GREMLIN Database
YECE - UPF0759 protein YecE
UniProt: P37348 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12379
Length: 272 (228)
Sequences: 2589 (1825)
Seq/√Len: 120.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
31_C232_F4.5971.00
214_Q251_D4.4861.00
210_R247_T3.9941.00
20_T23_E3.8211.00
54_T94_R3.0451.00
131_V146_L2.6771.00
28_H246_H2.6331.00
64_F100_L2.5721.00
49_R53_Q2.5341.00
69_S100_L2.5271.00
118_L155_V2.4251.00
44_P48_L2.3301.00
115_W153_R2.2811.00
51_R92_A2.2041.00
82_T86_T2.1641.00
119_D153_R2.1451.00
3_Y30_N2.1401.00
108_P135_Q2.0931.00
128_G158_V2.0441.00
213_F251_D1.9971.00
78_D120_S1.9881.00
247_T250_E1.9271.00
235_T241_A1.9061.00
200_F231_L1.8991.00
115_W119_D1.8471.00
42_P47_V1.8311.00
151_H190_V1.8131.00
37_T47_V1.7971.00
30_N249_W1.7721.00
220_L231_L1.7521.00
2_I224_H1.7461.00
198_I216_W1.7441.00
61_C232_F1.7331.00
217_L221_A1.7261.00
108_P146_L1.7151.00
102_L114_L1.7041.00
54_T60_F1.6991.00
220_L248_L1.6991.00
194_T227_T1.6721.00
195_N230_Y1.6681.00
115_W152_Q1.6661.00
22_L54_T1.6111.00
47_V91_L1.5961.00
11_H14_W1.5771.00
156_N193_A1.5661.00
121_L127_Y1.5361.00
25_Y32_V1.5291.00
96_G230_Y1.5141.00
6_L25_Y1.5141.00
43_K46_V1.4991.00
209_N212_L1.4771.00
23_E53_Q1.4521.00
59_R230_Y1.4401.00
7_P232_F1.4361.00
147_N190_V1.4101.00
149_G153_R1.4051.00
72_A76_H1.3991.00
129_V150_L1.3961.00
100_L127_Y1.3761.00
62_F91_L1.3701.00
79_D83_E1.3701.00
55_T94_R1.3641.00
48_L90_P1.3531.00
3_Y59_R1.3501.00
107_G133_H1.3271.00
156_N195_N1.3131.00
4_I249_W1.2831.00
64_F98_Y1.2731.00
9_W34_G1.2580.99
75_R113_A1.2570.99
49_R52_E1.2530.99
148_R152_Q1.2470.99
45_E48_L1.2350.99
18_G21_S1.2250.99
128_G156_N1.2240.99
59_R96_G1.2220.99
51_R94_R1.2220.99
196_P229_P1.2210.99
48_L52_E1.2190.99
115_W149_G1.2160.99
34_G46_V1.2090.99
111_L115_W1.2070.99
67_T80_L1.2020.99
61_C97_Q1.1930.99
47_V88_M1.1900.99
76_H80_L1.1850.99
97_Q230_Y1.1440.99
42_P87_R1.1400.99
189_A216_W1.1350.99
3_Y228_T1.1300.99
12_P18_G1.1290.99
114_L129_V1.1280.99
23_E27_R1.1180.99
68_I81_V1.1160.99
8_Q11_H1.1140.99
244_L247_T1.1120.99
126_N194_T1.1120.99
45_E49_R1.1070.99
95_I98_Y1.0990.99
201_I235_T1.0890.99
108_P111_L1.0810.98
97_Q195_N1.0750.98
111_L114_L1.0640.98
34_G60_F1.0580.98
85_L98_Y1.0460.98
4_I248_L1.0420.98
9_W50_W1.0340.98
72_A80_L1.0330.98
24_E28_H1.0250.98
154_G194_T1.0200.98
15_V21_S1.0180.98
83_E86_T1.0180.98
3_Y230_Y1.0170.98
73_A105_T1.0130.98
148_R151_H1.0060.98
210_R251_D1.0040.97
