GREMLIN Database
INTS - Putative prophage CPS-53 integrase
UniProt: P37326 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12413
Length: 385 (329)
Sequences: 19541 (16582)
Seq/√Len: 914.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
331_S348_L4.8241.00
131_L140_Q3.2791.00
243_W282_S3.1821.00
137_E140_Q2.9781.00
322_S325_G2.8521.00
228_L323_G2.8101.00
266_H349_A2.7781.00
251_R275_V2.7411.00
232_A330_F2.6681.00
235_T324_H2.6101.00
330_F347_Q2.5321.00
223_I281_L2.4471.00
148_F160_A2.3751.00
328_H362_H2.3601.00
254_T267_V2.3221.00
242_L290_E2.2761.00
247_D250_N2.2111.00
94_S125_L2.2041.00
66_K69_T2.1561.00
40_R47_E2.1141.00
228_L238_L2.1121.00
145_I161_R2.0881.00
127_I147_R2.0861.00
60_L64_R2.0521.00
252_I267_V2.0371.00
97_Y167_V2.0121.00
330_F334_M1.9631.00
97_Y120_F1.9531.00
341_A357_R1.9501.00
117_A121_D1.9211.00
170_Y174_T1.9131.00
94_S98_K1.8841.00
155_E159_K1.8511.00
308_V312_I1.8481.00
98_K125_L1.8351.00
340_P343_A1.8341.00
335_N344_I1.8331.00
243_W292_V1.8241.00
275_V279_T1.8201.00
70_A73_D1.8101.00
269_P347_Q1.8091.00
132_E135_D1.8041.00
96_I171_A1.7961.00
201_P204_Q1.7851.00
223_I280_T1.7831.00
101_Y117_A1.7731.00
230_Y271_S1.7531.00
233_L238_L1.7521.00
264_K351_A1.7331.00
169_R183_P1.7311.00
141_L182_A1.6901.00
96_I133_I1.6901.00
109_S259_V1.6661.00
119_M163_R1.6661.00
42_K47_E1.6631.00
335_N361_N1.6241.00
94_S130_G1.6141.00
175_G179_Y1.5951.00
59_T62_E1.5791.00
235_T239_R1.5611.00
69_T73_D1.5511.00
251_R272_D1.5221.00
242_L291_F1.5211.00
96_I170_Y1.5121.00
112_Y116_L1.5121.00
72_K76_V1.5061.00
237_E266_H1.5031.00
222_L226_K1.4931.00
40_R49_I1.4871.00
272_D276_E1.4831.00
136_I168_F1.4741.00
229_R326_F1.4711.00
66_K70_A1.4641.00
205_I229_R1.4631.00
354_G358_G1.4601.00
334_M339_W1.4461.00
99_E103_H1.4451.00
204_Q207_A1.4391.00
161_R165_G1.3891.00
223_I277_L1.3831.00
245_N256_D1.3791.00
142_L174_T1.3781.00
67_A71_R1.3761.00
334_M344_I1.3521.00
241_M246_V1.3491.00
352_N358_G1.3431.00
224_A238_L1.3421.00
92_S95_A1.3411.00
173_V186_A1.3391.00
244_K290_E1.3371.00
105_K113_A1.3331.00
207_A211_A1.3221.00
248_F279_T1.3221.00
118_K122_D1.3081.00
213_A222_L1.3061.00
101_Y113_A1.3021.00
342_D345_E1.3001.00
138_P173_V1.2861.00
331_S344_I1.2821.00
241_M253_I1.2661.00
339_W375_W1.2651.00
200_L208_F1.2601.00
113_A117_A1.2571.00
173_V184_D1.2541.00
247_D252_I1.2501.00
200_L329_E1.2481.00
142_L146_R1.2421.00
205_I333_I1.2381.00
227_V274_V1.2351.00
165_G169_R1.2321.00
172_I177_A1.2191.00
167_V171_A1.2131.00
116_L163_R1.2111.00
120_F125_L1.2111.00
64_R68_W1.2101.00
356_V359_I1.2031.00
110_V114_T1.1981.00
209_N226_K1.1921.00
202_A333_I1.1911.00
206_P210_K1.1891.00
