GREMLIN Database
YBCH - Uncharacterized protein YbcH
UniProt: P37325 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12448
Length: 296 (265)
Sequences: 235 (156)
Seq/√Len: 9.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
181_S243_V6.1141.00
83_Q135_T5.5851.00
264_E268_L4.9611.00
260_K264_E3.5860.97
146_D183_F3.5260.97
125_A170_I3.2040.94
41_Q84_Q2.7560.88
147_D226_Y2.7300.87
56_V272_R2.4040.79
26_W74_L2.3580.78
28_P59_W2.2530.75
210_Q214_G2.2150.73
181_S282_F2.0950.69
27_Q59_W2.0590.68
55_L87_L2.0560.67
58_Q92_G2.0370.67
146_D181_S2.0150.66
137_D199_H2.0020.65
144_E245_E1.9800.64
145_I181_S1.9770.64
76_F83_Q1.9580.64
90_I179_Y1.9410.63
88_K137_D1.9200.62
231_A235_S1.8840.60
58_Q93_L1.8840.60
48_R168_R1.8750.60
54_T137_D1.8690.60
32_D240_S1.8240.58
27_Q58_Q1.8100.57
87_L223_R1.7830.56
95_A100_F1.7730.56
140_Y144_E1.7160.53
140_Y245_E1.7160.53
201_K273_S1.6680.51
60_T87_L1.6640.51
114_L125_A1.6600.50
113_Y241_G1.6570.50
170_I178_V1.6460.50
126_R169_L1.6440.50
48_R53_D1.6350.49
211_D214_G1.6060.48
181_S197_L1.5950.48
93_L125_A1.5940.48
94_N212_G1.5650.46
194_R200_V1.5600.46
164_N168_R1.5460.45
136_P213_S1.5310.45
233_C275_C1.5290.45
83_Q136_P1.5210.44
182_S243_V1.5160.44
260_K268_L1.5110.44
144_E211_D1.4990.43
211_D245_E1.4990.43
38_T41_Q1.4800.42
266_A275_C1.4760.42
218_L222_Q1.4710.42
249_A257_A1.4680.42
36_T39_Q1.4600.42
127_L131_A1.4490.41
165_N227_L1.4330.40
101_M161_T1.4280.40
35_V100_F1.4210.40
73_T131_A1.4140.40
24_I197_L1.3930.39
146_D149_N1.3900.39
228_Q277_K1.3590.37
40_W139_W1.3590.37
87_L93_L1.3490.37
54_T90_I1.3320.36
66_F205_V1.3230.36
214_G245_E1.3210.36
144_E214_G1.3210.36
40_W51_G1.3190.36
28_P181_S1.3120.35
41_Q85_A1.3000.35
180_I189_S1.2800.34
38_T51_G1.2680.34
285_R288_P1.2670.33
55_L101_M1.2510.33
181_S227_L1.2430.33
52_F193_Y1.2380.32
96_D113_Y1.2370.32
138_G247_F1.2340.32
41_Q219_T1.2170.32
92_G247_F1.2160.31
147_D150_W1.2130.31
212_G255_F1.2060.31
25_I56_V1.2040.31
140_Y211_D1.1970.31
100_F287_L1.1960.31
275_C284_L1.1880.30
57_L91_V1.1860.30
180_I205_V1.1840.30
73_T132_P1.1830.30
144_E210_Q1.1820.30
210_Q245_E1.1820.30
138_G245_E1.1790.30
138_G144_E1.1790.30
93_L163_L1.1790.30
47_L129_S1.1730.30
272_R275_C1.1630.29
27_Q282_F1.1530.29
217_K246_L1.1430.29
133_G191_D1.1420.29
210_Q282_F1.1410.29
117_L125_A1.1400.29
34_Q45_S1.1380.29
222_Q227_L1.1350.28
160_L190_P1.1250.28
121_D205_V1.1190.28
260_K265_I1.1160.28
48_R142_S1.1080.27
195_Q224_E1.1000.27
118_L157_Q1.0960.27
132_P182_S1.0870.27
40_W235_S1.0850.27
138_G180_I1.0810.27
218_L257_A1.0730.26
232_D244_Y1.0690.26
78_R243_V1.0680.26
76_F91_V1.0640.26
182_S286_Y1.0580.26
49_L165_N1.0540.26
125_A178_V1.0450.25
62_Y226_Y1.0420.25
252_G283_S1.0420.25
30_N197_L1.0400.25
138_G210_Q1.0360.25
59_W181_S1.0350.25
114_L212_G1.0340.25
241_G284_L1.0250.25
213_S264_E1.0240.25
206_N259_P1.0220.24
