GREMLIN Database
NUDK - GDP-mannose pyrophosphatase NudK
UniProt: P37128 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12410
Length: 191 (165)
Sequences: 5806 (4108)
Seq/√Len: 319.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
49_T83_S3.0281.00
94_E98_R2.6081.00
111_E135_E2.5391.00
54_N59_T2.4801.00
102_I108_E2.4441.00
164_L185_Q2.3921.00
59_T159_P2.3521.00
163_A181_L2.2841.00
59_T157_E2.2811.00
81_I156_L2.1911.00
22_N38_K2.1891.00
14_S19_T2.1811.00
113_R135_E2.1521.00
165_E169_T2.1121.00
24_T36_R2.0951.00
114_K130_H2.0871.00
92_E95_V2.0871.00
61_V157_E2.0701.00
64_R154_E2.0321.00
117_E128_L1.9671.00
21_H43_D1.9661.00
26_D36_R1.9651.00
8_I24_T1.9651.00
88_L96_C1.9221.00
91_D99_K1.9081.00
43_D126_T1.9051.00
54_N157_E1.8961.00
114_K117_E1.8611.00
166_M171_E1.8591.00
11_K14_S1.8541.00
64_R156_L1.8191.00
98_R112_V1.8091.00
50_I97_I1.7881.00
158_L166_M1.7051.00
65_Q82_E1.6871.00
23_I68_V1.6751.00
24_T38_K1.6671.00
93_P130_H1.6491.00
10_D22_N1.6281.00
117_E130_H1.5941.00
101_A109_V1.5741.00
22_N40_E1.5711.00
159_P162_Q1.5491.00
162_Q165_E1.5181.00
119_Y173_R1.4981.00
94_E112_V1.4891.00
51_L180_L1.4791.00
95_V98_R1.4721.00
83_S180_L1.4581.00
27_L31_D1.4551.00
96_C99_K1.4431.00
78_G173_R1.4411.00
54_N57_K1.4201.00
9_K23_I1.3561.00
61_V107_Y1.3521.00
88_L93_P1.3461.00
15_D40_E1.3141.00
51_L184_L1.3021.00
84_C105_T1.2951.00
102_I146_G1.2881.00
9_K21_H1.2651.00
102_I143_N1.2391.00
68_V77_S1.2391.00
118_L179_L1.2241.00
139_N142_A1.1981.00
158_L163_A1.1851.00
30_K152_D1.1791.00
98_R102_I1.1571.00
114_K132_F1.1521.00
91_D96_C1.1471.00
70_T80_L1.1371.00
118_L131_F1.1351.00
70_T119_Y1.1291.00
46_N88_L1.1211.00
52_L101_A1.1181.00
93_P132_F1.1121.00
61_V155_V1.1081.00
121_S127_E1.0731.00
165_E168_K1.0701.00
164_L168_K1.0511.00
23_I41_V1.0271.00
162_Q166_M1.0201.00
167_I178_V1.0191.00
64_R79_Q0.9911.00
115_L133_I0.9851.00
110_G139_N0.9751.00
141_R144_A0.9631.00
48_A97_I0.9491.00
58_K160_F0.9461.00
109_V112_V0.9331.00
145_G148_V0.9291.00
18_F42_Y0.9141.00
131_F180_L0.9111.00
80_L122_P0.9111.00
11_K19_T0.9071.00
66_F77_S0.9031.00
53_Y133_I0.9011.00
7_L26_D0.8871.00
94_E114_K0.8781.00
44_R127_E0.8691.00
179_L182_N0.8661.00
60_V83_S0.8641.00
47_G129_I0.8551.00
49_T129_I0.8551.00
51_L60_V0.8501.00
107_Y142_A0.8451.00
97_I112_V0.8451.00
11_K21_H0.8361.00
10_D24_T0.8351.00
27_L30_K0.8271.00
46_N128_L0.8251.00
42_Y124_G0.8211.00
67_R82_E0.8171.00
60_V181_L0.8151.00
109_V134_A0.8111.00
50_I134_A0.8111.00
41_V68_V0.8081.00
110_G140_Q0.8021.00
174_D177_T0.8011.00
54_N107_Y0.7951.00
70_T78_G0.7901.00
53_Y160_F0.7871.00
119_Y128_L0.7711.00
51_L83_S0.7691.00
46_N130_H0.7580.99
60_V184_L0.7570.99
164_L181_L0.7550.99
83_S181_L0.7490.99
49_T176_K0.7480.99
108_E142_A0.7470.99
98_R108_E0.7450.99
20_L42_Y0.7450.99
