GREMLIN Database
CDAR - Carbohydrate diacid regulator
UniProt: P37047 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12335
Length: 385 (350)
Sequences: 6485 (5435)
Seq/√Len: 290.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
251_G263_S6.5841.00
333_H343_A5.8231.00
322_L325_R3.6021.00
359_S365_D3.3621.00
346_I350_T3.2741.00
368_N371_D3.0111.00
249_S270_T2.8451.00
340_T351_L2.7671.00
318_D321_G2.7601.00
325_R329_A2.7011.00
346_I351_L2.6951.00
333_H340_T2.6521.00
249_S267_A2.5861.00
332_R343_A2.5781.00
168_I267_A2.5291.00
117_E120_R2.5211.00
329_A333_H2.5121.00
252_N266_T2.4701.00
348_R352_E2.4071.00
328_A332_R2.3581.00
208_E268_K2.3491.00
370_D380_Q2.3391.00
327_L358_I2.3061.00
15_V28_V2.2611.00
170_E275_K2.2391.00
339_A342_K2.2241.00
359_S366_L2.2241.00
109_C113_E2.2141.00
166_V263_S2.1691.00
347_H350_T2.1651.00
364_L371_D2.1061.00
12_Q16_A2.0961.00
329_A340_T2.0641.00
210_V264_Y1.9851.00
169_V248_V1.9571.00
138_N152_W1.9181.00
30_D34_R1.8861.00
317_M321_G1.8761.00
356_N360_E1.8131.00
110_M113_E1.8001.00
274_G284_Y1.7951.00
285_F288_D1.7921.00
120_R123_H1.7751.00
372_R376_Y1.7541.00
356_N359_S1.7541.00
167_A250_L1.7531.00
326_T358_I1.7161.00
249_S271_M1.7031.00
326_T340_T1.6901.00
254_F266_T1.6861.00
373_L376_Y1.6851.00
337_P352_E1.6811.00
334_N368_N1.6751.00
338_L342_K1.6731.00
303_Q381_L1.6721.00
135_L153_A1.6541.00
137_M205_S1.6541.00
358_I362_T1.6531.00
357_R360_E1.6511.00
264_Y268_K1.6471.00
82_L90_G1.6421.00
256_G259_S1.6351.00
314_L358_I1.6241.00
53_L57_Q1.6081.00
19_M39_G1.6071.00
326_T351_L1.6041.00
333_H339_A1.6041.00
170_E247_R1.5981.00
118_Q121_L1.5881.00
329_A343_A1.5771.00
335_V372_R1.5661.00
261_A265_R1.5611.00
168_I268_K1.5491.00
109_C114_M1.5211.00
331_F372_R1.5211.00
165_V215_A1.5121.00
330_W335_V1.4881.00
338_L352_E1.4861.00
259_S262_R1.4841.00
326_T354_R1.4821.00
52_L56_S1.4711.00
364_L374_L1.4651.00
54_V57_Q1.4521.00
254_F259_S1.4451.00
359_S367_G1.4361.00
339_A343_A1.4271.00
170_E271_M1.4271.00
170_E208_E1.4151.00
362_T371_D1.3961.00
165_V253_Y1.3891.00
232_E236_T1.3711.00
102_R105_G1.3681.00
329_A344_L1.3541.00
164_R260_I1.3531.00
189_Q193_T1.3521.00
310_P313_R1.3501.00
338_L348_R1.3501.00
228_R232_E1.3471.00
323_L326_T1.3471.00
186_Q190_N1.3471.00
254_F263_S1.3451.00
109_C112_A1.3391.00
357_R361_L1.3391.00
250_L285_F1.3311.00
166_V267_A1.3261.00
314_L324_R1.3171.00
184_E189_Q1.3161.00
263_S267_A1.3161.00
116_L120_R1.3111.00
166_V212_L1.2971.00
166_V251_G1.2881.00
189_Q192_L1.2821.00
145_N148_A1.2711.00
51_A55_L1.2691.00
138_N143_E1.2641.00
335_V340_T1.2641.00
331_F335_V1.2631.00
137_M141_Q1.2621.00
251_G254_F1.2611.00
48_H51_A1.2561.00
270_T274_G1.2471.00
252_N287_Q1.2421.00
269_T297_S1.2371.00
336_Q339_A1.2201.00
212_L260_I1.2171.00
330_W337_P1.2141.00
50_G54_V1.2131.00
168_I249_S1.2111.00
323_L361_L1.1941.00
101_L105_G1.1901.00
349_N352_E1.1861.00
111_T114_M1.1861.00
332_R376_Y1.1581.00
323_L358_I1.1491.00
168_I264_Y1.1481.00
17_R20_R1.1431.00
353_Y357_R1.1391.00
337_P355_L1.1381.00
15_V26_I1.1331.00
168_I271_M1.1331.00
312_A316_T1.1301.00
334_N369_F1.1261.00
249_S274_G1.1261.00
79_N91_V1.1191.00
330_W355_L1.1051.00
146_T258_G1.1031.00
54_V58_G1.1021.00
292_P370_D1.1021.00
376_Y380_Q1.1011.00
344_L351_L1.0981.00
167_A211_V1.0941.00
128_D132_R1.0861.00
187_Q190_N1.0841.00
72_H75_R1.0811.00
83_R88_I1.0811.00
336_Q351_L1.0791.00
291_L377_V1.0721.00
126_A129_S1.0721.00
