YAEI - ECOLI - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

YAEI - Phosphodiesterase YaeI

UniProt:	P37049	Sequences: MISRRRFLQATAATIATSSGFGYMHYCEPGWFELIRHRLAFFKDNAAPFKILFLADLHYSRFVPLSLISDAIALGIEQKPDLILLGGDYVLFDMSLNFSAFSDVLSPLAECAPTFACFGNHDRPVGTEKNHLIGETLKSAGITVLFNQATVIATPNRQFELVGTGDLWAGQCKPPPASEANLPRLVLAHNPDSKEVMRDEPWDLMLCGHTHGGQLRVPLVGEPFAPVEDKRYVAGLNAFGERHIYTTRGVGSLYGLRLNCRPEVTMLELV	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG12337
Length:	270 (250)
Sequences:	4180 (3234)
Seq/√Len:	204.5

ECOLI - YAEI
BACSU - YKUE YKOQ YPBG

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
53_F	86_G	5.356	1.00
84_L	187_L	3.933	1.00
50_K	268_E	3.631	1.00
41_F	183_P	3.308	1.00
49_F	112_A	3.213	1.00
83_I	108_L	2.935	1.00
234_A	248_R	2.742	1.00
38_R	268_E	2.732	1.00
78_Q	266_M	2.729	1.00
52_L	266_M	2.702	1.00
143_T	150_T	2.490	1.00
134_G	146_F	2.449	1.00
245_Y	265_T	2.408	1.00
238_A	243_H	2.394	1.00
36_R	268_E	2.349	1.00
146_F	165_G	2.309	1.00
236_L	243_H	2.298	1.00
153_A	158_Q	2.261	1.00
52_L	75_G	2.245	1.00
116_A	144_V	2.117	1.00
52_L	80_P	2.081	1.00
69_S	107_P	2.043	1.00
55_A	247_T	2.018	1.00
115_F	161_L	1.964	1.00
162_V	184_R	1.956	1.00
50_K	266_M	1.934	1.00
54_L	75_G	1.916	1.00
51_I	82_L	1.870	1.00
53_F	206_L	1.866	1.00
205_M	242_R	1.860	1.00
151_V	160_E	1.843	1.00
114_T	142_I	1.828	1.00
37_H	245_Y	1.793	1.00
160_E	182_L	1.790	1.00
84_L	206_L	1.786	1.00
237_N	246_T	1.748	1.00
74_L	78_Q	1.721	1.00
85_L	89_Y	1.720	1.00
36_R	78_Q	1.677	1.00
72_I	76_I	1.657	1.00
115_F	150_T	1.629	1.00
160_E	184_R	1.611	1.00
173_K	176_P	1.600	1.00
206_L	267_L	1.595	1.00
118_F	134_G	1.575	1.00
188_A	207_C	1.572	1.00
76_I	111_C	1.567	1.00
43_K	46_A	1.531	1.00
238_A	241_E	1.527	1.00
143_T	148_Q	1.527	1.00
161_L	185_L	1.521	1.00
151_V	158_Q	1.511	1.00
149_A	160_E	1.499	1.00
69_S	73_A	1.497	1.00
31_W	261_R	1.494	1.00
52_L	78_Q	1.479	1.00
48_P	268_E	1.457	1.00
37_H	265_T	1.444	1.00
86_G	187_L	1.430	1.00
84_L	161_L	1.424	1.00
86_G	206_L	1.420	1.00
27_C	31_W	1.419	1.00
53_F	247_T	1.410	1.00
178_S	202_W	1.405	1.00
194_K	244_I	1.372	1.00
35_I	248_R	1.337	1.00
55_A	86_G	1.336	1.00
54_L	57_L	1.322	1.00
153_A	156_N	1.318	1.00
149_A	162_V	1.307	1.00
36_R	266_M	1.293	1.00
151_V	182_L	1.293	1.00
194_K	239_F	1.289	1.00
136_T	139_S	1.280	1.00
232_Y	237_N	1.270	1.00
166_D	190_N	1.270	1.00
45_N	157_R	1.270	1.00
46_A	154_T	1.258	1.00
164_T	188_A	1.257	1.00
