GREMLIN Database
ARCC - Carbamate kinase
UniProt: P37306 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12384
Length: 297 (288)
Sequences: 1295 (848)
Seq/√Len: 50.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
248_A269_R6.3691.00
130_P134_E6.3121.00
242_A247_L4.2701.00
228_Y238_A3.8101.00
3_T44_R3.7731.00
230_N235_Q3.7121.00
129_Q132_E3.3661.00
226_A240_R3.3411.00
239_I242_A3.3291.00
36_L45_L3.0531.00
48_V206_A2.9981.00
74_D197_E2.9501.00
251_A258_G2.4711.00
226_A238_A2.4291.00
274_P294_C2.4141.00
278_G286_T2.2961.00
34_P95_Q2.2961.00
182_S205_A2.2951.00
58_L80_S2.2571.00
130_P151_L2.2351.00
135_A139_A2.2121.00
89_A103_T2.1771.00
159_Q266_G2.1681.00
5_V215_A2.1391.00
268_V275_A2.1091.00
282_R285_E2.0751.00
182_S209_L2.0461.00
208_L212_Q2.0421.00
142_W153_R2.0001.00
229_E237_R1.9831.00
109_E191_D1.9440.99
6_V36_L1.9430.99
219_V283_I1.9230.99
221_L283_I1.8920.99
119_Q145_K1.8760.99
109_E162_K1.8570.99
244_P265_S1.8450.99
206_A218_L1.8360.99
37_A92_L1.8180.99
285_E290_E1.8080.99
225_D228_Y1.7850.99
268_V271_R1.7540.99
162_K212_Q1.7460.99
60_L128_Y1.7050.98
112_P192_D1.6810.98
127_V149_K1.6530.98
134_E138_A1.6340.98
278_G291_A1.6090.98
225_D291_A1.5770.97
44_R176_G1.5590.97
230_N237_R1.5560.97
217_G276_W1.5550.97
214_N273_K1.5540.97
243_T246_E1.5510.97
38_R284_E1.5430.97
207_A211_E1.5210.97
248_A252_K1.5190.97
247_L295_I1.5140.97
137_E144_M1.5140.97
204_L262_T1.4820.96
246_E249_P1.4750.96
46_A213_I1.4730.96
4_L43_Y1.4670.96
171_L175_E1.4430.96
162_K191_D1.4400.96
230_N233_T1.4400.96
211_E266_G1.4280.95
254_D258_G1.4270.95
109_E164_L1.4160.95
166_S213_I1.3980.95
73_L77_V1.3850.95
100_P167_E1.3670.94
170_E174_K1.3650.94
162_K166_S1.3560.94
61_Q83_M1.3550.94
75_V87_M1.3510.94
237_R246_E1.3500.94
226_A291_A1.3480.94
123_F145_K1.3450.94
93_S101_V1.3410.94
232_G236_Q1.3290.93
276_W286_T1.2940.92
261_V275_A1.2900.92
46_A173_L1.2850.92
61_Q79_E1.2740.92
264_V275_A1.2670.92
60_L126_P1.2490.91
219_V276_W1.2480.91
134_E151_L1.2450.91
207_A266_G1.2380.91
90_Q107_R1.2360.90
58_L61_Q1.2190.90
228_Y236_Q1.2100.90
123_F127_V1.2050.89
102_T168_A1.1940.89
168_A177_H1.1910.89
217_G274_P1.1710.88
89_A107_R1.1700.88
225_D282_R1.1650.88
13_L57_L1.1640.88
182_S206_A1.1580.87
253_A258_G1.1530.87
62_N79_E1.1490.87
278_G282_R1.1470.87
169_I181_C1.1440.87
86_Y195_G1.1340.86
26_Y91_S1.1160.85
133_Q137_E1.1090.85
133_Q141_G1.0950.84
248_A265_S1.0930.84
228_Y231_W1.0920.84
80_S83_M1.0890.84
127_V146_R1.0840.84
242_A250_F1.0800.83
173_L213_I1.0790.83
44_R99_P1.0760.83
14_L61_Q1.0700.83
45_L178_V1.0650.83
79_E83_M1.0630.82
14_L83_M1.0590.82
14_L24_N1.0580.82
248_A262_T1.0550.82
111_S161_R1.0520.82
98_M167_E1.0510.82
241_H294_C1.0470.81
128_Y136_L1.0420.81
4_L39_L1.0400.81
229_E250_F1.0390.81
229_E239_I1.0370.81
22_A75_V1.0360.81
146_R149_K1.0300.80
86_Y90_Q1.0290.80
77_V108_I1.0210.80
137_E142_W1.0210.80
136_L144_M1.0170.79
41_R288_A1.0130.79
22_A74_D1.0060.79
134_E137_E1.0050.79
284_E288_A1.0050.79
4_L280_L1.0020.78
145_K151_L1.0020.78
75_V83_M0.9940.78
208_L211_E0.9900.78
