GREMLIN Database
MDTK - Multidrug resistance protein MdtK
UniProt: P37340 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12400
Length: 457 (420)
Sequences: 18660 (14076)
Seq/√Len: 686.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
80_R83_R4.6841.00
140_G202_W3.9191.00
129_G191_V3.3471.00
48_A275_Q3.2871.00
341_A354_A3.1321.00
73_A300_G3.0691.00
336_L339_Q3.0491.00
236_K240_Q2.9301.00
307_S310_D2.9251.00
109_A112_I2.8141.00
156_K159_P2.7781.00
181_G186_P2.7741.00
111_Y128_V2.6891.00
133_A191_V2.5271.00
68_L91_G2.5051.00
232_P236_K2.4741.00
128_V132_R2.4651.00
170_V203_V2.4031.00
177_I186_P2.3831.00
75_L83_R2.3811.00
35_M179_I2.3401.00
35_M176_Y2.2971.00
42_T122_A2.2761.00
383_D439_R2.2671.00
46_A126_K2.2341.00
111_Y115_S2.2241.00
167_G204_M2.1891.00
295_V318_G2.1891.00
86_H231_D2.1251.00
126_K129_G2.1071.00
120_D268_I2.1061.00
163_M207_A2.1031.00
316_R320_M2.0721.00
348_P352_T2.0641.00
143_F205_F2.0551.00
302_R310_D2.0511.00
337_R359_L2.0261.00
417_G420_G2.0121.00
133_A194_G2.0021.00
356_H419_A1.9921.00
273_G353_L1.9901.00
338_E355_A1.9731.00
191_V195_V1.9441.00
125_D129_G1.9331.00
137_G198_A1.9311.00
32_D197_T1.9281.00
19_I290_S1.9241.00
75_L80_R1.9211.00
349_E352_T1.9091.00
188_L195_V1.8831.00
9_R13_A1.8791.00
95_A146_V1.8481.00
179_I193_C1.8331.00
36_A193_C1.8281.00
269_V349_E1.7811.00
35_M175_N1.7761.00
337_R355_A1.7651.00
75_L78_S1.7581.00
158_K162_V1.7551.00
40_S43_D1.7501.00
110_G128_V1.7341.00
41_A347_N1.7151.00
133_A195_V1.7041.00
206_L210_S1.6921.00
231_D234_V1.6921.00
16_I20_L1.6811.00
303_L381_Y1.6801.00
136_W139_P1.6791.00
107_W132_R1.6701.00
177_I181_G1.6691.00
163_M208_M1.6651.00
298_R314_A1.6631.00
313_T316_R1.6621.00
334_V359_L1.6601.00
315_A374_G1.6391.00
313_T317_T1.6301.00
178_F186_P1.6231.00
15_A294_A1.6211.00
169_L173_P1.6101.00
115_S124_A1.5961.00
367_S430_T1.5831.00
312_Q316_R1.5651.00
338_E342_L1.5631.00
140_G205_F1.5611.00
71_V87_Q1.5581.00
302_R307_S1.5571.00
303_L311_A1.5531.00
122_A268_I1.5471.00
322_G369_S1.5261.00
133_A198_A1.5081.00
176_Y180_Y1.5071.00
31_V172_I1.5011.00
175_N193_C1.4891.00
339_Q342_L1.4771.00
121_P125_D1.4751.00
124_A128_V1.4701.00
330_A334_V1.4691.00
110_G132_R1.4631.00
174_V196_A1.4591.00
83_R86_H1.4581.00
383_D386_S1.4551.00
315_A377_I1.4531.00
355_A359_L1.4531.00
434_I438_L1.4451.00
147_A208_M1.4421.00
81_R85_A1.4421.00
103_M139_P1.4371.00
122_A125_D1.4371.00
106_L135_L1.4361.00
181_G187_E1.4341.00
309_L313_T1.4291.00
438_L441_R1.4131.00
416_M420_G1.4001.00
173_P176_Y1.3901.00
50_G131_L1.3861.00
75_L87_Q1.3861.00
320_M324_C1.3841.00
74_Q78_S1.3831.00
170_V174_V1.3671.00
342_L351_V1.3541.00
210_S214_R1.3531.00
