GREMLIN Database
PSPF - Psp operon transcriptional activator
UniProt: P37344 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12344
Length: 325 (304)
Sequences: 26857 (17620)
Seq/√Len: 1010.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
298_G308_L3.9821.00
155_M160_T3.5171.00
81_E91_R2.8541.00
95_R130_E2.7051.00
150_A155_M2.7011.00
70_E115_M2.6861.00
37_E180_R2.6061.00
154_A158_E2.5571.00
24_H241_G2.5221.00
129_L140_V2.4821.00
128_E137_P2.4431.00
288_K292_Q2.3651.00
128_E139_Q2.2751.00
297_Q308_L2.2481.00
130_E137_P2.2391.00
96_F123_V2.1891.00
81_E134_G2.1591.00
196_Q230_K2.1411.00
105_F147_A2.1371.00
97_E131_R2.1071.00
22_V45_I2.0981.00
187_M214_R2.0421.00
298_G305_A2.0241.00
66_A118_E1.9041.00
187_M218_L1.8621.00
74_D119_K1.8571.00
287_E319_L1.8541.00
290_L294_S1.8171.00
304_R307_E1.8091.00
191_E214_R1.7991.00
314_H318_A1.7871.00
190_A233_V1.7861.00
210_T246_P1.7831.00
23_S52_L1.7771.00
155_M158_E1.7771.00
154_A157_N1.7521.00
101_G141_N1.7371.00
35_I175_Q1.7361.00
82_A91_R1.7351.00
82_A89_Q1.7301.00
222_W232_V1.7241.00
111_T150_A1.7111.00
11_E188_L1.6951.00
151_D154_A1.6881.00
183_E187_M1.6711.00
301_N304_R1.6651.00
35_I173_V1.6611.00
208_G244_D1.6581.00
45_I176_L1.6511.00
192_Y196_Q1.6441.00
220_Y223_P1.5971.00
93_P97_E1.5791.00
82_A90_K1.5711.00
80_H85_F1.5681.00
292_Q296_Q1.5441.00
73_L116_V1.5411.00
284_M322_K1.5181.00
25_L172_D1.5091.00
286_Q290_L1.4931.00
293_L297_Q1.4921.00
212_R247_L1.4841.00
134_G138_L1.4811.00
303_K307_E1.4741.00
12_A184_S1.4711.00
55_R141_N1.4591.00
295_L305_A1.4591.00
294_S298_G1.4511.00
153_P157_N1.4391.00
314_H317_R1.4371.00
97_E138_L1.4351.00
304_R308_L1.4161.00
43_E122_R1.4121.00
30_K234_E1.4081.00
210_T213_A1.4021.00
48_R52_L1.3981.00
205_L208_G1.3941.00
70_E113_P1.3851.00
10_G15_F1.3851.00
302_Q317_R1.3621.00
246_P249_D1.3601.00
7_N51_Y1.3551.00
125_E230_K1.3501.00
183_E186_I1.3421.00
47_S62_S1.3381.00
303_K313_Y1.3271.00
58_G101_G1.3261.00
213_A245_Y1.2931.00
190_A209_F1.2891.00
216_T247_L1.2791.00
294_S305_A1.2771.00
312_T315_Q1.2761.00
10_G19_L1.2631.00
213_A217_L1.2611.00
96_F104_L1.2561.00
220_Y228_E1.2561.00
8_L15_F1.2531.00
213_A247_L1.2441.00
193_F230_K1.2431.00
318_A322_K1.2421.00
215_E219_N1.2341.00
18_V45_I1.2321.00
100_D140_V1.2311.00
15_F19_L1.2301.00
81_E131_R1.2291.00
9_L192_Y1.2241.00
209_F233_V1.2191.00
183_E221_R1.2171.00
282_F286_Q1.2061.00
131_R134_G1.2061.00
240_H249_D1.2021.00