131_L135_D1.1821.00
270_M275_V1.1811.00
233_L255_I1.1791.00
270_M274_V1.1741.00
272_D374_Q1.1611.00
242_L245_N1.1581.00
69_T72_K1.1571.00
61_Q65_D1.1531.00
329_E333_I1.1501.00
121_D125_L1.1481.00
345_E353_G1.1441.00
98_K102_E1.1431.00
115_E118_K1.1391.00
104_K108_W1.1321.00
144_V160_A1.1321.00
169_R180_N1.1211.00
226_K277_L1.1201.00
352_N356_V1.1141.00
345_E357_R1.1071.00
309_L313_K1.1051.00
281_L285_T1.1041.00
109_S112_Y1.1001.00
68_W75_S1.0991.00
36_V51_T1.0961.00
108_W116_L1.0961.00
342_D346_V1.0941.00
271_S274_V1.0891.00
38_Q51_T1.0831.00
90_N134_Q1.0821.00
96_I174_T1.0791.00
202_A206_P1.0741.00
65_D69_T1.0721.00
224_A293_F1.0701.00
307_A310_L1.0691.00
128_I144_V1.0691.00
253_I257_A1.0641.00
144_V148_F1.0641.00
90_N132_E1.0621.00
68_W71_R1.0591.00
145_I149_E1.0591.00
332_T361_N1.0561.00
235_T323_G1.0531.00
309_L312_I1.0511.00
260_M265_I1.0481.00
273_Q276_E1.0451.00
339_W372_M1.0421.00
350_H356_V1.0401.00
336_E367_D1.0351.00
114_T118_K1.0341.00
343_A372_M1.0331.00
230_Y274_V1.0331.00
153_A156_R1.0261.00
39_L66_K1.0121.00
333_I336_E1.0111.00
139_M143_E1.0091.00
226_K273_Q1.0091.00
148_F157_A1.0081.00
245_N259_V1.0031.00
227_V238_L1.0011.00
159_K162_R1.0011.00
149_E157_A0.9991.00
199_F329_E0.9981.00
139_M174_T0.9971.00
346_V368_K0.9941.00
336_E364_Q0.9931.00
94_S129_G0.9881.00
168_F181_P0.9791.00
72_K75_S0.9751.00
158_N188_A0.9681.00
93_F167_V0.9631.00
71_R75_S0.9611.00
230_Y273_Q0.9601.00
172_I179_Y0.9591.00
73_D78_I0.9591.00
98_K117_A0.9571.00
62_E66_K0.9521.00
108_W113_A0.9501.00
62_E65_D0.9501.00
165_G183_P0.9481.00
172_I184_D0.9471.00
332_T362_H0.9441.00
244_K289_S0.9441.00
221_S307_A0.9431.00
371_E375_W0.9421.00
279_T282_S0.9421.00
227_V253_I0.9401.00
133_I168_F0.9351.00
115_E119_M0.9341.00
161_R182_A0.9331.00
30_P38_Q0.9291.00
91_N95_A0.9241.00
65_D68_W0.9241.00
345_E358_G0.9201.00
168_F177_A0.9181.00
168_F182_A0.9161.00
141_L164_C0.9161.00
156_R160_A0.9141.00
138_P175_G0.9101.00
97_Y101_Y0.9071.00
96_I167_V0.9041.00
137_E178_K0.9001.00
110_V113_A0.9001.00
65_D75_S0.8981.00
211_A314_Q0.8941.00
357_R361_N0.8931.00
104_K166_E0.8871.00
91_N99_E0.8791.00
155_E158_N0.8771.00
225_T326_F0.8761.00
68_W72_K0.8741.00
331_S361_N0.8741.00
241_M292_V0.8731.00
213_A226_K0.8701.00
52_V66_K0.8691.00
111_G114_T0.8681.00
64_R67_A0.8661.00
345_E356_V0.8631.00
61_Q64_R0.8611.00
104_K107_V0.8601.00
93_F164_C0.8601.00
339_W343_A0.8571.00
353_G358_G0.8521.00
172_I183_P0.8521.00
140_Q143_E0.8511.00
143_E147_R0.8501.00
236_K240_S0.8501.00
282_S285_T0.8481.00
227_V293_F0.8451.00
136_I141_L0.8421.00
330_F348_L0.8411.00
243_W285_T0.8401.00
180_N183_P0.8391.00
111_G115_E0.8361.00
165_G182_A0.8361.00
