ARCC - ECOLI - GREMLIN Contacts

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ARCC - Carbamate kinase

UniProt:	P37306	Sequences: MKTLVVALGGNALLQRGEALTAENQYRNIASAVPALARLARSYRLAIVHGNGPQVGLLALQNLAWKEVEPYPLDVLVAESQGMIGYMLAQSLSAQPQMPPVTTVLTRIEVSPDDPAFLQPEKFIGPVYQPEEQEALEAAYGWQMKRDGKYLRRVVASPQPRKILDSEAIELLLKEGHVVICSGGGGVPVTDDGAGSEAVIDKDLAAALLAEQINADGLVILTDADAVYENWGTPQQRAIRHATPDELAPFAKADGSMGPNVTAVSGYVRSRGKPAWIGALSRIEETLAGEAGTCISL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG12384
Length:	297 (288)
Sequences:	1295 (848)
Seq/√Len:	50.0

ECOLI - ARCC ARCM ARCL
HALSA - ARCC

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
248_A	269_R	6.369	1.00
130_P	134_E	6.312	1.00
242_A	247_L	4.270	1.00
228_Y	238_A	3.810	1.00
3_T	44_R	3.773	1.00
230_N	235_Q	3.712	1.00
129_Q	132_E	3.366	1.00
226_A	240_R	3.341	1.00
239_I	242_A	3.329	1.00
36_L	45_L	3.053	1.00
48_V	206_A	2.998	1.00
74_D	197_E	2.950	1.00
251_A	258_G	2.471	1.00
226_A	238_A	2.429	1.00
274_P	294_C	2.414	1.00
278_G	286_T	2.296	1.00
34_P	95_Q	2.296	1.00
182_S	205_A	2.295	1.00
58_L	80_S	2.257	1.00
130_P	151_L	2.235	1.00
135_A	139_A	2.212	1.00
89_A	103_T	2.177	1.00
159_Q	266_G	2.168	1.00
5_V	215_A	2.139	1.00
268_V	275_A	2.109	1.00
282_R	285_E	2.075	1.00
182_S	209_L	2.046	1.00
208_L	212_Q	2.042	1.00
142_W	153_R	2.000	1.00
229_E	237_R	1.983	1.00
109_E	191_D	1.944	0.99
6_V	36_L	1.943	0.99
219_V	283_I	1.923	0.99
221_L	283_I	1.892	0.99
119_Q	145_K	1.876	0.99
109_E	162_K	1.857	0.99
244_P	265_S	1.845	0.99
206_A	218_L	1.836	0.99
37_A	92_L	1.818	0.99
285_E	290_E	1.808	0.99
225_D	228_Y	1.785	0.99
268_V	271_R	1.754	0.99
162_K	212_Q	1.746	0.99
60_L	128_Y	1.705	0.98
112_P	192_D	1.681	0.98
127_V	149_K	1.653	0.98
134_E	138_A	1.634	0.98
278_G	291_A	1.609	0.98
225_D	291_A	1.577	0.97
44_R	176_G	1.559	0.97
230_N	237_R	1.556	0.97
217_G	276_W	1.555	0.97
214_N	273_K	1.554	0.97
243_T	246_E	1.551	0.97
38_R	284_E	1.543	0.97
207_A	211_E	1.521	0.97
248_A	252_K	1.519	0.97
247_L	295_I	1.514	0.97
137_E	144_M	1.514	0.97
204_L	262_T	1.482	0.96
246_E	249_P	1.475	0.96
46_A	213_I	1.473	0.96
4_L	43_Y	1.467	0.96
171_L	175_E	1.443	0.96
162_K	191_D	1.440	0.96
230_N	233_T	1.440	0.96
211_E	266_G	1.428	0.95
254_D	258_G	1.427	0.95
109_E	164_L	1.416	0.95
166_S	213_I	1.398	0.95
73_L	77_V	1.385	0.95
100_P	167_E	1.367	0.94
170_E	174_K	1.365	0.94
162_K	166_S	1.356	0.94
61_Q	83_M	1.355	0.94
75_V	87_M	1.351	0.94
237_R	246_E	1.350	0.94
226_A	291_A	1.348	0.94
123_F	145_K	1.345	0.94
93_S	101_V	1.341	0.94
232_G	236_Q	1.329	0.93
276_W	286_T	1.294	0.92
261_V	275_A	1.290	0.92
46_A	173_L	1.285	0.92
61_Q	79_E	1.274	0.92
264_V	275_A	1.267	0.92
60_L	126_P	1.249	0.91
219_V	276_W	1.248	0.91
134_E	151_L	1.245	0.91
207_A	266_G	1.238	0.91
90_Q	107_R	1.236	0.90
