GREMLIN Database
YAEI - Phosphodiesterase YaeI
UniProt: P37049 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12337
Length: 270 (250)
Sequences: 4180 (3234)
Seq/√Len: 204.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
53_F86_G5.3561.00
84_L187_L3.9331.00
50_K268_E3.6311.00
41_F183_P3.3081.00
49_F112_A3.2131.00
83_I108_L2.9351.00
234_A248_R2.7421.00
38_R268_E2.7321.00
78_Q266_M2.7291.00
52_L266_M2.7021.00
143_T150_T2.4901.00
134_G146_F2.4491.00
245_Y265_T2.4081.00
238_A243_H2.3941.00
36_R268_E2.3491.00
146_F165_G2.3091.00
236_L243_H2.2981.00
153_A158_Q2.2611.00
52_L75_G2.2451.00
116_A144_V2.1171.00
52_L80_P2.0811.00
69_S107_P2.0431.00
55_A247_T2.0181.00
115_F161_L1.9641.00
162_V184_R1.9561.00
50_K266_M1.9341.00
54_L75_G1.9161.00
51_I82_L1.8701.00
53_F206_L1.8661.00
205_M242_R1.8601.00
151_V160_E1.8431.00
114_T142_I1.8281.00
37_H245_Y1.7931.00
160_E182_L1.7901.00
84_L206_L1.7861.00
237_N246_T1.7481.00
74_L78_Q1.7211.00
85_L89_Y1.7201.00
36_R78_Q1.6771.00
72_I76_I1.6571.00
115_F150_T1.6291.00
160_E184_R1.6111.00
173_K176_P1.6001.00
206_L267_L1.5951.00
118_F134_G1.5751.00
188_A207_C1.5721.00
76_I111_C1.5671.00
43_K46_A1.5311.00
238_A241_E1.5271.00
143_T148_Q1.5271.00
161_L185_L1.5211.00
151_V158_Q1.5111.00
149_A160_E1.4991.00
69_S73_A1.4971.00
31_W261_R1.4941.00
52_L78_Q1.4791.00
48_P268_E1.4571.00
37_H265_T1.4441.00
86_G187_L1.4301.00
84_L161_L1.4241.00
86_G206_L1.4201.00
27_C31_W1.4191.00
53_F247_T1.4101.00
178_S202_W1.4051.00
194_K244_I1.3721.00
35_I248_R1.3371.00
55_A86_G1.3361.00
54_L57_L1.3221.00
153_A156_N1.3181.00
149_A162_V1.3071.00
36_R266_M1.2931.00
151_V182_L1.2931.00
194_K239_F1.2891.00
136_T139_S1.2801.00
232_Y237_N1.2701.00
166_D190_N1.2701.00
45_N157_R1.2701.00
46_A154_T1.2581.00
164_T188_A1.2571.00
24_M28_E1.2541.00
50_K78_Q1.2471.00
236_L245_Y1.2311.00
71_A250_V1.2201.00
179_E182_L1.2181.00
135_E139_S1.2141.00
194_K242_R1.2051.00
134_G138_K1.1691.00
162_V202_W1.1641.00
69_S104_V1.1621.00
154_T157_R1.1531.00
42_F48_P1.1471.00
33_E261_R1.1431.00
86_G247_T1.1401.00
34_L78_Q1.1361.00
186_V202_W1.1291.00
247_T265_T1.1201.00
173_K177_A1.1181.00
245_Y267_L1.1101.00
42_F269_L1.1091.00
134_G144_V1.1081.00
74_L77_E1.0971.00
42_F46_A1.0861.00
54_L85_L1.0821.00
85_L142_I1.0781.00
34_L264_V1.0661.00
152_I161_L1.0641.00
159_F183_P1.0631.00
35_I263_E1.0561.00
63_V68_I1.0531.00
23_Y27_C1.0511.00
110_E113_P1.0491.00
82_L115_F1.0491.00
46_A159_F1.0471.00
79_K111_C1.0421.00
51_I84_L1.0411.00
59_Y68_I1.0311.00
158_Q182_L1.0251.00
106_S140_A1.0231.00
30_G60_S1.0221.00
116_A137_L1.0221.00
83_I110_E1.0171.00
102_S139_S1.0131.00
53_F267_L1.0071.00
123_R165_G1.0041.00
225_A228_E0.9911.00
58_H211_H0.9881.00
