GREMLIN Database
PEPB - Peptidase B
UniProt: P37095 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12310
Length: 427 (348)
Sequences: 4196 (2618)
Seq/√Len: 140.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
265_Y271_V3.1661.00
325_D344_R2.9471.00
246_C287_G2.8231.00
159_G271_V2.7301.00
321_F374_A2.6961.00
232_A237_L2.6721.00
130_A226_T2.6691.00
114_I220_G2.6431.00
197_I248_A2.6181.00
309_A319_A2.6061.00
148_K151_D2.5821.00
126_L222_A2.4361.00
164_G171_P2.4101.00
168_E255_N2.3751.00
246_C283_V2.3211.00
122_G169_R2.3101.00
353_S356_P2.2901.00
321_F378_A2.2891.00
174_L247_C2.2031.00
145_R177_D2.1941.00
318_H416_L2.1781.00
352_R383_H2.1441.00
274_M365_T2.1411.00
288_L381_L2.1341.00
232_A241_V2.1321.00
244_F291_A2.1101.00
162_T263_I2.0591.00
159_G265_Y2.0241.00
317_Y348_A2.0101.00
105_M234_T1.9791.00
269_K383_H1.9671.00
129_R132_D1.9481.00
162_T257_F1.9051.00
197_I283_V1.9041.00
201_S251_L1.8921.00
204_Y252_I1.8711.00
190_A425_L1.8531.00
143_T177_D1.8361.00
328_A344_R1.8121.00
126_L247_C1.7851.00
331_L393_L1.7851.00
266_R289_I1.7631.00
322_S328_A1.7361.00
264_T270_K1.7211.00
151_D154_E1.7111.00
302_A421_I1.7051.00
358_N411_A1.7021.00
262_I359_F1.6991.00
180_P240_R1.6781.00
192_L225_V1.6681.00
292_S390_Q1.6681.00
230_A234_T1.6481.00
122_G125_Q1.6441.00
164_G248_A1.6441.00
274_M363_N1.6281.00
74_F77_G1.6151.00
235_R422_A1.6031.00
152_L173_L1.5751.00
106_I227_G1.5691.00
226_T245_L1.5331.00
134_I144_Y1.5331.00
334_S423_N1.5291.00
324_D391_G1.5241.00
148_K172_V1.5101.00
320_L395_I1.5031.00
318_H400_T1.4961.00
357_S360_A1.4951.00
301_D392_W1.4911.00
345_L374_A1.4861.00
308_A373_G1.4841.00
257_F263_I1.4831.00
292_S386_E1.4731.00
96_Q100_L1.4601.00
124_S169_R1.4571.00
148_K170_S1.4511.00
191_C291_A1.4411.00
337_Q423_N1.4371.00
149_G171_P1.4351.00
157_Y290_D1.4311.00
225_V243_L1.4261.00
149_G153_R1.4211.00
205_S209_T1.4171.00
121_L125_Q1.4111.00
321_F345_L1.4071.00
136_N230_A1.3961.00
123_P198_T1.3951.00
332_L342_F1.3951.00
192_L228_A1.3931.00
100_L104_L1.3891.00
165_R257_F1.3781.00
309_A345_L1.3771.00
189_Y242_K1.3741.00
112_D115_N1.3481.00
310_K371_P1.3401.00
269_K362_L1.3391.00
177_D294_Q1.3371.00
332_L344_R1.3361.00
110_V227_G1.3301.00
173_L287_G1.3181.00
266_R293_A1.3151.00
124_S172_V1.3111.00
232_A425_L1.3101.00
177_D240_R1.3041.00
102_N106_I1.2941.00
168_E253_S1.2941.00
362_L383_H1.2931.00
263_I282_L1.2931.00
149_G170_S1.2881.00
229_L232_A1.2781.00
309_A374_A1.2741.00
159_G263_I1.2661.00
231_F422_A1.2641.00
320_L393_L1.2611.00
181_T184_K1.2601.00
292_S387_N1.2571.00
267_N289_I1.2551.00
298_M424_L1.2541.00
106_I231_F1.2521.00
137_V230_A1.2471.00
325_D329_G1.2421.00
225_V302_A1.2411.00
147_T155_Q1.2291.00
213_D274_M1.2251.00
318_H395_I1.2221.00
320_L328_A1.2211.00
159_G285_A1.2081.00
190_A298_M1.2081.00
206_I209_T1.2061.00
