GREMLIN Database
LHGO - L-2-hydroxyglutarate oxidase LhgO
UniProt: P37339 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12387
Length: 422 (347)
Sequences: 21707 (15684)
Seq/√Len: 842.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
158_F163_G4.8911.00
34_K170_E3.6691.00
30_A166_I3.0261.00
5_V193_A3.0071.00
170_E186_R2.9581.00
5_V183_I2.8941.00
120_N123_E2.7891.00
74_K86_N2.7421.00
32_L191_Y2.5451.00
68_A387_A2.5071.00
5_V32_L2.4611.00
124_L136_G2.4141.00
22_D79_Q2.4081.00
21_I161_R2.4081.00
173_G184_R2.3961.00
123_E126_E2.3391.00
99_M135_G2.3361.00
117_E123_E2.2891.00
27_A394_Q2.2881.00
175_N184_R2.2731.00
21_I163_G2.2541.00
28_R164_E2.2331.00
5_V191_Y2.2091.00
4_F20_L2.2041.00
16_T197_I2.2001.00
186_R189_G2.1991.00
14_M155_A2.1861.00
182_V190_E2.1191.00
230_A337_D2.0911.00
177_H182_V2.0681.00
195_T369_I2.0451.00
14_M151_T2.0331.00
38_P167_Y2.0241.00
3_D194_S2.0001.00
18_M157_I1.9271.00
19_Q387_A1.9211.00
185_T189_G1.9091.00
224_G346_R1.8961.00
175_N182_V1.8681.00
184_R190_E1.8681.00
371_T385_I1.8551.00
3_D28_R1.8521.00
75_A79_Q1.8491.00
183_I186_R1.8421.00
371_T389_I1.8411.00
22_D161_R1.8271.00
121_A125_R1.7891.00
106_W110_A1.7881.00
204_A372_C1.7871.00
197_I393_V1.7771.00
107_E111_A1.7731.00
117_E140_P1.7731.00
320_S324_R1.7721.00
9_G38_P1.7641.00
4_F27_A1.7591.00
182_V192_E1.7561.00
18_M22_D1.7411.00
391_S396_L1.7281.00
369_I389_I1.7271.00
198_S204_A1.7101.00
103_R107_E1.7061.00
115_E141_S1.6981.00
369_I393_V1.6761.00
157_I160_S1.6741.00
166_I169_A1.6491.00
374_A385_I1.6371.00
103_R118_W1.6361.00
19_Q386_G1.6261.00
72_A387_A1.6231.00
156_K159_Q1.5871.00
21_I158_F1.5861.00
38_P155_A1.5861.00
155_A165_I1.5861.00
240_L243_P1.5721.00
107_E110_A1.5671.00
73_T150_V1.5481.00
157_I161_R1.5271.00
5_V30_A1.5211.00
30_A191_Y1.4901.00
230_A339_Q1.4871.00
100_E103_R1.4831.00
68_A71_R1.4821.00
229_L232_E1.4671.00
99_M103_R1.4591.00
119_L123_E1.4491.00
172_S186_R1.4481.00
198_S368_T1.4441.00
25_P394_Q1.4361.00
171_V183_I1.4301.00
25_P396_L1.4261.00
9_G31_L1.4231.00
96_D100_E1.4011.00
16_T371_T1.4011.00
146_S149_D1.3991.00
12_I371_T1.3961.00
35_E40_C1.3921.00
172_S184_R1.3921.00
37_A167_Y1.3911.00
155_A159_Q1.3891.00
35_E41_H1.3871.00
173_G210_M1.3771.00
391_S399_S1.3681.00
156_K160_S1.3681.00
323_L327_Q1.3661.00
122_D126_E1.3651.00
195_T393_V1.3601.00
17_A29_I1.3571.00
241_I244_I1.3561.00
9_G33_E1.3371.00
20_L390_V1.3311.00
193_A196_L1.3241.00
14_M158_F1.3151.00
255_H258_R1.3141.00
386_G390_V1.3061.00
175_N190_E1.3031.00
32_L193_A1.2991.00
15_S19_Q1.2981.00
177_H192_E1.2961.00
7_I200_S1.2941.00
88_G138_F1.2931.00
71_R75_A1.2831.00
93_A102_M1.2801.00
237_V240_L1.2791.00
117_E138_F1.2791.00
198_S370_H1.2791.00
11_I382_A1.2631.00
100_E104_A1.2591.00
185_T191_Y1.2561.00
