GREMLIN Database
SLP - Outer membrane protein slp
UniProt: P37194 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11890
Length: 188 (164)
Sequences: 410 (332)
Seq/√Len: 25.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
41_V55_F4.0411.00
60_I74_S3.5641.00
73_I112_V3.4531.00
96_A138_M3.3811.00
74_S118_I3.2651.00
94_L134_L3.1371.00
70_L97_R3.1351.00
72_E133_F2.9471.00
110_H143_V2.7691.00
155_N158_D2.7580.99
71_L102_L2.7530.99
101_F104_P2.7050.99
107_Y141_I2.4610.99
71_L112_V2.3280.98
72_E131_Y2.2340.98
72_E124_G2.1690.97
103_D106_N2.1680.97
122_Q135_E2.1650.97
83_K111_F2.0530.96
54_R82_A2.0050.95
59_V143_V1.8620.93
98_Q102_L1.8310.93
124_G133_F1.7980.92
26_I54_R1.7970.92
38_F41_V1.7930.92
70_L95_L1.7860.92
38_F75_V1.7860.92
121_E132_N1.6550.88
97_R122_Q1.5850.86
37_S40_A1.5830.86
161_Y164_F1.5770.86
25_N142_Q1.5510.85
55_F78_L1.4970.82
56_G78_L1.4880.82
45_P48_Y1.4860.82
114_I136_V1.4790.82
98_Q138_M1.4590.81
53_A136_V1.4520.80
8_L17_A1.4280.79
61_N72_E1.4230.79
23_P26_I1.4050.78
65_G68_D1.3900.77
64_N101_F1.3740.77
55_F76_L1.3670.76
110_H131_Y1.3530.75
69_T110_H1.3290.74
23_P140_G1.3210.74
54_R104_P1.3090.73
30_N115_L1.2980.72
160_G163_A1.2930.72
54_R101_F1.2890.72
54_R62_V1.2820.71
23_P54_R1.2650.70
102_L138_M1.2580.70
165_W168_P1.2380.69
123_P132_N1.2210.68
60_I133_F1.2010.66
16_L96_A1.1940.66
112_V141_I1.1850.65
62_V104_P1.1840.65
106_N162_G1.1460.63
38_F126_I1.1300.61
59_V110_H1.1060.60
38_F106_N1.0940.59
156_L160_G1.0930.59
76_L86_I1.0700.57
54_R126_I1.0690.57
159_Y163_A1.0670.57
35_Q53_A1.0620.57
96_A114_I1.0600.56
18_A155_N1.0540.56
26_I48_Y1.0290.54
71_L157_W1.0240.54
15_L18_A0.9920.51
159_Y164_F0.9730.50
64_N70_L0.9710.50
75_V91_Q0.9600.49
78_L83_K0.9450.48
15_L103_D0.9400.48
29_N33_D0.9290.47
20_S99_S0.9290.47
118_I150_V0.9230.46
65_G128_K0.9220.46
164_F169_G0.9200.46
20_S80_S0.9150.46
111_F147_R0.9080.45
62_V74_S0.9070.45
9_I17_A0.9060.45
13_S109_N0.9040.45
79_D171_G0.9010.45
114_I153_T0.8990.45
164_F168_P0.8900.44
86_I148_E0.8810.43
51_Q71_L0.8790.43
55_F145_H0.8780.43
96_A125_F0.8750.43
167_E171_G0.8750.43
62_V69_T0.8730.43
32_P54_R0.8650.42
61_N123_P0.8640.42
68_D97_R0.8640.42
73_I139_Q0.8590.42
12_L39_V0.8560.41
91_Q102_L0.8410.40
56_G122_Q0.8360.40
55_F94_L0.8270.39
53_A83_K0.8260.39
161_Y168_P0.8190.39
9_I114_I0.8150.39
163_A168_P0.8060.38
158_D166_P0.8040.38
90_Y159_Y0.8000.38
110_H133_F0.7980.37
80_S137_N0.7980.37
63_I70_L0.7840.36
41_V114_I0.7790.36
18_A22_I0.7750.36
162_G168_P0.7670.35
163_A166_P0.7670.35
41_V118_I0.7670.35
17_A150_V0.7630.35
158_D162_G0.7610.35
126_I133_F0.7530.34
25_N115_L0.7500.34
45_P120_G0.7470.34
53_A111_F0.7460.34
113_T144_W0.7460.34
53_A134_L0.7430.34
20_S82_A0.7420.34
158_D163_A0.7410.34