118_A260_G1.2031.00
152_L160_L1.2001.00
158_M264_T1.2001.00
263_I273_V1.2001.00
174_L245_L1.1981.00
229_L243_L1.1931.00
219_M223_A1.1871.00
160_L173_L1.1841.00
331_L424_L1.1771.00
134_I176_L1.1650.99
329_G332_L1.1610.99
165_R255_N1.1600.99
149_G164_G1.1580.99
153_R165_R1.1540.99
323_F382_S1.1490.99
179_N240_R1.1490.99
189_Y297_E1.1460.99
102_N235_R1.1430.99
128_Q132_D1.1380.99
98_Q101_D1.1320.99
144_Y176_L1.1290.99
131_V135_S1.1270.99
347_L378_A1.1240.99
342_F420_T1.1220.99
181_T240_R1.1210.99
145_R175_A1.1110.99
292_S385_V1.1110.99
189_Y240_R1.1110.99
317_Y341_P1.0890.99
191_C296_P1.0870.99
244_F287_G1.0870.99
127_A146_I1.0710.99
191_C244_F1.0670.99
327_L393_L1.0640.99
363_N366_G1.0580.99
329_G333_A1.0540.99
149_G172_V1.0530.99
197_I246_C1.0530.99
107_I419_R1.0470.99
175_A290_D1.0470.99
315_N371_P1.0430.99
160_L248_A1.0430.99
316_D350_F1.0400.99
351_H372_A1.0380.99
248_A283_V1.0380.99
141_R236_G1.0340.99
161_H165_R1.0310.99
153_R161_H1.0310.99
300_I424_L1.0290.99
151_D155_Q1.0290.99
205_S212_M1.0290.99
222_A245_L1.0290.99
208_Q311_T1.0230.99
243_L302_A1.0220.99
176_L229_L1.0200.99
289_I293_A1.0200.99
156_G266_R1.0200.99
109_W133_L1.0130.99
217_S402_R1.0100.99
157_Y266_R1.0100.99
318_H417_G1.0100.99
128_Q131_V1.0060.98
341_P348_A1.0040.98
224_T418_V1.0030.98
72_W77_G1.0030.98
147_T175_A1.0010.98
94_D98_Q0.9960.98
265_Y289_I0.9940.98
123_P249_D0.9930.98
311_T368_A0.9890.98
175_A242_K0.9890.98
126_L174_L0.9850.98
130_A174_L0.9840.98
332_L336_A0.9840.98
368_A371_P0.9810.98
116_A120_E0.9800.98
147_T151_D0.9780.98
298_M391_G0.9750.98
127_A174_L0.9740.98
164_G249_D0.9720.98
142_V229_L0.9700.98
257_F282_L0.9690.98
352_R382_S0.9680.98
150_E153_R0.9680.98
291_A299_I0.9680.98
257_F273_V0.9630.98
299_I385_V0.9610.98
169_R258_K0.9600.98
134_I142_V0.9580.98
228_A421_I0.9580.98
152_L157_Y0.9550.98
228_A232_A0.9550.98
379_G382_S0.9550.98
127_A131_V0.9520.98
125_Q128_Q0.9460.98
125_Q129_R0.9450.98
122_G258_K0.9410.98
310_K374_A0.9400.98
123_P164_G0.9390.98
302_A417_G0.9390.98
295_K390_Q0.9380.98
127_A172_V0.9350.98
331_L342_F0.9320.98
288_L385_V0.9300.97
330_R424_L0.9290.97
298_M327_L0.9280.97
375_S379_G0.9280.97
310_K315_N0.9240.97
415_G418_V0.9230.97
352_R379_G0.9230.97
146_I174_L0.9210.97
113_T219_M0.9140.97
311_T371_P0.9110.97
175_A244_F0.9090.97
178_Y236_G0.9090.97
347_L379_G0.9080.97
251_L258_K0.9070.97
110_V224_T0.9060.97
196_G222_A0.9050.97
133_L230_A0.9040.97
352_R356_P0.8990.97
175_A294_Q0.8880.97
176_L226_T0.8850.97
318_H342_F0.8840.97
327_L424_L0.8840.97
125_Q169_R0.8790.96
143_T179_N0.8780.96
149_G161_H0.8750.96
208_Q211_F0.8720.96
302_A395_I0.8710.96
355_L365_T0.8690.96
265_Y380_F0.8620.96
101_D105_M0.8610.96
77_G116_A0.8570.96
155_Q266_R0.8570.96
114_I413_A0.8540.96
142_V233_I0.8500.96
300_I421_I0.8460.96
191_C299_I0.8430.96
191_C294_Q0.8430.96