25_P390_V1.2541.00
369_I392_K1.2471.00
19_Q22_D1.2471.00
200_S207_L1.2471.00
123_E127_R1.2391.00
119_L127_R1.2371.00
174_L196_L1.2321.00
365_T370_H1.2281.00
3_D27_A1.2271.00
12_I374_A1.2231.00
387_A391_S1.2141.00
31_L165_I1.2111.00
32_L171_V1.2041.00
32_L166_I1.2041.00
127_R138_F1.1921.00
14_M31_L1.1831.00
72_A75_A1.1751.00
70_N74_K1.1741.00
84_Y143_G1.1631.00
96_D134_L1.1621.00
75_A78_D1.1591.00
176_E181_V1.1581.00
117_E127_R1.1571.00
39_A151_T1.1541.00
15_S154_M1.1391.00
177_H180_G1.1361.00
30_A164_E1.1311.00
19_Q25_P1.1271.00
15_S386_G1.1231.00
169_A185_T1.1131.00
7_I196_L1.1111.00
6_I17_A1.1091.00
104_A107_E1.1061.00
69_G73_T1.1051.00
200_S204_A1.1031.00
125_R133_G1.0961.00
388_H391_S1.0941.00
207_L210_M1.0921.00
7_I171_V1.0811.00
324_R327_Q1.0801.00
325_L328_K1.0741.00
83_R149_D1.0711.00
16_T386_G1.0611.00
198_S208_V1.0541.00
196_L367_R1.0501.00
6_I16_T1.0481.00
38_P165_I1.0431.00
88_G140_P1.0421.00
68_A72_A1.0341.00
17_A31_L1.0331.00
256_L259_M1.0311.00
15_S382_A1.0271.00
4_F195_T1.0251.00
371_T374_A1.0231.00
174_L181_V1.0151.00
145_V150_V1.0021.00
16_T199_C1.0011.00
80_N83_R0.9991.00
99_M118_W0.9981.00
17_A163_G0.9941.00
195_T364_T0.9941.00
18_M161_R0.9931.00
69_G72_A0.9911.00
20_L27_A0.9901.00
150_V379_A0.9901.00
25_P391_S0.9851.00
110_A116_R0.9771.00
48_G147_Y0.9721.00
324_R328_K0.9661.00
90_M124_L0.9651.00
68_A384_P0.9631.00
106_W118_W0.9581.00
17_A158_F0.9571.00
362_F385_I0.9571.00
106_W137_I0.9541.00
65_F69_G0.9531.00
145_V379_A0.9501.00
73_T382_A0.9431.00
14_M165_I0.9421.00
254_V258_R0.9341.00
45_H342_P0.9301.00
74_K78_D0.9251.00
169_A191_Y0.9241.00
31_L163_G0.9241.00
166_I191_Y0.9231.00
169_A189_G0.9211.00
148_R152_A0.9201.00
239_H243_P0.9171.00
95_S98_E0.9151.00
153_A157_I0.9151.00
319_K341_W0.9091.00
176_E180_G0.9021.00
166_I189_G0.8981.00
206_R209_K0.8951.00
362_F389_I0.8911.00
149_D152_A0.8851.00
29_I163_G0.8801.00
390_V393_V0.8771.00
364_T392_K0.8771.00
99_M134_L0.8701.00
364_T367_R0.8681.00
176_E367_R0.8681.00
73_T77_C0.8601.00
223_R271_V0.8581.00
209_K214_E0.8541.00
122_D125_R0.8411.00
106_W109_T0.8371.00
51_H377_P0.8361.00
99_M102_M0.8351.00
69_G384_P0.8331.00
31_L155_A0.8261.00
170_E206_R0.8241.00
18_M154_M0.8191.00
153_A156_K0.8171.00
159_Q165_I0.8161.00
51_H380_T0.8161.00
42_Q202_L0.8131.00
174_L183_I0.8121.00
240_L244_I0.8001.00
181_V196_L0.7941.00
195_T198_S0.7941.00
174_L211_L0.7931.00
364_T369_I0.7931.00
254_V257_T0.7921.00
11_I43_T0.7911.00
180_G192_E0.7821.00
158_F165_I0.7771.00
199_C371_T0.7741.00
101_R104_A0.7681.00
119_L124_L0.7681.00
208_V370_H0.7671.00
93_A99_M0.7671.00
37_A40_C0.7621.00
27_A195_T0.7621.00
235_Q238_N0.7621.00
62_K66_C0.7601.00
181_V185_T0.7561.00
43_T46_N0.7541.00
125_R132_T0.7511.00
228_R265_T0.7511.00