48_Y146_L0.7380.33
54_R115_L0.7360.33
18_A89_N0.7340.33
76_L115_L0.7280.33
16_L19_C0.7250.32
7_A11_S0.7230.32
37_S59_V0.7220.32
71_L159_Y0.7210.32
78_L148_E0.7210.32
136_V154_Y0.7180.32
57_G116_G0.7090.31
103_D124_G0.7090.31
26_I104_P0.7060.31
71_L141_I0.7050.31
7_A67_T0.7010.31
9_I13_S0.6940.31
74_S133_F0.6910.30
59_V106_N0.6860.30
90_Y127_N0.6860.30
12_L16_L0.6850.30
165_W171_G0.6820.30
41_V79_D0.6820.30
119_Q137_N0.6790.30
20_S59_V0.6780.30
60_I130_P0.6760.29
18_A133_F0.6740.29
78_L167_E0.6720.29
60_I143_V0.6680.29
99_S151_N0.6640.29
29_N55_F0.6630.29
55_F126_I0.6590.28
11_S17_A0.6580.28
82_A129_V0.6510.28
168_P171_G0.6480.28
13_S66_K0.6450.28
154_Y159_Y0.6440.27
10_L96_A0.6430.27
67_T115_L0.6420.27
107_Y112_V0.6400.27
136_V168_P0.6390.27
36_K43_N0.6380.27
64_N127_N0.6360.27
78_L118_I0.6330.27
36_K109_N0.6320.27
40_A103_D0.6280.27
70_L135_E0.6240.26
100_G136_V0.6190.26
162_G166_P0.6160.26
45_P50_G0.6160.26
83_K88_A0.6110.26
123_P135_E0.6110.26
76_L88_A0.6100.26
105_V124_G0.6090.25
117_T137_N0.6060.25
37_S133_F0.6050.25
12_L103_D0.6040.25
30_N102_L0.6030.25
25_N32_P0.5980.25
18_A131_Y0.5970.25
93_R101_F0.5970.25
114_I138_M0.5950.25
27_K98_Q0.5900.24
100_G141_I0.5850.24
109_N151_N0.5810.24
57_G144_W0.5790.24
36_K82_A0.5790.24
71_L100_G0.5770.24
57_G84_P0.5760.24
67_T132_N0.5740.24
95_L122_Q0.5740.24
22_I82_A0.5720.23
77_P87_E0.5680.23
46_G87_E0.5650.23
90_Y103_D0.5650.23
94_L154_Y0.5640.23
18_A81_Y0.5640.23
35_Q51_Q0.5580.23
32_P62_V0.5560.23
28_G107_Y0.5550.23
14_F63_I0.5540.23
88_A106_N0.5540.23
62_V98_Q0.5520.22
58_K109_N0.5520.22
62_V102_L0.5500.22
96_A120_G0.5500.22
29_N32_P0.5490.22
76_L108_R0.5470.22
34_I115_L0.5440.22
90_Y148_E0.5430.22
157_W162_G0.5400.22
35_Q136_V0.5380.22
72_E92_G0.5370.22
65_G161_Y0.5360.22
46_G139_Q0.5350.22
77_P106_N0.5260.21
53_A141_I0.5250.21
27_K147_R0.5240.21
18_A34_I0.5240.21
61_N108_R0.5230.21
65_G154_Y0.5200.21
44_Q151_N0.5200.21
71_L106_N0.5190.21
88_A111_F0.5170.21
38_F76_L0.5170.21
77_P85_D0.5160.21
24_Q27_K0.5160.21
36_K94_L0.5150.21
63_I122_Q0.5140.21
112_V130_P0.5120.20
114_I133_F0.5100.20
71_L98_Q0.5070.20
62_V101_F0.5070.20
84_P113_T0.5070.20
64_N82_A0.5060.20
138_M141_I0.5030.20
100_G138_M0.5000.20
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3zbiC 1 0.1436 81.1 0.929 Contact Map
4jg9A 2 0.5957 32.2 0.949 Contact Map
1sr3A 1 0.5266 28.7 0.95 Contact Map
4n6kA 1 0.8351 25.6 0.952 Contact Map
2y8nA 2 0.3936 23.7 0.952 Contact Map
2hyxA 2 0.8404 22.1 0.953 Contact Map
5a0uA 2 0.3989 22.1 0.953 Contact Map
1r9dA 2 0.3936 21 0.954 Contact Map
4immA 1 0.6117 20.8 0.954 Contact Map
4nx8A 1 0.5585 20.5 0.954 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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