172_I180_N0.8341.00
337_H375_W0.8321.00
310_L314_Q0.8301.00
149_E154_M0.8291.00
331_S335_N0.8291.00
353_G357_R0.8271.00
208_F225_T0.8251.00
212_L225_T0.8191.00
142_L145_I0.8191.00
93_F97_Y0.8121.00
58_M62_E0.8101.00
36_V54_K0.8031.00
73_D76_V0.8001.00
245_N257_A0.7981.00
91_N176_R0.7981.00
325_G328_H0.7971.00
243_W278_L0.7961.00
311_V315_I0.7931.00
37_W60_L0.7921.00
364_Q367_D0.7791.00
348_L357_R0.7791.00
127_I143_E0.7781.00
274_V277_L0.7751.00
248_F275_V0.7741.00
133_I171_A0.7731.00
331_S357_R0.7731.00
137_E175_G0.7691.00
350_H357_R0.7681.00
93_F136_I0.7671.00
69_T76_V0.7651.00
32_S35_K0.7651.00
227_V278_L0.7631.00
331_S356_V0.7621.00
335_N341_A0.7581.00
295_G301_K0.7561.00
158_N162_R0.7531.00
63_A67_A0.7511.00
211_A315_I0.7511.00
139_M175_G0.7491.00
200_L204_Q0.7461.00
138_P142_L0.7461.00
276_E279_T0.7451.00
328_H359_I0.7381.00
229_R329_E0.7351.00
219_I222_L0.7351.00
198_P318_E0.7351.00
103_H146_R0.7351.00
127_I144_V0.7341.00
95_A99_E0.7321.00
212_L222_L0.7261.00
60_L63_A0.7251.00
353_G356_V0.7241.00
168_F172_I0.7211.00
65_D72_K0.7211.00
108_W112_Y0.7181.00
335_N342_D0.7181.00
370_R374_Q0.7181.00
197_F322_S0.7181.00
99_E176_R0.7171.00
207_A210_K0.7171.00
238_L323_G0.7151.00
100_W166_E0.7141.00
115_E159_K0.7111.00
100_W170_Y0.7101.00
97_Y125_L0.7091.00
124_I164_C0.7051.00
175_G184_D0.7041.00
122_D160_A0.7041.00
282_S286_K0.7021.00
234_R324_H0.7021.00
347_Q373_M0.7001.00
233_L237_E0.6981.00
246_V278_L0.6981.00
118_K121_D0.6971.00
248_F251_R0.6951.00
41_Y48_K0.6941.00
306_N310_L0.6931.00
202_A337_H0.6921.00
96_I176_R0.6911.00
169_R172_I0.6901.00
105_K117_A0.6881.00
100_W104_K0.6881.00
227_V231_T0.6821.00
145_I157_A0.6811.00
92_S132_E0.6811.00
345_E352_N0.6791.00
253_I270_M0.6761.00
256_D265_I0.6761.00
74_I79_D0.6761.00
232_A348_L0.6751.00
231_T268_V0.6751.00
198_P204_Q0.6751.00
341_A358_G0.6741.00
331_S345_E0.6731.00
367_D370_R0.6711.00
254_T265_I0.6701.00
352_N357_R0.6671.00
235_T305_E0.6661.00
335_N364_Q0.6661.00
39_L70_A0.6641.00
99_E170_Y0.6631.00
166_E170_Y0.6631.00
99_E102_E0.6621.00
98_K121_D0.6611.00
38_Q49_I0.6591.00
219_I280_T0.6581.00
168_F180_N0.6551.00
248_F270_M0.6541.00
51_T54_K0.6531.00
342_D357_R0.6521.00
95_A98_K0.6501.00
122_D126_P0.6481.00
99_E174_T0.6471.00
205_I329_E0.6441.00
231_T274_V0.6441.00
233_L241_M0.6421.00
365_Y368_K0.6421.00
77_G80_P0.6401.00
342_D358_G0.6381.00
39_L67_A0.6371.00
119_M160_A0.6311.00
269_P368_K0.6311.00
161_R185_L0.6301.00
171_A177_A0.6291.00
200_L320_L0.6271.00
36_V58_M0.6271.00
102_E105_K0.6271.00
231_T271_S0.6271.00
177_A181_P0.6231.00
307_A311_V0.6201.00
209_N222_L0.6171.00
233_L268_V0.6131.00
219_I223_I0.6111.00
