_E0.9640.34
74_A114_G0.9600.34
116_D124_A0.9560.33
187_M398_I0.9510.33
404_I409_V0.9510.33
351_K355_Q0.9480.33
374_D438_L0.9360.32
203_Q357_Y0.9360.32
79_E468_F0.9340.32
198_P292_T0.9280.32
266_V455_P0.9260.32
363_E367_A0.9260.32
98_A239_F0.9240.32
82_L87_P0.9240.32
67_V86_A0.9210.32
108_T112_A0.9210.32
61_D69_M0.9200.31
408_T463_V0.9180.31
197_T409_V0.9140.31
135_L141_D0.9110.31
201_I321_L0.9100.31
369_Y428_V0.9090.31
402_E424_A0.9090.31
115_A124_A0.9070.31
258_G436_R0.9050.31
112_A115_A0.9050.31
281_E318_H0.9030.31
360_L380_L0.9020.31
238_N399_L0.9010.31
354_S373_D0.8980.30
67_V95_L0.8940.30
410_L445_Q0.8940.30
65_V74_A0.8910.30
95_L98_A0.8890.30
398_I407_S0.8880.30
393_F416_V0.8860.30
227_A314_I0.8850.30
376_L413_D0.8820.30
326_E405_Y0.8810.30
431_S444_C0.8800.30
431_S438_L0.8780.29
303_A308_L0.8780.29
180_L199_E0.8770.29
442_W463_V0.8760.29
84_L103_G0.8730.29
119_K355_Q0.8700.29
401_A404_I0.8650.29
103_G108_T0.8620.29
155_A220_K0.8610.29
115_A118_D0.8600.29
267_L349_V0.8600.29
124_A127_A0.8570.28
74_A78_A0.8570.28
74_A99_P0.8560.28
107_A124_A0.8560.28
428_V442_W0.8550.28
235_A323_D0.8550.28
168_L176_L0.8550.28
165_R254_P0.8530.28
95_L101_V0.8500.28
291_F470_R0.8500.28
111_A124_A0.8490.28
343_E383_L0.8450.28
114_G117_I0.8420.28
62_A69_M0.8420.28
454_Q457_E0.8410.28
292_T367_A0.8380.28
247_P391_P0.8380.28
257_S350_L0.8380.28
141_D283_D0.8370.27
256_V369_Y0.8370.27
204_I444_C0.8330.27
134_Q141_D0.8300.27
186_D262_Y0.8300.27
214_T421_C0.8270.27
234_L240_G0.8270.27
258_G428_V0.8220.27
180_L227_A0.8210.27
160_V231_F0.8200.27
409_V431_S0.8160.27
78_A81_A0.8150.26
289_I434_I0.8130.26
314_I433_L0.8120.26
354_S358_Q0.8110.26
282_Q332_S0.8090.26
135_L139_S0.8070.26
303_A342_A0.8050.26
374_D406_P0.8040.26
327_L349_V0.8020.26
183_F398_I0.8000.26
202_N364_Y0.7990.26
158_L217_L0.7980.26
254_P463_V0.7960.26
117_I125_M0.7930.25
330_A362_D0.7900.25
408_T436_R0.7880.25
164_N318_H0.7880.25
117_I123_D0.7870.25
421_C468_F0.7840.25
187_M217_L0.7830.25
115_A121_I0.7780.25
237_D240_G0.7770.25
433_L442_W0.7760.25
278_V335_L0.7760.25
77_S81_A0.7740.25
273_K375_L0.7740.25
99_P103_G0.7740.25
229_I446_Q0.7740.25
338_E468_F0.7730.25
70_D79_E0.7730.25
238_N341_T0.7700.24
208_Q261_F0.7690.24
176_L238_N0.7690.24
257_S376_L0.7670.24
378_R407_S0.7670.24
311_I434_I0.7660.24
332_S335_L0.7660.24
265_P303_A0.7630.24
106_A111_A0.7620.24
292_T375_L0.7620.24
65_V174_S0.7610.24
80_T407_S0.7610.24
158_L229_I0.7610.24
393_F396_P0.7610.24
104_T109_V0.7600.24
165_R341_T0.7590.24
282_Q336_Q0.7570.24
71_M75_L0.7560.24
61_D68_M0.7560.24
114_G118_D0.7540.24
287_Q454_Q0.7530.24
98_A101_V0.7500.24
102_E117_I0.7460.23
319_H465_T0.7430.23
352_E359_Q0.7410.23
133_E137_L0.7410.23
215_L350_L0.7400.23
105_L118_D0.7390.23
215_L450_L0.7370.23
70_D95_L0.7360.23
