GREMLIN Database
YHJA - Probable cytochrome c peroxidase
UniProt: P37197 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12244
Length: 465 (430)
Sequences: 245 (185)
Seq/√Len: 8.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
323_P339_Q8.1411.00
224_S236_A6.2401.00
341_K445_D5.8411.00
426_V447_V5.5981.00
338_Q445_D5.5211.00
227_V272_A5.5141.00
339_Q452_S5.2911.00
407_V450_L4.3000.99
409_L454_N4.2200.99
426_V446_I3.4910.96
408_A451_H3.3840.95
195_H213_L3.2780.94
299_Q305_N3.1510.92
384_I396_K3.1420.92
203_S282_K2.9570.90
336_T339_Q2.8970.89
321_D456_V2.6970.85
247_E365_F2.6460.83
194_Y313_F2.6350.83
160_A411_A2.5670.81
192_A292_Q2.5490.81
404_L407_V2.5360.81
265_P279_I2.5000.80
131_T134_H2.4670.79
404_L450_L2.4330.78
195_H313_F2.2840.73
252_G365_F2.2460.72
358_I442_D2.1990.70
349_N442_D2.1360.68
119_V124_T2.1060.66
133_L136_A2.0580.65
74_Y77_G1.9890.62
371_K418_D1.9860.62
221_R275_S1.9240.59
323_P452_S1.9140.59
196_D324_F1.8970.58
220_G411_A1.8800.57
338_Q444_D1.8570.56
209_H326_K1.8560.56
348_D442_D1.8250.55
306_I439_P1.8150.54
95_L335_L1.7990.54
194_Y289_L1.7780.53
186_K402_P1.7760.53
356_G364_S1.7360.51
378_E437_E1.7360.51
191_F393_E1.7350.51
25_Y298_P1.7330.51
271_M334_A1.7260.51
58_G194_Y1.7250.51
205_I271_M1.7180.50
241_N319_T1.7180.50
169_R244_F1.7160.50
157_E424_G1.7080.50
311_A335_L1.6900.49
426_V450_L1.6890.49
215_A220_G1.6870.49
115_K296_V1.6640.48
221_R225_I1.6540.47
323_P336_T1.6410.47
310_I360_L1.6360.47
248_Q271_M1.6320.47
262_G306_I1.6310.46
185_Q295_E1.6300.46
177_P252_G1.6260.46
297_Y308_D1.5800.44
244_F318_I1.5690.44
408_A452_S1.5640.44
428_L436_K1.5630.44
163_D340_K1.5430.43
339_Q451_H1.5380.42
325_D405_R1.5160.42
43_A46_E1.5110.41
275_S300_G1.5030.41
431_R437_E1.5010.41
279_I297_Y1.4910.41
439_P442_D1.4850.40
314_E360_L1.4830.40
141_D145_A1.4780.40
312_E315_K1.4720.40
251_D403_G1.4610.39
248_Q283_L1.4600.39
441_E445_D1.4520.39
339_Q402_P1.4360.38
332_E340_K1.4330.38
296_V336_T1.4270.38
212_A452_S1.4170.37
54_L244_F1.4140.37
142_E147_I1.4080.37
287_P448_A1.4030.37
114_N323_P1.3930.37
426_V443_V1.3830.36
319_T446_I1.3790.36
192_A321_D1.3770.36
122_Y127_P1.3710.36
186_K308_D1.3660.35
260_Q270_E1.3620.35
287_P426_V1.3580.35
160_A220_G1.3560.35
205_I273_S1.3530.35
74_Y80_Q1.3220.34
192_A197_P1.3180.34
243_V315_K1.3150.33
449_F453_L1.3110.33
399_Q416_R1.3090.33
271_M327_W1.3090.33
184_A333_N1.3080.33
98_V116_I1.2980.33
159_Y442_D1.2960.33
287_P321_D1.2880.32
167_E285_K1.2870.32
279_I353_T1.2830.32
275_S302_S1.2820.32
352_A417_G1.2820.32
284_E290_K1.2800.32
271_M390_T1.2740.32
241_N293_F1.2620.31
356_G363_R1.2550.31
326_K331_D1.2480.31
122_Y434_V1.2450.31
424_G428_L1.2440.31
252_G316_T1.2340.30
393_E396_K1.2340.30
155_R368_L1.2340.30
