GREMLIN Database
PURU - Formyltetrahydrofolate deformylase
UniProt: P37051 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11819
Length: 280 (275)
Sequences: 2341 (1254)
Seq/√Len: 75.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
219_Y265_V5.2031.00
125_R129_E5.0631.00
151_K154_D5.0461.00
122_D125_R4.5441.00
117_V128_V3.8531.00
231_M236_H3.7721.00
138_V148_H3.6851.00
200_R203_H3.4181.00
87_I112_V3.1641.00
26_I67_L3.1201.00
27_C32_L3.0891.00
141_E144_T2.9941.00
175_P222_D2.8101.00
85_R268_Q2.7891.00
112_V266_L2.7321.00
88_V116_A2.6391.00
86_R113_E2.6181.00
153_A180_R2.5541.00
241_Y249_A2.5241.00
233_D257_V2.4331.00
91_V119_G2.3771.00
157_D180_R2.3521.00
60_D64_L2.3161.00
154_D158_A2.3051.00
115_A161_P2.2951.00
84_R113_E2.2051.00
223_N226_E2.1901.00
86_R160_Q2.0401.00
181_F185_I2.0361.00
15_D33_N1.9861.00
90_L152_M1.9541.00
88_V161_P1.9481.00
149_D174_T1.8831.00
100_D104_K1.8671.00
101_L262_L1.8591.00
116_A159_Y1.8221.00
30_H66_D1.8021.00
95_A124_L1.7971.00
217_A261_A1.7931.00
144_T147_E1.7311.00
166_L220_V1.7291.00
15_D41_V1.7201.00
80_N268_Q1.7171.00
182_P185_I1.7141.00
118_I152_M1.7101.00
156_I164_V1.6601.00
6_R53_E1.6511.00
122_D137_L1.6381.00
26_I66_D1.5960.99
253_V257_V1.5960.99
183_N272_V1.5950.99
126_S129_E1.5860.99
163_Y262_L1.5730.99
36_Q53_E1.5360.99
104_K259_S1.5000.99
21_A25_N1.4750.99
93_K123_T1.4520.99
243_A247_M1.4480.99
153_A181_F1.4450.99
12_I76_V1.4430.99
273_Y278_I1.4420.99
235_I253_V1.4300.99
136_E159_Y1.4200.99
116_A161_P1.4180.99
25_N29_K1.3980.99
176_E179_A1.3940.99
87_I163_Y1.3850.99
86_R115_A1.3800.98
145_R174_T1.3730.98
243_A246_M1.3630.98
23_I50_M1.3530.98
59_N62_T1.3490.98
150_Q154_D1.3440.98
146_N176_E1.3220.98
8_V268_Q1.3090.98
146_N150_Q1.3090.98
88_V156_I1.3070.98
203_H207_E1.2860.98
22_R73_E1.2860.98
99_G103_M1.2840.98
238_D241_Y1.2780.98
242_T245_D1.2770.97
263_Y267_A1.2730.97
95_A103_M1.2570.97
186_I230_I1.2390.97
202_Y250_G1.2320.97
140_H145_R1.2280.97
203_H247_M1.2160.97
62_T65_A1.1950.96
175_P179_A1.1890.96
145_R171_R1.1640.96
140_H148_H1.1620.96
179_A182_P1.1570.95
16_Q73_E1.1570.95
147_E151_K1.1550.95
68_D72_P1.1460.95
138_V151_K1.1390.95
127_L131_F1.1360.95
138_V155_A1.1210.95
84_R111_D1.1100.94
136_E155_A1.1070.94
109_G251_R1.1060.94
9_L79_L1.1020.94
88_V118_I1.1010.94
24_T37_N1.0920.94
112_V115_A1.0870.94
126_S132_D1.0850.94
10_R78_E1.0850.94
165_V258_L1.0840.94
204_Q226_E1.0810.94
140_H144_T1.0800.94
100_D252_D1.0790.93
197_I226_E1.0760.93
100_D259_S1.0750.93
178_V185_I1.0660.93
85_R162_D1.0660.93
90_L164_V1.0640.93
67_L77_R1.0540.93
44_R207_E1.0470.92
39_E52_T1.0330.92
21_A28_Y1.0280.92
60_D81_P1.0210.91
32_L56_G1.0180.91
153_A176_E1.0090.91
233_D260_R1.0070.91
90_L118_I1.0000.91
69_S73_E0.9990.91
105_A114_I0.9970.90
23_I75_S0.9950.90
26_I30_H0.9860.90
95_A99_G0.9830.90
271_F280_L0.9790.90
265_V270_V0.9740.89
85_R266_L0.9730.89
99_G127_L0.9660.89
122_D129_E0.9650.89
150_Q176_E0.9630.89