325_P345_A0.7360.23
108_T111_A0.7350.23
355_Q459_L0.7340.23
255_P381_V0.7340.23
238_N342_A0.7320.23
200_S281_E0.7320.23
74_A131_K0.7320.23
72_G106_A0.7310.23
403_N468_F0.7310.23
86_A92_K0.7270.23
86_A90_A0.7250.23
354_S376_L0.7230.23
326_E329_A0.7230.23
367_A427_P0.7230.23
296_L300_T0.7230.23
107_A110_S0.7220.22
95_L130_A0.7210.22
114_G123_D0.7210.22
217_L266_V0.7200.22
170_V256_V0.7200.22
252_P374_D0.7180.22
376_L408_T0.7180.22
187_M199_E0.7170.22
361_D443_I0.7170.22
128_L353_L0.7140.22
70_D102_E0.7120.22
208_Q423_S0.7110.22
414_P440_I0.7100.22
204_I209_V0.7080.22
175_R382_H0.7080.22
189_L467_R0.7050.22
108_T114_G0.7030.22
80_T90_A0.7030.22
258_G379_T0.7030.22
204_I292_T0.7030.22
164_N176_L0.7020.22
263_Y396_P0.7010.22
196_V316_S0.7000.22
428_V463_V0.6980.22
179_T234_L0.6980.22
459_L470_R0.6960.21
330_A335_L0.6950.21
392_Q395_S0.6940.21
252_P441_G0.6930.21
83_E127_A0.6930.21
67_V72_G0.6900.21
310_D411_Q0.6880.21
107_A120_V0.6870.21
206_L289_I0.6860.21
69_M77_S0.6860.21
217_L286_R0.6820.21
413_D417_V0.6820.21
63_D67_V0.6820.21
118_D125_M0.6800.21
73_S99_P0.6780.21
109_V123_D0.6760.21
103_G128_L0.6750.21
81_A95_L0.6700.20
170_V379_T0.6690.20
110_S422_L0.6660.20
102_E107_A0.6630.20
260_A346_W0.6630.20
192_N227_A0.6630.20
110_S125_M0.6620.20
349_V434_I0.6620.20
72_G83_E0.6610.20
81_A117_I0.6610.20
104_T202_N0.6610.20
74_A101_V0.6600.20
158_L162_I0.6580.20
281_E292_T0.6550.20
142_T226_E0.6550.20
201_I217_L0.6530.20
162_I310_D0.6530.20
84_L204_I0.6530.20
142_T214_T0.6490.20
77_S103_G0.6490.20
81_A98_A0.6490.20
345_A360_L0.6480.20
190_E459_L0.6480.20
77_S124_A0.6480.20
161_V461_L0.6460.20
422_L451_Y0.6450.20
164_N204_I0.6450.20
73_S78_A0.6440.19
68_M95_L0.6440.19
257_S346_W0.6440.19
59_V68_M0.6420.19
420_I440_I0.6410.19
170_V208_Q0.6400.19
219_A360_L0.6390.19
59_V70_D0.6380.19
187_M231_F0.6340.19
157_S216_R0.6330.19
438_L461_L0.6310.19
405_Y409_V0.6290.19
328_L446_Q0.6290.19
83_E123_D0.6280.19
289_I318_H0.6270.19
77_S200_S0.6270.19
262_Y393_F0.6270.19
376_L445_Q0.6250.19
188_L398_I0.6220.19
70_D202_N0.6210.19
256_V409_V0.6200.19
181_S320_T0.6180.19
275_T307_G0.6170.19
256_V438_L0.6150.18
444_C447_G0.6150.18
259_K367_A0.6150.18
238_N366_Q0.6140.18
102_E106_A0.6140.18
432_A442_W0.6130.18
420_I468_F0.6120.18
298_T389_E0.6120.18
315_F381_V0.6110.18
213_D362_D0.6090.18
314_I410_L0.6080.18
354_S413_D0.6070.18
341_T445_Q0.6070.18
187_M454_Q0.6070.18
79_E95_L0.6060.18
313_A348_Q0.6060.18
145_S148_C0.6050.18
219_A227_A0.6050.18
152_D403_N0.6020.18
176_L350_L0.6020.18
406_P435_A0.6010.18
232_R383_L0.5990.18
96_C124_A0.5980.18
97_A125_M0.5940.18
241_E411_Q0.5940.18
93_V469_N0.5940.18
170_V259_K0.5940.18
258_G403_N0.5900.18
262_Y361_D0.5890.18
188_L448_E0.5880.18
165_R352_E0.5880.18
105_L109_V0.5870.17
92_K124_A0.5870.17