338_Q341_K1.2250.30
378_E431_R1.2130.30
289_L371_K1.2120.30
205_I227_V1.2060.29
111_S285_K1.1920.29
249_F317_L1.1890.29
338_Q448_A1.1810.28
194_Y358_I1.1770.28
137_G209_H1.1710.28
33_R37_A1.1680.28
283_L294_L1.1650.28
241_N409_L1.1620.28
360_L381_A1.1560.28
161_S352_A1.1490.27
430_L443_V1.1440.27
54_L179_K1.1440.27
104_A281_A1.1400.27
182_T187_V1.1400.27
98_V306_I1.1390.27
368_L447_V1.1300.27
227_V362_G1.1280.27
300_G447_V1.1260.27
122_Y364_S1.1260.27
118_W122_Y1.1260.27
349_N358_I1.1200.26
370_L442_D1.1190.26
191_F313_F1.1190.26
352_A421_T1.1120.26
201_A365_F1.1090.26
174_Q239_V1.1080.26
184_A340_K1.1030.26
306_I336_T1.1000.26
349_N438_L1.0990.26
208_A449_F1.0980.26
244_F408_A1.0980.26
25_Y29_H1.0980.26
358_I439_P1.0910.25
133_L296_V1.0910.25
348_D428_L1.0860.25
256_T259_D1.0820.25
161_S290_K1.0810.25
33_R197_P1.0810.25
184_A442_D1.0790.25
62_C263_G1.0700.25
258_Q388_N1.0700.25
348_D358_I1.0680.25
416_R428_L1.0660.25
185_Q424_G1.0660.25
122_Y428_L1.0580.24
311_A315_K1.0570.24
83_D127_P1.0520.24
222_K417_G1.0520.24
119_V401_V1.0500.24
357_G364_S1.0490.24
252_G395_D1.0440.24
238_T410_T1.0410.24
252_G307_T1.0370.24
326_K452_S1.0350.24
425_A429_M1.0340.24
335_L339_Q1.0320.24
292_Q296_V1.0300.23
212_A318_I1.0280.23
420_P424_G1.0270.23
208_A352_A1.0230.23
266_L306_I1.0210.23
267_N366_E1.0210.23
243_V414_F1.0200.23
167_E439_P1.0190.23
216_G426_V1.0180.23
251_D352_A1.0170.23
232_G250_W1.0160.23
127_P258_Q1.0150.23
197_P212_A1.0150.23
122_Y128_T1.0140.23
252_G263_G1.0110.23
122_Y436_K1.0100.23
360_L373_D1.0100.23
349_N436_K1.0090.23
99_R256_T1.0080.23
429_M432_Y1.0060.23
184_A291_T1.0060.23
123_E445_D1.0020.23
429_M433_Q1.0000.23
212_A215_A0.9990.23
234_I433_Q0.9940.22
316_T362_G0.9910.22
227_V271_M0.9910.22
169_R245_N0.9840.22
83_D123_E0.9720.22
258_Q269_I0.9690.22
280_I306_I0.9640.21
29_H236_A0.9590.21
423_D427_K0.9580.21
76_P245_N0.9560.21
295_E326_K0.9520.21
430_L438_L0.9500.21
358_I436_K0.9500.21
416_R429_M0.9470.21
123_E333_N0.9460.21
407_V445_D0.9440.21
384_I418_D0.9390.21
167_E203_S0.9370.21
320_P455_G0.9340.21
75_I436_K0.9310.21
307_T395_D0.9290.20
59_C62_C0.9280.20
281_A444_D0.9270.20
197_P224_S0.9270.20
198_R286_D0.9260.20
191_F378_E0.9260.20
73_Y381_A0.9210.20
257_L311_A0.9130.20
394_R446_I0.9080.20
69_L216_G0.9050.20
349_N428_L0.9050.20
443_V446_I0.9040.20
72_Y312_E0.9030.20
143_E313_F0.9030.20
158_Y446_I0.9020.20
283_L439_P0.9010.20
258_Q311_A0.9010.20
108_V321_D0.8980.20
26_V40_Q0.8960.20
265_P289_L0.8950.20
26_V282_K0.8940.20
120_M128_T0.8940.20
313_F321_D0.8930.19
259_D395_D0.8890.19
234_I416_R0.8880.19
118_W447_V0.8880.19
96_E340_K0.8850.19
314_E390_T0.8800.19
321_D442_D0.8800.19
70_P175_P0.8790.19
313_F358_I0.8780.19
34_S95_L0.8780.19