24_M	28_E	1.254	1.00
50_K	78_Q	1.247	1.00
236_L	245_Y	1.231	1.00
71_A	250_V	1.220	1.00
179_E	182_L	1.218	1.00
135_E	139_S	1.214	1.00
194_K	242_R	1.205	1.00
134_G	138_K	1.169	1.00
162_V	202_W	1.164	1.00
69_S	104_V	1.162	1.00
154_T	157_R	1.153	1.00
42_F	48_P	1.147	1.00
33_E	261_R	1.143	1.00
86_G	247_T	1.140	1.00
34_L	78_Q	1.136	1.00
186_V	202_W	1.129	1.00
247_T	265_T	1.120	1.00
173_K	177_A	1.118	1.00
245_Y	267_L	1.110	1.00
42_F	269_L	1.109	1.00
134_G	144_V	1.108	1.00
74_L	77_E	1.097	1.00
42_F	46_A	1.086	1.00
54_L	85_L	1.082	1.00
85_L	142_I	1.078	1.00
34_L	264_V	1.066	1.00
152_I	161_L	1.064	1.00
159_F	183_P	1.063	1.00
35_I	263_E	1.056	1.00
63_V	68_I	1.053	1.00
23_Y	27_C	1.051	1.00
110_E	113_P	1.049	1.00
82_L	115_F	1.049	1.00
46_A	159_F	1.047	1.00
79_K	111_C	1.042	1.00
51_I	84_L	1.041	1.00
59_Y	68_I	1.031	1.00
158_Q	182_L	1.025	1.00
106_S	140_A	1.023	1.00
30_G	60_S	1.022	1.00
116_A	137_L	1.022	1.00
83_I	110_E	1.017	1.00
102_S	139_S	1.013	1.00
53_F	267_L	1.007	1.00
123_R	165_G	1.004	1.00
225_A	228_E	0.991	1.00
58_H	211_H	0.988	1.00
147_N	165_G	0.987	1.00
188_A	193_S	0.980	1.00
233_V	237_N	0.978	1.00
53_F	84_L	0.970	1.00
24_M	258_L	0.970	1.00
237_N	244_I	0.969	1.00
82_L	152_I	0.969	1.00
23_Y	29_P	0.963	0.99
43_K	48_P	0.963	0.99
39_L	236_L	0.960	0.99
75_G	108_L	0.956	0.99
40_A	243_H	0.955	0.99
110_E	114_T	0.951	0.99
135_E	138_K	0.950	0.99
138_K	144_V	0.949	0.99
102_S	136_T	0.945	0.99
184_R	202_W	0.945	0.99
37_H	236_L	0.939	0.99
32_F	74_L	0.927	0.99
72_I	104_V	0.924	0.99
133_I	137_L	0.923	0.99
212_G	248_R	0.917	0.99
46_A	49_F	0.913	0.99
137_L	142_I	0.909	0.99
57_L	250_V	0.908	0.99
186_V	197_M	0.906	0.99
86_G	117_C	0.905	0.99
76_I	109_A	0.902	0.99
45_N	48_P	0.900	0.99
24_M	27_C	0.900	0.99
46_A	157_R	0.897	0.99
37_H	267_L	0.894	0.99
160_E	179_E	0.890	0.99
116_A	142_I	0.888	0.99
76_I	110_E	0.888	0.99
25_H	28_E	0.888	0.99
74_L	264_V	0.883	0.99
217_V	220_V	0.879	0.99
20_G	24_M	0.873	0.99
104_V	107_P	0.871	0.99
174_P	186_V	0.871	0.99
248_R	260_C	0.868	0.99
35_I	265_T	0.863	0.99
24_M	29_P	0.860	0.99
73_A	107_P	0.855	0.99
83_I	114_T	0.851	0.99
168_W	190_N	0.842	0.99
29_P	252_S	0.840	0.99
112_A	154_T	0.836	0.99
174_P	177_A	0.834	0.99
204_L	267_L	0.831	0.99
212_G	233_V	0.827	0.98
162_V	177_A	0.826	0.98
212_G	261_R	0.825	0.98
21_F	25_H	0.823	0.98
232_Y	244_I	0.822	0.98
122_D	133_I	0.820	0.98
251_G	257_R	0.816	0.98
53_F	245_Y	0.814	0.98
