GREMLIN Database
YFDC - Inner membrane protein YfdC
UniProt: P37327 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12420
Length: 310 (248)
Sequences: 2133 (1416)
Seq/√Len: 89.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
188_F266_C7.4031.00
188_F262_A4.7511.00
63_A146_G4.0001.00
210_A214_V3.9661.00
187_M260_T3.8411.00
124_V133_V3.7741.00
262_A266_C3.2521.00
64_I153_I3.2261.00
60_L146_G3.0951.00
144_L261_L3.0931.00
71_G154_A3.0361.00
184_P259_P2.7301.00
241_L244_N2.6061.00
76_A222_L2.6031.00
48_G123_P2.4481.00
238_I252_F2.4461.00
113_F117_T2.3051.00
60_L142_V2.2881.00
196_W271_I2.2351.00
156_W160_Y2.1981.00
48_G51_E2.1181.00
99_T217_I2.0231.00
124_V136_L2.0121.00
53_E135_L1.9581.00
136_L140_W1.9271.00
116_N139_L1.8591.00
64_I149_L1.8021.00
108_A276_S1.7821.00
140_W265_I1.7771.00
183_T186_E1.7681.00
192_I266_C1.7661.00
68_L196_W1.7581.00
56_A142_V1.7551.00
137_I141_G1.7531.00
59_L142_V1.7421.00
241_L245_G1.7381.00
103_I213_I1.7211.00
208_A211_A1.7191.00
104_I200_T1.6981.00
113_F265_I1.6571.00
124_V131_S1.6371.00
182_N190_N1.6201.00
108_A203_W1.6141.00
157_A189_A1.5821.00
174_K177_M1.5791.00
144_L231_I1.5761.00
148_I235_S1.5571.00
46_Q128_P1.5391.00
60_L64_I1.5061.00
35_S43_H1.5031.00
87_V90_S1.4951.00
123_P131_S1.4891.00
248_H251_D1.4771.00
41_H281_R1.4691.00
77_K94_E1.4630.99
117_T140_W1.4600.99
231_I261_L1.4360.99
72_A196_W1.4090.99
242_V249_W1.4080.99
60_L149_L1.4060.99
92_L221_W1.3960.99
185_S189_A1.3930.99
265_I269_T1.3730.99
271_I275_M1.3690.99
40_I207_A1.3640.99
134_G138_R1.3610.99
76_A221_W1.3560.99
204_M215_V1.3440.99
100_F222_L1.3040.99
36_R39_A1.3040.99
182_N187_M1.2930.99
80_F93_L1.2910.99
177_M181_K1.2690.99
253_I258_L1.2480.98
133_V137_I1.2440.98
132_N135_L1.2370.98
78_G175_I1.2270.98
95_N225_L1.2260.98
62_S279_Q1.2240.98
261_L265_I1.2220.98
76_A225_L1.2120.98
96_L217_I1.2100.98
145_L149_L1.2060.98
184_P262_A1.2050.98
258_L262_A1.1970.98
157_A193_I1.1880.98
177_M246_T1.1750.98
101_G224_A1.1750.98
178_D181_K1.1720.98
194_S232_V1.1720.98
155_A240_Y1.1700.98
44_I206_P1.1620.97
81_Q171_A1.1550.97
186_E190_N1.1530.97
141_G145_L1.1430.97
122_L273_A1.1370.97
152_G243_F1.1240.97
234_G256_F1.1210.97
144_L257_A1.1180.97
55_D58_A1.1150.97
86_G89_G1.1140.97
191_A259_P1.1080.97
110_Q276_S1.0950.96
270_F274_L1.0900.96
65_A275_M1.0770.96
75_L226_G1.0720.96
74_L237_E1.0710.96
106_I216_I1.0690.96
171_A174_K1.0630.96
68_L71_G1.0580.95
49_E128_P1.0500.95
62_S111_Q1.0470.95
105_V191_A1.0410.95
232_V235_S1.0390.95
272_F276_S1.0340.95
155_A243_F1.0320.95
78_G172_F1.0290.95
105_V110_Q1.0210.95
184_P188_F1.0160.94
148_I152_G1.0150.94
56_A60_L1.0140.94
191_A261_L0.9970.94
103_I218_L0.9970.94
240_Y244_N0.9940.94