58_L	61_Q	1.219	0.90
228_Y	236_Q	1.210	0.90
123_F	127_V	1.205	0.89
102_T	168_A	1.194	0.89
168_A	177_H	1.191	0.89
217_G	274_P	1.171	0.88
89_A	107_R	1.170	0.88
225_D	282_R	1.165	0.88
13_L	57_L	1.164	0.88
182_S	206_A	1.158	0.87
253_A	258_G	1.153	0.87
62_N	79_E	1.149	0.87
278_G	282_R	1.147	0.87
169_I	181_C	1.144	0.87
86_Y	195_G	1.134	0.86
26_Y	91_S	1.116	0.85
133_Q	137_E	1.109	0.85
133_Q	141_G	1.095	0.84
248_A	265_S	1.093	0.84
228_Y	231_W	1.092	0.84
80_S	83_M	1.089	0.84
127_V	146_R	1.084	0.84
242_A	250_F	1.080	0.83
173_L	213_I	1.079	0.83
44_R	99_P	1.076	0.83
14_L	61_Q	1.070	0.83
45_L	178_V	1.065	0.83
79_E	83_M	1.063	0.82
14_L	83_M	1.059	0.82
14_L	24_N	1.058	0.82
248_A	262_T	1.055	0.82
111_S	161_R	1.052	0.82
98_M	167_E	1.051	0.82
241_H	294_C	1.047	0.81
128_Y	136_L	1.042	0.81
4_L	39_L	1.040	0.81
229_E	250_F	1.039	0.81
229_E	239_I	1.037	0.81
22_A	75_V	1.036	0.81
146_R	149_K	1.030	0.80
86_Y	90_Q	1.029	0.80
77_V	108_I	1.021	0.80
137_E	142_W	1.021	0.80
136_L	144_M	1.017	0.79
41_R	288_A	1.013	0.79
22_A	74_D	1.006	0.79
134_E	137_E	1.005	0.79
284_E	288_A	1.005	0.79
4_L	280_L	1.002	0.78
145_K	151_L	1.002	0.78
75_V	83_M	0.994	0.78
208_L	211_E	0.990	0.78
14_L	74_D	0.984	0.77
62_N	68_V	0.979	0.77
86_Y	107_R	0.977	0.77
58_L	76_L	0.976	0.77
163_I	209_L	0.970	0.76
52_G	255_G	0.965	0.76
159_Q	262_T	0.962	0.76
244_P	248_A	0.962	0.76
65_W	71_Y	0.961	0.75
3_T	173_L	0.960	0.75
168_A	171_L	0.960	0.75
137_E	151_L	0.954	0.75
22_A	71_Y	0.951	0.75
14_L	22_A	0.948	0.74
227_V	277_I	0.943	0.74
89_A	105_L	0.939	0.74
57_L	61_Q	0.939	0.74
107_R	164_L	0.937	0.74
57_L	62_N	0.931	0.73
22_A	87_M	0.931	0.73
57_L	83_M	0.929	0.73
89_A	180_I	0.920	0.72
276_W	294_C	0.915	0.72
47_I	88_L	0.911	0.71
29_I	88_L	0.902	0.71
240_R	294_C	0.898	0.70
62_N	83_M	0.898	0.70
108_I	206_A	0.896	0.70
29_I	91_S	0.894	0.70
8_L	12_A	0.892	0.70
251_A	262_T	0.892	0.70
13_L	84_I	0.892	0.70
214_N	271_R	0.888	0.70
123_F	253_A	0.887	0.69
27_R	30_A	0.881	0.69
30_A	91_S	0.878	0.69
94_A	193_G	0.873	0.68
14_L	57_L	0.868	0.68
12_A	221_L	0.867	0.68
21_T	24_N	0.864	0.67
14_L	25_Q	0.863	0.67
33_V	91_S	0.858	0.67
112_P	190_T	0.857	0.67
15_Q	28_N	0.857	0.67
127_V	147_D	0.854	0.67
94_A	182_S	0.851	0.66
128_Y	144_M	0.850	0.66
68_V	87_M	0.849	0.66
232_G	268_V	0.849	0.66
3_T	43_Y	0.846	0.66
22_A	61_Q	0.842	0.65
8_L	280_L	0.836	0.65
108_I	205_A	0.833	0.65
161_R	208_L	0.830	0.64
26_Y	87_M	0.826	0.64
14_L	62_N	0.824	0.64
159_Q	204_L	0.824	0.64
106_T	163_I	0.823	0.64
33_V	88_L	0.819	0.63
74_D	86_Y	0.818	0.63
161_R	166_S	0.815	0.63
169_I	182_S	0.808	0.62
141_G	145_K	0.799	0.61
62_N	80_S	0.798	0.61
65_W	68_V	0.794	0.61
100_P	177_H	0.792	0.61
280_L	283_I	0.788	0.60
48_V	182_S	0.786	0.60
64_A	126_P	0.785	0.60
