GREMLIN Database
MODA - Molybdate-binding periplasmic protein
UniProt: P37329 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12427
Length: 257 (238)
Sequences: 15970 (11567)
Seq/√Len: 749.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
47_Q239_Y3.3111.00
28_K57_V3.1961.00
140_A188_A2.9351.00
30_T57_V2.9241.00
54_V232_T2.7671.00
115_K207_V2.7621.00
71_E93_K2.6451.00
97_D231_A2.5431.00
222_V237_Y2.5361.00
231_A234_K2.5201.00
28_K55_D2.5181.00
49_K55_D2.4161.00
51_E244_Q2.2711.00
51_E242_G2.1551.00
61_A65_T2.1201.00
45_A236_F2.0531.00
138_R189_P2.0431.00
96_I223_A2.0271.00
116_A205_K1.9981.00
234_K238_D1.9761.00
27_G232_T1.9651.00
117_S189_P1.9571.00
242_G245_A1.9381.00
42_Q46_T1.8851.00
243_P247_E1.8661.00
18_V21_N1.8661.00
247_E251_R1.8651.00
88_D92_D1.8421.00
47_Q248_I1.8121.00
48_F54_V1.8111.00
232_T235_A1.8071.00
47_Q50_K1.8021.00
68_R72_A1.7971.00
129_N132_S1.7261.00
114_P117_S1.7251.00
222_V240_L1.7141.00
47_Q51_E1.7081.00
45_A49_K1.6981.00
224_V234_K1.6551.00
235_A238_D1.6491.00
125_D212_E1.6451.00
90_A96_I1.5951.00
47_Q244_Q1.5541.00
224_V233_V1.5501.00
29_I232_T1.5381.00
46_T50_K1.5381.00
43_D251_R1.5341.00
45_A58_S1.5341.00
45_A56_V1.4961.00
80_I222_V1.4811.00
154_K158_Q1.4791.00
245_A248_I1.4541.00
112_V198_A1.4511.00
115_K205_K1.4461.00
228_H231_A1.4401.00
182_L187_E1.4331.00
126_S213_D1.4191.00
32_F76_A1.4151.00
156_A160_L1.4101.00
46_T49_K1.4071.00
70_I79_F1.3971.00
179_A191_G1.3911.00
78_L237_Y1.3681.00
224_V237_Y1.3661.00
48_F235_A1.3641.00
94_K226_E1.3611.00
67_A71_E1.3591.00
244_Q247_E1.3591.00
45_A55_D1.3491.00
97_D226_E1.3421.00
38_T42_Q1.3361.00
89_Y93_K1.3111.00
155_E216_K1.3061.00
248_I251_R1.2841.00
14_L17_A1.2831.00
157_L162_A1.2741.00
149_A152_Y1.2731.00
126_S129_N1.2731.00
158_Q162_A1.2691.00
164_D168_P1.2681.00
16_F19_A1.2661.00
49_K52_K1.2611.00
193_V198_A1.2431.00
103_T219_E1.2391.00
91_V96_I1.2371.00
54_V235_A1.2331.00
52_K235_A1.2291.00
125_D129_N1.2281.00
164_D167_S1.2201.00
165_T168_P1.2031.00
48_F239_Y1.1991.00
113_A207_V1.1901.00
107_N218_V1.1881.00
43_D46_T1.1781.00
71_E95_A1.1781.00
132_S135_N1.1761.00
67_A90_A1.1741.00
44_I245_A1.1691.00
157_L160_L1.1641.00
78_L233_V1.1531.00
43_D47_Q1.1451.00
44_I239_Y1.1441.00
110_V208_A1.1371.00
112_V193_V1.1301.00
83_D86_W1.1171.00
182_L188_A1.1121.00
29_I236_F1.1091.00
70_I225_V1.1081.00
79_F223_A1.1001.00
15_S18_V1.0981.00
246_A250_K1.0981.00
157_L161_G1.0961.00
147_V152_Y1.0951.00
47_Q245_A1.0951.00
102_Q241_K1.0911.00
239_Y245_A1.0901.00
181_A185_R1.0701.00
27_G230_N1.0641.00
54_V58_S1.0561.00