280_R283_D0.7501.00
110_A115_E0.7451.00
180_G194_S0.7441.00
253_G259_M0.7441.00
176_E366_P0.7431.00
181_V368_T0.7421.00
118_W135_G0.7391.00
219_I347_A0.7371.00
115_E140_P0.7361.00
124_L127_R0.7361.00
237_V241_I0.7361.00
230_A263_S0.7351.00
16_T389_I0.7341.00
257_T260_I0.7331.00
319_K323_L0.7321.00
229_L266_V0.7311.00
7_I198_S0.7281.00
124_L131_I0.7281.00
90_M136_G0.7261.00
327_Q334_S0.7241.00
64_Q68_A0.7241.00
266_V326_V0.7191.00
239_H242_Y0.7191.00
382_A386_G0.7181.00
67_L70_N0.7171.00
181_V367_R0.7151.00
256_L260_I0.7131.00
67_L71_R0.7111.00
65_F388_H0.7101.00
118_W137_I0.7101.00
20_L393_V0.7101.00
11_I151_T0.7051.00
86_N141_S0.7021.00
73_T383_I0.7001.00
243_P248_A0.7001.00
21_I25_P0.6981.00
66_C70_N0.6981.00
108_R111_A0.6961.00
89_K142_S0.6961.00
103_R106_W0.6951.00
377_P380_T0.6951.00
176_E179_N0.6951.00
37_A168_N0.6941.00
240_L245_P0.6941.00
238_N243_P0.6941.00
120_N124_L0.6921.00
32_L185_T0.6921.00
32_L169_A0.6911.00
149_D153_A0.6901.00
195_T367_R0.6901.00
34_K203_M0.6901.00
181_V184_R0.6891.00
72_A76_F0.6891.00
203_M206_R0.6871.00
334_S337_D0.6871.00
65_F68_A0.6871.00
5_V196_L0.6861.00
263_S339_Q0.6861.00
171_V174_L0.6851.00
50_I145_V0.6851.00
21_I28_R0.6831.00
127_R239_H0.6821.00
194_S367_R0.6781.00
360_F363_V0.6781.00
225_E271_V0.6781.00
150_V154_M0.6761.00
279_Y283_D0.6731.00
242_Y245_P0.6721.00
228_R340_P0.6721.00
121_A124_L0.6711.00
222_F348_Q0.6711.00
135_G139_V0.6701.00
128_E131_I0.6691.00
321_G324_R0.6661.00
349_A373_N0.6651.00
85_D144_I0.6641.00
236_I240_L0.6631.00
185_T190_E0.6631.00
327_Q335_L0.6601.00
80_N157_I0.6601.00
279_Y282_R0.6581.00
106_W116_R0.6551.00
15_S383_I0.6551.00
244_I247_P0.6531.00
243_P247_P0.6531.00
77_C82_I0.6521.00
169_A187_Q0.6521.00
255_H267_G0.6511.00
70_N73_T0.6501.00
155_A167_Y0.6491.00
391_S398_A0.6461.00
327_Q333_L0.6441.00
16_T393_V0.6421.00
236_I239_H0.6411.00
33_E167_Y0.6401.00
236_I241_I0.6381.00
151_T155_A0.6361.00
277_E281_K0.6351.00
25_P387_A0.6331.00
158_F162_G0.6331.00
45_H344_G0.6321.00
9_G167_Y0.6321.00
219_I372_C0.6301.00
253_G256_L0.6291.00
236_I242_Y0.6281.00
235_Q240_L0.6281.00
174_L210_M0.6241.00
128_E239_H0.6241.00
390_V394_Q0.6221.00
179_N366_P0.6221.00
159_Q164_E0.6201.00
12_I385_I0.6191.00
63_A67_L0.6181.00
65_F384_P0.6181.00
3_D30_A0.6171.00
158_F161_R0.6171.00
49_V142_S0.6161.00
331_P334_S0.6141.00
347_A374_A0.6121.00
197_I389_I0.6111.00
241_I245_P0.6101.00
243_P246_D0.6101.00
43_T151_T0.6081.00
349_A375_P0.6071.00
384_P387_A0.6071.00
208_V211_L0.6061.00
69_G74_K0.6061.00
34_K41_H0.6051.00
321_G325_L0.6021.00
120_N126_E0.6021.00
150_V383_I0.6011.00
227_F338_L0.6001.00
71_R74_K0.5991.00
220_C272_L0.5991.00
21_I29_I0.5971.00
333_L336_S0.5971.00
237_V242_Y0.5961.00
226_Y342_P0.5961.00