207_P243_S1.2021.00
289_E293_L1.2021.00
29_D55_R1.1921.00
251_I254_P1.1891.00
312_T318_A1.1891.00
289_E292_Q1.1861.00
278_D281_E1.1771.00
315_Q319_L1.1751.00
210_T244_D1.1701.00
313_Y317_R1.1681.00
17_E20_E1.1601.00
189_M193_F1.1591.00
27_P54_S1.1571.00
251_I255_F1.1561.00
112_A116_V1.1531.00
100_D141_N1.1491.00
35_I153_P1.1491.00
20_E23_S1.1481.00
40_T176_L1.1471.00
18_V174_V1.1461.00
14_S17_E1.1461.00
92_H135_S1.1461.00
198_C204_P1.1431.00
17_E21_Q1.1411.00
187_M190_A1.1261.00
197_M237_V1.1251.00
283_Q286_Q1.1201.00
152_L161_F1.1101.00
29_D200_E1.1091.00
284_M288_K1.1071.00
98_R135_S1.1031.00
93_P98_R1.0831.00
146_C169_L1.0811.00
302_Q313_Y1.0801.00
317_R321_K1.0751.00
183_E218_L1.0661.00
230_K234_E1.0621.00
279_L282_F1.0601.00
200_E234_E1.0581.00
76_E92_H1.0541.00
43_E62_S1.0511.00
30_K171_F1.0511.00
100_D142_V1.0431.00
187_M191_E1.0411.00
294_S309_L1.0401.00
110_A148_T1.0391.00
123_V129_L1.0381.00
184_S218_L1.0381.00
30_K238_Y1.0361.00
194_A209_F1.0351.00
124_I144_L1.0301.00
153_P253_D1.0291.00
14_S181_E1.0291.00
29_D54_S1.0261.00
80_H84_A1.0261.00
198_C205_L1.0201.00
282_F290_L1.0191.00
214_R218_L1.0191.00
66_A111_T1.0141.00
47_S51_Y1.0131.00
285_Q289_E1.0081.00
279_L283_Q1.0081.00
157_N163_A1.0061.00
195_I199_R1.0061.00
97_E129_L1.0051.00
95_R98_R1.0041.00
93_P135_S1.0031.00
30_K201_I0.9961.00
294_S308_L0.9941.00
198_C207_P0.9941.00
283_Q290_L0.9941.00
75_S80_H0.9931.00
129_L139_Q0.9921.00
32_V49_L0.9911.00
175_Q181_E0.9871.00
298_G304_R0.9771.00
235_R239_R0.9761.00
281_E285_Q0.9741.00
60_F102_G0.9681.00
282_F285_Q0.9671.00
19_L22_V0.9671.00
31_P127_G0.9651.00
170_A173_V0.9601.00
215_E218_L0.9591.00
295_L300_Y0.9581.00
197_M233_V0.9531.00
211_E215_E0.9531.00
50_H103_T0.9511.00
21_Q239_R0.9501.00
73_L77_L0.9481.00
278_D310_G0.9441.00
211_E214_R0.9431.00
13_N17_E0.9391.00
150_A160_T0.9361.00
197_M201_I0.9361.00
33_L146_C0.9351.00
37_E40_T0.9341.00
22_V48_R0.9311.00
193_F197_M0.9291.00
18_V22_V0.9291.00
191_E195_I0.9241.00
232_V236_S0.9231.00
197_M230_K0.9191.00
34_I46_A0.9111.00
315_Q318_A0.9091.00
296_Q300_Y0.9081.00
302_Q320_L0.9041.00
66_A119_K0.9031.00
62_S122_R0.9031.00
11_E16_L0.8881.00
212_R246_P0.8851.00
16_L19_L0.8841.00
236_S240_H0.8831.00
302_Q314_H0.8801.00
22_V174_V0.8791.00
311_L316_F0.8781.00
302_Q316_F0.8771.00
301_N313_Y0.8771.00
85_F88_A0.8761.00
186_I190_A0.8751.00
127_G139_Q0.8751.00
131_R138_L0.8731.00
198_C203_L0.8721.00