44_P87_R1.0030.97
57_D93_P1.0020.97
40_A43_K1.0000.97
147_N151_H0.9850.97
64_F81_V0.9850.97
78_D82_T0.9830.97
200_F234_H0.9780.97
116_H119_D0.9750.97
233_L248_L0.9720.97
196_P226_T0.9690.97
13_K239_A0.9690.97
203_S212_L0.9680.97
191_L196_P0.9660.97
51_R91_L0.9660.97
37_T84_F0.9660.97
22_L60_F0.9640.97
11_H236_P0.9640.97
215_V219_K0.9600.97
34_G62_F0.9500.96
112_P115_W0.9490.96
163_R202_G0.9470.96
147_N157_R0.9460.96
210_R214_Q0.9450.96
38_L70_H0.9430.96
129_V155_V0.9310.96
161_D203_S0.9280.96
79_D82_T0.9270.96
44_P86_T0.9160.96
44_P90_P0.9150.96
217_L248_L0.9110.96
67_T72_A0.9070.95
41_L87_R0.9060.95
80_L83_E0.9050.95
113_A117_F0.9010.95
24_E27_R0.8980.95
201_I244_L0.8960.95
217_L252_L0.8930.95
67_T71_Q0.8820.95
208_Q233_L0.8800.95
137_F157_R0.8740.94
97_Q128_G0.8630.94
233_L244_L0.8470.93
58_F94_R0.8430.93
116_H120_S0.8400.93
13_K236_P0.8370.93
70_H74_L0.8370.93
2_I252_L0.8350.93
201_I234_H0.8230.92
163_R183_P0.8190.92
114_L118_L0.8170.92
97_Q197_L0.8160.92
222_Q225_Q0.8150.92
26_A54_T0.8120.92
51_R93_P0.8120.92
204_D212_L0.8030.92
202_G235_T0.7970.91
4_I245_V0.7970.91
195_N228_T0.7950.91
233_L245_V0.7950.91
201_I208_Q0.7930.91
117_F121_L0.7920.91
202_G207_T0.7850.91
100_L129_V0.7750.90
240_Q243_E0.7750.90
56_D94_R0.7740.90
70_H103_P0.7700.90
66_A71_Q0.7620.89
189_A219_K0.7610.89
219_K222_Q0.7590.89
17_L239_A0.7560.89
64_F69_S0.7520.89
38_L103_P0.7490.88
4_I252_L0.7470.88
17_L243_E0.7470.88
16_R20_T0.7460.88
216_W219_K0.7440.88
203_S235_T0.7390.88
136_F146_L0.7370.88
203_S209_N0.7340.87
98_Y125_F0.7320.87
92_A125_F0.7250.87
7_P35_N0.7230.87
81_V85_L0.7180.86
214_Q217_L0.7160.86
126_N195_N0.7140.86
31_C230_Y0.7130.86
122_P127_Y0.7110.86
191_L226_T0.7090.86
47_V87_R0.7080.85
63_K101_Q0.7070.85
108_P138_A0.7040.85
216_W223_W0.7000.85
73_A113_A0.6970.85
126_N228_T0.6940.84
220_L229_P0.6940.84
62_F88_M0.6910.84
201_I236_P0.6910.84
212_L244_L0.6870.84
112_P119_D0.6870.84
11_H16_R0.6860.84
96_G228_T0.6830.83
41_L65_P0.6800.83
3_Y96_G0.6790.83
109_R113_A0.6790.83
109_R135_Q0.6760.83
57_D94_R0.6740.83
127_Y155_V0.6730.82
208_Q213_F0.6710.82
187_V219_K0.6690.82
134_P137_F0.6690.82
93_P250_E0.6680.82
117_F122_P0.6680.82
112_P116_H0.6660.82
34_G37_T0.6630.82
72_A75_R0.6600.81
159_I187_V0.6590.81
196_P223_W0.6590.81
200_F216_W0.6590.81
129_V146_L0.6580.81
10_S18_G0.6580.81
83_E87_R0.6550.81
86_T89_S0.6510.80
55_T58_F0.6500.80
73_A106_F0.6450.80
99_W235_T0.6440.80
163_R212_L0.6400.79