295_D301_A0.5870.17
78_A96_C0.5870.17
256_V403_N0.5860.17
101_V107_A0.5860.17
64_H170_V0.5850.17
292_T376_L0.5850.17
131_K135_L0.5840.17
70_D107_A0.5830.17
168_L417_V0.5820.17
77_S98_A0.5810.17
290_D294_L0.5810.17
308_L312_A0.5810.17
199_E421_C0.5800.17
346_W350_L0.5790.17
219_A455_P0.5790.17
310_D465_T0.5780.17
258_G442_W0.5780.17
256_V376_L0.5780.17
83_E364_Y0.5780.17
343_E464_K0.5770.17
139_S450_L0.5770.17
447_G450_L0.5760.17
77_S84_L0.5760.17
369_Y426_S0.5740.17
174_S252_P0.5730.17
95_L124_A0.5730.17
281_E341_T0.5730.17
120_V215_L0.5720.17
150_A245_V0.5700.17
383_L387_K0.5680.17
409_V447_G0.5670.17
168_L308_L0.5650.17
188_L454_Q0.5650.17
263_Y362_D0.5640.17
170_V410_L0.5630.17
287_Q338_E0.5630.17
116_D125_M0.5630.17
90_A208_Q0.5630.17
325_P352_E0.5620.17
73_S102_E0.5620.17
292_T437_E0.5620.17
275_T335_L0.5620.17
72_G77_S0.5590.17
398_I421_C0.5590.17
160_V240_G0.5590.17
106_A124_A0.5580.17
77_S205_A0.5580.17
407_S432_A0.5570.17
210_R284_R0.5550.16
65_V70_D0.5550.16
285_L378_R0.5540.16
201_I263_Y0.5530.16
320_T360_L0.5530.16
228_L236_E0.5520.16
166_N263_Y0.5500.16
162_I187_M0.5490.16
261_F443_I0.5490.16
230_A428_V0.5480.16
290_D313_A0.5460.16
65_V69_M0.5450.16
77_S82_L0.5450.16
78_A83_E0.5450.16
92_K96_C0.5440.16
375_L404_I0.5440.16
72_G99_P0.5430.16
325_P342_A0.5420.16
128_L450_L0.5410.16
69_M79_E0.5410.16
375_L420_I0.5400.16
120_V320_T0.5390.16
110_S124_A0.5390.16
458_T461_L0.5390.16
177_V469_N0.5360.16
256_V442_W0.5360.16
198_P217_L0.5350.16
77_S127_A0.5320.16
147_T290_D0.5320.16
286_R294_L0.5320.16
384_T437_E0.5280.16
73_S114_G0.5280.16
287_Q383_L0.5270.16
262_Y291_F0.5260.16
133_E140_S0.5240.15
166_N241_E0.5240.15
281_E332_S0.5230.15
234_L238_N0.5230.15
354_S445_Q0.5230.15
254_P363_E0.5230.15
344_Y348_Q0.5220.15
389_E393_F0.5210.15
70_D76_L0.5210.15
205_A364_Y0.5210.15
60_A407_S0.5200.15
215_L348_Q0.5200.15
126_H429_S0.5180.15
74_A107_A0.5180.15
349_V419_G0.5170.15
77_S80_T0.5150.15
144_I470_R0.5150.15
422_L435_A0.5130.15
341_T344_Y0.5130.15
67_V357_Y0.5130.15
76_L296_L0.5100.15
238_N434_I0.5080.15
374_D426_S0.5050.15
92_K125_M0.5040.15
253_V448_E0.5040.15
64_H441_G0.5030.15
293_L323_D0.5030.15
103_G131_K0.5020.15
364_Y372_V0.5010.15
95_L125_M0.5010.15
303_A307_G0.5000.15
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1zymA 2 0.4725 100 0.636 Contact Map
2wqdA 2 0.4788 100 0.648 Contact Map
2hwgA 2 0.4725 100 0.654 Contact Map
1kblA 2 0.7246 100 0.811 Contact Map
2x0sA 2 0.7585 100 0.818 Contact Map
1vbgA 2 0.7542 100 0.827 Contact Map
1pchA 1 0.1843 99.9 0.844 Contact Map
3le1A 1 0.1843 99.9 0.845 Contact Map
1sphA 2 0.1822 99.9 0.847 Contact Map
1y51A 1 0.1822 99.9 0.848 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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