14_L74_D0.9840.77
62_N68_V0.9790.77
86_Y107_R0.9770.77
58_L76_L0.9760.77
163_I209_L0.9700.76
52_G255_G0.9650.76
159_Q262_T0.9620.76
244_P248_A0.9620.76
65_W71_Y0.9610.75
3_T173_L0.9600.75
168_A171_L0.9600.75
137_E151_L0.9540.75
22_A71_Y0.9510.75
14_L22_A0.9480.74
227_V277_I0.9430.74
89_A105_L0.9390.74
57_L61_Q0.9390.74
107_R164_L0.9370.74
57_L62_N0.9310.73
22_A87_M0.9310.73
57_L83_M0.9290.73
89_A180_I0.9200.72
276_W294_C0.9150.72
47_I88_L0.9110.71
29_I88_L0.9020.71
240_R294_C0.8980.70
62_N83_M0.8980.70
108_I206_A0.8960.70
29_I91_S0.8940.70
8_L12_A0.8920.70
251_A262_T0.8920.70
13_L84_I0.8920.70
214_N271_R0.8880.70
123_F253_A0.8870.69
27_R30_A0.8810.69
30_A91_S0.8780.69
94_A193_G0.8730.68
14_L57_L0.8680.68
12_A221_L0.8670.68
21_T24_N0.8640.67
14_L25_Q0.8630.67
33_V91_S0.8580.67
112_P190_T0.8570.67
15_Q28_N0.8570.67
127_V147_D0.8540.67
94_A182_S0.8510.66
128_Y144_M0.8500.66
68_V87_M0.8490.66
232_G268_V0.8490.66
3_T43_Y0.8460.66
22_A61_Q0.8420.65
8_L280_L0.8360.65
108_I205_A0.8330.65
161_R208_L0.8300.64
26_Y87_M0.8260.64
14_L62_N0.8240.64
159_Q204_L0.8240.64
106_T163_I0.8230.64
33_V88_L0.8190.63
74_D86_Y0.8180.63
161_R166_S0.8150.63
169_I182_S0.8080.62
141_G145_K0.7990.61
62_N80_S0.7980.61
65_W68_V0.7940.61
100_P177_H0.7920.61
280_L283_I0.7880.60
48_V182_S0.7860.60
64_A126_P0.7850.60
221_L280_L0.7810.60
102_T177_H0.7800.59
172_L179_V0.7770.59
204_L263_A0.7720.59
115_P118_L0.7670.58
237_R240_R0.7670.58
228_Y240_R0.7660.58
116_A121_E0.7650.58
285_E291_A0.7570.57
80_S105_L0.7560.57
14_L80_S0.7480.56
13_L62_N0.7460.56
247_L261_V0.7450.56
14_L59_A0.7450.56
124_I155_V0.7450.56
77_V83_M0.7410.56
162_K208_L0.7410.56
23_E27_R0.7390.55
136_L140_Y0.7380.55
74_D87_M0.7340.55
58_L83_M0.7280.54
170_E214_N0.7250.54
14_L87_M0.7240.54
171_L177_H0.7210.54
279_A282_R0.7210.54
94_A107_R0.7200.53
14_L79_E0.7200.53
216_D273_K0.7200.53
78_A272_G0.7180.53
47_I178_V0.7170.53
224_A231_W0.7170.53
285_E288_A0.7150.53
169_I209_L0.7130.53
35_A38_R0.7100.52
190_T196_S0.7080.52
43_Y216_D0.7030.52
26_Y90_Q0.7010.51
24_N28_N0.7010.51
74_D83_M0.7010.51
136_L139_A0.7000.51
229_E234_P0.6960.51
249_P252_K0.6950.51
127_V150_Y0.6900.50
180_I220_I0.6890.50
140_Y144_M0.6880.50
61_Q87_M0.6880.50
6_V39_L0.6870.50
245_D269_R0.6860.50
21_T124_I0.6860.50
130_P146_R0.6830.50
271_R274_P0.6810.49
137_E141_G0.6760.49
40_A162_K0.6760.49
105_L192_D0.6760.49
31_S281_S0.6750.49
39_L283_I0.6740.49
50_G201_D0.6730.49
11_N52_G0.6720.48
137_E145_K0.6710.48
38_R42_S0.6700.48
164_L189_V0.6690.48
282_R291_A0.6690.48
211_E271_R0.6680.48
74_D126_P0.6680.48
59_A74_D0.6670.48
109_E112_P0.6660.48
135_A138_A0.6650.48
28_N73_L0.6650.48
71_Y75_V0.6590.47
11_N157_S0.6540.47
204_L266_G0.6530.47
231_W252_K0.6530.47
166_S212_Q0.6510.46
28_N87_M0.6510.46
93_S107_R0.6480.46
48_V108_I0.6460.46
119_Q254_D0.6460.46
225_D279_A0.6460.46
149_K223_D0.6430.46
73_L197_E0.6430.46
10_G50_G0.6420.45
10_G201_D0.6400.45
77_V99_P0.6400.45
116_A263_A0.6390.45
15_Q223_D0.6350.45
30_A94_A0.6330.45
247_L251_A0.6320.44
269_R295_I0.6310.44
22_A83_M0.6280.44