150_L155_V0.6390.79
61_C197_L0.6390.79
64_F121_L0.6360.79
207_T234_H0.6360.79
198_I220_L0.6330.78
150_L157_R0.6330.78
43_K87_R0.6280.78
65_P68_I0.6260.78
235_T244_L0.6240.77
99_W158_V0.6220.77
7_P234_H0.6210.77
106_F109_R0.6180.77
25_Y29_F0.6170.77
62_F84_F0.6160.77
70_H73_A0.6150.76
64_F127_Y0.6120.76
63_K132_R0.6070.76
118_L122_P0.6040.75
7_P14_W0.6030.75
69_S103_P0.6020.75
157_R160_L0.6010.75
72_A77_C0.6010.75
231_L248_L0.5990.75
22_L26_A0.5970.74
207_T236_P0.5960.74
74_L117_F0.5960.74
47_V62_F0.5960.74
131_V147_N0.5920.74
99_W201_I0.5880.73
34_G47_V0.5870.73
65_P84_F0.5860.73
88_M98_Y0.5830.73
24_E246_H0.5810.72
117_F127_Y0.5800.72
23_E28_H0.5780.72
218_Q222_Q0.5780.72
159_I223_W0.5770.72
246_H249_W0.5770.72
3_Y57_D0.5770.72
88_M95_I0.5760.72
190_V226_T0.5750.72
2_I15_V0.5710.71
56_D93_P0.5710.71
10_S36_T0.5670.71
106_F131_V0.5660.70
101_Q132_R0.5640.70
77_C120_S0.5630.70
26_A53_Q0.5630.70
159_I198_I0.5630.70
42_P49_R0.5630.70
102_L106_F0.5620.70
37_T88_M0.5610.70
202_G234_H0.5590.69
15_V18_G0.5580.69
124_E221_A0.5580.69
106_F114_L0.5570.69
29_F242_P0.5570.69
75_R116_H0.5550.69
126_N156_N0.5540.69
139_K147_N0.5520.68
10_S40_A0.5520.68
196_P227_T0.5510.68
60_F94_R0.5490.68
25_Y42_P0.5480.68
214_Q247_T0.5480.68
113_A116_H0.5460.68
137_F147_N0.5450.68
201_I241_A0.5440.67
35_N232_F0.5440.67
235_T239_A0.5420.67
68_I80_L0.5410.67
163_R234_H0.5410.67
157_R188_H0.5380.67
192_T196_P0.5370.66
44_P89_S0.5360.66
46_V49_R0.5340.66
139_K148_R0.5330.66
14_W243_E0.5310.66
131_V136_F0.5270.65
218_Q221_A0.5240.65
107_G134_P0.5230.64
13_K238_I0.5200.64
250_E254_K0.5200.64
162_S186_P0.5190.64
103_P106_F0.5190.64
148_R218_Q0.5190.64
74_L102_L0.5160.63
33_E199_R0.5160.63
211_E215_V0.5150.63
131_V150_L0.5140.63
30_N57_D0.5120.63
70_H101_Q0.5090.62
7_P11_H0.5080.62
9_W22_L0.5060.62
5_G8_Q0.5050.62
13_K242_P0.5020.61
106_F113_A0.5020.61
41_L83_E0.5010.61
108_P149_G0.5010.61
33_E50_W0.5000.61
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vpqA 2 0.8493 100 0.178 Contact Map
1vpyA 1 0.8419 100 0.188 Contact Map
3wqoA 2 0.886 84.9 0.943 Contact Map
3vylA 4 0.9007 82.2 0.945 Contact Map
2hk0A 3 0.8529 81.7 0.945 Contact Map
2qw5A 3 0.8713 79.8 0.946 Contact Map
4hnoA 1 0.8934 79.3 0.947 Contact Map
1k77A 1 0.8456 77.6 0.948 Contact Map
3kwsA 2 0.8456 77.1 0.948 Contact Map
3obeA 1 0.8566 67.2 0.951 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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