GREMLIN Database
DPPF - Dipeptide transport ATP-binding protein DppF
UniProt: P37313 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12628
Length: 334 (274)
Sequences: 48773 (30184)
Seq/√Len: 1823.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
49_K231_E4.2331.00
100_K181_D3.5411.00
14_Q44_N3.3151.00
17_D40_G3.2161.00
16_I78_E3.1561.00
20_K67_L3.0041.00
36_K39_D2.9691.00
51_L233_M2.9601.00
82_Q181_D2.6511.00
245_T248_Q2.6451.00
78_E85_D2.6351.00
52_A229_A2.5951.00
21_H36_K2.5501.00
46_E49_K2.5121.00
154_H157_R2.4561.00
233_M240_C2.4521.00
231_E243_K2.4491.00
14_Q80_Y2.3571.00
19_K76_G2.3491.00
133_S136_Q2.3251.00
15_A18_L2.2661.00
39_D239_R2.2591.00
226_E247_D2.2091.00
47_R181_D2.1411.00
19_K40_G2.1081.00
140_K143_S2.0761.00
85_D88_K2.0461.00
65_G218_I2.0201.00
144_M177_M1.9661.00
244_G249_I1.9501.00
16_I80_Y1.9371.00
140_K179_D1.9251.00
142_L155_Y1.9041.00
116_K120_Q1.8991.00
11_P14_Q1.8881.00
22_Y63_T1.8631.00
11_P46_E1.8501.00
157_R161_M1.7581.00
19_K36_K1.7461.00
52_A225_V1.7151.00
21_H75_T1.7151.00
20_K72_E1.7011.00
65_G184_I1.6941.00
21_H34_L1.6901.00
219_S225_V1.6841.00
143_S147_K1.6551.00
207_L213_L1.6511.00
233_M243_K1.6291.00
23_P34_L1.6211.00
119_G155_Y1.6091.00
248_Q252_N1.6031.00
22_Y37_A1.6031.00
20_K75_T1.5911.00
82_Q100_K1.5901.00
119_G156_D1.5771.00
123_E141_A1.5631.00
244_G248_Q1.5621.00
15_A43_F1.5581.00
17_D42_S1.5571.00
123_E137_R1.5501.00
138_R142_L1.5421.00
18_L74_P1.5361.00
127_L137_R1.5141.00
154_H162_F1.5121.00
205_M208_Q1.5061.00
122_L145_M1.4811.00
205_M227_H1.4711.00
11_P44_N1.4351.00
185_A215_Y1.4261.00
19_K39_D1.4221.00
117_K120_Q1.4191.00
50_T208_Q1.4081.00
43_F64_L1.3771.00
109_Y167_R1.3531.00
119_G123_E1.3511.00
15_A68_L1.3271.00
138_R155_Y1.3101.00
49_K230_D1.2981.00
43_F233_M1.2941.00
201_L224_V1.2931.00
139_E143_S1.2791.00
293_C299_C1.2791.00
120_Q123_E1.2611.00
45_L51_L1.2581.00
115_R160_H1.2561.00
104_V185_A1.2471.00
119_G138_R1.2381.00
16_I44_N1.2311.00
162_F170_I1.2311.00
50_T215_Y1.2301.00
204_M215_Y1.2291.00
80_Y85_D1.2251.00
69_T103_I1.2221.00
51_L231_E1.2201.00
16_I42_S1.2071.00
41_V64_L1.2021.00
117_K156_D1.1941.00
247_D251_N1.1921.00
53_V216_V1.1881.00
84_Q89_H1.1771.00
142_L152_T1.1761.00
151_K154_H1.1701.00
70_M73_M1.1691.00
153_E157_R1.1681.00
291_P296_N1.1641.00
149_G206_D1.1561.00
51_L243_K1.1451.00
123_E127_L1.1401.00
47_R82_Q1.1351.00
136_Q139_E1.1351.00
146_A152_T1.1321.00
67_L74_P1.1271.00
145_M155_Y1.1211.00
116_K124_E1.1151.00
256_P259_Q1.1071.00
50_T229_A1.0941.00
259_Q263_S1.0851.00
140_K144_M1.0641.00
66_R71_I1.0631.00
292_G296_N1.0461.00
122_L177_M1.0451.00
47_R212_G1.0401.00
45_L182_V1.0381.00
142_L146_A1.0341.00
208_Q215_Y1.0321.00
208_Q230_D1.0311.00
232_V246_K1.0291.00
121_I174_R1.0251.00
137_R141_A1.0211.00
144_M147_K1.0181.00
143_S146_A1.0161.00
97_R101_I1.0071.00
192_L200_V1.0011.00
132_L136_Q1.0001.00
135_E139_E0.9931.00
123_E138_R0.9931.00
183_V215_Y0.9911.00
293_C296_N0.9901.00
