GREMLIN Database
HYBB - Probable Ni/Fe-hydrogenase 2 b-type cytochrome subunit
UniProt: P37180 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11800
Length: 392 (352)
Sequences: 1427 (1046)
Seq/√Len: 55.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
30_L353_L5.4321.00
21_G25_V3.9161.00
251_T314_L3.5461.00
57_F326_A3.5051.00
227_F315_F3.4311.00
24_I361_I3.2731.00
20_F360_A3.2581.00
25_V29_L3.0491.00
24_I364_C2.8891.00
223_S318_A2.8521.00
29_L33_K2.7641.00
285_S289_W2.7601.00
118_Y121_I2.6651.00
34_R54_W2.5831.00
208_M264_L2.5611.00
44_D348_T2.4841.00
319_L323_L2.4361.00
23_L360_A2.3231.00
301_V317_S2.3131.00
42_V350_E2.3091.00
345_Y351_E2.2991.00
227_F318_A2.2821.00
118_Y122_P2.2471.00
115_N118_Y2.2171.00
16_P367_I2.2171.00
64_G217_A2.2111.00
107_T116_L2.1971.00
297_F320_S2.1881.00
33_K37_F2.1871.00
32_V36_V2.1791.00
26_I353_L2.1631.00
274_K278_A2.1391.00
310_D313_M2.0721.00
301_V307_L2.0651.00
18_M22_P2.0621.00
230_S315_F2.0051.00
254_I257_L1.9631.00
15_K19_I1.9261.00
295_M298_P1.9121.00
251_T302_L1.9081.00
249_K252_N1.8971.00
272_R278_A1.8941.00
67_C181_P1.8941.00
45_L54_W1.8470.99
254_I321_A1.8400.99
19_I23_L1.8370.99
347_P351_E1.8330.99
231_L235_G1.8120.99
70_W177_G1.7780.99
357_G367_I1.7650.99
294_L320_S1.7480.99
43_S54_W1.7420.99
161_V164_Q1.7340.99
205_S335_V1.7320.99
352_L356_I1.7310.99
272_R276_S1.7250.99
288_F291_E1.7070.99
219_I321_A1.7050.99
15_K18_M1.7000.99
17_V364_C1.6640.99
307_L313_M1.6470.99
368_V372_L1.6260.99
90_P229_G1.6210.99
248_V309_N1.6100.98
126_N129_S1.6100.98
102_G148_E1.6030.98
53_V56_A1.5930.98
248_V252_N1.5860.98
215_L260_I1.5800.98
304_V307_L1.5750.98
103_G107_T1.5690.98
348_T351_E1.5440.98
52_G56_A1.5390.98
272_R277_L1.5360.98
274_K277_L1.5250.98
216_T329_R1.4970.98
257_L260_I1.4960.98
284_Y288_F1.4960.98
262_I299_L1.4750.97
28_M32_V1.4690.97
273_D277_L1.4660.97
226_I318_A1.4630.97
266_F292_V1.4370.97
290_I294_L1.4360.97
255_S262_I1.4340.97
296_L300_V1.4280.97
312_R316_L1.4280.97
19_I356_I1.4230.97
109_D188_M1.4070.96
177_G183_M1.4050.96
139_T191_L1.4020.96
297_F323_L1.3980.96
247_F314_L1.3960.96
295_M299_L1.3620.96
25_V28_M1.3580.96
227_F322_L1.3500.95
117_P120_Y1.3450.95
34_R39_L1.3410.95
22_P28_M1.3400.95
213_S332_Y1.3330.95
314_L363_I1.3330.95
193_I209_L1.3300.95
141_Y185_Q1.3250.95
101_L362_E1.3240.95
345_Y348_T1.3210.95
93_L369_L1.3200.95
22_P25_V1.3140.95
260_I264_L1.3110.95
299_L303_R1.2980.94
232_V366_Y1.2960.94
135_A139_T1.2900.94
49_F53_V1.2750.94
292_V320_S1.2630.93
133_E137_C1.2600.93
33_K350_E1.2550.93
134_T138_M1.2500.93
349_W353_L1.2490.93
216_T322_L1.2470.93
97_F362_E1.2440.93
143_G187_S1.2420.93
301_V304_V1.2410.93
288_F324_G1.2380.93
91_A141_Y1.2240.92
91_A225_V1.2230.92
306_K309_N1.2140.92
325_C328_W1.2130.92
70_W95_S1.2130.92
59_L329_R1.2110.92