188_L191_E0.8691.00
8_L45_I0.8691.00
209_F213_A0.8661.00
293_L296_Q0.8651.00
48_R51_Y0.8601.00
291_L319_L0.8591.00
279_L286_Q0.8581.00
305_A308_L0.8581.00
209_F214_R0.8571.00
317_R320_L0.8541.00
37_E178_P0.8481.00
305_A316_F0.8461.00
197_M234_E0.8451.00
316_F320_L0.8441.00
166_L170_A0.8371.00
198_C237_V0.8321.00
8_L44_L0.8301.00
153_P156_V0.8201.00
178_P181_E0.8191.00
196_Q200_E0.8181.00
19_L23_S0.8121.00
153_P173_V0.8111.00
295_L302_Q0.8101.00
103_T145_V0.8041.00
10_G188_L0.8001.00
311_L315_Q0.7991.00
15_F18_V0.7961.00
92_H98_R0.7951.00
16_L20_E0.7941.00
203_L207_P0.7921.00
201_I238_Y0.7921.00
13_N16_L0.7901.00
171_F231_N0.7891.00
46_A60_F0.7891.00
312_T317_R0.7861.00
34_I45_I0.7831.00
290_L293_L0.7831.00
96_F142_V0.7781.00
84_A88_A0.7731.00
318_A321_K0.7701.00
76_E95_R0.7691.00
194_A237_V0.7691.00
47_S126_Y0.7691.00
110_A152_L0.7641.00
61_I99_A0.7631.00
245_Y250_I0.7631.00
89_Q92_H0.7631.00
19_L45_I0.7621.00
55_R58_G0.7611.00
183_E188_L0.7591.00
303_K317_R0.7581.00
110_A150_A0.7561.00
287_E290_L0.7531.00
30_K172_D0.7531.00
8_L19_L0.7531.00
291_L316_F0.7511.00
285_Q288_K0.7501.00
94_G97_E0.7401.00
295_L320_L0.7391.00
190_A194_A0.7361.00
197_M200_E0.7291.00
9_L188_L0.7251.00
236_S245_Y0.7251.00
280_R284_M0.7221.00
98_R134_G0.7201.00
20_E24_H0.7201.00
28_L238_Y0.7191.00
63_L95_R0.7181.00
192_Y195_I0.7141.00
129_L138_L0.7101.00
18_V176_L0.7031.00
156_V166_L0.6991.00
96_F140_V0.6991.00
281_E289_E0.6971.00
122_R126_Y0.6951.00
22_V49_L0.6901.00
302_Q309_L0.6901.00
283_Q287_E0.6821.00
110_A149_N0.6801.00
92_H95_R0.6791.00
201_I237_V0.6771.00
20_E241_G0.6771.00
123_V142_V0.6761.00
235_R238_Y0.6761.00
64_N111_T0.6731.00
65_C106_L0.6731.00
245_Y249_D0.6691.00
301_N305_A0.6661.00
190_A214_R0.6641.00
73_L112_A0.6641.00
313_Y318_A0.6621.00
300_Y320_L0.6621.00
314_H321_K0.6601.00
290_L309_L0.6561.00
80_H92_H0.6561.00
204_P207_P0.6551.00
31_P146_C0.6541.00
94_G98_R0.6541.00
186_I217_L0.6501.00
24_H239_R0.6441.00
25_L32_V0.6431.00
68_L77_L0.6431.00
252_I255_F0.6391.00
194_A198_C0.6371.00
277_L282_F0.6321.00
183_E219_N0.6311.00
277_L281_E0.6301.00
213_A216_T0.6301.00
291_L305_A0.6231.00
22_V52_L0.6221.00
153_P163_A0.6221.00
104_L144_L0.6211.00
191_E208_G0.6211.00
188_L192_Y0.6181.00
209_F245_Y0.6171.00
84_A132_V0.6151.00
26_A52_L0.6151.00
71_N74_D0.6111.00
21_Q172_D0.6101.00
19_L48_R0.6101.00
279_L290_L0.6081.00
111_T149_N0.6061.00
232_V235_R0.6061.00
193_F233_V0.6051.00