92_T119_G0.9520.88
7_K54_L0.9500.88
164_V181_F0.9450.88
65_A68_D0.9420.88
35_V55_E0.9360.87
33_N55_E0.9340.87
87_I115_A0.9290.87
33_N39_E0.9270.87
111_D266_L0.9190.86
37_N52_T0.9110.86
20_I24_T0.9050.86
119_G169_Y0.8960.85
231_M260_R0.8900.85
16_Q22_R0.8840.84
6_R35_V0.8840.84
115_A159_Y0.8840.84
245_D248_R0.8730.84
69_S72_P0.8710.83
248_R263_Y0.8700.83
88_V155_A0.8660.83
196_F210_V0.8650.83
16_Q74_G0.8640.83
104_K252_D0.8630.83
141_E147_E0.8610.83
212_I236_H0.8570.82
95_A106_N0.8530.82
19_L23_I0.8510.82
235_I249_A0.8500.82
153_A157_D0.8480.82
47_R273_Y0.8420.81
119_G133_I0.8360.81
19_L39_E0.8350.81
71_L77_R0.8350.81
66_D69_S0.8330.81
80_N83_G0.8300.80
179_A222_D0.8290.80
64_L77_R0.8270.80
115_A118_I0.8250.80
47_R76_V0.8150.79
17_K28_Y0.8130.79
233_D236_H0.8130.79
104_K109_G0.8130.79
154_D157_D0.8120.79
149_D153_A0.8120.79
173_L177_F0.8050.78
62_T66_D0.8040.78
152_M177_F0.8020.78
89_I114_I0.8010.78
60_D79_L0.7990.78
61_S64_L0.7990.78
19_L33_N0.7980.78
15_D37_N0.7970.78
36_Q240_T0.7970.78
87_I266_L0.7970.78
9_L54_L0.7970.78
178_V222_D0.7890.77
27_C54_L0.7880.77
67_L79_L0.7880.77
124_L135_F0.7870.77
99_G255_K0.7840.76
252_D256_N0.7810.76
128_V133_I0.7750.76
152_M156_I0.7700.75
17_K33_N0.7670.75
178_V184_K0.7620.74
12_I47_R0.7610.74
148_H152_M0.7610.74
200_R247_M0.7550.74
105_A113_E0.7540.74
103_M131_F0.7510.73
87_I162_D0.7490.73
29_K66_D0.7450.73
174_T261_A0.7390.72
60_D82_A0.7370.72
116_A155_A0.7350.72
91_V98_L0.7310.71
205_A250_G0.7270.71
24_T28_Y0.7260.71
7_K60_D0.7240.70
156_I161_P0.7240.70
140_H169_Y0.7210.70
233_D253_V0.7190.70
64_L81_P0.7190.70
86_R161_P0.7190.70
176_E180_R0.7170.70
11_T50_M0.7160.70
116_A136_E0.7150.70
212_I231_M0.7150.70
149_D261_A0.7110.69
78_E268_Q0.7090.69
94_E204_Q0.7070.69
191_S220_V0.7060.69
237_V241_Y0.7060.69
202_Y205_A0.7050.68
33_N185_I0.7030.68
27_C63_L0.7020.68
13_C75_S0.7020.68
140_H171_R0.7010.68
173_L178_V0.6970.68
117_V129_E0.6920.67
26_I70_A0.6920.67
163_Y266_L0.6910.67
94_E124_L0.6890.67
95_A109_G0.6870.66
206_Y276_R0.6860.66
19_L41_V0.6860.66
26_I77_R0.6860.66
20_I34_I0.6830.66
213_I221_N0.6820.66
105_A133_I0.6810.66
197_I223_N0.6790.66
17_K31_E0.6780.65
11_T23_I0.6710.65
190_H215_A0.6700.65
150_Q160_Q0.6700.65
238_D249_A0.6690.64
207_E275_N0.6680.64
98_L117_V0.6660.64
129_E132_D0.6660.64
203_H243_A0.6640.64
117_V132_D0.6600.63
178_V183_N0.6600.63
102_L133_I0.6590.63
138_V152_M0.6570.63
22_R25_N0.6560.63
240_T279_I0.6550.63
17_K57_I0.6530.63
89_I101_L0.6520.62
256_N260_R0.6510.62
241_Y245_D0.6500.62
182_P272_V0.6500.62
87_I165_V0.6490.62
204_Q207_E0.6470.62
177_F181_F0.6460.62
233_D256_N0.6450.62
65_A69_S0.6450.62
54_L177_F0.6440.61
190_H201_P0.6430.61
35_V249_A0.6430.61
15_D19_L0.6400.61
149_D173_L0.6380.61
70_A73_E0.6370.61
42_D273_Y0.6360.61
124_L127_L0.6350.60
44_R206_Y0.6340.60
189_H198_G0.6340.60
189_H225_D0.6320.60
164_V185_I0.6310.60
12_I37_N0.6270.59
159_Y162_D0.6230.59
174_T177_F0.6230.59