221_L	280_L	0.781	0.60
102_T	177_H	0.780	0.59
172_L	179_V	0.777	0.59
204_L	263_A	0.772	0.59
115_P	118_L	0.767	0.58
237_R	240_R	0.767	0.58
228_Y	240_R	0.766	0.58
116_A	121_E	0.765	0.58
285_E	291_A	0.757	0.57
80_S	105_L	0.756	0.57
14_L	80_S	0.748	0.56
13_L	62_N	0.746	0.56
247_L	261_V	0.745	0.56
14_L	59_A	0.745	0.56
124_I	155_V	0.745	0.56
77_V	83_M	0.741	0.56
162_K	208_L	0.741	0.56
23_E	27_R	0.739	0.55
136_L	140_Y	0.738	0.55
74_D	87_M	0.734	0.55
58_L	83_M	0.728	0.54
170_E	214_N	0.725	0.54
14_L	87_M	0.724	0.54
171_L	177_H	0.721	0.54
279_A	282_R	0.721	0.54
94_A	107_R	0.720	0.53
14_L	79_E	0.720	0.53
216_D	273_K	0.720	0.53
78_A	272_G	0.718	0.53
47_I	178_V	0.717	0.53
224_A	231_W	0.717	0.53
285_E	288_A	0.715	0.53
169_I	209_L	0.713	0.53
35_A	38_R	0.710	0.52
190_T	196_S	0.708	0.52
43_Y	216_D	0.703	0.52
26_Y	90_Q	0.701	0.51
24_N	28_N	0.701	0.51
74_D	83_M	0.701	0.51
136_L	139_A	0.700	0.51
229_E	234_P	0.696	0.51
249_P	252_K	0.695	0.51
127_V	150_Y	0.690	0.50
180_I	220_I	0.689	0.50
140_Y	144_M	0.688	0.50
61_Q	87_M	0.688	0.50
6_V	39_L	0.687	0.50
245_D	269_R	0.686	0.50
21_T	124_I	0.686	0.50
130_P	146_R	0.683	0.50
271_R	274_P	0.681	0.49
137_E	141_G	0.676	0.49
40_A	162_K	0.676	0.49
105_L	192_D	0.676	0.49
31_S	281_S	0.675	0.49
39_L	283_I	0.674	0.49
50_G	201_D	0.673	0.49
11_N	52_G	0.672	0.48
137_E	145_K	0.671	0.48
38_R	42_S	0.670	0.48
164_L	189_V	0.669	0.48
282_R	291_A	0.669	0.48
211_E	271_R	0.668	0.48
74_D	126_P	0.668	0.48
59_A	74_D	0.667	0.48
109_E	112_P	0.666	0.48
135_A	138_A	0.665	0.48
28_N	73_L	0.665	0.48
71_Y	75_V	0.659	0.47
11_N	157_S	0.654	0.47
204_L	266_G	0.653	0.47
231_W	252_K	0.653	0.47
166_S	212_Q	0.651	0.46
28_N	87_M	0.651	0.46
93_S	107_R	0.648	0.46
48_V	108_I	0.646	0.46
119_Q	254_D	0.646	0.46
225_D	279_A	0.646	0.46
149_K	223_D	0.643	0.46
73_L	197_E	0.643	0.46
10_G	50_G	0.642	0.45
10_G	201_D	0.640	0.45
77_V	99_P	0.640	0.45
116_A	263_A	0.639	0.45
15_Q	223_D	0.635	0.45
30_A	94_A	0.633	0.45
247_L	251_A	0.632	0.44
269_R	295_I	0.631	0.44
22_A	83_M	0.628	0.44
102_T	172_L	0.627	0.44
133_Q	151_L	0.625	0.44
217_G	283_I	0.625	0.44
92_L	178_V	0.625	0.44
169_I	200_I	0.623	0.44
211_E	270_S	0.617	0.43
243_T	247_L	0.616	0.43
261_V	295_I	0.615	0.43
246_E	250_F	0.615	0.43
140_Y	153_R	0.614	0.43
59_A	73_L	0.613	0.42
140_Y	145_K	0.612	0.42
137_E	153_R	0.611	0.42
73_L	87_M	0.611	0.42
65_W	156_A	0.610	0.42
93_S	100_P	0.607	0.42
117_F	196_S	0.607	0.42
12_A	280_L	0.606	0.42
32_A	278_G	0.604	0.42
204_L	211_E	0.604	0.42
130_P	138_A	0.602	0.41
43_Y	69_E	0.601	0.41
22_A	72_P	0.601	0.41
251_A	265_S	0.600	0.41
123_F	146_R	0.600	0.41
265_S	269_R	0.599	0.41
13_L	87_M	0.599	0.41
93_S	165_D	0.599	0.41
40_A	231_W	0.593	0.41
71_Y	83_M	0.592	0.40
201_D	255_G	0.592	0.40
269_R	272_G	0.592	0.40