147_N165_G0.9871.00
188_A193_S0.9801.00
233_V237_N0.9781.00
53_F84_L0.9701.00
24_M258_L0.9701.00
237_N244_I0.9691.00
82_L152_I0.9691.00
23_Y29_P0.9630.99
43_K48_P0.9630.99
39_L236_L0.9600.99
75_G108_L0.9560.99
40_A243_H0.9550.99
110_E114_T0.9510.99
135_E138_K0.9500.99
138_K144_V0.9490.99
102_S136_T0.9450.99
184_R202_W0.9450.99
37_H236_L0.9390.99
32_F74_L0.9270.99
72_I104_V0.9240.99
133_I137_L0.9230.99
212_G248_R0.9170.99
46_A49_F0.9130.99
137_L142_I0.9090.99
57_L250_V0.9080.99
186_V197_M0.9060.99
86_G117_C0.9050.99
76_I109_A0.9020.99
45_N48_P0.9000.99
24_M27_C0.9000.99
46_A157_R0.8970.99
37_H267_L0.8940.99
160_E179_E0.8900.99
116_A142_I0.8880.99
76_I110_E0.8880.99
25_H28_E0.8880.99
74_L264_V0.8830.99
217_V220_V0.8790.99
20_G24_M0.8730.99
104_V107_P0.8710.99
174_P186_V0.8710.99
248_R260_C0.8680.99
35_I265_T0.8630.99
24_M29_P0.8600.99
73_A107_P0.8550.99
83_I114_T0.8510.99
168_W190_N0.8420.99
29_P252_S0.8400.99
112_A154_T0.8360.99
174_P177_A0.8340.99
204_L267_L0.8310.99
212_G233_V0.8270.98
162_V177_A0.8260.98
212_G261_R0.8250.98
21_F25_H0.8230.98
232_Y244_I0.8220.98
122_D133_I0.8200.98
251_G257_R0.8160.98
53_F245_Y0.8140.98
22_G26_Y0.8120.98
89_Y137_L0.8070.98
89_Y116_A0.8070.98
149_A177_A0.8070.98
120_N209_H0.8030.98
212_G234_A0.7980.98
192_D228_E0.7900.98
198_R239_F0.7880.98
60_S91_L0.7870.98
120_N211_H0.7860.98
34_L266_M0.7850.98
185_L204_L0.7840.98
58_H121_H0.7830.98
39_L204_L0.7790.98
121_H211_H0.7710.98
169_A172_C0.7700.98
25_H29_P0.7700.98
217_V224_F0.7650.97
15_I19_S0.7650.97
195_E231_R0.7640.97
57_L71_A0.7600.97
85_L114_T0.7590.97
145_L148_Q0.7590.97
35_I245_Y0.7570.97
195_E232_Y0.7560.97
52_L264_V0.7530.97
226_P229_D0.7520.97
70_D74_L0.7520.97
102_S140_A0.7510.97
226_P233_V0.7450.97
167_L190_N0.7450.97
109_A113_P0.7430.97
25_H258_L0.7380.97
174_P202_W0.7370.97
28_E262_P0.7360.97
29_P32_F0.7350.97
51_I267_L0.7350.97
42_F47_A0.7350.97
41_F203_D0.7350.97
194_K205_M0.7310.97
106_S141_G0.7290.97
26_Y29_P0.7230.96
167_L172_C0.7210.96
225_A230_K0.7140.96
197_M205_M0.7120.96
183_P203_D0.7120.96
205_M244_I0.7110.96
136_T140_A0.7090.96
114_T161_L0.7080.96
91_L253_L0.7070.96
234_A265_T0.7070.96
90_V256_L0.7060.96
73_A77_E0.7030.96
207_C244_I0.6940.96
150_T154_T0.6940.96
195_E199_D0.6900.95
248_R262_P0.6900.95
28_E261_R0.6900.95
42_F45_N0.6890.95
218_P259_N0.6880.95
239_F242_R0.6860.95
118_F165_G0.6820.95
187_L206_L0.6820.95
53_F265_T0.6810.95
118_F122_D0.6800.95
58_H120_N0.6770.95
57_L85_L0.6770.95
226_P230_K0.6760.95
138_K148_Q0.6760.95
65_L103_D0.6760.95
28_E31_W0.6740.95
41_F204_L0.6730.95
190_N228_E0.6630.94
138_K146_F0.6620.94
212_G260_C0.6610.94
190_N210_T0.6600.94
186_V205_M0.6560.94
88_D211_H0.6560.94
59_Y101_F0.6550.94
