GREMLIN Database
RIR4 - Ribonucleoside-diphosphate reductase 2 subunit beta
UniProt: P37146 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12381
Length: 319 (298)
Sequences: 2222 (806)
Seq/√Len: 46.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
133_R235_Q5.8661.00
238_D251_K5.0591.00
50_V53_Q4.3181.00
234_L255_C4.1531.00
36_V104_S4.1111.00
259_N272_P4.0411.00
57_M117_D3.8311.00
132_Q136_Q3.7581.00
54_Q58_R3.5171.00
279_N282_I3.3411.00
227_L270_L3.2941.00
49_T52_E3.2031.00
223_F270_L3.0981.00
230_Y271_F3.0891.00
156_F226_L2.9081.00
223_F268_E2.5771.00
223_F262_L2.5621.00
278_V282_I2.3461.00
234_L251_K2.3401.00
216_E220_S2.3221.00
158_E192_E2.3181.00
149_K221_F2.2881.00
277_E282_I2.2831.00
224_D228_E2.2731.00
230_Y258_A2.2571.00
223_F267_Y2.2391.00
129_A133_R2.2211.00
152_I222_A2.2121.00
98_E158_E2.2081.00
45_W53_Q2.1461.00
216_E219_K2.1391.00
255_C273_A2.0971.00
231_D235_Q2.0901.00
192_E195_H2.0891.00
151_K202_K2.0611.00
227_L271_F2.0521.00
203_Y210_I1.9870.99
67_D105_Y1.9810.99
172_F178_L1.9590.99
27_T32_L1.9550.99
104_S184_L1.9200.99
38_L107_S1.8720.99
92_S95_S1.8590.99
11_W89_A1.8570.99
57_M113_C1.8530.99
26_L97_M1.8490.99
70_Q142_Y1.8460.99
42_I46_Q1.8120.99
220_S224_D1.8000.99
222_A267_Y1.7920.99
98_E192_E1.7650.98
223_F227_L1.7430.98
18_K205_K1.7290.98
92_S99_A1.7160.98
33_P104_S1.7020.98
16_D84_T1.6280.97
90_V198_Y1.6190.97
187_L190_R1.6130.97
203_Y267_Y1.6020.97
24_N34_E1.5770.97
45_W57_M1.5670.97
209_K213_G1.5550.97
249_D252_A1.4820.95
263_M269_P1.4370.95
101_H195_H1.4320.95
227_L231_D1.4270.94
134_K233_E1.3950.94
221_F224_D1.3720.93
162_F188_I1.3720.93
93_N97_M1.3700.93
26_L94_I1.3660.93
248_D252_A1.3570.93
42_I111_T1.3570.93
27_T33_P1.3550.93
133_R228_E1.3490.93
55_L240_L1.3410.92
140_Q228_E1.3360.92
251_K255_C1.3310.92
183_D302_S1.3290.92
162_F192_E1.3230.92
33_P36_V1.3210.92
62_G236_Y1.3120.91
52_E177_K1.2990.91
63_L70_Q1.2860.91
295_D298_S1.2860.91
93_N96_F1.2790.90
22_V88_E1.2520.89
136_Q140_Q1.2470.89
242_A247_A1.2330.89
205_K209_K1.2280.89
160_F226_L1.2250.88
71_N99_A1.2220.88
24_N103_R1.2200.88
46_Q114_Q1.2200.88
166_F304_Y1.2080.88
53_Q57_M1.2060.88
108_I181_T1.2030.87
234_L238_D1.2010.87
43_P46_Q1.2000.87
167_W237_T1.1980.87
98_E162_F1.1960.87
162_F166_F1.1900.87
134_K236_Y1.1870.87
219_K268_E1.1650.86
117_D120_A1.1570.85
294_H299_G1.1490.85
144_G149_K1.1470.85
206_N209_K1.1400.84
