MDTK - ECOLI - GREMLIN Contacts

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MDTK - Multidrug resistance protein MdtK

UniProt:	P37340	Sequences: MQKYISEARLLLALAIPVILAQIAQTAMGFVDTVMAGGYSATDMAAVAIGTSIWLPAILFGHGLLLALTPVIAQLNGSGRRERIAHQVRQGFWLAGFVSVLIMLVLWNAGYIIRSMENIDPALADKAVGYLRALLWGAPGYLFFQVARNQCEGLAKTKPGMVMGFIGLLVNIPVNYIFIYGHFGMPELGGVGCGVATAAVYWVMFLAMVSYIKRARSMRDIRNEKGTAKPDPAVMKRLIQLGLPIALALFFEVTLFAVVALLVSPLGIVDVAGHQIALNFSSLMFVLPMSLAAAVTIRVGYRLGQGSTLDAQTAARTGLMVGVCMATLTAIFTVSLREQIALLYNDNPEVVTLAAHLMLLAAVYQISDSIQVIGSGILRGYKDTRSIFYITFTAYWVLGLPSGYILALTDLVVEPMGPAGFWIGFIIGLTSAAIMMMLRMRFLQRLPSAIILQRASR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG12400
Length:	457 (420)
Sequences:	18660 (14076)
Seq/√Len:	686.8

ECOLI - MDTK YEEO DINF WZXE MURJ
BACSU - NORM YISQ YOEA YPNP EPSK
HALSA - Q9HMS7 Q9HRF7 Q9HN79 Q9HRF2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
80_R	83_R	4.684	1.00
140_G	202_W	3.919	1.00
129_G	191_V	3.347	1.00
48_A	275_Q	3.287	1.00
341_A	354_A	3.132	1.00
73_A	300_G	3.069	1.00
336_L	339_Q	3.049	1.00
236_K	240_Q	2.930	1.00
307_S	310_D	2.925	1.00
109_A	112_I	2.814	1.00
156_K	159_P	2.778	1.00
181_G	186_P	2.774	1.00
111_Y	128_V	2.689	1.00
133_A	191_V	2.527	1.00
68_L	91_G	2.505	1.00
232_P	236_K	2.474	1.00
128_V	132_R	2.465	1.00
170_V	203_V	2.403	1.00
177_I	186_P	2.383	1.00
75_L	83_R	2.381	1.00
35_M	179_I	2.340	1.00
35_M	176_Y	2.297	1.00
42_T	122_A	2.276	1.00
383_D	439_R	2.267	1.00
46_A	126_K	2.234	1.00
111_Y	115_S	2.224	1.00
167_G	204_M	2.189	1.00
295_V	318_G	2.189	1.00
86_H	231_D	2.125	1.00
126_K	129_G	2.107	1.00
120_D	268_I	2.106	1.00
163_M	207_A	2.103	1.00
316_R	320_M	2.072	1.00
348_P	352_T	2.064	1.00
143_F	205_F	2.055	1.00
302_R	310_D	2.051	1.00
337_R	359_L	2.026	1.00
417_G	420_G	2.012	1.00
133_A	194_G	2.002	1.00
356_H	419_A	1.992	1.00
273_G	353_L	1.990	1.00
338_E	355_A	1.973	1.00
191_V	195_V	1.944	1.00
125_D	129_G	1.933	1.00
137_G	198_A	1.931	1.00
32_D	197_T	1.928	1.00
19_I	290_S	1.924	1.00
75_L	80_R	1.921	1.00
349_E	352_T	1.909	1.00
188_L	195_V	1.883	1.00
9_R	13_A	1.879	1.00
95_A	146_V	1.848	1.00
179_I	193_C	1.833	1.00
36_A	193_C	1.828	1.00
269_V	349_E	1.781	1.00
35_M	175_N	1.776	1.00
337_R	355_A	1.765	1.00
75_L	78_S	1.758	1.00
158_K	162_V	1.755	1.00
40_S	43_D	1.750	1.00
