GREMLIN Database
FXSA - UPF0716 protein FxsA
UniProt: P37147 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12382
Length: 158 (142)
Sequences: 1479 (1080)
Seq/√Len: 90.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
29_V33_L4.1421.00
23_V90_F3.6461.00
15_I91_F3.5271.00
81_A99_L3.1621.00
101_L104_V3.0471.00
19_I91_F2.6901.00
61_K66_E2.6691.00
38_F42_I2.4601.00
18_S29_V2.3571.00
74_K109_T2.3241.00
59_Q63_A2.3131.00
27_L31_L2.2631.00
39_T96_G2.1851.00
12_Y92_T2.1051.00
83_L87_L2.0671.00
47_V82_G1.9801.00
57_L71_E1.8981.00
56_V59_Q1.8711.00
124_G128_A1.8361.00
36_V39_T1.7921.00
20_F90_F1.7901.00
98_L108_L1.7551.00
104_V107_H1.7001.00
44_M86_L1.6841.00
115_H118_F1.6281.00
34_V38_F1.6121.00
54_N78_L1.5811.00
74_K105_Q1.5281.00
10_F13_V1.4951.00
60_Q64_A1.4941.00
14_Y18_S1.4701.00
81_A96_G1.4400.99
21_I24_A1.4220.99
58_M62_M1.3940.99
23_V35_L1.3800.99
30_L34_V1.3650.99
103_P107_H1.3370.99
128_A131_G1.2930.99
77_S99_L1.2840.99
20_F36_V1.2800.99
28_G32_T1.2420.98
140_Y143_K1.2400.98
101_L107_H1.2110.98
24_A28_G1.2070.98
80_I83_L1.1870.98
58_M76_V1.1620.97
60_Q63_A1.1380.97
51_G75_S1.1290.97
39_T92_T1.1250.97
45_S49_N1.1210.97
20_F32_T1.1150.97
12_Y91_F1.1140.97
104_V109_T1.1140.97
87_L97_L1.1040.97
106_K109_T1.0890.96
81_A104_V1.0890.96
82_G93_D1.0860.96
6_F9_I1.0630.96
22_Q25_H1.0510.95
26_V30_L1.0430.95
94_F98_L1.0280.95
117_R121_M1.0230.95
19_I23_V1.0110.94
77_S108_L1.0110.94
82_G86_L1.0090.94
39_T86_L0.9990.94
61_K71_E0.9990.94
27_L90_F0.9850.94
39_T93_D0.9840.94
24_A29_V0.9760.93
51_G93_D0.9750.93
58_M77_S0.9700.93
17_I20_F0.9650.93
140_Y145_D0.9630.93
48_R52_F0.9380.92
50_Q53_K0.9320.92
11_L14_Y0.9130.91
39_T97_L0.9110.91
52_F69_A0.9090.90
68_P75_S0.9050.90
56_V60_Q0.9050.90
53_K57_L0.9030.90
107_H111_K0.9030.90
17_I76_V0.8990.90
126_F130_T0.8940.90
127_S130_T0.8930.90
36_V96_G0.8900.90
14_Y17_I0.8810.89
5_P44_M0.8750.89
46_L50_Q0.8690.88
142_R145_D0.8680.88
72_M79_I0.8630.88
127_S132_G0.8600.88
78_L105_Q0.8560.88
17_I21_I0.8480.87
58_M75_S0.8450.87
132_G135_T0.8450.87
140_Y144_D0.8370.86
125_G130_T0.8360.86
35_L90_F0.8360.86
54_N57_L0.8360.86
138_G143_K0.8280.86
123_G135_T0.8190.85
44_M87_L0.8180.85
133_G136_F0.8150.85
20_F91_F0.8030.84
50_Q100_L0.7990.84
100_L106_K0.7970.84
75_S96_G0.7890.83
125_G131_G0.7880.83
13_V17_I0.7870.83
103_P106_K0.7850.83
91_F111_K0.7850.83
138_G142_R0.7770.82