208_A211_P1.0391.00
113_A209_T1.0361.00
154_K157_L1.0311.00
68_R71_E1.0281.00
48_F236_F1.0191.00
67_A86_W1.0191.00
225_V228_H1.0181.00
224_V231_A1.0171.00
131_T165_T1.0111.00
31_V236_F1.0031.00
112_V183_V1.0021.00
171_A174_E0.9991.00
136_G169_K0.9981.00
67_A89_Y0.9981.00
156_A162_A0.9851.00
148_P151_I0.9821.00
124_I129_N0.9791.00
156_A159_K0.9761.00
87_M223_A0.9741.00
48_F232_T0.9711.00
131_T166_L0.9681.00
12_A15_S0.9641.00
148_P152_Y0.9641.00
135_N190_L0.9441.00
175_D178_G0.9431.00
99_A234_K0.9371.00
49_K56_V0.9341.00
202_K207_V0.9201.00
29_I233_V0.9141.00
163_W166_L0.9121.00
154_K162_A0.9121.00
128_T131_T0.9121.00
19_A22_A0.9081.00
147_V150_G0.9021.00
128_T132_S0.9021.00
195_G199_V0.9021.00
155_E158_Q0.8991.00
69_Q73_G0.8911.00
11_G14_L0.8901.00
166_L169_K0.8881.00
24_A27_G0.8871.00
111_V190_L0.8831.00
97_D234_K0.8751.00
33_A58_S0.8731.00
13_A16_F0.8681.00
91_V101_R0.8661.00
148_P153_A0.8621.00
84_Q219_E0.8611.00
108_S195_G0.8611.00
51_E239_Y0.8591.00
89_Y92_D0.8561.00
126_S212_E0.8561.00
173_A182_L0.8521.00
29_I56_V0.8501.00
113_A123_T0.8461.00
163_W167_S0.8391.00
238_D241_K0.8281.00
159_K162_A0.8271.00
174_E178_G0.8241.00
245_A249_F0.8241.00
27_G54_V0.8211.00
19_A23_L0.8161.00
240_L245_A0.8101.00
78_L236_F0.8091.00
155_E159_K0.8091.00
41_M44_I0.8071.00
59_S69_Q0.8061.00
154_K163_W0.8051.00
86_W89_Y0.8001.00
79_F90_A0.7991.00
63_S81_S0.7921.00
228_H233_V0.7921.00
105_L249_F0.7911.00
118_V135_N0.7851.00
165_T169_K0.7821.00
147_V151_I0.7811.00
184_E201_S0.7791.00
194_Y197_D0.7771.00
141_V170_L0.7771.00
158_Q161_G0.7761.00
77_D228_H0.7741.00
132_S136_G0.7691.00
206_V211_P0.7661.00
77_D230_N0.7661.00
119_Q123_T0.7651.00
127_K192_I0.7641.00
17_A20_G0.7561.00
26_E55_D0.7561.00
27_G235_A0.7541.00
183_V191_G0.7411.00
15_S19_A0.7391.00
150_G153_A0.7391.00
31_V78_L0.7321.00
9_F12_A0.7291.00
97_D227_G0.7291.00
48_F52_K0.7231.00
76_A225_V0.7221.00
11_G15_S0.7211.00
80_I104_L0.7211.00
65_T69_Q0.7171.00
10_A14_L0.7161.00
10_A13_A0.7151.00
112_V206_V0.7151.00
90_A95_A0.7141.00
99_A238_D0.7141.00
32_F59_S0.7131.00
71_E89_Y0.7131.00
69_Q72_A0.7111.00
156_A161_G0.7081.00
178_G181_A0.7071.00
97_D228_H0.7071.00
31_V58_S0.7061.00
70_I95_A0.7041.00
100_T234_K0.7041.00
12_A16_F0.7031.00
114_P205_K0.7021.00
43_D248_I0.6991.00
23_L26_E0.6981.00
180_L184_E0.6951.00
224_V228_H0.6941.00
103_T107_N0.6921.00
22_A26_E0.6911.00
25_D28_K0.6891.00
118_V123_T0.6871.00
103_T221_P0.6861.00
149_A153_A0.6811.00
42_Q45_A0.6811.00
113_A190_L0.6791.00
69_Q74_A0.6751.00
139_L190_L0.6751.00
52_K232_T0.6701.00
172_P176_V0.6671.00