26_V454_N0.8760.19
242_S411_A0.8760.19
58_G265_P0.8740.19
221_R352_A0.8680.19
240_F297_Y0.8680.19
214_N337_A0.8670.19
291_T408_A0.8640.19
59_C125_M0.8630.19
217_G429_M0.8620.19
150_W155_R0.8620.19
427_K438_L0.8600.19
124_T289_L0.8580.19
302_S365_F0.8530.18
332_E420_P0.8520.18
215_A320_P0.8490.18
194_Y403_G0.8470.18
209_H399_Q0.8460.18
173_V360_L0.8450.18
344_Q348_D0.8440.18
66_S90_Y0.8440.18
25_Y32_K0.8430.18
253_R321_D0.8420.18
428_L433_Q0.8400.18
188_A447_V0.8390.18
365_F386_R0.8380.18
142_E329_R0.8360.18
275_S411_A0.8350.18
184_A188_A0.8320.18
408_A454_N0.8310.18
431_R445_D0.8290.18
225_I231_V0.8290.18
193_L306_I0.8290.18
151_I155_R0.8270.18
271_M331_D0.8270.18
226_G450_L0.8250.18
125_M271_M0.8240.18
401_V423_D0.8220.18
241_N320_P0.8190.18
219_D410_T0.8170.17
139_V306_I0.8160.17
414_F428_L0.8160.17
339_Q423_D0.8160.17
66_S372_K0.8160.17
101_A166_P0.8150.17
149_A278_E0.8140.17
174_Q252_G0.8140.17
83_D348_D0.8130.17
396_K418_D0.8130.17
302_S305_N0.8120.17
393_E408_A0.8100.17
240_F262_G0.8100.17
162_N244_F0.8100.17
390_T402_P0.8080.17
273_S338_Q0.8060.17
251_D345_L0.8050.17
206_S449_F0.8050.17
244_F368_L0.8020.17
407_V446_I0.8000.17
159_Y187_V0.8000.17
344_Q436_K0.7990.17
29_H37_A0.7980.17
226_G319_T0.7970.17
379_I424_G0.7960.17
83_D358_I0.7960.17
153_K158_Y0.7960.17
48_N162_N0.7960.17
153_K451_H0.7940.17
91_K390_T0.7930.17
252_G386_R0.7920.17
411_A420_P0.7920.17
244_F378_E0.7910.17
101_A321_D0.7900.17
106_K291_T0.7900.17
348_D352_A0.7880.17
162_N168_H0.7830.17
63_H357_G0.7820.17
323_P334_A0.7790.17
104_A153_K0.7790.17
364_S436_K0.7770.17
34_S280_I0.7750.16
215_A229_G0.7750.16
122_Y430_L0.7740.16
425_A433_Q0.7680.16
53_F275_S0.7670.16
323_P335_L0.7670.16
194_Y436_K0.7670.16
258_Q315_K0.7660.16
219_D399_Q0.7660.16
203_S441_E0.7650.16
81_L392_E0.7640.16
411_A451_H0.7630.16
191_F292_Q0.7620.16
433_Q436_K0.7560.16
271_M362_G0.7550.16
261_A271_M0.7540.16
100_A420_P0.7530.16
238_T286_D0.7500.16
118_W124_T0.7490.16
305_N441_E0.7480.16
251_D353_T0.7470.16
407_V431_R0.7470.16
160_A244_F0.7470.16
317_L400_K0.7440.16
245_N414_F0.7440.16
371_K434_V0.7430.16
289_L358_I0.7430.16
83_D122_Y0.7430.16
84_Y164_T0.7430.16
89_G314_E0.7410.16
201_A407_V0.7400.16
337_A341_K0.7380.16
95_L445_D0.7370.16
125_M327_W0.7360.16
151_I284_E0.7350.16
257_L310_I0.7350.16
93_F450_L0.7330.15
93_F446_I0.7320.15
141_D146_E0.7300.15
374_F416_R0.7300.15
349_N430_L0.7280.15
326_K456_V0.7280.15
234_I429_M0.7280.15
62_C155_R0.7270.15
428_L434_V0.7260.15
255_A331_D0.7260.15
145_A162_N0.7260.15
244_F350_K0.7240.15
58_G289_L0.7230.15
127_P371_K0.7230.15
64_T297_Y0.7230.15
52_G58_G0.7220.15
348_D430_L0.7220.15
335_L389_V0.7210.15
63_H76_P0.7210.15
366_E400_K0.7210.15
68_E87_K0.7200.15
201_A318_I0.7190.15