136_Q268_E1.1390.84
305_V310_V1.1340.84
24_N32_L1.1310.84
235_Q238_D1.1200.83
174_S281_A1.1200.83
8_A13_K1.1170.83
48_L178_L1.1160.83
300_S306_M1.1160.83
210_I213_G1.1090.83
298_S301_G1.1000.82
40_N44_A1.0950.82
173_S182_A1.0820.81
56_T181_T1.0790.81
278_V281_A1.0520.79
33_P100_V1.0460.79
88_E92_S1.0430.79
17_D21_E1.0380.78
18_K21_E1.0380.78
36_V187_L1.0310.78
219_K223_F1.0200.77
51_V243_E1.0020.76
230_Y255_C1.0010.76
148_L203_Y0.9950.75
204_Q207_M0.9880.75
200_G264_N0.9880.75
224_D231_D0.9870.75
20_L24_N0.9870.75
196_G261_A0.9810.74
33_P107_S0.9790.74
170_M189_I0.9680.73
259_N269_P0.9670.73
101_H191_D0.9670.73
27_T100_V0.9660.73
101_H304_Y0.9660.73
133_R137_I0.9490.72
196_G260_K0.9420.71
169_P185_I0.9340.71
252_A273_A0.9280.70
231_D234_L0.9280.70
46_Q224_D0.9200.69
50_V248_D0.9170.69
167_W281_A0.9170.69
221_F225_L0.9150.69
165_G188_I0.9090.69
46_Q51_V0.9070.68
166_F192_E0.9050.68
156_F229_L0.9050.68
160_F164_S0.9000.68
20_L103_R0.8960.67
223_F269_P0.8930.67
256_Y260_K0.8840.66
183_D187_L0.8820.66
212_L268_E0.8750.66
30_F93_N0.8720.65
158_E166_F0.8720.65
154_S199_I0.8690.65
75_A80_P0.8640.65
248_D251_K0.8640.65
138_I157_L0.8630.65
166_F195_H0.8630.65
268_E272_P0.8620.64
237_T254_L0.8600.64
106_S110_S0.8540.64
89_A99_A0.8540.64
19_D205_K0.8520.63
61_T121_A0.8490.63
96_F100_V0.8490.63
26_L29_N0.8490.63
23_W103_R0.8450.63
89_A92_S0.8440.63
77_S80_P0.8440.63
158_E195_H0.8420.63
18_K201_Y0.8410.62
44_A172_F0.8390.62
257_N261_A0.8380.62
159_S261_A0.8340.62
207_M219_K0.8290.61
38_L184_L0.8270.61
136_Q271_F0.8260.61
87_E202_K0.8240.61
156_F222_A0.8200.61
129_A268_E0.8170.60
198_Y202_K0.8160.60
16_D205_K0.8140.60
92_S221_F0.8120.60
36_V190_R0.8120.60
148_L221_F0.8090.59
81_D150_K0.8080.59
67_D181_T0.8080.59
259_N262_L0.8040.59
37_P40_N0.8020.59
120_A127_E0.7950.58
24_N28_S0.7950.58
237_T251_K0.7940.58
143_R146_D0.7930.58
255_C271_F0.7860.57
292_E299_G0.7850.57
292_E303_S0.7790.57
71_N95_S0.7770.56
173_S186_R0.7760.56
134_K295_D0.7740.56
8_A12_N0.7730.56
123_A127_E0.7710.56
38_L180_N0.7680.55
44_A47_T0.7670.55
209_K212_L0.7670.55
107_S110_S0.7640.55
195_H304_Y0.7640.55
294_H301_G0.7640.55
43_P235_Q0.7600.55
136_Q270_L0.7600.55
63_L165_G0.7550.54
15_S85_P0.7550.54
296_F301_G0.7540.54
10_N13_K0.7520.54
251_K254_L0.7490.54
50_V212_L0.7450.53
22_V197_Y0.7420.53
203_Y265_L0.7410.53
75_A79_M0.7360.52
26_L198_Y0.7350.52
67_D191_D0.7340.52