43_D126_K1.3501.00
360_L423_I1.3491.00
173_P177_I1.3471.00
162_V166_I1.3471.00
32_D171_N1.3431.00
82_E86_H1.3421.00
36_A47_V1.3411.00
437_M441_R1.3381.00
24_A165_F1.3361.00
77_G304_G1.3341.00
112_I115_S1.3321.00
45_A272_A1.3301.00
405_I409_T1.3071.00
20_L161_M1.3061.00
308_T312_Q1.2981.00
334_V362_A1.2951.00
339_Q343_L1.2811.00
191_V194_G1.2801.00
76_N301_Y1.2781.00
352_T356_H1.2771.00
398_L431_S1.2741.00
76_N84_I1.2731.00
103_M107_W1.2701.00
83_R234_V1.2511.00
385_R389_Y1.2471.00
178_F188_L1.2391.00
163_M211_Y1.2291.00
233_A236_K1.2271.00
322_G373_I1.2211.00
386_S439_R1.2201.00
33_T279_N1.2151.00
393_T397_V1.2031.00
438_L442_F1.1981.00
404_Y408_L1.1971.00
111_Y124_A1.1961.00
114_R124_A1.1961.00
331_I335_S1.1951.00
112_I116_M1.1841.00
74_Q300_G1.1841.00
90_Q235_M1.1741.00
420_G424_G1.1661.00
90_Q230_P1.1631.00
38_G346_D1.1621.00
174_V199_A1.1621.00
341_A351_V1.1591.00
72_I153_G1.1561.00
41_A269_V1.1551.00
280_F340_I1.1551.00
299_V311_A1.1491.00
171_N197_T1.1411.00
74_Q382_K1.1391.00
175_N196_A1.1371.00
115_S121_P1.1351.00
230_P235_M1.1311.00
178_F199_A1.1261.00
416_M423_I1.1251.00
401_P405_I1.1251.00
46_A123_L1.1241.00
33_T44_M1.1231.00
439_R442_F1.1201.00
353_L356_H1.1181.00
166_I207_A1.1161.00
108_N112_I1.1081.00
42_T268_I1.1031.00
88_V150_Q1.0981.00
176_Y179_I1.0901.00
47_V190_G1.0841.00
406_L416_M1.0841.00
243_L247_L1.0811.00
389_Y393_T1.0761.00
261_L265_P1.0731.00
292_A376_G1.0701.00
38_G180_Y1.0701.00
270_D418_P1.0701.00
95_A142_L1.0621.00
111_Y125_D1.0531.00
156_K160_G1.0491.00
159_P211_Y1.0481.00
409_T416_M1.0471.00
155_A301_Y1.0461.00
32_D175_N1.0461.00
277_A357_L1.0421.00
170_V200_V1.0401.00
397_V401_P1.0321.00
11_L318_G1.0271.00
317_T321_V1.0231.00
96_G143_F1.0221.00
42_T126_K1.0171.00
114_R127_A1.0171.00
178_F181_G1.0141.00
260_A264_S1.0121.00
302_R314_A1.0121.00
94_L235_M1.0101.00
371_Q429_L1.0061.00
390_I436_M1.0051.00
269_V353_L1.0051.00
374_G440_M1.0021.00
315_A440_M0.9981.00
77_G305_Q0.9981.00
86_H234_V0.9921.00
378_L439_R0.9861.00
39_Y43_D0.9841.00
181_G188_L0.9811.00
91_G238_L0.9791.00
195_V198_A0.9791.00
338_E352_T0.9741.00
87_Q234_V0.9741.00
324_C328_L0.9731.00
176_Y181_G0.9731.00
132_R136_W0.9701.00
93_W230_P0.9651.00
12_L16_I0.9591.00
345_N350_V0.9581.00
351_V354_A0.9581.00
76_N154_L0.9551.00
61_G142_L0.9531.00
273_G350_V0.9511.00
360_L419_A0.9441.00
352_T355_A0.9401.00
237_R240_Q0.9381.00
224_E227_T0.9331.00
290_S294_A0.9251.00
276_I344_Y0.9171.00
74_Q303_L0.9171.00
49_I119_I0.9161.00
76_N81_R0.9141.00
402_S427_I0.9141.00
398_L401_P0.9131.00
165_F169_L0.9131.00
327_T331_I0.9111.00
147_A205_F0.9101.00
175_N197_T0.9081.00
103_M136_W0.9051.00
198_A202_W0.9051.00