110_G	128_V	1.734	1.00
41_A	347_N	1.715	1.00
133_A	195_V	1.704	1.00
206_L	210_S	1.692	1.00
231_D	234_V	1.692	1.00
16_I	20_L	1.681	1.00
303_L	381_Y	1.680	1.00
136_W	139_P	1.679	1.00
107_W	132_R	1.670	1.00
177_I	181_G	1.669	1.00
163_M	208_M	1.665	1.00
298_R	314_A	1.663	1.00
313_T	316_R	1.662	1.00
334_V	359_L	1.660	1.00
315_A	374_G	1.639	1.00
313_T	317_T	1.630	1.00
178_F	186_P	1.623	1.00
15_A	294_A	1.621	1.00
169_L	173_P	1.610	1.00
115_S	124_A	1.596	1.00
367_S	430_T	1.583	1.00
312_Q	316_R	1.565	1.00
338_E	342_L	1.563	1.00
140_G	205_F	1.561	1.00
71_V	87_Q	1.558	1.00
302_R	307_S	1.557	1.00
303_L	311_A	1.553	1.00
122_A	268_I	1.547	1.00
322_G	369_S	1.526	1.00
133_A	198_A	1.508	1.00
176_Y	180_Y	1.507	1.00
31_V	172_I	1.501	1.00
175_N	193_C	1.489	1.00
339_Q	342_L	1.477	1.00
121_P	125_D	1.475	1.00
124_A	128_V	1.470	1.00
330_A	334_V	1.469	1.00
110_G	132_R	1.463	1.00
174_V	196_A	1.459	1.00
83_R	86_H	1.458	1.00
383_D	386_S	1.455	1.00
315_A	377_I	1.453	1.00
355_A	359_L	1.453	1.00
434_I	438_L	1.445	1.00
147_A	208_M	1.442	1.00
81_R	85_A	1.442	1.00
103_M	139_P	1.437	1.00
122_A	125_D	1.437	1.00
106_L	135_L	1.436	1.00
181_G	187_E	1.434	1.00
309_L	313_T	1.429	1.00
438_L	441_R	1.413	1.00
416_M	420_G	1.400	1.00
173_P	176_Y	1.390	1.00
50_G	131_L	1.386	1.00
75_L	87_Q	1.386	1.00
320_M	324_C	1.384	1.00
74_Q	78_S	1.383	1.00
170_V	174_V	1.367	1.00
342_L	351_V	1.354	1.00
210_S	214_R	1.353	1.00
43_D	126_K	1.350	1.00
360_L	423_I	1.349	1.00
173_P	177_I	1.347	1.00
162_V	166_I	1.347	1.00
32_D	171_N	1.343	1.00
82_E	86_H	1.342	1.00
36_A	47_V	1.341	1.00
437_M	441_R	1.338	1.00
24_A	165_F	1.336	1.00
77_G	304_G	1.334	1.00
112_I	115_S	1.332	1.00
45_A	272_A	1.330	1.00
405_I	409_T	1.307	1.00
20_L	161_M	1.306	1.00
308_T	312_Q	1.298	1.00
334_V	362_A	1.295	1.00
339_Q	343_L	1.281	1.00
191_V	194_G	1.280	1.00
76_N	301_Y	1.278	1.00
352_T	356_H	1.277	1.00
398_L	431_S	1.274	1.00
76_N	84_I	1.273	1.00
103_M	107_W	1.270	1.00
83_R	234_V	1.251	1.00
385_R	389_Y	1.247	1.00
178_F	188_L	1.239	1.00
163_M	211_Y	1.229	1.00
233_A	236_K	1.227	1.00
322_G	373_I	1.221	1.00
386_S	439_R	1.220	1.00
33_T	279_N	1.215	1.00
393_T	397_V	1.203	1.00
438_L	442_F	1.198	1.00
404_Y	408_L	1.197	1.00
111_Y	124_A	1.196	1.00
114_R	124_A	1.196	1.00
331_I	335_S	1.195	1.00
112_I	116_M	1.184	1.00