102_Q175_G0.9881.00
46_E231_E0.9851.00
217_F228_I0.9851.00
285_S288_N0.9821.00
119_G141_A0.9811.00
126_L177_M0.9791.00
248_Q251_N0.9781.00
179_D213_L0.9711.00
116_K121_I0.9691.00
17_D76_G0.9681.00
267_R270_P0.9601.00
68_L216_V0.9541.00
66_R72_E0.9541.00
183_V213_L0.9521.00
21_H39_D0.9521.00
85_D89_H0.9471.00
239_R294_A0.9461.00
38_L67_L0.9461.00
147_K206_D0.9411.00
46_E214_S0.9381.00
295_F299_C0.9311.00
132_L137_R0.9271.00
23_P33_R0.9201.00
64_L235_M0.9201.00
144_M173_A0.9151.00
142_L150_L0.9061.00
69_T184_I0.9051.00
67_L72_E0.9011.00
15_A79_L0.8971.00
53_V233_M0.8971.00
20_K63_T0.8911.00
290_P296_N0.8851.00
50_T205_M0.8831.00
205_M228_I0.8821.00
18_L67_L0.8771.00
59_C235_M0.8731.00
258_T262_L0.8731.00
133_S137_R0.8731.00
185_A204_M0.8721.00
197_R221_D0.8711.00
158_Y161_M0.8661.00
39_D294_A0.8621.00
249_I258_T0.8601.00
11_P47_R0.8511.00
53_V64_L0.8501.00
118_V170_I0.8491.00
256_P260_A0.8481.00
138_R156_D0.8471.00
139_E142_L0.8461.00
102_Q180_P0.8451.00
101_I182_V0.8441.00
81_Y100_K0.8391.00
12_L82_Q0.8391.00
294_A297_A0.8371.00
263_S277_I0.8371.00
134_K137_R0.8371.00
201_L227_H0.8251.00
234_V253_P0.8251.00
104_V172_I0.8221.00
250_F253_P0.8201.00
117_K158_Y0.8191.00
224_V228_I0.8171.00
197_R224_V0.8111.00
113_N116_K0.8081.00
112_L167_R0.8071.00
217_F229_A0.7981.00
129_N178_L0.7971.00
292_G299_C0.7921.00
292_G295_F0.7911.00
276_R280_S0.7901.00
240_C243_K0.7881.00
13_L68_L0.7871.00
54_V225_V0.7831.00
67_L79_L0.7811.00
149_G199_Q0.7781.00
45_L214_S0.7781.00
125_P174_R0.7761.00
290_P297_A0.7761.00
203_L206_D0.7761.00
229_A232_V0.7721.00
99_Q130_T0.7721.00
41_V240_C0.7701.00
246_K250_F0.7701.00
118_V162_F0.7671.00
45_L216_V0.7591.00
38_L41_V0.7581.00
280_S283_L0.7571.00
12_L81_Y0.7551.00
290_P293_C0.7551.00
286_P290_P0.7531.00
296_N299_C0.7531.00
289_P294_A0.7501.00
236_Y239_R0.7491.00
269_N272_D0.7431.00
289_P292_G0.7431.00
17_D20_K0.7401.00
159_P170_I0.7391.00
148_V173_A0.7391.00
141_A155_Y0.7371.00
231_E242_E0.7341.00
293_C298_R0.7331.00
130_T133_S0.7311.00
187_E220_H0.7281.00
184_I216_V0.7271.00
37_A63_T0.7201.00
127_L134_K0.7191.00
20_K38_L0.7171.00
162_F166_Q0.7141.00
281_G284_P0.7091.00
130_T140_K0.7091.00
22_Y72_E0.7051.00
288_N291_P0.7051.00
62_S66_R0.7051.00
234_V249_I0.7021.00
291_P295_F0.7011.00
202_N205_M0.6981.00
51_L216_V0.6981.00
182_V214_S0.6971.00
154_H166_Q0.6941.00
50_T228_I0.6941.00
79_L87_L0.6921.00
205_M209_Q0.6921.00
122_L141_A0.6911.00
284_P288_N0.6901.00
222_L250_F0.6891.00
69_T101_I0.6881.00
282_E285_S0.6861.00
125_P178_L0.6851.00
66_R103_I0.6841.00
104_V175_G0.6831.00
71_I105_F0.6821.00
146_A151_K0.6801.00
40_G239_R0.6781.00
189_V224_V0.6761.00
202_N227_H0.6751.00
138_R141_A0.6731.00
229_A246_K0.6731.00
140_K147_K0.6721.00
86_L91_P0.6711.00
130_T137_R0.6691.00
202_N206_D0.6661.00
260_A264_A0.6651.00
54_V234_V0.6631.00
265_T269_N0.6621.00
182_V216_V0.6611.00
21_H76_G0.6581.00
150_L154_H0.6571.00
246_K257_Y0.6571.00