156_K215_A0.9041.00
240_Q385_R0.9041.00
357_L418_P0.9021.00
34_V37_G0.9001.00
419_A423_I0.8971.00
203_V207_A0.8971.00
334_V338_E0.8951.00
328_L332_F0.8931.00
156_K211_Y0.8921.00
174_V178_F0.8911.00
428_G432_A0.8911.00
207_A210_S0.8871.00
367_S433_A0.8851.00
104_L108_N0.8821.00
18_V293_A0.8821.00
68_L72_I0.8821.00
299_V377_I0.8811.00
311_A315_A0.8771.00
280_F333_T0.8761.00
251_F392_F0.8751.00
403_G407_A0.8741.00
151_C212_I0.8741.00
202_W206_L0.8701.00
29_G51_T0.8701.00
129_G132_R0.8701.00
319_L370_I0.8691.00
31_V171_N0.8641.00
89_R228_A0.8641.00
273_G354_A0.8601.00
288_P326_A0.8581.00
337_R358_M0.8571.00
328_L331_I0.8571.00
394_A432_A0.8531.00
214_R217_S0.8511.00
93_W228_A0.8491.00
136_W198_A0.8481.00
270_D353_L0.8461.00
424_G428_G0.8451.00
126_K190_G0.8431.00
311_A381_Y0.8431.00
35_M180_Y0.8391.00
147_A212_I0.8381.00
264_S271_V0.8381.00
349_E353_L0.8371.00
10_L13_A0.8331.00
74_Q237_R0.8301.00
97_F101_L0.8271.00
302_R305_Q0.8251.00
299_V380_G0.8221.00
54_W134_L0.8221.00
171_N175_N0.8201.00
162_V165_F0.8201.00
351_V355_A0.8191.00
335_S339_Q0.8161.00
262_L265_P0.8131.00
14_L157_T0.8111.00
274_H422_W0.8091.00
144_F204_M0.8071.00
125_D128_V0.8071.00
341_A355_A0.8061.00
267_G270_D0.8041.00
107_W111_Y0.8031.00
72_I150_Q0.8001.00
402_S406_L0.7991.00
313_T320_M0.7971.00
302_R311_A0.7961.00
110_G135_L0.7921.00
31_V168_L0.7921.00
195_V199_A0.7911.00
45_A123_L0.7891.00
110_G131_L0.7891.00
101_L105_V0.7871.00
276_I354_A0.7801.00
317_T320_M0.7791.00
175_N179_I0.7791.00
310_D313_T0.7781.00
121_P124_A0.7771.00
291_L318_G0.7771.00
263_V421_F0.7771.00
89_R227_T0.7771.00
161_M165_F0.7761.00
93_W97_F0.7741.00
406_L420_G0.7721.00
133_A136_W0.7701.00
71_V241_L0.7701.00
420_G423_I0.7681.00
39_Y187_E0.7671.00
42_T123_L0.7671.00
91_G146_V0.7661.00
324_C327_T0.7651.00
209_V213_K0.7631.00
360_L426_I0.7621.00
262_L403_G0.7621.00
24_A168_L0.7611.00
370_I433_A0.7611.00
11_L317_T0.7601.00
104_L107_W0.7581.00
171_N200_V0.7581.00
273_G357_L0.7571.00
334_V337_R0.7561.00
418_P422_W0.7541.00
10_L298_R0.7521.00
123_L271_V0.7501.00
430_T434_I0.7491.00
309_L316_R0.7461.00
263_V418_P0.7461.00
114_R128_V0.7451.00
279_N344_Y0.7441.00
73_A153_G0.7431.00
166_I170_V0.7431.00
70_P74_Q0.7421.00
71_V75_L0.7421.00
189_G192_G0.7411.00
247_L388_F0.7401.00
348_P351_V0.7371.00
152_E160_G0.7351.00
188_L192_G0.7321.00
323_V327_T0.7311.00
423_I426_I0.7291.00
299_V315_A0.7281.00
262_L404_Y0.7271.00
41_A350_V0.7261.00
37_G44_M0.7261.00
234_V237_R0.7261.00
21_A164_G0.7251.00
266_L407_A0.7251.00
151_C159_P0.7231.00
10_L301_Y0.7221.00
187_E191_V0.7221.00
374_G436_M0.7211.00
129_G190_G0.7161.00
363_V366_I0.7151.00
407_A420_G0.7151.00