74_Q	300_G	1.184	1.00
90_Q	235_M	1.174	1.00
420_G	424_G	1.166	1.00
90_Q	230_P	1.163	1.00
38_G	346_D	1.162	1.00
174_V	199_A	1.162	1.00
341_A	351_V	1.159	1.00
72_I	153_G	1.156	1.00
41_A	269_V	1.155	1.00
280_F	340_I	1.155	1.00
299_V	311_A	1.149	1.00
171_N	197_T	1.141	1.00
74_Q	382_K	1.139	1.00
175_N	196_A	1.137	1.00
115_S	121_P	1.135	1.00
230_P	235_M	1.131	1.00
178_F	199_A	1.126	1.00
416_M	423_I	1.125	1.00
401_P	405_I	1.125	1.00
46_A	123_L	1.124	1.00
33_T	44_M	1.123	1.00
439_R	442_F	1.120	1.00
353_L	356_H	1.118	1.00
166_I	207_A	1.116	1.00
108_N	112_I	1.108	1.00
42_T	268_I	1.103	1.00
88_V	150_Q	1.098	1.00
176_Y	179_I	1.090	1.00
47_V	190_G	1.084	1.00
406_L	416_M	1.084	1.00
243_L	247_L	1.081	1.00
389_Y	393_T	1.076	1.00
261_L	265_P	1.073	1.00
292_A	376_G	1.070	1.00
38_G	180_Y	1.070	1.00
270_D	418_P	1.070	1.00
95_A	142_L	1.062	1.00
111_Y	125_D	1.053	1.00
156_K	160_G	1.049	1.00
159_P	211_Y	1.048	1.00
409_T	416_M	1.047	1.00
155_A	301_Y	1.046	1.00
32_D	175_N	1.046	1.00
277_A	357_L	1.042	1.00
170_V	200_V	1.040	1.00
397_V	401_P	1.032	1.00
11_L	318_G	1.027	1.00
317_T	321_V	1.023	1.00
96_G	143_F	1.022	1.00
42_T	126_K	1.017	1.00
114_R	127_A	1.017	1.00
178_F	181_G	1.014	1.00
260_A	264_S	1.012	1.00
302_R	314_A	1.012	1.00
94_L	235_M	1.010	1.00
371_Q	429_L	1.006	1.00
390_I	436_M	1.005	1.00
269_V	353_L	1.005	1.00
374_G	440_M	1.002	1.00
315_A	440_M	0.998	1.00
77_G	305_Q	0.998	1.00
86_H	234_V	0.992	1.00
378_L	439_R	0.986	1.00
39_Y	43_D	0.984	1.00
181_G	188_L	0.981	1.00
91_G	238_L	0.979	1.00
195_V	198_A	0.979	1.00
338_E	352_T	0.974	1.00
87_Q	234_V	0.974	1.00
324_C	328_L	0.973	1.00
176_Y	181_G	0.973	1.00
132_R	136_W	0.970	1.00
93_W	230_P	0.965	1.00
12_L	16_I	0.959	1.00
345_N	350_V	0.958	1.00
351_V	354_A	0.958	1.00
76_N	154_L	0.955	1.00
61_G	142_L	0.953	1.00
273_G	350_V	0.951	1.00
360_L	419_A	0.944	1.00
352_T	355_A	0.940	1.00
237_R	240_Q	0.938	1.00
224_E	227_T	0.933	1.00
290_S	294_A	0.925	1.00
276_I	344_Y	0.917	1.00
74_Q	303_L	0.917	1.00
49_I	119_I	0.916	1.00
76_N	81_R	0.914	1.00
402_S	427_I	0.914	1.00
398_L	401_P	0.913	1.00
165_F	169_L	0.913	1.00
327_T	331_I	0.911	1.00
147_A	205_F	0.910	1.00
175_N	197_T	0.908	1.00
103_M	136_W	0.905	1.00
198_A	202_W	0.905	1.00
156_K	215_A	0.904	1.00
240_Q	385_R	0.904	1.00
357_L	418_P	0.902	1.00