87_I114_I0.6230.59
42_D45_T0.6230.59
6_R55_E0.6210.59
92_T168_K0.6200.59
67_L71_L0.6170.58
14_P74_G0.6130.58
236_H264_K0.6120.58
22_R28_Y0.6120.58
142_G147_E0.6110.57
39_E50_M0.6100.57
22_R29_K0.6070.57
151_K158_A0.6060.57
94_E247_M0.6060.57
27_C52_T0.6040.57
149_D217_A0.6040.57
155_A158_A0.5990.56
19_L37_N0.5980.56
35_V43_H0.5980.56
28_Y276_R0.5960.56
111_D267_A0.5930.55
7_K81_P0.5920.55
262_L265_V0.5900.55
12_I273_Y0.5870.54
9_L77_R0.5870.54
266_L272_V0.5870.54
134_P159_Y0.5850.54
52_T217_A0.5830.54
99_G107_Y0.5810.54
229_I232_Q0.5800.54
95_A127_L0.5800.54
85_R134_P0.5790.53
212_I257_V0.5770.53
112_V163_Y0.5760.53
117_V130_R0.5760.53
192_F208_R0.5760.53
156_I181_F0.5740.53
140_H174_T0.5730.53
123_T128_V0.5720.53
244_E251_R0.5700.52
87_I262_L0.5690.52
64_L68_D0.5690.52
165_V262_L0.5680.52
45_T278_I0.5670.52
83_G157_D0.5660.52
128_V132_D0.5660.52
173_L185_I0.5650.52
99_G131_F0.5640.52
206_Y213_I0.5640.52
62_T68_D0.5630.51
61_S160_Q0.5630.51
59_N70_A0.5610.51
33_N41_V0.5610.51
106_N131_F0.5590.51
118_I155_A0.5580.51
115_A133_I0.5550.50
127_L142_G0.5540.50
136_E158_A0.5530.50
64_L73_E0.5530.50
142_G160_Q0.5530.50
86_R158_A0.5520.50
217_A276_R0.5510.50
199_A204_Q0.5500.50
181_F184_K0.5500.50
114_I133_I0.5500.50
84_R87_I0.5480.50
75_S168_K0.5470.49
147_E150_Q0.5470.49
172_V272_V0.5440.49
104_K199_A0.5430.49
117_V133_I0.5430.49
174_T217_A0.5430.49
84_R164_V0.5420.49
37_N41_V0.5400.49
25_N65_A0.5400.49
33_N195_A0.5400.49
141_E146_N0.5390.48
197_I220_V0.5390.48
155_A159_Y0.5350.48
111_D117_V0.5350.48
175_P237_V0.5350.48
192_F257_V0.5320.48
154_D180_R0.5310.47
71_L97_C0.5310.47
185_I220_V0.5300.47
23_I278_I0.5290.47
90_L156_I0.5290.47
126_S130_R0.5280.47
156_I180_R0.5280.47
201_P215_A0.5280.47
54_L152_M0.5270.47
38_N280_L0.5270.47
21_A24_T0.5260.47
208_R211_K0.5250.47
6_R117_V0.5240.47
11_T52_T0.5230.46
94_E251_R0.5210.46
119_G223_N0.5210.46
37_N48_F0.5210.46
190_H239_H0.5180.46
135_F221_N0.5180.46
16_Q35_V0.5170.46
10_R271_F0.5170.46
185_I195_A0.5160.46
157_D160_Q0.5140.45
121_H140_H0.5140.45
204_Q247_M0.5120.45
105_A119_G0.5100.45
21_A103_M0.5090.45
10_R36_Q0.5090.45
132_D136_E0.5080.45
197_I204_Q0.5080.45
157_D181_F0.5070.44
153_A156_I0.5050.44
109_G263_Y0.5050.44
24_T212_I0.5050.44
192_F234_V0.5050.44
182_P222_D0.5040.44
170_M218_H0.5040.44
178_V182_P0.5040.44
36_Q40_F0.5020.44
128_V185_I0.5000.44
102_L131_F0.5000.44
137_L260_R0.5000.44
131_F195_A0.5000.44
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3nrbA 4 0.9929 100 0.251 Contact Map
3louA 3 0.9893 100 0.253 Contact Map
3obiA 4 0.9893 100 0.259 Contact Map
3n0vA 4 0.9857 100 0.267 Contact Map
3o1lA 3 1 100 0.268 Contact Map
3w7bA 3 0.9893 100 0.273 Contact Map
1jkxA 2 0.7 100 0.504 Contact Map
3tqrA 2 0.7 100 0.507 Contact Map
2ywrA 2 0.7036 100 0.511 Contact Map
3aufA 2 0.7393 100 0.511 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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