223_S322_L1.2090.92
73_A91_A1.2040.92
262_I266_F1.1980.92
369_L373_L1.1970.92
81_R84_Y1.1890.91
64_G67_C1.1840.91
237_R297_F1.1730.91
263_V267_G1.1710.91
22_P29_L1.1620.90
272_R279_F1.1550.90
134_T188_M1.1510.90
31_I108_I1.1430.89
42_V353_L1.1350.89
261_F265_R1.1290.89
226_I314_L1.1260.89
295_M300_V1.1210.89
24_I28_M1.1110.88
302_L317_S1.1070.88
18_M25_V1.1030.88
273_D276_S1.0960.87
97_F366_Y1.0840.87
18_M24_I1.0770.86
21_G36_V1.0720.86
38_G52_G1.0700.86
112_R115_N1.0700.86
275_L278_A1.0590.86
293_L298_P1.0590.86
125_F128_N1.0570.85
131_L191_L1.0560.85
217_A329_R1.0550.85
37_F42_V1.0490.85
184_H188_M1.0490.85
134_T187_S1.0470.85
305_A309_N1.0410.85
15_K22_P1.0390.84
147_L173_I1.0380.84
310_D315_F1.0350.84
230_S247_F1.0280.84
252_N256_V1.0240.84
190_S210_P1.0220.83
29_L231_L1.0150.83
140_I192_M1.0100.83
274_K279_F1.0090.83
20_F364_C1.0020.82
104_L107_T0.9950.82
39_L54_W0.9930.82
187_S191_L0.9900.81
69_G221_G0.9880.81
215_L264_L0.9880.81
293_L297_F0.9870.81
16_P19_I0.9840.81
97_F365_A0.9820.81
109_D141_Y0.9820.81
29_L36_V0.9810.81
255_S303_R0.9790.81
103_G138_M0.9770.81
185_Q217_A0.9670.80
298_P321_A0.9660.80
281_G288_F0.9640.80
25_V316_L0.9610.79
117_P121_I0.9600.79
275_L279_F0.9580.79
133_E145_M0.9540.79
16_P297_F0.9510.79
65_F68_G0.9490.79
90_P366_Y0.9480.79
244_K248_V0.9480.79
39_L43_S0.9470.78
29_L355_S0.9430.78
281_G289_W0.9430.78
139_T143_G0.9420.78
33_K36_V0.9410.78
252_N267_G0.9330.77
261_F328_W0.9300.77
170_M173_I0.9300.77
143_G284_Y0.9250.77
100_S142_I0.9230.77
272_R275_L0.9230.77
363_I367_I0.9140.76
276_S279_F0.9120.76
256_V263_V0.9080.75
282_D289_W0.9080.75
69_G102_G0.9070.75
287_M327_T0.9050.75
250_L270_I0.9040.75
73_A141_Y0.9020.75
17_V20_F0.9020.75
83_Q249_K0.8940.74
250_L360_A0.8890.74
262_I295_M0.8870.74
144_V176_L0.8860.74
79_F84_Y0.8850.74
18_M21_G0.8800.73
30_L350_E0.8790.73
31_I35_L0.8760.73
52_G55_I0.8710.72
66_A221_G0.8690.72
261_F264_L0.8630.72
19_I22_P0.8620.72
57_F355_S0.8610.72
100_S365_A0.8600.71
66_A141_Y0.8590.71
306_K310_D0.8580.71
24_I29_L0.8570.71
33_K42_V0.8570.71
103_G131_L0.8560.71
15_K344_A0.8560.71
17_V21_G0.8510.71
144_V180_L0.8470.70
72_L225_V0.8460.70
248_V308_R0.8450.70
293_L310_D0.8420.70
227_F316_L0.8390.70
63_T102_G0.8370.69
350_E353_L0.8340.69
70_W217_A0.8340.69
261_F268_E0.8320.69
138_M187_S0.8320.69
200_H336_A0.8280.69
186_S208_M0.8280.69
215_L366_Y0.8270.68
279_F287_M0.8230.68
89_R92_L0.8180.68
264_L267_G0.8180.68
54_W134_T0.8140.67
22_P26_I0.8130.67
73_A148_E0.8090.67
295_M302_L0.8090.67
146_A310_D0.8080.67
293_L312_R0.8070.67
263_V266_F0.8050.66
177_G210_P0.8040.66
24_I30_L0.8030.66
44_D264_L0.8020.66
28_M361_I0.8010.66
132_F136_V0.7980.66
301_V313_M0.7950.65
21_G29_L0.7920.65
222_F253_T0.7900.65
73_A184_H0.7890.65
21_G28_M0.7890.65
24_I37_F0.7860.64
173_I179_L0.7850.64