22_G	26_Y	0.812	0.98
89_Y	137_L	0.807	0.98
89_Y	116_A	0.807	0.98
149_A	177_A	0.807	0.98
120_N	209_H	0.803	0.98
212_G	234_A	0.798	0.98
192_D	228_E	0.790	0.98
198_R	239_F	0.788	0.98
60_S	91_L	0.787	0.98
120_N	211_H	0.786	0.98
34_L	266_M	0.785	0.98
185_L	204_L	0.784	0.98
58_H	121_H	0.783	0.98
39_L	204_L	0.779	0.98
121_H	211_H	0.771	0.98
169_A	172_C	0.770	0.98
25_H	29_P	0.770	0.98
217_V	224_F	0.765	0.97
15_I	19_S	0.765	0.97
195_E	231_R	0.764	0.97
57_L	71_A	0.760	0.97
85_L	114_T	0.759	0.97
145_L	148_Q	0.759	0.97
35_I	245_Y	0.757	0.97
195_E	232_Y	0.756	0.97
52_L	264_V	0.753	0.97
226_P	229_D	0.752	0.97
70_D	74_L	0.752	0.97
102_S	140_A	0.751	0.97
226_P	233_V	0.745	0.97
167_L	190_N	0.745	0.97
109_A	113_P	0.743	0.97
25_H	258_L	0.738	0.97
174_P	202_W	0.737	0.97
28_E	262_P	0.736	0.97
29_P	32_F	0.735	0.97
51_I	267_L	0.735	0.97
42_F	47_A	0.735	0.97
41_F	203_D	0.735	0.97
194_K	205_M	0.731	0.97
106_S	141_G	0.729	0.97
26_Y	29_P	0.723	0.96
167_L	172_C	0.721	0.96
225_A	230_K	0.714	0.96
197_M	205_M	0.712	0.96
183_P	203_D	0.712	0.96
205_M	244_I	0.711	0.96
136_T	140_A	0.709	0.96
114_T	161_L	0.708	0.96
91_L	253_L	0.707	0.96
234_A	265_T	0.707	0.96
90_V	256_L	0.706	0.96
73_A	77_E	0.703	0.96
207_C	244_I	0.694	0.96
150_T	154_T	0.694	0.96
195_E	199_D	0.690	0.95
248_R	262_P	0.690	0.95
28_E	261_R	0.690	0.95
42_F	45_N	0.689	0.95
218_P	259_N	0.688	0.95
239_F	242_R	0.686	0.95
118_F	165_G	0.682	0.95
187_L	206_L	0.682	0.95
53_F	265_T	0.681	0.95
118_F	122_D	0.680	0.95
58_H	120_N	0.677	0.95
57_L	85_L	0.677	0.95
226_P	230_K	0.676	0.95
138_K	148_Q	0.676	0.95
65_L	103_D	0.676	0.95
28_E	31_W	0.674	0.95
41_F	204_L	0.673	0.95
190_N	228_E	0.663	0.94
138_K	146_F	0.662	0.94
212_G	260_C	0.661	0.94
190_N	210_T	0.660	0.94
186_V	205_M	0.656	0.94
88_D	211_H	0.656	0.94
59_Y	101_F	0.655	0.94
71_A	75_G	0.653	0.94
147_N	164_T	0.652	0.94
238_A	242_R	0.651	0.94
51_I	269_L	0.650	0.94
215_L	254_Y	0.650	0.94
103_D	106_S	0.650	0.94
202_W	205_M	0.649	0.94
175_P	200_E	0.647	0.94
195_E	239_F	0.642	0.93
162_V	178_S	0.642	0.93
183_P	204_L	0.642	0.93
198_R	242_R	0.636	0.93
137_L	144_V	0.635	0.93
218_P	248_R	0.634	0.93
150_T	161_L	0.632	0.93
100_A	103_D	0.630	0.93
162_V	186_V	0.630	0.93
76_I	107_P	0.627	0.92
12_A	16_A	0.627	0.92
12_A	20_G	0.627	0.92
62_F	252_S	0.627	0.92
185_L	206_L	0.625	0.92
39_L	267_L	0.624	0.92
32_F	250_V	0.621	0.92
97_N	100_A	0.619	0.92
224_F	227_V	0.619	0.92