34_V	37_G	0.900	1.00
419_A	423_I	0.897	1.00
203_V	207_A	0.897	1.00
334_V	338_E	0.895	1.00
328_L	332_F	0.893	1.00
156_K	211_Y	0.892	1.00
174_V	178_F	0.891	1.00
428_G	432_A	0.891	1.00
207_A	210_S	0.887	1.00
367_S	433_A	0.885	1.00
104_L	108_N	0.882	1.00
18_V	293_A	0.882	1.00
68_L	72_I	0.882	1.00
299_V	377_I	0.881	1.00
311_A	315_A	0.877	1.00
280_F	333_T	0.876	1.00
251_F	392_F	0.875	1.00
403_G	407_A	0.874	1.00
151_C	212_I	0.874	1.00
202_W	206_L	0.870	1.00
29_G	51_T	0.870	1.00
129_G	132_R	0.870	1.00
319_L	370_I	0.869	1.00
31_V	171_N	0.864	1.00
89_R	228_A	0.864	1.00
273_G	354_A	0.860	1.00
288_P	326_A	0.858	1.00
337_R	358_M	0.857	1.00
328_L	331_I	0.857	1.00
394_A	432_A	0.853	1.00
214_R	217_S	0.851	1.00
93_W	228_A	0.849	1.00
136_W	198_A	0.848	1.00
270_D	353_L	0.846	1.00
424_G	428_G	0.845	1.00
126_K	190_G	0.843	1.00
311_A	381_Y	0.843	1.00
35_M	180_Y	0.839	1.00
147_A	212_I	0.838	1.00
264_S	271_V	0.838	1.00
349_E	353_L	0.837	1.00
10_L	13_A	0.833	1.00
74_Q	237_R	0.830	1.00
97_F	101_L	0.827	1.00
302_R	305_Q	0.825	1.00
299_V	380_G	0.822	1.00
54_W	134_L	0.822	1.00
171_N	175_N	0.820	1.00
162_V	165_F	0.820	1.00
351_V	355_A	0.819	1.00
335_S	339_Q	0.816	1.00
262_L	265_P	0.813	1.00
14_L	157_T	0.811	1.00
274_H	422_W	0.809	1.00
144_F	204_M	0.807	1.00
125_D	128_V	0.807	1.00
341_A	355_A	0.806	1.00
267_G	270_D	0.804	1.00
107_W	111_Y	0.803	1.00
72_I	150_Q	0.800	1.00
402_S	406_L	0.799	1.00
313_T	320_M	0.797	1.00
302_R	311_A	0.796	1.00
110_G	135_L	0.792	1.00
31_V	168_L	0.792	1.00
195_V	199_A	0.791	1.00
45_A	123_L	0.789	1.00
110_G	131_L	0.789	1.00
101_L	105_V	0.787	1.00
276_I	354_A	0.780	1.00
317_T	320_M	0.779	1.00
175_N	179_I	0.779	1.00
310_D	313_T	0.778	1.00
121_P	124_A	0.777	1.00
291_L	318_G	0.777	1.00
263_V	421_F	0.777	1.00
89_R	227_T	0.777	1.00
161_M	165_F	0.776	1.00
93_W	97_F	0.774	1.00
406_L	420_G	0.772	1.00
133_A	136_W	0.770	1.00
71_V	241_L	0.770	1.00
420_G	423_I	0.768	1.00
39_Y	187_E	0.767	1.00
42_T	123_L	0.767	1.00
91_G	146_V	0.766	1.00
324_C	327_T	0.765	1.00
209_V	213_K	0.763	1.00
360_L	426_I	0.762	1.00
262_L	403_G	0.762	1.00
24_A	168_L	0.761	1.00
370_I	433_A	0.761	1.00
11_L	317_T	0.760	1.00
104_L	107_W	0.758	1.00
171_N	200_V	0.758	1.00
273_G	357_L	0.757	1.00
334_V	337_R	0.756	1.00
418_P	422_W	0.754	1.00