28_N	278_G	0.589	0.40
173_L	176_G	0.588	0.40
8_L	25_Q	0.588	0.40
124_I	151_L	0.586	0.40
25_Q	84_I	0.586	0.40
138_A	187_V	0.585	0.40
181_C	286_T	0.583	0.40
36_L	226_A	0.583	0.40
10_G	157_S	0.583	0.40
144_M	153_R	0.583	0.40
48_V	181_C	0.581	0.39
214_N	241_H	0.580	0.39
108_I	181_C	0.580	0.39
220_I	236_Q	0.579	0.39
88_L	92_L	0.578	0.39
83_M	223_D	0.577	0.39
13_L	59_A	0.574	0.39
104_V	271_R	0.573	0.39
156_A	166_S	0.572	0.38
36_L	47_I	0.572	0.38
62_N	87_M	0.571	0.38
38_R	95_Q	0.568	0.38
99_P	176_G	0.567	0.38
59_A	62_N	0.567	0.38
150_Y	224_A	0.566	0.38
80_S	180_I	0.565	0.38
83_M	87_M	0.565	0.38
71_Y	76_L	0.565	0.38
89_A	165_D	0.565	0.38
267_Y	271_R	0.558	0.37
264_V	295_I	0.557	0.37
39_L	219_V	0.557	0.37
70_P	232_G	0.557	0.37
231_W	253_A	0.557	0.37
27_R	31_S	0.557	0.37
115_P	245_D	0.556	0.37
33_V	92_L	0.554	0.37
226_A	242_A	0.553	0.37
65_W	123_F	0.553	0.37
223_D	283_I	0.550	0.36
252_K	265_S	0.550	0.36
14_L	84_I	0.550	0.36
123_F	150_Y	0.549	0.36
71_Y	80_S	0.545	0.36
57_L	79_E	0.545	0.36
76_L	83_M	0.544	0.36
115_P	234_P	0.543	0.36
61_Q	126_P	0.543	0.36
126_P	153_R	0.543	0.36
22_A	77_V	0.542	0.36
52_G	157_S	0.541	0.35
77_V	223_D	0.540	0.35
11_N	255_G	0.540	0.35
59_A	153_R	0.540	0.35
57_L	80_S	0.539	0.35
81_Q	289_G	0.537	0.35
13_L	83_M	0.536	0.35
156_A	197_E	0.535	0.35
233_T	249_P	0.533	0.35
270_S	273_K	0.532	0.35
71_Y	128_Y	0.532	0.35
29_I	87_M	0.530	0.34
120_P	156_A	0.528	0.34
289_G	294_C	0.527	0.34
63_L	286_T	0.527	0.34
28_N	223_D	0.526	0.34
41_R	284_E	0.525	0.34
244_P	247_L	0.525	0.34
29_I	57_L	0.524	0.34
62_N	74_D	0.524	0.34
14_L	223_D	0.523	0.34
282_R	286_T	0.523	0.34
14_L	75_V	0.522	0.34
170_E	249_P	0.522	0.34
86_Y	187_V	0.520	0.34
65_W	69_E	0.520	0.34
146_R	163_I	0.519	0.33
82_G	105_L	0.517	0.33
61_Q	74_D	0.517	0.33
113_D	269_R	0.517	0.33
244_P	269_R	0.516	0.33
101_V	124_I	0.514	0.33
103_T	180_I	0.513	0.33
61_Q	68_V	0.513	0.33
229_E	261_V	0.512	0.33
49_H	183_G	0.511	0.33
29_I	77_V	0.511	0.33
24_N	57_L	0.511	0.33
57_L	87_M	0.508	0.32
224_A	262_T	0.508	0.32
59_A	63_L	0.507	0.32
39_L	287_L	0.506	0.32
7_A	10_G	0.505	0.32
223_D	253_A	0.505	0.32
240_R	247_L	0.504	0.32
103_T	182_S	0.504	0.32
265_S	268_V	0.503	0.32
132_E	135_A	0.501	0.32
6_V	45_L	0.500	0.32

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1e19A	2	1	100	0.502	Contact Map
2e9yA	2	1	100	0.506	Contact Map
4jz8A	2	1	100	0.522	Contact Map
4axsA	2	0.9226	100	0.525	Contact Map
2we5A	2	0.9865	100	0.528	Contact Map
3wwnA	2	0.8283	100	0.707	Contact Map
2ap9A	3	0.8384	100	0.709	Contact Map
2bufA	3	0.8148	100	0.713	Contact Map
2btyA	3	0.8182	100	0.718	Contact Map
3l86A	1	0.7677	100	0.722	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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