50_V227_L0.7330.52
116_K120_A0.7310.52
20_L23_W0.7310.52
230_Y234_L0.7260.51
94_I162_F0.7230.51
101_H192_E0.7220.51
101_H166_F0.7200.51
208_E267_Y0.7190.51
164_S254_L0.7160.50
32_L100_V0.7130.50
67_D195_H0.7120.50
201_Y205_K0.7120.50
259_N273_A0.7110.50
191_D195_H0.7100.50
233_E236_Y0.7090.50
158_E162_F0.7080.50
192_E304_Y0.7080.50
196_G256_Y0.7080.50
37_P180_N0.7060.49
70_Q157_L0.7050.49
295_D301_G0.7040.49
186_R292_E0.7000.49
226_L258_A0.7000.49
18_K33_P0.6990.49
108_I163_Y0.6980.49
174_S183_D0.6950.48
189_I286_L0.6930.48
66_L70_Q0.6910.48
126_E129_A0.6910.48
120_A238_D0.6870.47
262_L270_L0.6840.47
198_Y201_Y0.6810.47
69_L134_K0.6780.47
106_S306_M0.6780.47
31_W41_D0.6780.47
26_L194_V0.6780.47
49_T251_K0.6770.47
98_E195_H0.6750.46
219_K267_Y0.6720.46
19_D201_Y0.6720.46
65_L187_L0.6710.46
178_L184_L0.6690.46
55_L168_L0.6660.45
128_N239_E0.6660.45
35_K300_S0.6650.45
238_D242_A0.6650.45
127_E268_E0.6630.45
176_G287_S0.6600.45
109_F244_T0.6590.45
156_F253_F0.6590.45
150_K153_A0.6590.45
67_D304_Y0.6570.45
139_Q143_R0.6550.44
176_G302_S0.6550.44
67_D162_F0.6480.44
40_N43_P0.6440.43
297_F301_G0.6430.43
159_S180_N0.6380.43
152_I218_L0.6360.43
61_T193_A0.6360.43
39_S42_I0.6340.42
167_W249_D0.6340.42
160_F258_A0.6330.42
63_L295_D0.6310.42
48_L53_Q0.6300.42
152_I265_L0.6260.42
165_G169_P0.6260.42
255_C259_N0.6250.41
162_F195_H0.6250.41
64_T109_F0.6180.41
140_Q212_L0.6170.41
38_L111_T0.6170.41
47_T53_Q0.6160.41
130_P239_E0.6150.40
26_L93_N0.6120.40
105_Y166_F0.6090.40
133_R232_N0.6080.40
133_R139_Q0.6080.40
133_R238_D0.6080.40
269_P272_P0.6070.40
268_E273_A0.6060.40
67_D256_Y0.6050.40
43_P47_T0.6050.40
129_A231_D0.6030.39
56_T63_L0.6030.39
137_I228_E0.6030.39
105_Y195_H0.6010.39
285_A289_N0.6010.39
148_L210_I0.6000.39
50_V238_D0.6000.39
219_K224_D0.6000.39
50_V222_A0.6000.39
60_F64_T0.5980.39
145_D203_Y0.5980.39
11_W16_D0.5970.39
26_L90_V0.5950.39
268_E274_E0.5950.39
135_A141_H0.5940.38
309_A312_T0.5940.38
167_W285_A0.5930.38
46_Q120_A0.5930.38
58_R240_L0.5930.38
96_F99_A0.5910.38
76_P79_M0.5880.38
67_D106_S0.5880.38
19_D87_E0.5870.38
205_K208_E0.5850.38
238_D254_L0.5840.38
154_S196_G0.5840.38
30_F66_L0.5830.37
50_V129_A0.5810.37
191_D304_Y0.5800.37
182_A186_R0.5790.37
100_V307_G0.5770.37
205_K212_L0.5770.37
146_D208_E0.5770.37
227_L274_E0.5760.37
134_K162_F0.5750.37
183_D288_P0.5740.37
156_F225_L0.5740.37
49_T177_K0.5730.37
122_Y125_S0.5730.37