288_L299_I0.8410.95
192_L425_L0.8410.95
72_W75_W0.8390.95
275_N373_G0.8390.95
166_G252_I0.8320.95
335_A420_T0.8250.95
77_G120_E0.8230.95
310_K399_A0.8190.95
290_D294_Q0.8170.95
351_H375_S0.8140.95
299_I390_Q0.8120.95
338_E423_N0.8070.94
206_I252_I0.8070.94
333_A337_Q0.8050.94
191_C242_K0.8040.94
352_R362_L0.8030.94
74_F78_Y0.8020.94
224_T228_A0.8020.94
131_V144_Y0.8020.94
242_K294_Q0.7980.94
309_A400_T0.7980.94
173_L244_F0.7960.94
193_V299_I0.7960.94
320_L332_L0.7960.94
354_Q376_T0.7950.94
145_R151_D0.7930.94
109_W230_A0.7920.94
72_W115_N0.7920.94
152_L161_H0.7910.94
349_E382_S0.7890.94
354_Q366_G0.7890.94
116_A121_L0.7820.93
228_A422_A0.7810.93
244_F294_Q0.7800.93
372_A375_S0.7800.93
168_E254_G0.7730.93
126_L226_T0.7710.93
152_L266_R0.7680.93
99_E103_R0.7650.93
120_E125_Q0.7630.92
147_T290_D0.7590.92
356_P383_H0.7560.92
387_N390_Q0.7560.92
173_L246_C0.7550.92
76_Q116_A0.7530.92
323_F385_V0.7520.92
127_A144_Y0.7500.92
345_L375_S0.7480.92
271_V362_L0.7460.92
308_A311_T0.7440.92
75_W79_K0.7440.92
103_R422_A0.7410.91
159_G273_V0.7390.91
160_L283_V0.7390.91
197_I287_G0.7380.91
229_L233_I0.7370.91
244_F290_D0.7350.91
177_D242_K0.7320.91
282_L364_N0.7310.91
160_L164_G0.7300.91
252_I256_A0.7290.91
293_A386_E0.7280.91
205_S274_M0.7270.91
334_S338_E0.7260.91
166_G253_S0.7220.90
75_W78_Y0.7210.90
102_N234_T0.7200.90
149_G248_A0.7190.90
137_V142_V0.7190.90
220_G224_T0.7160.90
216_K359_F0.7140.90
347_L392_W0.7140.90
237_L425_L0.7120.90
355_L362_L0.7110.90
181_T185_E0.7090.89
121_L126_L0.7080.89
300_I425_L0.7080.89
71_C74_F0.7070.89
362_L384_F0.7050.89
152_L172_V0.7030.89
217_S413_A0.7020.89
275_N365_T0.7020.89
341_P350_F0.7020.89
265_Y285_A0.6980.89
292_S299_I0.6970.89
192_L241_V0.6970.89
332_L335_A0.6960.89
417_G420_T0.6950.89
373_G376_T0.6930.88
124_S128_Q0.6930.88
209_T213_D0.6910.88
340_E416_L0.6910.88
247_C283_V0.6900.88
152_L248_A0.6890.88
217_S220_G0.6890.88
283_V287_G0.6880.88
289_I386_E0.6880.88
112_D129_R0.6880.88
217_S401_Y0.6880.88
111_R410_S0.6860.88
132_D136_N0.6860.88
239_K425_L0.6850.88
74_F79_K0.6820.88
331_L420_T0.6800.87
69_D72_W0.6790.87
354_Q368_A0.6750.87
180_P183_D0.6750.87
205_S208_Q0.6740.87
137_V233_I0.6730.87
99_E422_A0.6720.87
228_A425_L0.6700.87
180_P238_N0.6690.87
416_L420_T0.6660.86
182_G240_R0.6650.86
338_E341_P0.6640.86
137_V234_T0.6620.86
322_S344_R0.6590.86
367_S371_P0.6580.86
290_D293_A0.6560.86
354_Q367_S0.6550.85
321_F347_L0.6510.85
348_A351_H0.6510.85
133_L226_T0.6490.85
103_R231_F0.6490.85
201_S216_K0.6480.85
320_L342_F0.6480.85
385_V390_Q0.6470.85
131_V146_I0.6460.85
106_I230_A0.6460.85
271_V380_F0.6450.85
216_K272_E0.6440.84
273_V365_T0.6440.84
204_Y211_F0.6430.84
72_W112_D0.6430.84
351_H379_G0.6420.84
123_P248_A0.6390.84
109_W129_R0.6380.84
224_T302_A0.6370.84
269_K386_E0.6360.84
133_L142_V0.6340.84
