GREMLIN Database
PTKB - Galactitol-specific phosphotransferase enzyme IIB component
UniProt: P37188 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12415
Length: 94 (89)
Sequences: 458 (316)
Seq/√Len: 33.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
86_N90_T4.4051.00
23_I55_C3.3411.00
19_A57_T3.3071.00
74_P84_L3.0351.00
20_A36_L2.6991.00
7_V23_I2.4911.00
30_H89_L2.4080.99
83_A87_K2.1250.99
3_R92_L1.9990.98
4_K35_E1.9730.98
39_C43_E1.9410.97
26_L85_Q1.9030.97
5_I27_C1.8960.97
5_I34_V1.8490.97
53_L92_L1.8150.96
24_K28_Q1.7520.95
70_V91_I1.7480.95
75_F85_Q1.7130.95
82_E86_N1.6540.94
26_L75_F1.5710.92
19_A76_I1.5020.90
11_G40_R1.4710.89
48_M67_I1.3940.86
26_L30_H1.3410.84
84_L87_K1.3270.83
87_K90_T1.3260.83
41_V58_A1.2870.81
17_T38_Q1.2630.80
39_C44_I1.2500.79
49_D65_G1.2390.79
27_C34_V1.2360.79
85_Q89_L1.2350.78
11_G58_A1.2220.78
80_G83_A1.2150.77
40_R43_E1.1760.75
8_A51_V1.1640.74
11_G24_K1.1410.73
27_C73_M1.1350.72
6_I40_R1.0940.69
53_L88_I1.0110.63
3_R58_A1.0090.63
20_A24_K1.0040.63
45_E62_R0.9970.62
70_V84_L0.9830.61
74_P80_G0.9770.61
43_E71_H0.9400.58
12_A41_V0.9360.57
70_V88_I0.9320.57
21_E76_I0.9270.56
22_E72_G0.9220.56
38_Q57_T0.9080.55
24_K79_I0.8730.52
55_C88_I0.8690.52
28_Q34_V0.8670.51
4_K37_I0.8650.51
13_V17_T0.8540.50
56_T61_D0.8320.49
22_E55_C0.8280.48
21_E24_K0.8270.48
7_V10_G0.8130.47
12_A77_S0.7980.46
6_I51_V0.7960.46
31_N86_N0.7930.45
11_G41_V0.7630.43
79_I82_E0.7630.43
23_I36_L0.7580.42
25_E81_I0.7530.42
31_N49_D0.7350.40
26_L89_L0.7250.40
39_C54_I0.7180.39
19_A58_A0.7180.39
60_V69_L0.7090.38
11_G42_N0.7070.38
44_I54_I0.7070.38
30_H85_Q0.6990.38
56_T60_V0.6950.37
23_I88_I0.6820.36
83_A90_T0.6800.36
73_M76_I0.6740.36
38_Q43_E0.6600.35
18_M72_G0.6530.34
83_A86_N0.6520.34
42_N57_T0.6500.34
40_R47_Y0.6260.32
17_T54_I0.6260.32
4_K33_P0.6250.32
25_E83_A0.6240.32
81_I86_N0.6240.32
8_A43_E0.6220.32
11_G38_Q0.6150.31
24_K50_G0.6040.30
74_P77_S0.6030.30
4_K47_Y0.5990.30
71_H74_P0.5970.30
37_I47_Y0.5960.30
42_N73_M0.5940.30
7_V48_M0.5920.30
81_I85_Q0.5880.29
33_P83_A0.5860.29
41_V56_T0.5840.29
7_V24_K0.5790.29
29_N86_N0.5790.29
33_P86_N0.5740.28
11_G19_A0.5730.28
83_A91_I0.5670.28
27_C55_C0.5660.28
4_K10_G0.5620.28
55_C72_G0.5590.27
21_E25_E0.5590.27
61_D65_G0.5580.27
4_K31_N0.5540.27
20_A39_C0.5530.27
72_G80_G0.5520.27
12_A76_I0.5500.27
73_M80_G0.5440.26
41_V62_R0.5430.26
23_I27_C0.5430.26
12_A75_F0.5410.26
37_I50_G0.5370.26
12_A40_R0.5320.26
20_A38_Q0.5320.26
44_I68_P0.5280.25
6_I54_I0.5260.25
33_P82_E0.5260.25
26_L29_N0.5240.25
8_A39_C0.5230.25
44_I65_G0.5220.25
25_E33_P0.5180.25
30_H86_N0.5160.25
10_G40_R0.5150.25
29_N85_Q0.5140.24
55_C80_G0.5110.24
40_R73_M0.5040.24
38_Q53_L0.5000.24
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1tvmA 1 1 99.8 0.457 Contact Map
3nbmA 1 0.9574 99.7 0.494 Contact Map
1e2bA 1 0.9787 99.7 0.502 Contact Map
4mgeA 3 0.9468 99.7 0.508 Contact Map
2l2qA 1 0.9574 99.7 0.517 Contact Map
1vkrA 1 0.9681 99.6 0.552 Contact Map
3czcA 1 0.9362 99.5 0.567 Contact Map
2kyrA 1 1 99.5 0.571 Contact Map
4tn5A 2 0.9894 99.5 0.574 Contact Map
2m1zA 1 0.9787 99.4 0.587 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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