196_W272_F0.9920.94
72_A154_A0.9840.93
72_A197_L0.9790.93
195_G223_I0.9760.93
81_Q94_E0.9700.93
96_L221_W0.9640.93
251_D255_P0.9600.93
231_I257_A0.9500.92
126_Q277_H0.9490.92
156_W243_F0.9480.92
139_L143_V0.9450.92
125_M277_H0.9320.91
59_L138_R0.9280.91
154_A196_W0.9270.91
69_S110_Q0.9240.91
172_F240_Y0.9180.91
65_A69_S0.9100.90
198_I223_I0.9080.90
46_Q50_K0.9060.90
161_M193_I0.8920.89
184_P255_P0.8880.89
179_V195_G0.8860.89
39_A42_E0.8790.89
179_V233_V0.8700.88
104_I197_L0.8630.88
179_V234_G0.8570.88
255_P259_P0.8560.87
57_M278_A0.8560.87
82_V171_A0.8560.87
125_M274_L0.8470.87
203_W276_S0.8440.87
190_N229_T0.8430.87
107_M207_A0.8320.86
43_H206_P0.8300.86
259_P262_A0.8290.86
108_A204_M0.8270.86
113_F232_V0.8260.86
165_N186_E0.8260.86
59_L143_V0.8260.86
78_G236_V0.8260.86
133_V136_L0.8240.85
113_F261_L0.8240.85
69_S276_S0.8180.85
179_V223_I0.8180.85
170_D174_K0.8090.84
135_L138_R0.8050.84
49_E53_E0.8040.84
35_S39_A0.7990.84
152_G155_A0.7960.83
144_L148_I0.7950.83
85_E88_P0.7950.83
152_G239_L0.7930.83
184_P187_M0.7910.83
52_L131_S0.7840.82
187_M191_A0.7780.82
106_I202_V0.7770.82
45_R126_Q0.7760.82
242_V252_F0.7710.81
223_I234_G0.7700.81
204_M219_M0.7690.81
108_A200_T0.7660.81
80_F97_G0.7630.81
197_L216_I0.7580.80
83_E95_N0.7560.80
119_T123_P0.7540.80
162_P190_N0.7530.80
42_E46_Q0.7520.80
127_K133_V0.7480.79
62_S203_W0.7440.79
96_L103_I0.7430.79
281_R284_M0.7410.79
117_T121_V0.7400.79
201_M223_I0.7390.79
56_A141_G0.7370.78
268_G273_A0.7370.78
196_W200_T0.7360.78
111_Q116_N0.7350.78
39_A209_G0.7340.78
117_T268_G0.7320.78
170_D173_V0.7270.77
118_V213_I0.7200.77
158_F161_M0.7190.77
111_Q143_V0.7130.76
160_Y189_A0.7130.76
144_L232_V0.7120.76
176_G238_I0.7110.76
203_W272_F0.7110.76
46_Q49_E0.7110.76
238_I242_V0.7100.76
246_T251_D0.7100.76
100_F104_I0.7080.76
161_M189_A0.7060.75
153_I156_W0.7020.75
143_V203_W0.6970.74
195_G220_T0.6970.74
69_S104_I0.6950.74
103_I216_I0.6920.74
61_W275_M0.6890.74
49_E131_S0.6870.73
63_A143_V0.6870.73
114_T194_S0.6840.73
53_E247_L0.6820.73
113_F144_L0.6760.72
37_A280_I0.6750.72
77_K81_Q0.6740.72
99_T103_I0.6670.71
216_I220_T0.6650.71
269_T273_A0.6640.71
247_L251_D0.6620.71
180_M251_D0.6610.70
37_A40_I0.6600.70
113_F268_G0.6580.70
118_V272_F0.6540.70
120_A123_P0.6530.70
36_R40_I0.6520.69
177_M247_L0.6510.69
140_W231_I0.6510.69
121_V125_M0.6480.69
78_G237_E0.6450.69
184_P258_L0.6450.69
77_K224_A0.6450.69
223_I233_V0.6430.68
84_L89_G0.6400.68
137_I266_C0.6370.68
270_F275_M0.6370.68
236_V239_L0.6360.68
194_S260_T0.6360.68
155_A239_L0.6320.67
175_I237_E0.6300.67
87_V262_A0.6300.67
157_A161_M0.6290.67
37_A232_V0.6290.67
57_M127_K0.6260.66
229_T234_G0.6240.66
124_V127_K0.6230.66
71_G236_V0.6210.66
163_I166_E0.6190.65