116_I182_T0.7180.15
223_T233_P0.7180.15
225_I282_K0.7160.15
151_I295_E0.7160.15
254_A297_Y0.7160.15
214_N280_I0.7130.15
63_H119_V0.7100.15
323_P326_K0.7100.15
37_A214_N0.7070.15
61_Y443_V0.7070.15
219_D267_N0.7050.15
104_A426_V0.7050.15
81_L389_V0.7020.15
163_D421_T0.7000.15
312_E319_T0.6990.15
252_G261_A0.6960.15
223_T381_A0.6960.15
166_P340_K0.6960.15
238_T242_S0.6920.15
221_R231_V0.6880.14
197_P391_K0.6850.14
195_H266_L0.6830.14
336_T402_P0.6830.14
185_Q408_A0.6820.14
239_V433_Q0.6800.14
206_S306_I0.6780.14
186_K374_F0.6780.14
186_K335_L0.6770.14
113_L155_R0.6740.14
122_Y438_L0.6720.14
59_C63_H0.6720.14
173_V176_I0.6700.14
158_Y187_V0.6660.14
229_G232_G0.6660.14
179_K242_S0.6640.14
257_L317_L0.6630.14
71_A264_P0.6630.14
29_H242_S0.6630.14
129_R439_P0.6630.14
184_A331_D0.6620.14
251_D438_L0.6610.14
56_E310_I0.6590.14
41_A44_V0.6580.14
195_H259_D0.6570.14
241_N251_D0.6550.14
162_N423_D0.6530.14
323_P352_A0.6520.14
216_G282_K0.6520.14
66_S362_G0.6520.14
206_S265_P0.6520.14
188_A302_S0.6510.14
73_Y434_V0.6500.14
187_V402_P0.6500.14
43_A252_G0.6500.14
252_G310_I0.6500.14
233_P382_A0.6490.14
75_I264_P0.6490.14
339_Q418_D0.6460.14
100_A166_P0.6450.14
335_L414_F0.6440.14
443_V451_H0.6440.14
372_K431_R0.6440.14
272_A360_L0.6430.14
251_D413_Y0.6400.13
297_Y336_T0.6390.13
79_K82_M0.6380.13
408_A440_Q0.6370.13
98_V203_S0.6340.13
81_L443_V0.6330.13
58_G152_A0.6330.13
339_Q352_A0.6330.13
191_F352_A0.6320.13
106_K244_F0.6320.13
427_K442_D0.6290.13
195_H306_I0.6290.13
204_T361_G0.6280.13
254_A307_T0.6280.13
400_K413_Y0.6250.13
103_L311_A0.6240.13
25_Y28_Y0.6230.13
119_V122_Y0.6230.13
188_A192_A0.6230.13
329_R367_P0.6230.13
425_A432_Y0.6230.13
300_G326_K0.6210.13
168_H310_I0.6210.13
249_F253_R0.6200.13
102_L296_V0.6190.13
122_Y349_N0.6190.13
187_V335_L0.6180.13
261_A365_F0.6170.13
379_I444_D0.6160.13
282_K336_T0.6160.13
174_Q183_D0.6160.13
106_K185_Q0.6160.13
404_L408_A0.6150.13
59_C135_W0.6130.13
271_M398_R0.6120.13
289_L349_N0.6120.13
217_G433_Q0.6120.13
414_F430_L0.6110.13
241_N392_E0.6100.13
47_N440_Q0.6090.13
81_L312_E0.6080.13
284_E368_L0.6080.13
175_P361_G0.6070.13
47_N221_R0.6070.13
257_L449_F0.6060.13
186_K315_K0.6060.13
298_P362_G0.6050.13
64_T310_I0.6050.13
381_A403_G0.6050.13
71_A216_G0.6010.13
295_E441_E0.6010.13
234_I348_D0.6000.13
213_L433_Q0.5990.13
27_W45_S0.5990.13
231_V417_G0.5990.13
349_N360_L0.5980.13
348_D436_K0.5960.13
131_T135_W0.5950.13
229_G317_L0.5940.13
25_Y296_V0.5930.13
37_A209_H0.5930.13
239_V319_T0.5920.13
203_S283_L0.5920.13
278_E452_S0.5910.13
66_S163_D0.5910.13
341_K441_E0.5900.13
213_L232_G0.5860.12
169_R181_P0.5840.12
148_L155_R0.5830.12
226_G254_A0.5830.12
275_S329_R0.5830.12
206_S251_D0.5810.12
241_N455_G0.5810.12
348_D433_Q0.5800.12