71_A75_G0.6530.94
147_N164_T0.6520.94
238_A242_R0.6510.94
51_I269_L0.6500.94
215_L254_Y0.6500.94
103_D106_S0.6500.94
202_W205_M0.6490.94
175_P200_E0.6470.94
195_E239_F0.6420.93
162_V178_S0.6420.93
183_P204_L0.6420.93
198_R242_R0.6360.93
137_L144_V0.6350.93
218_P248_R0.6340.93
150_T161_L0.6320.93
100_A103_D0.6300.93
162_V186_V0.6300.93
76_I107_P0.6270.92
12_A16_A0.6270.92
12_A20_G0.6270.92
62_F252_S0.6270.92
185_L206_L0.6250.92
39_L267_L0.6240.92
32_F250_V0.6210.92
97_N100_A0.6190.92
224_F227_V0.6190.92
26_Y30_G0.6170.92
231_R239_F0.6170.92
117_C187_L0.6160.92
164_T193_S0.6140.92
65_L69_S0.6100.91
132_L135_E0.6100.91
224_F228_E0.6100.91
58_H88_D0.6070.91
252_S255_G0.6060.91
168_W172_C0.6040.91
210_T229_D0.6030.91
78_Q264_V0.6020.91
219_L226_P0.5980.91
248_R263_E0.5960.90
63_V71_A0.5920.90
118_F133_I0.5920.90
76_I83_I0.5890.90
18_S22_G0.5880.90
248_R265_T0.5870.90
102_S106_S0.5860.90
49_F152_I0.5860.90
63_V113_P0.5850.90
72_I78_Q0.5840.90
65_L104_V0.5760.89
52_L86_G0.5760.89
226_P254_Y0.5750.89
62_F250_V0.5740.89
37_H40_A0.5710.88
76_I112_A0.5710.88
49_F82_L0.5700.88
49_F154_T0.5690.88
22_G25_H0.5680.88
153_A157_R0.5680.88
31_W258_L0.5670.88
45_N156_N0.5660.88
124_P253_L0.5620.88
147_N166_D0.5610.88
99_S103_D0.5610.88
41_F243_H0.5600.87
35_I234_A0.5590.87
80_P266_M0.5550.87
116_A122_D0.5540.87
197_M202_W0.5530.87
54_L86_G0.5530.87
85_L116_A0.5520.87
23_Y28_E0.5510.87
80_P112_A0.5490.86
57_L63_V0.5460.86
118_F144_V0.5450.86
73_A76_I0.5440.86
122_D190_N0.5440.86
28_E258_L0.5390.85
99_S139_S0.5380.85
85_L105_L0.5370.85
193_S196_V0.5360.85
198_R201_P0.5340.85
214_Q255_G0.5330.85
42_F183_P0.5320.85
34_L74_L0.5320.85
167_L192_D0.5300.85
118_F146_F0.5270.84
22_G256_L0.5250.84
84_L185_L0.5250.84
19_S23_Y0.5220.84
252_S256_L0.5200.83
13_A17_T0.5190.83
219_L259_N0.5180.83
124_P226_P0.5160.83
220_V258_L0.5160.83
234_A247_T0.5150.83
46_A269_L0.5140.83
121_H124_P0.5130.83
70_D73_A0.5120.82
184_R203_D0.5110.82
101_F105_L0.5090.82
190_N253_L0.5090.82
115_F143_T0.5080.82
43_K269_L0.5080.82
124_P165_G0.5080.82
43_K159_F0.5050.82
98_F136_T0.5050.82
191_P209_H0.5040.81
91_L166_D0.5030.81
196_V199_D0.5020.81
231_R237_N0.5000.81
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4fbkA 2 0.9259 100 0.63 Contact Map
3rl5A 1 0.8222 100 0.642 Contact Map
4fbwA 2 0.8111 100 0.643 Contact Map
3t1iA 2 0.837 99.9 0.665 Contact Map
4ykeA 2 0.8333 99.9 0.671 Contact Map
1ii7A 2 0.7963 99.9 0.679 Contact Map
4nzvA 1 0.8556 99.9 0.686 Contact Map
2z1aA 1 0.8 99.9 0.688 Contact Map
3d03A 5 0.7111 99.9 0.692 Contact Map
3thoB 2 0.8111 99.9 0.694 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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