134_T137_C0.7820.64
113_Y129_S0.7810.64
55_I141_Y0.7760.63
168_K171_F0.7750.63
59_L217_A0.7730.63
129_S210_P0.7720.63
207_E271_Y0.7710.63
208_M215_L0.7690.63
336_A351_E0.7690.63
56_A334_L0.7660.62
70_W145_M0.7650.62
212_F318_A0.7640.62
334_L337_F0.7620.62
296_L316_L0.7580.62
245_S249_K0.7560.61
137_C187_S0.7560.61
226_I250_L0.7540.61
146_A150_A0.7520.61
294_L297_F0.7500.61
17_V27_C0.7500.61
59_L67_C0.7490.61
290_I318_A0.7480.61
21_G364_C0.7480.61
17_V24_I0.7470.61
348_T352_L0.7460.60
23_L357_G0.7440.60
167_N170_M0.7440.60
177_G180_L0.7420.60
37_F40_G0.7400.60
52_G129_S0.7380.60
28_M276_S0.7370.59
298_P320_S0.7360.59
95_S149_F0.7350.59
18_M26_I0.7340.59
49_F334_L0.7340.59
368_V371_R0.7290.59
53_V355_S0.7280.59
212_F328_W0.7270.58
45_L52_G0.7240.58
115_N119_F0.7240.58
296_L299_L0.7230.58
301_V309_N0.7210.58
61_I326_A0.7190.58
76_V88_V0.7180.58
84_Y249_K0.7170.57
79_F194_S0.7170.57
284_Y289_W0.7140.57
68_G292_V0.7140.57
69_G90_P0.7110.57
27_C30_L0.7100.57
173_I177_G0.7080.56
29_L35_L0.7070.56
234_A237_R0.7050.56
28_M36_V0.7040.56
101_L105_S0.7030.56
270_I275_L0.7020.56
230_S318_A0.7020.56
138_M220_M0.7010.56
31_I34_R0.7000.56
96_L146_A0.6990.55
266_F270_I0.6980.55
161_V165_R0.6980.55
96_L142_I0.6880.54
75_A218_F0.6870.54
101_L361_I0.6860.54
34_R42_V0.6860.54
26_I356_I0.6840.54
243_E246_L0.6810.54
137_C145_M0.6800.53
89_R156_R0.6780.53
62_G101_L0.6780.53
293_L306_K0.6780.53
355_S359_V0.6760.53
301_V323_L0.6750.53
51_W129_S0.6750.53
69_G91_A0.6740.53
18_M35_L0.6730.53
76_V84_Y0.6730.53
226_I254_I0.6720.53
153_L157_L0.6720.53
277_L344_A0.6700.52
245_S356_I0.6700.52
45_L128_N0.6660.52
281_G285_S0.6640.52
253_T263_V0.6630.52
178_A186_S0.6620.51
111_G354_I0.6610.51
116_L182_T0.6580.51
101_L150_A0.6580.51
59_L106_I0.6570.51
65_F98_G0.6560.51
229_G242_D0.6560.51
257_L294_L0.6540.51
102_G141_Y0.6530.51
23_L27_C0.6510.50
291_E331_T0.6490.50
113_Y116_L0.6480.50
82_G85_H0.6470.50
59_L188_M0.6470.50
69_G141_Y0.6470.50
69_G94_A0.6450.50
278_A281_G0.6410.49
287_M290_I0.6400.49
106_I109_D0.6400.49
298_P302_L0.6390.49
116_L122_P0.6380.49
106_I110_V0.6380.49
96_L357_G0.6370.49
318_A322_L0.6340.48
18_M28_M0.6340.48
110_V122_P0.6340.48
109_D130_V0.6290.48
185_Q188_M0.6290.48
87_L178_A0.6260.48
96_L155_E0.6230.47
67_C189_G0.6210.47
24_I36_V0.6210.47
92_L186_S0.6180.47
18_M29_L0.6180.47
136_V139_T0.6160.47
23_L29_L0.6140.46
313_M317_S0.6130.46
134_T184_H0.6100.46
120_Y139_T0.6100.46
115_N120_Y0.6100.46
141_Y217_A0.6070.46
66_A224_I0.6060.45
66_A111_G0.6050.45
264_L271_Y0.6030.45
148_E188_M0.6010.45
175_A179_L0.5970.44
262_I305_A0.5950.44
59_L186_S0.5950.44
54_W57_F0.5950.44
70_W325_C0.5930.44
181_P188_M0.5930.44
34_R40_G0.5920.44
148_E167_N0.5920.44
195_A199_V0.5910.44
71_A210_P0.5900.44
226_I230_S0.5900.44
127_V130_V0.5880.44