336_L340_I0.7111.00
27_A31_V0.7091.00
34_V343_L0.7081.00
78_S304_G0.7081.00
151_C208_M0.7071.00
327_T366_I0.7071.00
318_G373_I0.7061.00
265_P408_L0.7051.00
85_A227_T0.7041.00
166_I203_V0.7031.00
107_W135_L0.7011.00
225_K228_A0.7011.00
250_F254_T0.7001.00
320_M323_V0.7001.00
323_V369_S0.7001.00
309_L312_Q0.6991.00
23_I27_A0.6991.00
82_E85_A0.6951.00
122_A126_K0.6941.00
36_A179_I0.6941.00
398_L402_S0.6941.00
210_S213_K0.6941.00
86_H89_R0.6941.00
207_A211_Y0.6921.00
386_S390_I0.6921.00
46_A190_G0.6901.00
262_L266_L0.6881.00
159_P207_A0.6871.00
244_P388_F0.6831.00
281_S365_Q0.6821.00
136_W140_G0.6821.00
347_N351_V0.6811.00
28_M197_T0.6791.00
130_Y175_N0.6781.00
46_A127_A0.6751.00
263_V274_H0.6731.00
131_L135_L0.6731.00
11_L294_A0.6721.00
147_A209_V0.6721.00
34_V38_G0.6721.00
237_R382_K0.6711.00
359_L363_V0.6691.00
72_I84_I0.6691.00
335_S338_E0.6681.00
107_W136_W0.6671.00
338_E351_V0.6671.00
262_L407_A0.6631.00
376_G380_G0.6631.00
83_R87_Q0.6601.00
24_A27_A0.6601.00
137_G140_G0.6591.00
119_I264_S0.6591.00
60_F246_A0.6551.00
400_L404_Y0.6541.00
216_R219_R0.6521.00
405_I408_L0.6511.00
78_S306_G0.6501.00
31_V35_M0.6491.00
132_R191_V0.6481.00
199_A202_W0.6481.00
135_L138_A0.6471.00
326_A369_S0.6461.00
406_L409_T0.6451.00
291_L325_M0.6451.00
137_G201_Y0.6441.00
291_L322_G0.6441.00
108_N111_Y0.6421.00
96_G100_V0.6391.00
111_Y114_R0.6381.00
39_Y190_G0.6381.00
123_L126_K0.6371.00
135_L139_P0.6361.00
295_V299_V0.6351.00
241_L384_T0.6341.00
377_I381_Y0.6301.00
188_L191_V0.6291.00
30_F283_L0.6271.00
242_G246_A0.6271.00
239_I243_L0.6241.00
337_R341_A0.6241.00
269_V272_A0.6231.00
259_V403_G0.6221.00
15_A290_S0.6221.00
325_M329_T0.6221.00
303_L308_T0.6221.00
36_A190_G0.6211.00
101_L104_L0.6181.00
36_A43_D0.6171.00
285_F368_D0.6171.00
345_N351_V0.6161.00
323_V366_I0.6151.00
308_T311_A0.6151.00
435_M438_L0.6141.00
194_G198_A0.6141.00
70_P241_L0.6121.00
178_F193_C0.6111.00
233_A237_R0.6111.00
345_N348_P0.6091.00
287_L325_M0.6091.00
284_M329_T0.6091.00
253_V259_V0.6091.00
28_M167_G0.6081.00
43_D189_G0.6081.00
399_G428_G0.6071.00
105_V108_N0.6051.00
114_R131_L0.6041.00
165_F168_L0.6031.00
166_I169_L0.6031.00
44_M345_N0.6031.00
86_H90_Q0.6021.00
374_G437_M0.6001.00
36_A39_Y0.5991.00
45_A48_A0.5991.00
370_I437_M0.5991.00
211_Y215_A0.5971.00
301_Y305_Q0.5961.00
100_V104_L0.5961.00
170_V199_A0.5951.00
399_G403_G0.5951.00
99_S135_L0.5951.00
215_A219_R0.5931.00
144_F205_F0.5931.00
80_R86_H0.5911.00
148_R152_E0.5871.00
273_G422_W0.5861.00
200_V203_V0.5861.00
243_L246_A0.5851.00
258_V400_L0.5841.00
99_S139_P0.5821.00
57_A138_A0.5811.00
69_T149_N0.5771.00
296_T379_R0.5761.00
350_V354_A0.5761.00
28_M201_Y0.5761.00