10_L	298_R	0.752	1.00
123_L	271_V	0.750	1.00
430_T	434_I	0.749	1.00
309_L	316_R	0.746	1.00
263_V	418_P	0.746	1.00
114_R	128_V	0.745	1.00
279_N	344_Y	0.744	1.00
73_A	153_G	0.743	1.00
166_I	170_V	0.743	1.00
70_P	74_Q	0.742	1.00
71_V	75_L	0.742	1.00
189_G	192_G	0.741	1.00
247_L	388_F	0.740	1.00
348_P	351_V	0.737	1.00
152_E	160_G	0.735	1.00
188_L	192_G	0.732	1.00
323_V	327_T	0.731	1.00
423_I	426_I	0.729	1.00
299_V	315_A	0.728	1.00
262_L	404_Y	0.727	1.00
41_A	350_V	0.726	1.00
37_G	44_M	0.726	1.00
234_V	237_R	0.726	1.00
21_A	164_G	0.725	1.00
266_L	407_A	0.725	1.00
151_C	159_P	0.723	1.00
10_L	301_Y	0.722	1.00
187_E	191_V	0.722	1.00
374_G	436_M	0.721	1.00
129_G	190_G	0.716	1.00
363_V	366_I	0.715	1.00
407_A	420_G	0.715	1.00
336_L	340_I	0.711	1.00
27_A	31_V	0.709	1.00
34_V	343_L	0.708	1.00
78_S	304_G	0.708	1.00
151_C	208_M	0.707	1.00
327_T	366_I	0.707	1.00
318_G	373_I	0.706	1.00
265_P	408_L	0.705	1.00
85_A	227_T	0.704	1.00
166_I	203_V	0.703	1.00
107_W	135_L	0.701	1.00
225_K	228_A	0.701	1.00
250_F	254_T	0.700	1.00
320_M	323_V	0.700	1.00
323_V	369_S	0.700	1.00
309_L	312_Q	0.699	1.00
23_I	27_A	0.699	1.00
82_E	85_A	0.695	1.00
122_A	126_K	0.694	1.00
36_A	179_I	0.694	1.00
398_L	402_S	0.694	1.00
210_S	213_K	0.694	1.00
86_H	89_R	0.694	1.00
207_A	211_Y	0.692	1.00
386_S	390_I	0.692	1.00
46_A	190_G	0.690	1.00
262_L	266_L	0.688	1.00
159_P	207_A	0.687	1.00
244_P	388_F	0.683	1.00
281_S	365_Q	0.682	1.00
136_W	140_G	0.682	1.00
347_N	351_V	0.681	1.00
28_M	197_T	0.679	1.00
130_Y	175_N	0.678	1.00
46_A	127_A	0.675	1.00
263_V	274_H	0.673	1.00
131_L	135_L	0.673	1.00
11_L	294_A	0.672	1.00
147_A	209_V	0.672	1.00
34_V	38_G	0.672	1.00
237_R	382_K	0.671	1.00
359_L	363_V	0.669	1.00
72_I	84_I	0.669	1.00
335_S	338_E	0.668	1.00
107_W	136_W	0.667	1.00
338_E	351_V	0.667	1.00
262_L	407_A	0.663	1.00
376_G	380_G	0.663	1.00
83_R	87_Q	0.660	1.00
24_A	27_A	0.660	1.00
137_G	140_G	0.659	1.00
119_I	264_S	0.659	1.00
60_F	246_A	0.655	1.00
400_L	404_Y	0.654	1.00
216_R	219_R	0.652	1.00
405_I	408_L	0.651	1.00
78_S	306_G	0.650	1.00
31_V	35_M	0.649	1.00
132_R	191_V	0.648	1.00
199_A	202_W	0.648	1.00
135_L	138_A	0.647	1.00
326_A	369_S	0.646	1.00
406_L	409_T	0.645	1.00
291_L	325_M	0.645	1.00
137_G	201_Y	0.644	1.00
291_L	322_G	0.644	1.00
108_N	111_Y	0.642	1.00