102_T172_L0.6270.44
133_Q151_L0.6250.44
217_G283_I0.6250.44
92_L178_V0.6250.44
169_I200_I0.6230.44
211_E270_S0.6170.43
243_T247_L0.6160.43
261_V295_I0.6150.43
246_E250_F0.6150.43
140_Y153_R0.6140.43
59_A73_L0.6130.42
140_Y145_K0.6120.42
137_E153_R0.6110.42
73_L87_M0.6110.42
65_W156_A0.6100.42
93_S100_P0.6070.42
117_F196_S0.6070.42
12_A280_L0.6060.42
32_A278_G0.6040.42
204_L211_E0.6040.42
130_P138_A0.6020.41
43_Y69_E0.6010.41
22_A72_P0.6010.41
251_A265_S0.6000.41
123_F146_R0.6000.41
265_S269_R0.5990.41
13_L87_M0.5990.41
93_S165_D0.5990.41
40_A231_W0.5930.41
71_Y83_M0.5920.40
201_D255_G0.5920.40
269_R272_G0.5920.40
28_N278_G0.5890.40
173_L176_G0.5880.40
8_L25_Q0.5880.40
124_I151_L0.5860.40
25_Q84_I0.5860.40
138_A187_V0.5850.40
181_C286_T0.5830.40
36_L226_A0.5830.40
10_G157_S0.5830.40
144_M153_R0.5830.40
48_V181_C0.5810.39
214_N241_H0.5800.39
108_I181_C0.5800.39
220_I236_Q0.5790.39
88_L92_L0.5780.39
83_M223_D0.5770.39
13_L59_A0.5740.39
104_V271_R0.5730.39
156_A166_S0.5720.38
36_L47_I0.5720.38
62_N87_M0.5710.38
38_R95_Q0.5680.38
99_P176_G0.5670.38
59_A62_N0.5670.38
150_Y224_A0.5660.38
80_S180_I0.5650.38
83_M87_M0.5650.38
71_Y76_L0.5650.38
89_A165_D0.5650.38
267_Y271_R0.5580.37
264_V295_I0.5570.37
39_L219_V0.5570.37
70_P232_G0.5570.37
231_W253_A0.5570.37
27_R31_S0.5570.37
115_P245_D0.5560.37
33_V92_L0.5540.37
226_A242_A0.5530.37
65_W123_F0.5530.37
223_D283_I0.5500.36
252_K265_S0.5500.36
14_L84_I0.5500.36
123_F150_Y0.5490.36
71_Y80_S0.5450.36
57_L79_E0.5450.36
76_L83_M0.5440.36
115_P234_P0.5430.36
61_Q126_P0.5430.36
126_P153_R0.5430.36
22_A77_V0.5420.36
52_G157_S0.5410.35
77_V223_D0.5400.35
11_N255_G0.5400.35
59_A153_R0.5400.35
57_L80_S0.5390.35
81_Q289_G0.5370.35
13_L83_M0.5360.35
156_A197_E0.5350.35
233_T249_P0.5330.35
270_S273_K0.5320.35
71_Y128_Y0.5320.35
29_I87_M0.5300.34
120_P156_A0.5280.34
289_G294_C0.5270.34
63_L286_T0.5270.34
28_N223_D0.5260.34
41_R284_E0.5250.34
244_P247_L0.5250.34
29_I57_L0.5240.34
62_N74_D0.5240.34
14_L223_D0.5230.34
282_R286_T0.5230.34
14_L75_V0.5220.34
170_E249_P0.5220.34
86_Y187_V0.5200.34
65_W69_E0.5200.34
146_R163_I0.5190.33
82_G105_L0.5170.33
61_Q74_D0.5170.33
113_D269_R0.5170.33
244_P269_R0.5160.33
101_V124_I0.5140.33
103_T180_I0.5130.33
61_Q68_V0.5130.33
229_E261_V0.5120.33
49_H183_G0.5110.33
29_I77_V0.5110.33
24_N57_L0.5110.33
57_L87_M0.5080.32
224_A262_T0.5080.32
59_A63_L0.5070.32
39_L287_L0.5060.32
7_A10_G0.5050.32
223_D253_A0.5050.32
240_R247_L0.5040.32
103_T182_S0.5040.32
265_S268_V0.5030.32
132_E135_A0.5010.32
6_V45_L0.5000.32
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1e19A 2 1 100 0.502 Contact Map
2e9yA 2 1 100 0.506 Contact Map
4jz8A 2 1 100 0.522 Contact Map
4axsA 2 0.9226 100 0.525 Contact Map
2we5A 2 0.9865 100 0.528 Contact Map
3wwnA 2 0.8283 100 0.707 Contact Map
2ap9A 3 0.8384 100 0.709 Contact Map
2bufA 3 0.8148 100 0.713 Contact Map
2btyA 3 0.8182 100 0.718 Contact Map
3l86A 1 0.7677 100 0.722 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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