9_I12_N0.5720.36
154_S164_S0.5700.36
67_D101_H0.5690.36
199_I254_L0.5670.36
79_M95_S0.5670.36
31_W101_H0.5670.36
100_V240_L0.5630.36
188_I192_E0.5620.36
57_M71_N0.5620.36
64_T241_Y0.5610.35
230_Y254_L0.5580.35
283_L286_L0.5570.35
67_D199_I0.5570.35
112_L289_N0.5570.35
141_H221_F0.5560.35
70_Q74_G0.5550.35
231_D274_E0.5550.35
231_D263_M0.5550.35
206_N210_I0.5540.35
157_L169_P0.5530.35
98_E166_F0.5520.35
230_Y259_N0.5520.35
231_D238_D0.5510.35
93_N99_A0.5510.35
162_F304_Y0.5490.34
22_V198_Y0.5490.34
51_V212_L0.5470.34
22_V45_W0.5460.34
15_S100_V0.5450.34
207_M210_I0.5450.34
144_G228_E0.5450.34
108_I112_L0.5440.34
50_V268_E0.5430.34
294_H298_S0.5430.34
36_V180_N0.5400.34
177_K227_L0.5390.33
136_Q231_D0.5380.33
140_Q143_R0.5380.33
55_L243_E0.5370.33
93_N100_V0.5350.33
149_K218_L0.5340.33
101_H162_F0.5340.33
43_P224_D0.5340.33
159_S196_G0.5330.33
153_A225_L0.5320.33
66_L104_S0.5310.33
122_Y172_F0.5300.33
167_W254_L0.5290.33
144_G147_P0.5290.33
292_E302_S0.5290.33
25_R57_M0.5280.33
278_V283_L0.5280.33
86_H283_L0.5270.32
54_Q59_V0.5270.32
264_N298_S0.5270.32
127_E136_Q0.5260.32
85_P88_E0.5250.32
86_H110_S0.5240.32
130_P240_L0.5230.32
159_S195_H0.5230.32
15_S18_K0.5200.32
58_R254_L0.5200.32
197_Y261_A0.5200.32
253_F282_I0.5190.32
60_F181_T0.5190.32
139_Q235_Q0.5170.32
253_F296_F0.5160.31
136_Q224_D0.5160.31
128_N132_Q0.5150.31
64_T188_I0.5150.31
105_Y158_E0.5140.31
200_G265_L0.5130.31
78_L98_E0.5130.31
122_Y131_L0.5120.31
218_L267_Y0.5110.31
78_L150_K0.5110.31
104_S188_I0.5110.31
13_K86_H0.5100.31
76_P80_P0.5100.31
21_E228_E0.5090.31
21_E25_R0.5090.31
278_V298_S0.5080.31
7_S126_E0.5080.31
208_E228_E0.5070.31
70_Q199_I0.5070.31
91_L199_I0.5070.31
233_E266_G0.5060.31
263_M272_P0.5040.30
66_L282_I0.5030.30
98_E105_Y0.5030.30
43_P306_M0.5030.30
143_R147_P0.5020.30
134_K232_N0.5020.30
47_T120_A0.5010.30
244_T252_A0.5000.30
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3n37A 2 0.884 100 0.072 Contact Map
3dhzA 2 0.8997 100 0.083 Contact Map
4dr0A 2 0.8934 100 0.086 Contact Map
4n83A 4 0.8871 100 0.091 Contact Map
4bmoA 2 0.884 100 0.091 Contact Map
2rccA 4 0.8934 100 0.101 Contact Map
1mxrA 2 0.8871 100 0.109 Contact Map
1jk0A 1 0.8621 100 0.118 Contact Map
1jk0B 1 0.7712 100 0.123 Contact Map
1syyA 2 0.8715 100 0.126 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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