GREMLIN Database
ARSR - Arsenical resistance operon repressor
UniProt: P37309 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12235
Length: 117 (94)
Sequences: 2565 (1867)
Seq/√Len: 192.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
30_E63_R4.9931.00
61_L74_S2.9591.00
62_D69_V2.3611.00
20_G99_I2.2841.00
12_I57_S2.2321.00
33_V51_L2.2161.00
30_E72_R2.1991.00
52_A56_E2.1821.00
64_K69_V2.1791.00
61_L72_R2.1571.00
25_L60_L2.1121.00
55_R62_D2.0431.00
37_C44_Q2.0321.00
42_Q46_K1.8721.00
46_K49_R1.6531.00
95_K99_I1.6041.00
42_Q47_I1.5531.00
21_I36_L1.5121.00
8_Q56_E1.4981.00
13_L22_V1.4511.00
40_L47_I1.4471.00
36_L47_I1.4471.00
24_L39_A1.4451.00
12_I53_L1.4311.00
51_L60_L1.3511.00
22_V73_L1.3321.00
7_I16_E1.2811.00
53_L57_S1.2791.00
54_L60_L1.2631.00
32_C68_W1.2511.00
22_V59_L1.2211.00
34_C37_C1.1941.00
82_A86_D1.1871.00
43_S46_K1.1591.00
61_L75_P1.1431.00
21_I25_L1.1241.00
7_I19_L1.1211.00
34_C68_W1.1211.00
19_L22_V1.1141.00
96_V100_V1.0711.00
33_V44_Q1.0661.00
11_K64_K1.0531.00
25_L31_L1.0471.00
10_F81_A1.0431.00
31_L35_D1.0341.00
77_I80_W1.0341.00
27_E100_V0.9920.99
94_E98_A0.9800.99
93_Q97_Q0.9760.99
49_R67_K0.9730.99
83_K86_D0.9060.99
24_L31_L0.8980.99
35_D38_T0.8950.99
9_L81_A0.8870.99
84_I88_A0.8870.99
33_V49_R0.8860.99
17_T47_I0.8740.99
97_Q100_V0.8600.99
83_K87_E0.8590.99
15_D49_R0.8580.99
37_C47_I0.8530.98
12_I59_L0.8520.98
82_A89_W0.8410.98
79_A83_K0.8330.98
96_V99_I0.8310.98
51_L71_Y0.8260.98
76_H79_A0.8240.98
34_C64_K0.8230.98
86_D89_W0.8220.98
33_V39_A0.8180.98
30_E65_Q0.8140.98
53_L56_E0.8110.98
58_G74_S0.8050.98
10_F13_L0.8010.98
9_L57_S0.7970.98
65_Q68_W0.7960.98
49_R53_L0.7870.97
17_T42_Q0.7820.97
31_L36_L0.7810.97
21_I51_L0.7680.97
52_A55_R0.7620.97
23_L88_A0.7540.97
47_I52_A0.7410.96
31_L70_H0.7400.96
51_L55_R0.7350.96
92_E99_I0.7270.96
27_E93_Q0.7200.96
87_E91_C0.7150.95
67_K73_L0.7060.95
8_Q83_K0.7040.95
23_L26_S0.7030.95
15_D68_W0.6920.95
12_I54_L0.6840.94
49_R62_D0.6840.94
31_L39_A0.6790.94
41_D91_C0.6660.93
17_T67_K0.6630.93
62_D71_Y0.6630.93
30_E70_H0.6580.93
49_R52_A0.6550.93
76_H94_E0.6450.92
87_E90_R0.6440.92
83_K91_C0.6420.92
32_C35_D0.6380.92
11_K15_D0.6370.92
27_E97_Q0.6330.92
15_D46_K0.6220.91
60_L71_Y0.6200.91
65_Q70_H0.6150.90
81_A84_I0.6140.90
83_K100_V0.6110.90
85_I88_A0.6100.90
21_I47_I0.6080.90
23_L27_E0.6040.90
46_K50_H0.6020.89
20_G24_L0.5980.89
25_L29_G0.5960.89
35_D70_H0.5940.89
6_P10_F0.5850.88
55_R71_Y0.5750.87
29_G34_C0.5750.87
42_Q49_R0.5710.87
10_F19_L0.5630.86
77_I84_I0.5620.86
10_F85_I0.5590.86
20_G39_A0.5580.86
26_S96_V0.5560.85
55_R60_L0.5510.85
10_F14_A0.5470.85
19_L84_I0.5450.84
47_I51_L0.5430.84
8_Q57_S0.5430.84
42_Q45_P0.5310.83
13_L16_E0.5270.82
43_S67_K0.5220.82
88_A91_C0.5160.81
24_L40_L0.5150.81
88_A92_E0.5130.81
80_W88_A0.5050.80
37_C45_P0.5050.80
64_K68_W0.5000.79
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1u2wA 2 0.7949 99.7 0.531 Contact Map
1r1tA 2 0.7778 99.6 0.537 Contact Map
3f6vA 2 0.8205 99.6 0.539 Contact Map
2kkoA 2 0.8462 99.6 0.541 Contact Map
2zkzA 2 0.7436 99.6 0.549 Contact Map
4k2eA 2 0.7692 99.6 0.552 Contact Map
2jscA 2 0.8291 99.6 0.554 Contact Map
1q1hA 1 0.6752 99.6 0.558 Contact Map
3pqkA 2 0.812 99.6 0.559 Contact Map
1r1uA 2 0.7863 99.6 0.564 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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