HYBD - ECOLI - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

HYBD - Hydrogenase 2 maturation protease

UniProt:	P37182	Sequences: MRILVLGVGNILLTDEAIGVRIVEALEQRYILPDYVEILDGGTAGMELLGDMANRDHLIIADAIVSKKNAPGTMMILRDEEVPALFTNKISPHQLGLADVLSALRFTGEFPKKLTLVGVIPESLEPHIGLTPTVEAMIEPALEQVLAALRESGVEAIPREAIHD	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG11802
Length:	164 (147)
Sequences:	1442 (1110)
Seq/√Len:	91.6

ECOLI - HYBD HYAD HYCI

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
122_E	133_T	5.934	1.00
23_V	38_I	3.693	1.00
76_I	148_A	3.017	1.00
18_I	119_V	2.744	1.00
65_V	120_I	2.729	1.00
21_R	24_E	2.632	1.00
61_A	145_V	2.560	1.00
76_I	117_V	2.309	1.00
29_R	146_L	2.302	1.00
121_P	124_L	2.247	1.00
14_T	123_S	2.233	1.00
57_H	113_K	2.189	1.00
22_I	61_A	2.149	1.00
68_K	120_I	2.078	1.00
69_N	73_T	2.013	1.00
37_E	55_R	1.934	1.00
25_A	139_E	1.911	1.00
76_I	115_T	1.889	1.00
70_A	73_T	1.887	1.00
64_I	118_G	1.815	1.00
56_D	112_K	1.812	1.00
7_G	23_V	1.794	1.00
134_V	137_M	1.750	1.00
119_V	134_V	1.748	1.00
25_A	28_Q	1.741	1.00
117_V	141_A	1.712	1.00
132_P	136_A	1.697	1.00
22_I	138_I	1.656	1.00
117_V	145_V	1.601	1.00
132_P	135_E	1.591	1.00
144_Q	147_A	1.590	1.00
18_I	141_A	1.555	1.00
67_K	75_M	1.552	1.00
59_I	145_V	1.534	1.00
75_M	120_I	1.508	1.00
25_A	29_R	1.500	1.00
53_A	109_E	1.496	1.00
69_N	75_M	1.471	1.00
25_A	142_L	1.469	1.00
4_L	55_R	1.467	1.00
148_A	151_E	1.457	1.00
11_I	20_V	1.395	0.99
140_P	144_Q	1.384	0.99
139_E	143_E	1.373	0.99
61_A	141_A	1.314	0.99
11_I	16_E	1.287	0.99
119_V	141_A	1.253	0.99
96_G	99_D	1.250	0.98
67_K	120_I	1.249	0.98
5_V	149_L	1.237	0.98
22_I	142_L	1.230	0.98
4_L	58_L	1.204	0.98
137_M	140_P	1.195	0.98
60_I	114_L	1.190	0.98
78_R	81_E	1.160	0.98
20_V	40_D	1.146	0.97
23_V	61_A	1.145	0.97
78_R	113_K	1.143	0.97
137_M	141_A	1.124	0.97
140_P	143_E	1.118	0.97
32_L	146_L	1.101	0.97
57_H	115_T	1.093	0.96
24_E	40_D	1.085	0.96
69_N	120_I	1.082	0.96
58_L	114_L	1.069	0.96
147_A	150_R	1.061	0.96
13_L	16_E	1.044	0.95
74_M	141_A	1.043	0.95
3_I	57_H	1.036	0.95
115_T	148_A	1.016	0.95
139_E	142_L	1.006	0.94
118_G	121_P	0.996	0.94
33_P	36_V	0.980	0.94
59_I	148_A	0.976	0.93
21_R	129_G	0.963	0.93
7_G	19_G	0.952	0.93
17_A	20_V	0.950	0.92
6_L	41_G	0.949	0.92
138_I	141_A	0.949	0.92
18_I	63_A	0.940	0.92
64_I	75_M	0.932	0.92
119_V	137_M	0.920	0.91
117_V	148_A	0.902	0.90
64_I	67_K	0.901	0.90
105_R	110_F	0.900	0.90
75_M	118_G	0.899	0.90
92_P	95_L	0.897	0.90
60_I	97_L	0.893	0.90
79_D	116_L	0.885	0.90
71_P	120_I	0.885	0.90
129_G	135_E	0.880	0.89
49_L	104_L	0.879	0.89
41_G	48_L	0.873	0.89
46_M	103_A	0.872	0.89
76_I	144_Q	0.863	0.88
59_I	117_V	0.858	0.88
53_A	107_T	0.850	0.88
16_E	106_F	0.849	0.88
143_E	147_A	0.847	0.87
32_L	38_I	0.840	0.87
11_I	24_E	0.833	0.87
4_L	39_L	0.830	0.86
26_L	61_A	0.828	0.86
14_T	127_H	0.820	0.86
74_M	140_P	0.815	0.85
17_A	21_R	0.813	0.85
18_I	134_V	0.805	0.85
3_I	149_L	0.804	0.85
23_V	40_D	0.800	0.84