335_A338_E0.6340.84
106_I110_V0.6330.83
325_D328_A0.6290.83
326_A330_R0.6280.83
110_V418_V0.6270.83
74_F84_T0.6260.83
204_Y213_D0.6230.82
309_A312_A0.6210.82
233_I237_L0.6210.82
265_Y269_K0.6180.82
386_E390_Q0.6170.82
210_A213_D0.6150.82
160_L171_P0.6120.81
349_E353_S0.6120.81
166_G256_A0.6090.81
150_E154_E0.6070.81
249_D258_K0.6070.81
272_E357_S0.6050.81
77_G84_T0.6050.81
162_T165_R0.6040.81
108_D112_D0.6040.81
126_L245_L0.6030.80
377_A381_L0.6000.80
112_D116_A0.5980.80
126_L130_A0.5970.80
271_V285_A0.5960.80
205_S213_D0.5940.79
228_A243_L0.5920.79
308_A377_A0.5920.79
213_D260_G0.5920.79
379_G383_H0.5920.79
329_G344_R0.5910.79
98_Q102_N0.5860.79
173_L283_V0.5860.79
328_A332_L0.5830.78
403_K410_S0.5820.78
273_V276_T0.5820.78
136_N141_R0.5800.78
311_T374_A0.5780.78
408_Q419_R0.5780.78
331_L421_I0.5770.77
355_L379_G0.5770.77
120_E262_I0.5760.77
263_I271_V0.5750.77
204_Y214_S0.5740.77
116_A125_Q0.5740.77
105_M230_A0.5720.77
189_Y296_P0.5710.77
107_I418_V0.5690.76
115_N413_A0.5690.76
233_I243_L0.5680.76
75_W84_T0.5680.76
166_G204_Y0.5670.76
209_T212_M0.5670.76
405_P411_A0.5650.76
137_V141_R0.5640.76
119_E165_R0.5630.76
109_W226_T0.5630.76
397_C401_Y0.5610.75
327_L391_G0.5580.75
133_L137_V0.5580.75
385_V392_W0.5580.75
222_A247_C0.5560.75
368_A372_A0.5560.75
313_L318_H0.5550.75
220_G413_A0.5530.74
104_L108_D0.5510.74
275_N308_A0.5500.74
205_S260_G0.5480.74
309_A321_F0.5480.74
97_R100_L0.5450.73
321_F375_S0.5440.73
220_G401_Y0.5430.73
214_S217_S0.5420.73
193_V288_L0.5420.73
142_V178_Y0.5410.73
166_G255_N0.5400.73
198_T248_A0.5400.73
183_D240_R0.5390.73
201_S204_Y0.5370.72
146_I172_V0.5360.72
366_G376_T0.5360.72
144_Y174_L0.5350.72
158_M162_T0.5340.72
116_A129_R0.5330.72
95_A98_Q0.5320.72
342_F417_G0.5300.71
213_D365_T0.5290.71
176_L245_L0.5280.71
180_P184_K0.5280.71
102_N231_F0.5260.71
204_Y251_L0.5260.71
134_I137_V0.5230.70
106_I109_W0.5210.70
266_R290_D0.5200.70
141_R178_Y0.5190.70
343_W346_P0.5190.70
130_A245_L0.5180.70
335_A341_P0.5170.69
126_L198_T0.5170.69
181_T189_Y0.5140.69
354_Q371_P0.5140.69
347_L382_S0.5130.69
152_L171_P0.5110.69
273_V364_N0.5100.68
289_I292_S0.5090.68
110_V223_A0.5080.68
142_V176_L0.5060.68
323_F392_W0.5060.68
342_F416_L0.5040.68
338_E420_T0.5020.67
205_S211_F0.5020.67
313_L319_A0.5010.67
208_Q212_M0.5000.67
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3peiA 5 0.8876 100 0.09 Contact Map
1gytA 6 0.9485 100 0.092 Contact Map
3h8gF 5 0.9766 100 0.094 Contact Map
3jruB 5 0.9461 100 0.094 Contact Map
1lamA 5 0.9766 100 0.1 Contact Map
3kzwA 6 0.9532 100 0.105 Contact Map
4ksiA 5 0.9438 100 0.118 Contact Map
3kr4A 5 0.9719 100 0.126 Contact Map
3ij3A 5 0.9649 100 0.131 Contact Map
4efdA 5 0.9649 100 0.144 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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