90_K135_S0.6031.00
207_P237_V0.6031.00
21_Q24_H0.6021.00
234_E237_V0.6021.00
250_I253_D0.6021.00
34_I145_V0.6011.00
80_H89_Q0.6011.00
91_R136_Q0.6001.00
252_I256_K0.5981.00
11_E184_S0.5971.00
235_R251_I0.5941.00
216_T219_N0.5941.00
14_S18_V0.5941.00
250_I254_P0.5861.00
242_T249_D0.5851.00
295_L299_K0.5841.00
114_M118_E0.5831.00
29_D201_I0.5791.00
33_L109_L0.5791.00
216_T254_P0.5791.00
10_G16_L0.5791.00
247_L251_I0.5791.00
172_D239_R0.5771.00
59_P98_R0.5771.00
203_L237_V0.5771.00
173_V235_R0.5751.00
93_P131_R0.5741.00
300_Y305_A0.5731.00
277_L285_Q0.5711.00
233_V236_S0.5701.00
15_F45_I0.5701.00
190_A236_S0.5661.00
175_Q178_P0.5651.00
73_L119_K0.5651.00
170_A235_R0.5651.00
29_D141_N0.5591.00
291_L294_S0.5591.00
38_R163_A0.5581.00
281_E284_M0.5571.00
69_N132_V0.5571.00
294_S297_Q0.5551.00
276_P279_L0.5551.00
306_A316_F0.5551.00
313_Y316_F0.5531.00
216_T220_Y0.5531.00
34_I176_L0.5531.00
303_K314_H0.5531.00
287_E291_L0.5531.00
104_L123_V0.5511.00
69_N72_L0.5491.00
319_L322_K0.5491.00
80_H88_A0.5491.00
216_T251_I0.5491.00
24_H203_L0.5481.00
236_S250_I0.5461.00
100_D138_L0.5431.00
305_A309_L0.5421.00
237_V240_H0.5421.00
186_I218_L0.5381.00
71_N115_M0.5361.00
242_T246_P0.5361.00
275_L279_L0.5361.00
96_F129_L0.5351.00
225_N228_E0.5351.00
274_T277_L0.5341.00
161_F165_L0.5301.00
23_S48_R0.5281.00
8_L48_R0.5281.00
213_A236_S0.5251.00
28_L201_I0.5221.00
284_M287_E0.5221.00
75_S85_F0.5221.00
68_L73_L0.5221.00
207_P240_H0.5201.00
53_S56_W0.5191.00
286_Q289_E0.5181.00
281_E286_Q0.5161.00
127_G140_V0.5141.00
14_S184_S0.5141.00
19_L52_L0.5141.00
40_T44_L0.5131.00
83_G86_T0.5121.00
240_H243_S0.5121.00
204_P243_S0.5111.00
244_D247_L0.5101.00
222_W228_E0.5101.00
205_L237_V0.5101.00
312_T322_K0.5091.00
224_G228_E0.5091.00
116_V119_K0.5081.00
129_L137_P0.5051.00
31_P171_F0.5051.00
153_P166_L0.5051.00
217_L232_V0.5041.00
7_N47_S0.5031.00
43_E126_Y0.5021.00
65_C112_A0.5021.00
179_L229_L0.5021.00
189_M192_Y0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4l4uA 2 0.7662 100 0.069 Contact Map
1ojlA 3 0.9262 100 0.202 Contact Map
3dzdA 2 0.7538 100 0.317 Contact Map
4qosA 1 0.7415 100 0.443 Contact Map
4qhsA 3 0.7508 100 0.448 Contact Map
1r6bX 1 0.8123 100 0.474 Contact Map
1qvrA 3 0.7877 100 0.497 Contact Map
1hqcA 1 0.8246 100 0.504 Contact Map
1in4A 1 0.7938 100 0.509 Contact Map
3vkgA 2 0.9662 100 0.517 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0108 seconds.