283_L286_P0.6571.00
285_S289_P0.6551.00
86_L101_I0.6541.00
117_K121_I0.6491.00
198_A202_N0.6471.00
84_Q100_K0.6451.00
253_P258_T0.6451.00
67_L75_T0.6441.00
281_G286_P0.6401.00
50_T230_D0.6391.00
13_L81_Y0.6381.00
176_L213_L0.6381.00
121_I159_P0.6361.00
12_L182_V0.6361.00
78_E88_K0.6311.00
136_Q140_K0.6311.00
236_Y241_V0.6281.00
144_M176_L0.6271.00
38_L64_L0.6261.00
78_E87_L0.6251.00
285_S290_P0.6221.00
119_G122_L0.6211.00
110_G167_R0.6211.00
287_L290_P0.6171.00
265_T268_L0.6161.00
139_E146_A0.6161.00
260_A263_S0.6151.00
172_I200_V0.6141.00
40_G76_G0.6121.00
141_A144_M0.6091.00
281_G285_S0.6081.00
286_P289_P0.6081.00
283_L296_N0.6051.00
13_L182_V0.6031.00
112_L170_I0.6021.00
126_L131_S0.5991.00
125_P128_I0.5981.00
15_A64_L0.5981.00
112_L121_I0.5981.00
126_L129_N0.5971.00
126_L130_T0.5971.00
80_Y83_G0.5971.00
86_L89_H0.5961.00
241_V255_H0.5931.00
284_P290_P0.5911.00
252_N256_P0.5911.00
286_P293_C0.5891.00
19_K75_T0.5871.00
86_L97_R0.5851.00
292_G297_A0.5851.00
255_H258_T0.5821.00
81_Y86_L0.5821.00
48_G214_S0.5791.00
257_Y261_L0.5771.00
81_Y182_V0.5731.00
111_S171_A0.5681.00
56_E59_C0.5671.00
123_E155_Y0.5661.00
275_E278_K0.5651.00
291_P294_A0.5641.00
249_I253_P0.5601.00
295_F298_R0.5601.00
288_N292_G0.5591.00
286_P291_P0.5571.00
157_R162_F0.5551.00
279_L294_A0.5551.00
119_G142_L0.5541.00
144_M148_V0.5531.00
244_G250_F0.5531.00
285_S292_G0.5531.00
290_P294_A0.5521.00
225_V229_A0.5511.00
291_P297_A0.5491.00
47_R214_S0.5481.00
68_L79_L0.5481.00
248_Q254_R0.5471.00
282_E286_P0.5451.00
293_C297_A0.5451.00
290_P295_F0.5441.00
121_I125_P0.5441.00
257_Y260_A0.5431.00
122_L125_P0.5401.00
130_T179_D0.5381.00
134_K138_R0.5381.00
225_V232_V0.5351.00
150_L166_Q0.5351.00
126_L178_L0.5351.00
131_S136_Q0.5351.00
287_L292_G0.5321.00
294_A299_C0.5321.00
287_L291_P0.5291.00
226_E250_F0.5271.00
294_A298_R0.5271.00
244_G253_P0.5261.00
12_L214_S0.5261.00
236_Y260_A0.5261.00
89_H97_R0.5261.00
284_P287_L0.5251.00
44_N243_K0.5241.00
70_M91_P0.5231.00
276_R279_L0.5231.00
11_P82_Q0.5231.00
254_R259_Q0.5221.00
70_M98_R0.5211.00
262_L266_P0.5211.00
91_P97_R0.5171.00
241_V294_A0.5171.00
268_L272_D0.5151.00
89_H92_Q0.5111.00
274_R278_K0.5111.00
107_N110_G0.5111.00
145_M154_H0.5101.00
114_P160_H0.5101.00
21_H37_A0.5091.00
283_L287_L0.5071.00
12_L46_E0.5071.00
282_E288_N0.5061.00
164_G169_R0.5061.00
123_E126_L0.5051.00
12_L47_R0.5041.00
284_P289_P0.5031.00
290_P299_C0.5031.00
56_E236_Y0.5031.00
153_E156_D0.5031.00
279_L283_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4f4cA 1 0.7066 100 0.235 Contact Map
4ry2A 2 0.7216 100 0.236 Contact Map
3tuiC 2 0.9371 100 0.241 Contact Map
4q9hA 1 0.7455 100 0.254 Contact Map
2oljA 2 0.7246 100 0.255 Contact Map
2it1A 1 0.8323 100 0.256 Contact Map
4ymuJ 2 0.7186 100 0.256 Contact Map
4u00A 1 0.7216 100 0.257 Contact Map
3b5xA 2 0.7395 100 0.257 Contact Map
2yyzA 1 0.8383 100 0.257 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0123 seconds.