53_D177_P1.0200.24
142_S230_S1.0180.24
60_T157_Q1.0050.24
27_Q283_S1.0000.24
130_A269_L0.9870.23
67_T73_T0.9830.23
126_R180_I0.9790.23
182_S206_N0.9750.23
113_Y117_L0.9730.23
91_V215_V0.9710.23
26_W197_L0.9700.23
139_W210_Q0.9670.23
213_S260_K0.9640.23
115_N161_T0.9510.22
140_Y214_G0.9500.22
41_Q45_S0.9490.22
200_V205_V0.9450.22
62_Y102_H0.9430.22
26_W100_F0.9410.22
176_K228_Q0.9340.22
195_Q263_A0.9300.22
56_V280_L0.9260.21
64_D91_V0.9260.21
98_E221_E0.9200.21
135_T160_L0.9170.21
116_R157_Q0.9160.21
146_D170_I0.9150.21
29_Q265_I0.9100.21
156_R196_L0.9060.21
212_G257_A0.9050.21
54_T99_F0.9020.21
64_D258_K0.9010.21
38_T82_A0.8980.21
99_F240_S0.8960.21
48_R81_A0.8930.20
263_A267_S0.8900.20
175_A196_L0.8900.20
57_L161_T0.8870.20
32_D53_D0.8810.20
142_S281_Y0.8790.20
200_V259_P0.8760.20
157_Q198_E0.8760.20
139_W157_Q0.8750.20
132_P286_Y0.8740.20
25_I82_A0.8740.20
35_V43_L0.8710.20
170_I226_Y0.8680.20
140_Y210_Q0.8600.20
90_I137_D0.8570.19
141_I204_G0.8520.19
128_W204_G0.8510.19
43_L226_Y0.8480.19
198_E236_P0.8470.19
184_F209_V0.8470.19
54_T178_V0.8470.19
163_L255_F0.8440.19
137_D194_R0.8330.19
248_V258_K0.8320.19
77_K189_S0.8320.19
135_T231_A0.8310.19
243_V282_F0.8280.19
23_G136_P0.8270.19
25_I40_W0.8270.19
50_Q226_Y0.8260.19
147_D208_W0.8190.18
99_F132_P0.8170.18
73_T182_S0.8170.18
19_F26_W0.8140.18
126_R229_A0.8120.18
94_N99_F0.8120.18
163_L218_L0.8100.18
28_P240_S0.8050.18
27_Q159_L0.8050.18
46_Q84_Q0.8040.18
141_I167_Q0.8010.18
145_I150_W0.7970.18
244_Y279_T0.7950.18
26_W285_R0.7940.18
124_Q252_G0.7920.18
60_T222_Q0.7910.18
46_Q89_L0.7880.18
99_F147_D0.7870.18
150_W246_L0.7860.18
183_F260_K0.7820.17
36_T261_P0.7810.17
180_I212_G0.7800.17
103_Q193_Y0.7800.17
139_W180_I0.7770.17
112_S123_Q0.7750.17
163_L196_L0.7730.17
86_G152_S0.7730.17
173_V276_G0.7690.17
114_L135_T0.7670.17
59_W212_G0.7610.17
152_S192_G0.7590.17
23_G280_L0.7560.17
207_V220_A0.7550.17
81_A283_S0.7540.17
103_Q205_V0.7460.17
173_V198_E0.7430.16
77_K127_L0.7410.16
32_D207_V0.7370.16
26_W52_F0.7360.16
26_W81_A0.7350.16
268_L279_T0.7350.16
113_Y162_W0.7290.16
47_L283_S0.7290.16
44_M89_L0.7290.16
132_P179_Y0.7270.16
81_A280_L0.7270.16
49_L160_L0.7260.16
93_L141_I0.7250.16
147_D186_G0.7200.16
82_A91_V0.7200.16
146_D159_L0.7150.16
103_Q182_S0.7140.16
179_Y208_W0.7090.16
212_G234_Q0.7090.16
82_A196_L0.7060.16
125_A128_W0.7030.15
95_A136_P0.7020.15
88_K123_Q0.7010.15
28_P60_T0.7010.15
240_S268_L0.6990.15
112_S151_R0.6970.15
59_W255_F0.6950.15
84_Q178_V0.6950.15
59_W93_L0.6940.15
55_L157_Q0.6930.15
37_D56_V0.6900.15
48_R202_A0.6890.15
161_T279_T0.6870.15
168_R195_Q0.6860.15
95_A143_A0.6850.15
209_V288_P0.6830.15
86_G232_D0.6810.15
246_L281_Y0.6810.15
89_L114_L0.6800.15
25_I255_F0.6790.15
131_A134_I0.6790.15
233_C242_V0.6780.15
50_Q216_D0.6750.15
88_K166_A0.6750.15
243_V280_L0.6740.15
144_E247_F0.6740.15
276_G284_L0.6680.15