368_L418_D0.5780.12
149_A396_K0.5780.12
352_A356_G0.5770.12
156_A280_I0.5770.12
345_L438_L0.5770.12
197_P205_I0.5750.12
273_S350_K0.5740.12
61_Y64_T0.5720.12
183_D296_V0.5720.12
104_A110_Q0.5720.12
203_S258_Q0.5720.12
244_F432_Y0.5710.12
73_Y419_V0.5710.12
289_L364_S0.5710.12
102_L327_W0.5700.12
186_K406_N0.5700.12
285_K439_P0.5690.12
251_D415_H0.5680.12
396_K446_I0.5670.12
88_L438_L0.5670.12
52_G446_I0.5670.12
302_S450_L0.5660.12
359_I401_V0.5660.12
345_L403_G0.5660.12
333_N387_M0.5660.12
63_H73_Y0.5640.12
424_G444_D0.5640.12
232_G374_F0.5640.12
90_Y336_T0.5620.12
48_N90_Y0.5620.12
100_A393_E0.5620.12
284_E321_D0.5620.12
316_T350_K0.5610.12
313_F436_K0.5610.12
113_L305_N0.5590.12
103_L456_V0.5590.12
182_T278_E0.5580.12
83_D344_Q0.5560.12
110_Q338_Q0.5540.12
61_Y311_A0.5540.12
165_A171_E0.5530.12
349_N429_M0.5530.12
171_E243_V0.5520.12
181_P321_D0.5520.12
31_N242_S0.5520.12
85_D216_G0.5500.12
294_L360_L0.5500.12
150_W232_G0.5480.12
186_K404_L0.5480.12
58_G306_I0.5480.12
308_D439_P0.5460.12
228_G272_A0.5440.12
87_K157_E0.5440.12
194_Y433_Q0.5420.12
280_I283_L0.5410.12
106_K197_P0.5400.12
184_A391_K0.5400.12
367_P399_Q0.5390.12
356_G397_L0.5370.12
107_P183_D0.5350.12
197_P236_A0.5330.11
144_R452_S0.5330.11
315_K396_K0.5320.11
353_T403_G0.5320.11
196_D302_S0.5320.11
263_G316_T0.5300.11
54_L198_R0.5290.11
386_R389_V0.5290.11
349_N432_Y0.5290.11
137_G178_Q0.5290.11
169_R367_P0.5270.11
313_F437_E0.5270.11
74_Y341_K0.5260.11
209_H230_A0.5260.11
82_M144_R0.5250.11
438_L442_D0.5240.11
197_P206_S0.5240.11
252_G402_P0.5240.11
284_E439_P0.5230.11
271_M320_P0.5220.11
128_T138_K0.5220.11
337_A397_L0.5210.11
115_K254_A0.5200.11
57_K443_V0.5200.11
165_A259_D0.5200.11
290_K301_F0.5180.11
340_K384_I0.5180.11
66_S329_R0.5170.11
215_A221_R0.5170.11
272_A316_T0.5170.11
195_H299_Q0.5160.11
86_I224_S0.5150.11
229_G295_E0.5140.11
187_V263_G0.5140.11
160_A321_D0.5130.11
419_V425_A0.5110.11
74_Y348_D0.5100.11
40_Q185_Q0.5100.11
344_Q419_V0.5100.11
138_K277_D0.5090.11
345_L352_A0.5080.11
155_R232_G0.5070.11
72_Y328_L0.5040.11
105_D116_I0.5040.11
193_L327_W0.5030.11
28_Y35_K0.5020.11
184_A431_R0.5010.11
62_C156_A0.5000.11
248_Q323_P0.5000.11
378_E387_M0.5000.11
74_Y213_L0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3sjlA 1 0.5849 100 0.501 Contact Map
2c1vA 2 0.6774 100 0.543 Contact Map
1zzhA 3 0.6344 100 0.547 Contact Map
1nmlA 2 0.6387 100 0.547 Contact Map
3hq9A 2 0.6409 100 0.549 Contact Map
2vhdA 2 0.6602 100 0.552 Contact Map
4aanA 2 0.6581 100 0.552 Contact Map
1iqcA 2 0.6301 100 0.561 Contact Map
3o5cA 2 0.6258 100 0.566 Contact Map
4b2nA 1 0.8022 100 0.849 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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