125_G128_A0.7750.82
120_R123_G0.7730.82
65_G68_P0.7710.82
48_R85_L0.7710.82
4_L8_A0.7690.81
124_G127_S0.7670.81
15_I19_I0.7650.81
22_Q26_V0.7650.81
10_F40_S0.7600.81
70_A113_M0.7520.80
92_T96_G0.7500.80
138_G145_D0.7460.79
27_L35_L0.7340.78
46_L57_L0.7290.78
4_L103_P0.7290.78
129_G132_G0.7290.78
26_V33_L0.7290.78
9_I32_T0.7260.78
13_V44_M0.7240.77
50_Q57_L0.7200.77
70_A110_V0.7200.77
129_G135_T0.7110.76
53_K58_M0.7060.76
58_M73_I0.7060.76
5_P9_I0.7010.75
47_V138_G0.7000.75
18_S22_Q0.6980.75
16_E50_Q0.6950.74
139_E142_R0.6950.74
81_A100_L0.6940.74
74_K78_L0.6940.74
8_A76_V0.6930.74
70_A74_K0.6890.74
61_K78_L0.6880.74
124_G129_G0.6870.74
73_I115_H0.6850.73
74_K77_S0.6830.73
41_V126_F0.6810.73
31_L34_V0.6670.71
54_N62_M0.6530.70
4_L116_L0.6500.69
100_L104_V0.6500.69
6_F10_F0.6470.69
39_T85_L0.6460.69
62_M65_G0.6390.68
58_M81_A0.6310.67
19_I83_L0.6300.67
33_L36_V0.6290.67
77_S105_Q0.6240.66
12_Y87_L0.6200.66
108_L111_K0.6120.65
92_T145_D0.6060.64
24_A105_Q0.6040.64
99_L104_V0.5990.63
47_V79_I0.5970.63
53_K81_A0.5940.63
40_S86_L0.5910.62
8_A13_V0.5900.62
73_I76_V0.5880.62
19_I22_Q0.5800.61
123_G129_G0.5720.60
119_S122_P0.5710.60
130_T133_G0.5670.59
38_F94_F0.5650.59
24_A54_N0.5650.59
57_L72_M0.5630.58
138_G144_D0.5630.58
85_L97_L0.5610.58
75_S102_P0.5610.58
37_I41_V0.5570.58
20_F30_L0.5530.57
46_L78_L0.5480.56
29_V92_T0.5470.56
98_L117_R0.5460.56
75_S105_Q0.5440.56
70_A109_T0.5420.56
23_V77_S0.5410.55
99_L142_R0.5400.55
13_V24_A0.5400.55
87_L93_D0.5370.55
62_M67_N0.5320.54
81_A118_F0.5310.54
131_G137_D0.5290.54
11_L44_M0.5290.54
46_L100_L0.5270.54
78_L96_G0.5260.53
91_F94_F0.5210.53
37_I84_L0.5200.53
131_G135_T0.5180.52
95_L130_T0.5140.52
13_V92_T0.5120.52
46_L72_M0.5120.52
61_K64_A0.5120.52
114_P117_R0.5120.52
48_R51_G0.5110.51
83_L97_L0.5070.51
72_M101_L0.5040.50
20_F96_G0.5030.50
44_M78_L0.5000.50
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4mt1A 3 0.6899 32.8 0.924 Contact Map
4ev6A 3 0.3354 31.2 0.925 Contact Map
4i0uA 4 0.3228 28.2 0.927 Contact Map
4dx5A 3 0.7468 22.2 0.93 Contact Map
3w9iA 3 0.6899 19 0.932 Contact Map
4k0jA 3 0.6582 16.3 0.935 Contact Map
4m64A 1 0.7278 12.7 0.938 Contact Map
3ne5A 3 0.6835 11.4 0.939 Contact Map
4pypA 1 0.6392 11.2 0.939 Contact Map
4mndA 2 0.6582 9.1 0.942 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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