221_E271_K0.6670.15
182_S208_W0.6660.15
125_A146_D0.6630.15
124_Q223_R0.6620.15
58_Q96_D0.6620.15
94_N235_S0.6610.15
58_Q212_G0.6610.15
162_W246_L0.6610.15
92_G212_G0.6610.15
165_N265_I0.6590.14
38_T49_L0.6590.14
179_Y182_S0.6540.14
63_G99_F0.6530.14
148_L183_F0.6520.14
86_G167_Q0.6510.14
179_Y277_K0.6490.14
275_C288_P0.6470.14
97_P194_R0.6450.14
209_V234_Q0.6440.14
114_L234_Q0.6420.14
180_I198_E0.6420.14
135_T272_R0.6410.14
142_S249_A0.6410.14
190_P194_R0.6400.14
173_V178_V0.6400.14
61_R223_R0.6370.14
146_D150_W0.6330.14
170_I269_L0.6270.14
160_L192_G0.6270.14
151_R185_A0.6240.14
208_W246_L0.6230.14
96_D212_G0.6230.14
46_Q237_A0.6210.14
23_G154_A0.6190.14
138_G179_Y0.6180.14
34_Q222_Q0.6150.14
183_F215_V0.6150.14
29_Q240_S0.6080.13
182_S276_G0.6060.13
96_D255_F0.6050.13
100_F260_K0.6010.13
138_G211_D0.6010.13
21_M52_F0.6000.13
118_L162_W0.5990.13
55_L223_R0.5980.13
157_Q187_N0.5980.13
157_Q166_A0.5980.13
44_M209_V0.5950.13
24_I35_V0.5940.13
125_A162_W0.5940.13
67_T99_F0.5930.13
145_I226_Y0.5920.13
184_F227_L0.5900.13
106_S142_S0.5880.13
44_M135_T0.5880.13
95_A287_L0.5870.13
27_Q214_G0.5850.13
230_S260_K0.5840.13
91_V220_A0.5820.13
181_S186_G0.5780.13
200_V206_N0.5760.13
85_A200_V0.5750.13
42_G167_Q0.5750.13
123_Q152_S0.5750.13
248_V254_T0.5740.13
59_W92_G0.5740.13
113_Y179_Y0.5710.13
74_L89_L0.5700.13
99_F226_Y0.5700.13
192_G232_D0.5690.13
130_A191_D0.5690.13
59_W243_V0.5660.13
70_E141_I0.5650.13
95_A213_S0.5650.13
133_G256_T0.5610.12
112_S115_N0.5590.12
181_S255_F0.5590.12
102_H183_F0.5580.12
34_Q277_K0.5550.12
81_A84_Q0.5530.12
58_Q283_S0.5510.12
126_R198_E0.5500.12
36_T42_G0.5480.12
73_T79_A0.5440.12
45_S49_L0.5440.12
92_G144_E0.5420.12
92_G245_E0.5420.12
90_I241_G0.5420.12
69_P229_A0.5410.12
243_V285_R0.5410.12
215_V265_I0.5390.12
146_D265_I0.5390.12
64_D116_R0.5390.12
180_I193_Y0.5380.12
200_V238_P0.5360.12
51_G129_S0.5320.12
100_F143_A0.5320.12
25_I100_F0.5310.12
25_I39_Q0.5300.12
223_R286_Y0.5300.12
62_Y91_V0.5280.12
99_F276_G0.5240.12
164_N204_G0.5240.12
34_Q55_L0.5230.12
58_Q257_A0.5220.12
156_R163_L0.5190.12
213_S241_G0.5170.12
101_M195_Q0.5140.12
91_V171_S0.5140.12
143_A162_W0.5100.11
138_G214_G0.5090.11
38_T220_A0.5050.11
100_F212_G0.5040.11
204_G275_C0.5030.11
80_A84_Q0.5030.11
25_I211_D0.5010.11
171_S206_N0.5010.11
71_Q263_A0.5000.11
87_L117_L0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4h41A 3 0.9223 100 0.645 Contact Map
4p7oA 1 0.8885 98.7 0.88 Contact Map
1kwgA 3 0.8986 98.6 0.881 Contact Map
2jepA 1 0.8818 98.6 0.882 Contact Map
4uozA 3 0.9426 98.6 0.883 Contact Map
3u7vA 3 0.8581 98.5 0.887 Contact Map
4f9dA 1 0.875 98.4 0.889 Contact Map
4v2xA 2 0.8851 98.4 0.891 Contact Map
3ttyA 4 0.9122 98.3 0.892 Contact Map
4oifA 3 0.9493 98.3 0.894 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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