40_D	43_T	0.797	0.84
101_L	105_R	0.790	0.83
39_L	51_D	0.781	0.83
91_S	119_V	0.779	0.83
24_E	27_E	0.774	0.82
4_L	126_P	0.772	0.82
67_K	73_T	0.761	0.81
14_T	125_E	0.760	0.81
26_L	146_L	0.759	0.81
136_A	140_P	0.758	0.81
17_A	40_D	0.746	0.80
3_I	35_Y	0.745	0.80
45_G	96_G	0.740	0.79
78_R	115_T	0.737	0.79
91_S	99_D	0.735	0.79
52_M	114_L	0.731	0.78
14_T	129_G	0.730	0.78
3_I	36_V	0.712	0.77
10_N	17_A	0.710	0.76
14_T	128_I	0.710	0.76
62_D	93_H	0.705	0.76
67_K	121_P	0.703	0.76
102_S	105_R	0.697	0.75
91_S	96_G	0.691	0.74
100_V	120_I	0.684	0.74
133_T	137_M	0.682	0.73
20_V	23_V	0.677	0.73
89_K	94_Q	0.667	0.72
55_R	111_P	0.665	0.72
45_G	48_L	0.657	0.71
17_A	130_L	0.656	0.71
13_L	47_E	0.652	0.70
16_E	41_G	0.640	0.69
85_L	88_N	0.632	0.68
104_L	110_F	0.631	0.68
22_I	145_V	0.631	0.68
74_M	117_V	0.629	0.67
26_L	32_L	0.625	0.67
140_P	147_A	0.623	0.67
104_L	111_P	0.622	0.67
101_L	110_F	0.618	0.66
46_M	96_G	0.618	0.66
136_A	143_E	0.617	0.66
14_T	121_P	0.616	0.66
133_T	136_A	0.609	0.65
74_M	144_Q	0.605	0.64
11_I	40_D	0.602	0.64
27_E	38_I	0.600	0.64
9_G	15_D	0.597	0.63
122_E	132_P	0.596	0.63
14_T	131_T	0.595	0.63
52_M	58_L	0.593	0.63
20_V	121_P	0.592	0.63
25_A	135_E	0.592	0.63
86_F	103_A	0.590	0.62
18_I	111_P	0.587	0.62
20_V	75_M	0.581	0.61
71_P	136_A	0.572	0.60
12_L	128_I	0.570	0.60
73_T	140_P	0.570	0.60
5_V	26_L	0.569	0.60
10_N	93_H	0.568	0.60
44_A	92_P	0.568	0.60
110_F	114_L	0.565	0.59
47_E	91_S	0.562	0.59
45_G	101_L	0.560	0.58
42_G	118_G	0.559	0.58
135_E	138_I	0.557	0.58
55_R	58_L	0.557	0.58
18_I	22_I	0.553	0.58
67_K	118_G	0.553	0.58
138_I	142_L	0.553	0.58
16_E	93_H	0.551	0.57
7_G	13_L	0.550	0.57
59_I	115_T	0.550	0.57
16_E	121_P	0.548	0.57
23_V	27_E	0.548	0.57
98_A	116_L	0.548	0.57
123_S	133_T	0.546	0.57
84_A	112_K	0.545	0.56
70_A	133_T	0.543	0.56
76_I	141_A	0.543	0.56
31_I	119_V	0.542	0.56
57_H	112_K	0.541	0.56
136_A	144_Q	0.541	0.56
27_E	135_E	0.538	0.55
72_G	137_M	0.535	0.55
12_L	95_L	0.535	0.55
69_N	85_L	0.534	0.55
133_T	151_E	0.531	0.55
20_V	100_V	0.528	0.54
29_R	32_L	0.527	0.54
6_L	119_V	0.524	0.54
90_I	104_L	0.520	0.53
98_A	114_L	0.518	0.53
29_R	139_E	0.518	0.53
8_V	97_L	0.517	0.53
21_R	130_L	0.515	0.52
89_K	118_G	0.514	0.52
91_S	95_L	0.514	0.52
141_A	148_A	0.511	0.52
129_G	132_P	0.510	0.52
17_A	24_E	0.510	0.52
18_I	138_I	0.510	0.52
132_P	140_P	0.508	0.51
68_K	71_P	0.507	0.51
143_E	151_E	0.503	0.51
74_M	119_V	0.503	0.51
21_R	135_E	0.503	0.51
123_S	131_T	0.500	0.50
60_I	129_G	0.500	0.50

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1cfzA	1	0.9817	100	0.117	Contact Map
2e85A	2	0.9268	100	0.224	Contact Map
3pu6A	1	0.811	100	0.26	Contact Map
1c8bA	3	0.7683	97.5	0.827	Contact Map
4hs4A	6	0.9085	87.1	0.892	Contact Map
3b1fA	2	0.8841	83.8	0.897	Contact Map
1t0iA	2	0.8902	79	0.902	Contact Map
4xdzA	2	0.872	78.4	0.902	Contact Map
3gt0A	3	0.8476	77.2	0.904	Contact Map
4wjiA	2	0.8963	77.1	0.904	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0072 seconds.