175_N192_E0.5951.00
66_C69_G0.5941.00
174_L198_S0.5931.00
105_L108_R0.5921.00
4_F197_I0.5881.00
171_V207_L0.5881.00
37_A152_A0.5871.00
183_I187_Q0.5871.00
255_H260_I0.5851.00
6_I29_I0.5851.00
19_Q72_A0.5831.00
50_I84_Y0.5831.00
139_V142_S0.5831.00
18_M21_I0.5831.00
97_L100_E0.5811.00
213_L365_T0.5811.00
128_E238_N0.5811.00
223_R343_A0.5791.00
204_A219_I0.5791.00
154_M382_A0.5791.00
374_A378_A0.5771.00
183_I196_L0.5761.00
104_A108_R0.5751.00
25_P395_T0.5741.00
209_K212_G0.5731.00
235_Q243_P0.5721.00
76_F80_N0.5721.00
72_A384_P0.5691.00
89_K92_V0.5691.00
320_S335_L0.5691.00
46_N379_A0.5681.00
242_Y247_P0.5681.00
171_V185_T0.5661.00
238_N242_Y0.5651.00
102_M106_W0.5641.00
33_E37_A0.5631.00
72_A383_I0.5621.00
371_T386_G0.5621.00
392_K395_T0.5611.00
4_F194_S0.5601.00
351_S359_D0.5591.00
11_I150_V0.5591.00
349_A361_L0.5581.00
97_L101_R0.5571.00
383_I386_G0.5561.00
96_D99_M0.5551.00
237_V243_P0.5481.00
6_I13_G0.5481.00
110_A113_G0.5471.00
265_T269_N0.5471.00
218_I350_V0.5471.00
172_S185_T0.5451.00
148_R340_P0.5441.00
93_A98_E0.5441.00
320_S323_L0.5431.00
42_Q48_G0.5401.00
227_F322_Y0.5401.00
39_A44_G0.5391.00
28_R194_S0.5391.00
197_I369_I0.5391.00
255_H259_M0.5391.00
325_L329_Y0.5391.00
55_Y58_P0.5381.00
346_R374_A0.5381.00
124_L128_E0.5381.00
147_Y379_A0.5371.00
109_T116_R0.5371.00
105_L109_T0.5341.00
208_V368_T0.5331.00
184_R187_Q0.5321.00
169_A186_R0.5321.00
30_A193_A0.5321.00
224_G269_N0.5311.00
174_L368_T0.5311.00
57_T60_S0.5301.00
54_V57_T0.5291.00
90_M138_F0.5281.00
11_I379_A0.5281.00
9_G155_A0.5281.00
22_D157_I0.5271.00
61_L65_F0.5271.00
275_K279_Y0.5261.00
117_E126_E0.5241.00
66_C381_S0.5211.00
230_A233_H0.5201.00
276_R279_Y0.5201.00
180_G366_P0.5201.00
130_N332_R0.5191.00
238_N241_I0.5191.00
66_C73_T0.5181.00
360_F364_T0.5171.00
198_S207_L0.5171.00
108_R112_N0.5151.00
221_P345_V0.5151.00
19_Q390_V0.5121.00
3_D193_A0.5121.00
211_L368_T0.5101.00
65_F70_N0.5091.00
125_R131_I0.5081.00
172_S175_N0.5081.00
241_I246_D0.5081.00
119_L136_G0.5081.00
4_F29_I0.5071.00
269_N346_R0.5071.00
172_S189_G0.5061.00
233_H236_I0.5051.00
346_R376_S0.5041.00
6_I197_I0.5031.00
33_E165_I0.5031.00
240_L246_D0.5021.00
39_A148_R0.5021.00
50_I380_T0.5021.00
159_Q162_G0.5011.00
360_F381_S0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4h1bA 1 0.846 100 0.362 Contact Map
4x9mA 1 0.8744 100 0.365 Contact Map
1y56B 1 0.8626 100 0.387 Contact Map
2gf3A 1 0.8768 100 0.388 Contact Map
3axbA 2 0.872 100 0.39 Contact Map
1ryiA 4 0.827 100 0.39 Contact Map
3dmeA 2 0.8246 100 0.391 Contact Map
2gagB 1 0.8673 100 0.4 Contact Map
3pvcA 1 0.8436 100 0.403 Contact Map
4rslA 1 0.9147 100 0.41 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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