GREMLIN Database
HYBD - Hydrogenase 2 maturation protease
UniProt: P37182 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11802
Length: 164 (147)
Sequences: 1442 (1110)
Seq/√Len: 91.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
122_E133_T5.9341.00
23_V38_I3.6931.00
76_I148_A3.0171.00
18_I119_V2.7441.00
65_V120_I2.7291.00
21_R24_E2.6321.00
61_A145_V2.5601.00
76_I117_V2.3091.00
29_R146_L2.3021.00
121_P124_L2.2471.00
14_T123_S2.2331.00
57_H113_K2.1891.00
22_I61_A2.1491.00
68_K120_I2.0781.00
69_N73_T2.0131.00
37_E55_R1.9341.00
25_A139_E1.9111.00
76_I115_T1.8891.00
70_A73_T1.8871.00
64_I118_G1.8151.00
56_D112_K1.8121.00
7_G23_V1.7941.00
134_V137_M1.7501.00
119_V134_V1.7481.00
25_A28_Q1.7411.00
117_V141_A1.7121.00
132_P136_A1.6971.00
22_I138_I1.6561.00
117_V145_V1.6011.00
132_P135_E1.5911.00
144_Q147_A1.5901.00
18_I141_A1.5551.00
67_K75_M1.5521.00
59_I145_V1.5341.00
75_M120_I1.5081.00
25_A29_R1.5001.00
53_A109_E1.4961.00
69_N75_M1.4711.00
25_A142_L1.4691.00
4_L55_R1.4671.00
148_A151_E1.4571.00
11_I20_V1.3950.99
140_P144_Q1.3840.99
139_E143_E1.3730.99
61_A141_A1.3140.99
11_I16_E1.2870.99
119_V141_A1.2530.99
96_G99_D1.2500.98
67_K120_I1.2490.98
5_V149_L1.2370.98
22_I142_L1.2300.98
4_L58_L1.2040.98
137_M140_P1.1950.98
60_I114_L1.1900.98
78_R81_E1.1600.98
20_V40_D1.1460.97
23_V61_A1.1450.97
78_R113_K1.1430.97
137_M141_A1.1240.97
140_P143_E1.1180.97
32_L146_L1.1010.97
57_H115_T1.0930.96
24_E40_D1.0850.96
69_N120_I1.0820.96
58_L114_L1.0690.96
147_A150_R1.0610.96
13_L16_E1.0440.95
74_M141_A1.0430.95
3_I57_H1.0360.95
115_T148_A1.0160.95
139_E142_L1.0060.94
118_G121_P0.9960.94
33_P36_V0.9800.94
59_I148_A0.9760.93
21_R129_G0.9630.93
7_G19_G0.9520.93
17_A20_V0.9500.92
6_L41_G0.9490.92
138_I141_A0.9490.92
18_I63_A0.9400.92
64_I75_M0.9320.92
119_V137_M0.9200.91
117_V148_A0.9020.90
64_I67_K0.9010.90
105_R110_F0.9000.90
75_M118_G0.8990.90
92_P95_L0.8970.90
60_I97_L0.8930.90
79_D116_L0.8850.90
71_P120_I0.8850.90
129_G135_E0.8800.89
49_L104_L0.8790.89
41_G48_L0.8730.89
46_M103_A0.8720.89
76_I144_Q0.8630.88
59_I117_V0.8580.88
53_A107_T0.8500.88
16_E106_F0.8490.88
143_E147_A0.8470.87
32_L38_I0.8400.87
11_I24_E0.8330.87
4_L39_L0.8300.86
26_L61_A0.8280.86
14_T127_H0.8200.86
74_M140_P0.8150.85
17_A21_R0.8130.85
18_I134_V0.8050.85
3_I149_L0.8040.85
23_V40_D0.8000.84
40_D43_T0.7970.84
101_L105_R0.7900.83
39_L51_D0.7810.83
91_S119_V0.7790.83
24_E27_E0.7740.82
4_L126_P0.7720.82
67_K73_T0.7610.81
14_T125_E0.7600.81