266_L270_D0.5751.00
213_K216_R0.5751.00
82_E227_T0.5741.00
43_D46_A0.5741.00
362_A366_I0.5731.00
100_V103_M0.5731.00
321_V324_C0.5731.00
44_M276_I0.5721.00
139_P202_W0.5711.00
107_W110_G0.5701.00
332_F336_L0.5691.00
262_L408_L0.5681.00
333_T340_I0.5671.00
70_P300_G0.5671.00
111_Y132_R0.5671.00
270_D273_G0.5671.00
63_G246_A0.5661.00
124_A127_A0.5651.00
105_V109_A0.5621.00
129_G133_A0.5611.00
298_R302_R0.5611.00
72_I87_Q0.5591.00
99_S103_M0.5591.00
259_V262_L0.5581.00
342_L346_D0.5581.00
67_A242_G0.5561.00
288_P369_S0.5561.00
89_R93_W0.5551.00
391_T394_A0.5541.00
205_F209_V0.5541.00
251_F388_F0.5531.00
192_G196_A0.5531.00
64_L246_A0.5521.00
130_Y193_C0.5511.00
356_H359_L0.5511.00
63_G296_T0.5511.00
170_V173_P0.5501.00
269_V350_V0.5501.00
109_A113_I0.5491.00
423_I427_I0.5481.00
316_R440_M0.5481.00
259_V421_F0.5481.00
10_L310_D0.5481.00
330_A366_I0.5471.00
378_L383_D0.5461.00
180_Y188_L0.5441.00
49_I127_A0.5421.00
163_M204_M0.5391.00
384_T388_F0.5381.00
276_I350_V0.5341.00
34_V344_Y0.5341.00
323_V370_I0.5341.00
123_L268_I0.5321.00
319_L323_V0.5301.00
171_N196_A0.5301.00
90_Q234_V0.5291.00
144_F148_R0.5281.00
85_A224_E0.5271.00
27_A168_L0.5271.00
79_G305_Q0.5261.00
258_V261_L0.5261.00
152_E157_T0.5261.00
42_T45_A0.5261.00
31_V34_V0.5251.00
172_I176_Y0.5241.00
402_S431_S0.5241.00
269_V347_N0.5231.00
390_I435_M0.5231.00
434_I437_M0.5221.00
110_G114_R0.5221.00
296_T376_G0.5201.00
402_S405_I0.5190.99
225_K229_K0.5190.99
113_I116_M0.5170.99
295_V373_I0.5140.99
41_A272_A0.5130.99
431_S435_M0.5130.99
149_N152_E0.5130.99
47_V130_Y0.5130.99
406_L424_G0.5120.99
347_N350_V0.5120.99
368_D429_L0.5110.99
281_S361_A0.5100.99
394_A435_M0.5100.99
266_L417_G0.5090.99
95_A99_S0.5090.99
64_L98_V0.5090.99
106_L110_G0.5080.99
151_C211_Y0.5080.99
66_L293_A0.5070.99
326_A362_A0.5070.99
88_V147_A0.5060.99
103_M135_L0.5060.99
433_A437_M0.5060.99
277_A358_M0.5050.99
393_T435_M0.5050.99
404_Y409_T0.5040.99
374_G377_I0.5040.99
403_G421_F0.5040.99
151_C154_L0.5040.99
402_S424_G0.5030.99
404_Y407_A0.5030.99
315_A319_L0.5030.99
316_R319_L0.5030.99
11_L321_V0.5020.99
213_K217_S0.5020.99
72_I88_V0.5010.99
29_G134_L0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3mktA 1 0.9978 100 0.232 Contact Map
4humA 1 0.9891 100 0.235 Contact Map
4lz6A 1 0.9584 100 0.277 Contact Map
3w4tA 1 0.954 100 0.323 Contact Map
2cfqA 1 0.8775 86.9 0.933 Contact Map
4xnjA 1 0.8621 83.1 0.936 Contact Map
3wdoA 1 0.8621 78.4 0.939 Contact Map
4ikvA 1 0.8709 78.1 0.939 Contact Map
4tphA 2 0.8359 68.8 0.943 Contact Map
4w6vA 1 0.8425 57.7 0.947 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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