19_T43_D0.7420.99
147_G153_I0.7410.99
7_L36_R0.7370.99
49_T131_F0.7360.99
62_L158_L0.7310.99
10_D21_H0.7300.99
112_V134_A0.7280.99
62_L156_L0.7250.99
113_R133_I0.7230.99
62_L81_I0.7230.99
167_I172_I0.7230.99
55_T135_E0.7220.99
120_M124_G0.7220.99
166_M169_T0.7090.99
58_K161_S0.7070.99
84_C101_A0.7000.99
118_L175_G0.6940.99
111_E114_K0.6940.99
116_F179_L0.6920.99
107_Y141_R0.6920.99
53_Y60_V0.6910.99
25_Y37_H0.6880.99
31_D152_D0.6820.99
172_I177_T0.6810.99
129_I176_K0.6760.99
79_Q152_D0.6680.99
94_E132_F0.6660.99
121_S125_V0.6570.98
112_V132_F0.6550.98
52_L133_I0.6550.98
85_A176_K0.6550.98
53_Y58_K0.6550.98
81_I158_L0.6490.98
52_L63_I0.6470.98
110_G141_R0.6460.98
63_I153_I0.6440.98
62_L163_A0.6370.98
163_A167_I0.6370.98
48_A93_P0.6360.98
13_L17_Y0.6350.98
12_I20_L0.6340.98
64_R81_I0.6300.98
102_I144_A0.6290.98
53_Y135_E0.6270.98
60_V160_F0.6240.98
116_F183_Y0.6240.98
140_Q143_N0.6200.98
97_I132_F0.6170.98
85_A123_G0.6160.98
128_L173_R0.6100.97
139_N143_N0.6100.97
116_F170_G0.6100.97
8_I36_R0.6090.97
10_D38_K0.6070.97
15_D19_T0.5990.97
117_E173_R0.5970.97
8_I26_D0.5950.97
167_I181_L0.5890.97
182_N185_Q0.5890.97
27_L37_H0.5850.97
108_E141_R0.5830.97
55_T58_K0.5800.97
97_I101_A0.5800.97
158_L162_Q0.5770.97
120_M175_G0.5770.97
47_G87_L0.5760.96
179_L183_Y0.5760.96
159_P164_L0.5740.96
161_S164_L0.5740.96
80_L119_Y0.5730.96
45_G87_L0.5730.96
60_V163_A0.5730.96
81_I166_M0.5690.96
111_E139_N0.5660.96
49_T85_A0.5660.96
120_M125_V0.5650.96
16_N22_N0.5640.96
160_F164_L0.5630.96
46_N87_L0.5620.96
156_L166_M0.5620.96
12_I15_D0.5620.96
52_L109_V0.5610.96
178_V182_N0.5610.96
118_L178_V0.5570.96
166_M172_I0.5490.95
67_R123_G0.5480.95
108_E140_Q0.5430.95
8_I11_K0.5380.95
53_Y184_L0.5380.95
52_L83_S0.5360.95
143_N146_G0.5350.95
20_L40_E0.5320.95
16_N40_E0.5320.95
181_L185_Q0.5310.95
50_I84_C0.5300.94
44_R124_G0.5290.94
116_F178_V0.5250.94
23_I77_S0.5190.94
160_F185_Q0.5180.94
88_L130_H0.5170.94
26_D33_E0.5160.94
13_L20_L0.5160.94
92_E132_F0.5160.94
141_R145_G0.5150.94
14_S22_N0.5150.94
145_G155_V0.5140.94
25_Y68_V0.5130.93
57_K157_E0.5130.93
54_N61_V0.5120.93
115_L184_L0.5120.93
12_I22_N0.5120.93
100_E104_E0.5110.93
162_Q171_E0.5080.93
143_N147_G0.5060.93
133_I183_Y0.5030.93
140_Q144_A0.5000.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1g0sA 2 0.9895 100 0.334 Contact Map
2dscA 2 0.9215 100 0.353 Contact Map
1vhzA 2 0.9215 100 0.363 Contact Map
3o6zA 2 0.9948 100 0.376 Contact Map
1mk1A 2 0.8429 100 0.405 Contact Map
2yvpA 2 0.9162 100 0.438 Contact Map
3q91A 2 0.7173 99.9 0.486 Contact Map
1v8yA 2 0.7749 99.9 0.492 Contact Map
2w4eA 2 0.6963 99.9 0.561 Contact Map
2fvvA 1 0.7016 99.8 0.605 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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