26_L146_L0.7590.81
136_A140_P0.7580.81
17_A40_D0.7460.80
3_I35_Y0.7450.80
45_G96_G0.7400.79
78_R115_T0.7370.79
91_S99_D0.7350.79
52_M114_L0.7310.78
14_T129_G0.7300.78
3_I36_V0.7120.77
10_N17_A0.7100.76
14_T128_I0.7100.76
62_D93_H0.7050.76
67_K121_P0.7030.76
102_S105_R0.6970.75
91_S96_G0.6910.74
100_V120_I0.6840.74
133_T137_M0.6820.73
20_V23_V0.6770.73
89_K94_Q0.6670.72
55_R111_P0.6650.72
45_G48_L0.6570.71
17_A130_L0.6560.71
13_L47_E0.6520.70
16_E41_G0.6400.69
85_L88_N0.6320.68
104_L110_F0.6310.68
22_I145_V0.6310.68
74_M117_V0.6290.67
26_L32_L0.6250.67
140_P147_A0.6230.67
104_L111_P0.6220.67
101_L110_F0.6180.66
46_M96_G0.6180.66
136_A143_E0.6170.66
14_T121_P0.6160.66
133_T136_A0.6090.65
74_M144_Q0.6050.64
11_I40_D0.6020.64
27_E38_I0.6000.64
9_G15_D0.5970.63
122_E132_P0.5960.63
14_T131_T0.5950.63
52_M58_L0.5930.63
20_V121_P0.5920.63
25_A135_E0.5920.63
86_F103_A0.5900.62
18_I111_P0.5870.62
20_V75_M0.5810.61
71_P136_A0.5720.60
12_L128_I0.5700.60
73_T140_P0.5700.60
5_V26_L0.5690.60
10_N93_H0.5680.60
44_A92_P0.5680.60
110_F114_L0.5650.59
47_E91_S0.5620.59
45_G101_L0.5600.58
42_G118_G0.5590.58
135_E138_I0.5570.58
55_R58_L0.5570.58
18_I22_I0.5530.58
67_K118_G0.5530.58
138_I142_L0.5530.58
16_E93_H0.5510.57
7_G13_L0.5500.57
59_I115_T0.5500.57
16_E121_P0.5480.57
23_V27_E0.5480.57
98_A116_L0.5480.57
123_S133_T0.5460.57
84_A112_K0.5450.56
70_A133_T0.5430.56
76_I141_A0.5430.56
31_I119_V0.5420.56
57_H112_K0.5410.56
136_A144_Q0.5410.56
27_E135_E0.5380.55
72_G137_M0.5350.55
12_L95_L0.5350.55
69_N85_L0.5340.55
133_T151_E0.5310.55
20_V100_V0.5280.54
29_R32_L0.5270.54
6_L119_V0.5240.54
90_I104_L0.5200.53
98_A114_L0.5180.53
29_R139_E0.5180.53
8_V97_L0.5170.53
21_R130_L0.5150.52
89_K118_G0.5140.52
91_S95_L0.5140.52
141_A148_A0.5110.52
129_G132_P0.5100.52
17_A24_E0.5100.52
18_I138_I0.5100.52
132_P140_P0.5080.51
68_K71_P0.5070.51
143_E151_E0.5030.51
74_M119_V0.5030.51
21_R135_E0.5030.51
123_S131_T0.5000.50
60_I129_G0.5000.50
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1cfzA 1 0.9817 100 0.117 Contact Map
2e85A 2 0.9268 100 0.224 Contact Map
3pu6A 1 0.811 100 0.26 Contact Map
1c8bA 3 0.7683 97.5 0.827 Contact Map
4hs4A 6 0.9085 87.1 0.892 Contact Map
3b1fA 2 0.8841 83.8 0.897 Contact Map
1t0iA 2 0.8902 79 0.902 Contact Map
4xdzA 2 0.872 78.4 0.902 Contact Map
3gt0A 3 0.8476 77.2 0.904 Contact Map
4wjiA 2 0.8963 77.1 0.904 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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