96_G	100_V	0.639	1.00
111_Y	114_R	0.638	1.00
39_Y	190_G	0.638	1.00
123_L	126_K	0.637	1.00
135_L	139_P	0.636	1.00
295_V	299_V	0.635	1.00
241_L	384_T	0.634	1.00
377_I	381_Y	0.630	1.00
188_L	191_V	0.629	1.00
30_F	283_L	0.627	1.00
242_G	246_A	0.627	1.00
239_I	243_L	0.624	1.00
337_R	341_A	0.624	1.00
269_V	272_A	0.623	1.00
259_V	403_G	0.622	1.00
15_A	290_S	0.622	1.00
325_M	329_T	0.622	1.00
303_L	308_T	0.622	1.00
36_A	190_G	0.621	1.00
101_L	104_L	0.618	1.00
36_A	43_D	0.617	1.00
285_F	368_D	0.617	1.00
345_N	351_V	0.616	1.00
323_V	366_I	0.615	1.00
308_T	311_A	0.615	1.00
435_M	438_L	0.614	1.00
194_G	198_A	0.614	1.00
70_P	241_L	0.612	1.00
178_F	193_C	0.611	1.00
233_A	237_R	0.611	1.00
345_N	348_P	0.609	1.00
287_L	325_M	0.609	1.00
284_M	329_T	0.609	1.00
253_V	259_V	0.609	1.00
28_M	167_G	0.608	1.00
43_D	189_G	0.608	1.00
399_G	428_G	0.607	1.00
105_V	108_N	0.605	1.00
114_R	131_L	0.604	1.00
165_F	168_L	0.603	1.00
166_I	169_L	0.603	1.00
44_M	345_N	0.603	1.00
86_H	90_Q	0.602	1.00
374_G	437_M	0.600	1.00
36_A	39_Y	0.599	1.00
45_A	48_A	0.599	1.00
370_I	437_M	0.599	1.00
211_Y	215_A	0.597	1.00
301_Y	305_Q	0.596	1.00
100_V	104_L	0.596	1.00
170_V	199_A	0.595	1.00
399_G	403_G	0.595	1.00
99_S	135_L	0.595	1.00
215_A	219_R	0.593	1.00
144_F	205_F	0.593	1.00
80_R	86_H	0.591	1.00
148_R	152_E	0.587	1.00
273_G	422_W	0.586	1.00
200_V	203_V	0.586	1.00
243_L	246_A	0.585	1.00
258_V	400_L	0.584	1.00
99_S	139_P	0.582	1.00
57_A	138_A	0.581	1.00
69_T	149_N	0.577	1.00
296_T	379_R	0.576	1.00
350_V	354_A	0.576	1.00
28_M	201_Y	0.576	1.00
266_L	270_D	0.575	1.00
213_K	216_R	0.575	1.00
82_E	227_T	0.574	1.00
43_D	46_A	0.574	1.00
362_A	366_I	0.573	1.00
100_V	103_M	0.573	1.00
321_V	324_C	0.573	1.00
44_M	276_I	0.572	1.00
139_P	202_W	0.571	1.00
107_W	110_G	0.570	1.00
332_F	336_L	0.569	1.00
262_L	408_L	0.568	1.00
333_T	340_I	0.567	1.00
70_P	300_G	0.567	1.00
111_Y	132_R	0.567	1.00
270_D	273_G	0.567	1.00
63_G	246_A	0.566	1.00
124_A	127_A	0.565	1.00
105_V	109_A	0.562	1.00
129_G	133_A	0.561	1.00
298_R	302_R	0.561	1.00
72_I	87_Q	0.559	1.00
99_S	103_M	0.559	1.00
259_V	262_L	0.558	1.00
342_L	346_D	0.558	1.00
67_A	242_G	0.556	1.00
288_P	369_S	0.556	1.00
89_R	93_W	0.555	1.00
391_T	394_A	0.554	1.00
205_F	209_V	0.554	1.00
251_F	388_F	0.553	1.00
192_G	196_A	0.553	1.00