229_R333_I0.6111.00
142_L173_V0.6111.00
146_R149_E0.6091.00
101_Y105_K0.6081.00
169_R173_V0.6071.00
104_K116_L0.6061.00
262_G349_A0.6051.00
198_P319_G0.6041.00
220_V281_L0.6041.00
331_S350_H0.6041.00
128_I136_I0.6041.00
116_L119_M0.6031.00
73_D77_G0.6021.00
343_A371_E0.6021.00
144_V147_R0.5991.00
204_Q318_E0.5991.00
308_V323_G0.5991.00
54_K59_T0.5981.00
246_V253_I0.5971.00
234_R257_A0.5951.00
138_P184_D0.5951.00
350_H354_G0.5941.00
367_D371_E0.5931.00
202_A336_E0.5921.00
120_F124_I0.5921.00
345_E348_L0.5901.00
124_I129_G0.5901.00
146_R174_T0.5901.00
334_M347_Q0.5891.00
277_L280_T0.5881.00
39_L52_V0.5861.00
172_I175_G0.5861.00
164_C182_A0.5851.00
125_L129_G0.5821.00
154_M158_N0.5821.00
309_L319_G0.5811.00
233_L253_I0.5811.00
276_E280_T0.5801.00
203_D207_A0.5791.00
341_A345_E0.5791.00
239_R305_E0.5771.00
347_Q368_K0.5771.00
291_F294_A0.5761.00
199_F332_T0.5731.00
128_I140_Q0.5721.00
320_L325_G0.5711.00
120_F163_R0.5711.00
335_N363_A0.5711.00
222_L277_L0.5701.00
335_N357_R0.5701.00
291_F302_P0.5681.00
209_N230_Y0.5681.00
366_L370_R0.5671.00
280_T283_S0.5661.00
336_E366_L0.5661.00
71_R74_I0.5661.00
138_P174_T0.5641.00
211_A214_T0.5621.00
94_S120_F0.5611.00
91_N134_Q0.5591.00
99_E143_E0.5581.00
336_E363_A0.5571.00
146_R150_D0.5561.00
144_V164_C0.5551.00
280_T284_I0.5521.00
324_H348_L0.5511.00
231_T238_L0.5501.00
173_V183_P0.5491.00
30_P34_K0.5461.00
317_Y320_L0.5461.00
310_L313_K0.5451.00
209_N213_A0.5441.00
103_H170_Y0.5441.00
247_D254_T0.5431.00
167_V170_Y0.5421.00
242_L257_A0.5401.00
339_W344_I0.5401.00
297_N301_K0.5401.00
193_R263_R0.5361.00
119_M159_K0.5331.00
148_F152_G0.5321.00
335_N340_P0.5291.00
147_R151_R0.5271.00
50_L70_A0.5251.00
92_S130_G0.5221.00
124_I144_V0.5181.00
341_A353_G0.5181.00
332_T363_A0.5171.00
212_L311_V0.5161.00
169_R184_D0.5141.00
333_I337_H0.5141.00
223_I293_F0.5131.00
343_A368_K0.5121.00
224_A323_G0.5121.00
248_F278_L0.5111.00
226_K274_V0.5091.00
79_D82_K0.5091.00
198_P325_G0.5081.00
197_F325_G0.5051.00
162_R166_E0.5041.00
91_N132_E0.5041.00
237_E349_A0.5041.00
32_S38_Q0.5041.00
34_K54_K0.5031.00
226_K230_Y0.5011.00
120_F167_V0.5011.00
112_Y115_E0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1z1bA 3 0.8701 100 0.305 Contact Map
1z19A 3 0.7013 100 0.37 Contact Map
1a0pA 1 0.6623 100 0.373 Contact Map
2a3vA 3 0.7117 100 0.379 Contact Map
4a8eA 2 0.6727 100 0.416 Contact Map
1xo0A 3 0.7247 100 0.429 Contact Map
3nkhA 2 0.4831 100 0.524 Contact Map
1ae9A 4 0.4104 100 0.591 Contact Map
1aihA 2 0.4364 99.9 0.605 Contact Map
4e0gA 2 0.6805 99.9 0.63 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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