173_A178_G0.6651.00
181_A184_E0.6641.00
247_E250_K0.6641.00
22_A25_D0.6631.00
199_V202_K0.6621.00
87_M221_P0.6611.00
44_I47_Q0.6601.00
238_D242_G0.6581.00
39_N42_Q0.6561.00
21_N25_D0.6531.00
84_Q88_D0.6521.00
49_K54_V0.6511.00
104_L107_N0.6501.00
236_F240_L0.6471.00
222_V241_K0.6461.00
244_Q248_I0.6451.00
141_V153_A0.6401.00
67_A93_K0.6361.00
119_Q124_I0.6351.00
62_S65_T0.6291.00
19_A24_A0.6261.00
106_G219_E0.6251.00
65_T68_R0.6201.00
131_T169_K0.6191.00
17_A21_N0.6151.00
97_D100_T0.6111.00
79_F225_V0.6071.00
13_A17_A0.6071.00
154_K159_K0.6061.00
154_K161_G0.6041.00
39_N177_R0.6031.00
40_A249_F0.6021.00
32_F66_L0.6011.00
179_A183_V0.6001.00
114_P118_V0.5971.00
61_A66_L0.5961.00
183_V188_A0.5951.00
33_A41_M0.5901.00
73_G76_A0.5901.00
140_A173_A0.5881.00
110_V198_A0.5871.00
66_L79_F0.5871.00
137_G189_P0.5861.00
49_K53_G0.5841.00
65_T174_E0.5841.00
177_R180_L0.5831.00
94_K98_T0.5821.00
182_L185_R0.5821.00
20_G24_A0.5821.00
48_F56_V0.5821.00
54_V57_V0.5821.00
118_V190_L0.5791.00
16_F20_G0.5781.00
155_E160_L0.5771.00
23_L27_G0.5721.00
21_N24_A0.5711.00
136_G144_P0.5661.00
88_D91_V0.5651.00
37_L80_I0.5641.00
145_E154_K0.5631.00
110_V195_G0.5611.00
153_A156_A0.5601.00
143_D146_H0.5571.00
102_Q238_D0.5551.00
26_E230_N0.5531.00
31_V56_V0.5531.00
66_L81_S0.5511.00
51_E235_A0.5501.00
52_K56_V0.5451.00
237_Y241_K0.5451.00
128_T213_D0.5451.00
195_G209_T0.5441.00
26_E53_G0.5431.00
227_G231_A0.5431.00
141_V148_P0.5411.00
167_S170_L0.5391.00
142_G179_A0.5391.00
212_E215_H0.5371.00
31_V45_A0.5341.00
145_E149_A0.5341.00
118_V124_I0.5321.00
210_F215_H0.5311.00
151_I154_K0.5301.00
109_L194_Y0.5301.00
61_A69_Q0.5301.00
99_A237_Y0.5291.00
71_E90_A0.5261.00
105_L220_Y0.5241.00
116_A119_Q0.5241.00
103_T106_G0.5221.00
106_G217_K0.5221.00
42_Q60_F0.5211.00
29_I228_H0.5191.00
9_F13_A0.5171.00
243_P246_A0.5141.00
116_A206_V0.5131.00
113_A117_S0.5131.00
174_E177_R0.5101.00
128_T160_L0.5101.00
80_I240_L0.5091.00
81_S86_W0.5051.00
173_A177_R0.5031.00
99_A224_V0.5021.00
20_G23_L0.5021.00
171_A182_L0.5001.00
178_G182_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3r26A 1 0.8872 100 0.34 Contact Map
4rxlA 1 0.8755 100 0.365 Contact Map
3c9hA 1 0.9377 100 0.383 Contact Map
4edpA 1 0.8755 100 0.397 Contact Map
3rpwA 1 0.8833 100 0.414 Contact Map
3k6vA 1 0.8755 100 0.421 Contact Map
3gzgA 1 0.8988 100 0.425 Contact Map
3waeA 2 0.8872 100 0.429 Contact Map
2vozA 3 0.8755 100 0.437 Contact Map
4kd5C 3 0.8794 100 0.442 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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