131_S135_L0.6190.65
197_L219_M0.6190.65
124_V137_I0.6180.65
72_A232_V0.6160.65
195_G234_G0.6140.65
52_L120_A0.6120.65
36_R48_G0.6120.65
159_E243_F0.6120.65
85_E90_S0.6090.64
257_A260_T0.6040.64
42_E45_R0.6020.63
51_E236_V0.6010.63
174_K178_D0.6010.63
84_L90_S0.5990.63
231_I260_T0.5880.61
113_F231_I0.5860.61
213_I218_L0.5850.61
198_I220_T0.5840.61
188_F191_A0.5830.61
163_I190_N0.5820.61
74_L77_K0.5820.61
119_T131_S0.5800.60
145_L253_I0.5760.60
158_F193_I0.5750.60
211_A214_V0.5740.60
73_S101_G0.5720.59
97_G221_W0.5720.59
64_I271_I0.5710.59
276_S280_I0.5700.59
124_V135_L0.5700.59
177_M180_M0.5680.59
66_A115_E0.5680.59
141_G258_L0.5670.59
73_S95_N0.5670.59
45_R281_R0.5660.59
35_S46_Q0.5650.58
151_T235_S0.5640.58
35_S209_G0.5640.58
84_L87_V0.5640.58
180_M247_L0.5640.58
242_V245_G0.5610.58
47_D50_K0.5600.58
162_P186_E0.5590.58
195_G233_V0.5580.58
45_R48_G0.5570.57
43_H47_D0.5550.57
187_M255_P0.5540.57
167_E170_D0.5530.57
161_M190_N0.5510.57
217_I220_T0.5510.57
57_M282_N0.5500.56
86_G90_S0.5500.56
62_S110_Q0.5490.56
99_T220_T0.5470.56
34_P37_A0.5470.56
154_A232_V0.5450.56
74_L236_V0.5450.56
62_S105_V0.5450.56
98_Y223_I0.5450.56
199_A229_T0.5420.55
229_T256_F0.5420.55
93_L140_W0.5410.55
250_S255_P0.5390.55
115_E178_D0.5370.55
60_L132_N0.5360.55
113_F121_V0.5350.54
54_R59_L0.5350.54
40_I203_W0.5340.54
257_A261_L0.5340.54
243_F249_W0.5310.54
52_L139_L0.5300.54
41_H203_W0.5300.54
203_W280_I0.5280.53
168_T190_N0.5280.53
118_V280_I0.5280.53
239_L242_V0.5270.53
61_W279_Q0.5270.53
199_A235_S0.5250.53
47_D51_E0.5240.53
59_L116_N0.5240.53
178_D183_T0.5220.53
106_I205_F0.5210.52
83_E86_G0.5200.52
207_A280_I0.5200.52
137_I140_W0.5200.52
108_A207_A0.5200.52
223_I256_F0.5190.52
42_E128_P0.5190.52
42_E149_L0.5180.52
253_I259_P0.5170.52
41_H122_L0.5160.52
104_I151_T0.5160.52
170_D248_H0.5150.52
76_A190_N0.5150.52
97_G108_A0.5140.52
127_K132_N0.5140.52
72_A119_T0.5120.51
148_I253_I0.5110.51
111_Q139_L0.5100.51
255_P258_L0.5090.51
84_L93_L0.5090.51
101_G143_V0.5070.51
138_R155_A0.5060.50
60_L191_A0.5060.50
64_I68_L0.5040.50
102_F118_V0.5030.50
171_A175_I0.5020.50
95_N224_A0.5020.50
112_L268_G0.5020.50
187_M259_P0.5010.50
56_A138_R0.5000.50
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3kcuA 3 0.729 100 0.229 Contact Map
3klyA 3 0.7452 100 0.233 Contact Map
3tdsE 3 0.8226 100 0.257 Contact Map
4fc4A 3 0.7806 100 0.266 Contact Map
3iyzA 3 0.6613 96.2 0.926 Contact Map
3zojA 3 0.7903 95.9 0.928 Contact Map
3llqA 3 0.7258 94 0.936 Contact Map
2b6oA 6 0.7032 93.5 0.937 Contact Map
2zz9A 3 0.6613 93 0.938 Contact Map
4oj2X 3 0.7355 92.1 0.94 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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