25_V37_F0.5880.44
22_P37_F0.5860.43
194_S199_V0.5850.43
208_M335_V0.5830.43
66_A184_H0.5820.43
26_I29_L0.5820.43
134_T185_Q0.5820.43
22_P110_V0.5810.43
252_N309_N0.5810.43
154_F275_L0.5790.43
286_V289_W0.5790.43
144_V220_M0.5780.42
51_W56_A0.5770.42
309_N360_A0.5770.42
338_N351_E0.5760.42
266_F303_R0.5740.42
273_D278_A0.5730.42
55_I111_G0.5710.42
171_F299_L0.5710.42
181_P210_P0.5690.42
244_K260_I0.5680.41
252_N319_L0.5680.41
141_Y184_H0.5680.41
290_I320_S0.5670.41
107_T138_M0.5670.41
69_G95_S0.5660.41
306_K313_M0.5650.41
255_S266_F0.5650.41
323_L326_A0.5620.41
298_P324_G0.5620.41
350_E365_A0.5620.41
77_Y88_V0.5610.41
53_V57_F0.5610.41
127_V131_L0.5600.41
24_I365_A0.5600.41
142_I146_A0.5590.40
114_W120_Y0.5590.40
288_F293_L0.5580.40
218_F221_G0.5570.40
264_L377_P0.5570.40
79_F316_L0.5560.40
34_R43_S0.5560.40
19_I26_I0.5550.40
214_L225_V0.5530.40
245_S252_N0.5530.40
355_S358_F0.5520.40
187_S194_S0.5520.40
190_S194_S0.5520.40
151_P154_F0.5500.40
229_G232_V0.5490.39
284_Y324_G0.5480.39
38_G111_G0.5470.39
287_M292_V0.5460.39
247_F276_S0.5450.39
346_F349_W0.5440.39
130_V135_A0.5430.39
181_P185_Q0.5420.39
287_M352_L0.5410.39
216_T325_C0.5400.38
253_T260_I0.5400.38
70_W328_W0.5400.38
106_I121_I0.5400.38
22_P323_L0.5400.38
59_L193_I0.5390.38
139_T194_S0.5390.38
69_G110_V0.5390.38
73_A213_S0.5390.38
290_I309_N0.5380.38
303_R306_K0.5380.38
66_A174_I0.5360.38
162_S165_R0.5350.38
265_R325_C0.5330.38
145_M148_E0.5330.38
149_F369_L0.5310.38
22_P356_I0.5310.38
87_L249_K0.5310.38
209_L332_Y0.5300.37
144_V149_F0.5300.37
49_F55_I0.5300.37
74_W326_A0.5290.37
102_G217_A0.5270.37
51_W203_W0.5270.37
59_L134_T0.5240.37
232_V302_L0.5240.37
211_L264_L0.5230.37
365_A378_P0.5230.37
236_L370_I0.5220.37
355_S363_I0.5210.37
245_S257_L0.5210.37
42_V361_I0.5180.36
220_M320_S0.5170.36
89_R332_Y0.5170.36
300_V319_L0.5160.36
275_L370_I0.5160.36
28_M368_V0.5150.36
25_V310_D0.5140.36
56_A330_L0.5120.36
78_V193_I0.5120.36
20_F24_I0.5120.36
22_P36_V0.5110.36
365_A373_L0.5110.36
226_I251_T0.5110.36
24_I31_I0.5100.35
17_V32_V0.5080.35
54_W59_L0.5080.35
90_P232_V0.5050.35
87_L291_E0.5050.35
92_L137_C0.5040.35
49_F73_A0.5040.35
172_F175_A0.5030.35
66_A355_S0.5020.35
42_V143_G0.5010.35
84_Y253_T0.5010.35
274_K282_D0.5000.34
259_A262_I0.5000.34
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2vpzC 2 0.6301 100 0.629 Contact Map
4o6yA 2 0.523 68.9 0.951 Contact Map
3mk7A 1 0.574 47.2 0.957 Contact Map
4djkA 2 0.8673 23.7 0.963 Contact Map
4ev6A 3 0.1862 23.5 0.963 Contact Map
3l1lA 2 0.8444 21.3 0.964 Contact Map
3s8fA 1 0.7117 21.2 0.964 Contact Map
4i0uA 4 0.1811 20.8 0.964 Contact Map
2l8sA 1 0.1148 19.9 0.965 Contact Map
2a65A 2 0.7168 17.7 0.966 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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