64_L	246_A	0.552	1.00
130_Y	193_C	0.551	1.00
356_H	359_L	0.551	1.00
63_G	296_T	0.551	1.00
170_V	173_P	0.550	1.00
269_V	350_V	0.550	1.00
109_A	113_I	0.549	1.00
423_I	427_I	0.548	1.00
316_R	440_M	0.548	1.00
259_V	421_F	0.548	1.00
10_L	310_D	0.548	1.00
330_A	366_I	0.547	1.00
378_L	383_D	0.546	1.00
180_Y	188_L	0.544	1.00
49_I	127_A	0.542	1.00
163_M	204_M	0.539	1.00
384_T	388_F	0.538	1.00
276_I	350_V	0.534	1.00
34_V	344_Y	0.534	1.00
323_V	370_I	0.534	1.00
123_L	268_I	0.532	1.00
319_L	323_V	0.530	1.00
171_N	196_A	0.530	1.00
90_Q	234_V	0.529	1.00
144_F	148_R	0.528	1.00
85_A	224_E	0.527	1.00
27_A	168_L	0.527	1.00
79_G	305_Q	0.526	1.00
258_V	261_L	0.526	1.00
152_E	157_T	0.526	1.00
42_T	45_A	0.526	1.00
31_V	34_V	0.525	1.00
172_I	176_Y	0.524	1.00
402_S	431_S	0.524	1.00
269_V	347_N	0.523	1.00
390_I	435_M	0.523	1.00
434_I	437_M	0.522	1.00
110_G	114_R	0.522	1.00
296_T	376_G	0.520	1.00
402_S	405_I	0.519	0.99
225_K	229_K	0.519	0.99
113_I	116_M	0.517	0.99
295_V	373_I	0.514	0.99
41_A	272_A	0.513	0.99
431_S	435_M	0.513	0.99
149_N	152_E	0.513	0.99
47_V	130_Y	0.513	0.99
406_L	424_G	0.512	0.99
347_N	350_V	0.512	0.99
368_D	429_L	0.511	0.99
281_S	361_A	0.510	0.99
394_A	435_M	0.510	0.99
266_L	417_G	0.509	0.99
95_A	99_S	0.509	0.99
64_L	98_V	0.509	0.99
106_L	110_G	0.508	0.99
151_C	211_Y	0.508	0.99
66_L	293_A	0.507	0.99
326_A	362_A	0.507	0.99
88_V	147_A	0.506	0.99
103_M	135_L	0.506	0.99
433_A	437_M	0.506	0.99
277_A	358_M	0.505	0.99
393_T	435_M	0.505	0.99
404_Y	409_T	0.504	0.99
374_G	377_I	0.504	0.99
403_G	421_F	0.504	0.99
151_C	154_L	0.504	0.99
402_S	424_G	0.503	0.99
404_Y	407_A	0.503	0.99
315_A	319_L	0.503	0.99
316_R	319_L	0.503	0.99
11_L	321_V	0.502	0.99
213_K	217_S	0.502	0.99
72_I	88_V	0.501	0.99
29_G	134_L	0.500	0.99

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3mktA	1	0.9978	100	0.232	Contact Map
4humA	1	0.9891	100	0.235	Contact Map
4lz6A	1	0.9584	100	0.277	Contact Map
3w4tA	1	0.954	100	0.323	Contact Map
2cfqA	1	0.8775	86.9	0.933	Contact Map
4xnjA	1	0.8621	83.1	0.936	Contact Map
3wdoA	1	0.8621	78.4	0.939	Contact Map
4ikvA	1	0.8709	78.1	0.939	Contact Map
4tphA	2	0.8359	68.8	0.943	Contact Map
4w6vA	1	0.8425	57.7	0.947	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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