26_Y	30_G	0.617	0.92
231_R	239_F	0.617	0.92
117_C	187_L	0.616	0.92
164_T	193_S	0.614	0.92
65_L	69_S	0.610	0.91
132_L	135_E	0.610	0.91
224_F	228_E	0.610	0.91
58_H	88_D	0.607	0.91
252_S	255_G	0.606	0.91
168_W	172_C	0.604	0.91
210_T	229_D	0.603	0.91
78_Q	264_V	0.602	0.91
219_L	226_P	0.598	0.91
248_R	263_E	0.596	0.90
63_V	71_A	0.592	0.90
118_F	133_I	0.592	0.90
76_I	83_I	0.589	0.90
18_S	22_G	0.588	0.90
248_R	265_T	0.587	0.90
102_S	106_S	0.586	0.90
49_F	152_I	0.586	0.90
63_V	113_P	0.585	0.90
72_I	78_Q	0.584	0.90
65_L	104_V	0.576	0.89
52_L	86_G	0.576	0.89
226_P	254_Y	0.575	0.89
62_F	250_V	0.574	0.89
37_H	40_A	0.571	0.88
76_I	112_A	0.571	0.88
49_F	82_L	0.570	0.88
49_F	154_T	0.569	0.88
22_G	25_H	0.568	0.88
153_A	157_R	0.568	0.88
31_W	258_L	0.567	0.88
45_N	156_N	0.566	0.88
124_P	253_L	0.562	0.88
147_N	166_D	0.561	0.88
99_S	103_D	0.561	0.88
41_F	243_H	0.560	0.87
35_I	234_A	0.559	0.87
80_P	266_M	0.555	0.87
116_A	122_D	0.554	0.87
197_M	202_W	0.553	0.87
54_L	86_G	0.553	0.87
85_L	116_A	0.552	0.87
23_Y	28_E	0.551	0.87
80_P	112_A	0.549	0.86
57_L	63_V	0.546	0.86
118_F	144_V	0.545	0.86
73_A	76_I	0.544	0.86
122_D	190_N	0.544	0.86
28_E	258_L	0.539	0.85
99_S	139_S	0.538	0.85
85_L	105_L	0.537	0.85
193_S	196_V	0.536	0.85
198_R	201_P	0.534	0.85
214_Q	255_G	0.533	0.85
42_F	183_P	0.532	0.85
34_L	74_L	0.532	0.85
167_L	192_D	0.530	0.85
118_F	146_F	0.527	0.84
22_G	256_L	0.525	0.84
84_L	185_L	0.525	0.84
19_S	23_Y	0.522	0.84
252_S	256_L	0.520	0.83
13_A	17_T	0.519	0.83
219_L	259_N	0.518	0.83
124_P	226_P	0.516	0.83
220_V	258_L	0.516	0.83
234_A	247_T	0.515	0.83
46_A	269_L	0.514	0.83
121_H	124_P	0.513	0.83
70_D	73_A	0.512	0.82
184_R	203_D	0.511	0.82
101_F	105_L	0.509	0.82
190_N	253_L	0.509	0.82
115_F	143_T	0.508	0.82
43_K	269_L	0.508	0.82
124_P	165_G	0.508	0.82
43_K	159_F	0.505	0.82
98_F	136_T	0.505	0.82
191_P	209_H	0.504	0.81
91_L	166_D	0.503	0.81
196_V	199_D	0.502	0.81
231_R	237_N	0.500	0.81

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4fbkA	2	0.9259	100	0.63	Contact Map
3rl5A	1	0.8222	100	0.642	Contact Map
4fbwA	2	0.8111	100	0.643	Contact Map
3t1iA	2	0.837	99.9	0.665	Contact Map
4ykeA	2	0.8333	99.9	0.671	Contact Map
1ii7A	2	0.7963	99.9	0.679	Contact Map
4nzvA	1	0.8556	99.9	0.686	Contact Map
2z1aA	1	0.8	99.9	0.688	Contact Map
3d03A	5	0.7111	99.9	0.692	Contact Map
3thoB	2	0.8111	99.9	0.694	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0092 seconds.