167_A213_K1.0621.00
324_R328_A1.0611.00
109_C116_L1.0401.00
77_G80_L1.0371.00
52_L55_L1.0351.00
229_K233_Q1.0341.00
55_L58_G1.0271.00
326_T346_I1.0261.00
310_P374_L1.0091.00
270_T286_Y1.0081.00
228_R285_F1.0071.00
53_L56_S1.0031.00
294_L306_E1.0021.00
62_D65_D1.0021.00
110_M115_M1.0001.00
331_F376_Y0.9991.00
47_L55_L0.9981.00
51_A54_V0.9921.00
50_G53_L0.9901.00
61_V64_D0.9891.00
51_A58_G0.9891.00
247_R275_K0.9831.00
96_G99_E0.9821.00
250_L283_C0.9821.00
290_M293_V0.9771.00
49_E53_L0.9731.00
233_Q237_R0.9731.00
337_P349_N0.9671.00
108_V111_T0.9621.00
28_V92_I0.9591.00
50_G55_L0.9581.00
163_P253_Y0.9571.00
182_M185_L0.9561.00
371_D374_L0.9511.00
202_A211_V0.9491.00
249_S266_T0.9481.00
187_Q191_A0.9441.00
29_M93_G0.9441.00
315_K324_R0.9421.00
328_A380_Q0.9411.00
40_D43_R0.9391.00
313_R361_L0.9321.00
336_Q348_R0.9321.00
186_Q189_Q0.9201.00
166_V264_Y0.9191.00
28_V82_L0.9181.00
308_A316_T0.9121.00
103_K106_E0.9081.00
159_D162_Q0.9071.00
133_E137_M0.9061.00
333_H351_L0.9031.00
150_T153_A0.9011.00
127_Q130_R0.8991.00
142_A261_A0.8911.00
355_L358_I0.8901.00
324_R379_L0.8891.00
254_F260_I0.8871.00
373_L380_Q0.8871.00
109_C117_E0.8841.00
11_A36_I0.8791.00
74_V77_G0.8791.00
308_A312_A0.8761.00
328_A379_L0.8731.00
108_V114_M0.8701.00
327_L331_F0.8701.00
50_G58_G0.8681.00
348_R356_N0.8651.00
53_L58_G0.8651.00
108_V112_A0.8651.00
19_M25_N0.8631.00
307_L312_A0.8621.00
229_K232_E0.8601.00
355_L359_S0.8591.00
79_N82_L0.8591.00
290_M309_R0.8541.00
293_V309_R0.8531.00
315_K318_D0.8481.00
332_R370_D0.8381.00
369_F376_Y0.8361.00
126_A130_R0.8331.00
69_R74_V0.8301.00
306_E310_P0.8261.00
17_R21_I0.8261.00
329_A332_R0.8241.00
299_R303_Q0.8231.00
165_V287_Q0.8211.00
27_N33_G0.8201.00
190_N193_T0.8201.00
158_I164_R0.8171.00
153_A160_L0.8151.00
130_R134_E0.8151.00
232_E285_F0.8141.00
168_I210_V0.8141.00
362_T375_L0.8131.00
74_V79_N0.8111.00
184_E188_L0.8061.00
254_F262_R0.8040.99
330_W340_T0.8020.99
326_T344_L0.8020.99
370_D374_L0.7930.99
112_A115_M0.7920.99
345_F353_Y0.7920.99
29_M38_S0.7900.99
367_G372_R0.7860.99
117_E121_L0.7850.99
172_D247_R0.7820.99
267_A270_T0.7790.99
289_L293_V0.7780.99
366_L372_R0.7760.99
232_E235_I0.7730.99
326_T353_Y0.7720.99
23_D26_I0.7720.99
186_Q192_L0.7710.99
139_L257_P0.7700.99
210_V268_K0.7650.99
191_A194_T0.7630.99
25_N39_G0.7630.99
292_P380_Q0.7630.99
152_W156_L0.7620.99
51_A57_Q0.7600.99
359_S362_T0.7570.99
135_L152_W0.7560.99
24_T94_L0.7560.99
47_L51_A0.7550.99
45_G48_H0.7530.99
60_V63_I0.7520.99
270_T289_L0.7490.99
304_A308_A0.7490.99
147_P151_E0.7470.99
48_H54_V0.7470.99
47_L50_G0.7460.99
169_V211_V0.7450.99
290_M306_E0.7450.99
366_L371_D0.7450.99
369_F372_R0.7410.99
130_R133_E0.7400.99
310_P371_D0.7390.99
317_M320_N0.7370.99
77_G93_G0.7370.99
370_D373_L0.7360.99
306_E312_A0.7350.99
14_I19_M0.7350.99
168_I208_E0.7350.99
310_P378_A0.7340.99
118_Q122_M0.7310.99
262_R266_T0.7300.99
251_G267_A0.7290.99
353_Y360_E0.7270.99
29_M77_G0.7250.99
72_H82_L0.7240.99
135_L156_L0.7230.99
262_R265_R0.7220.99
44_I48_H0.7210.99
116_L119_S0.7200.99
266_T305_N0.7200.99
265_R269_T0.7190.99
365_D368_N0.7160.99
90_G95_T0.7130.99
148_A151_E0.7130.99
119_S122_M0.7130.99
77_G90_G0.7120.99
15_V37_G0.7060.99
248_V283_C0.7060.99
94_L109_C0.7050.99
82_L85_E0.7020.99
336_Q352_E0.7000.99
77_G89_V0.7000.99
373_L377_V0.7000.99
348_R376_Y0.6990.99
311_L378_A0.6970.99
233_Q236_T0.6970.99
190_N194_T0.6940.99
365_D371_D0.6910.98
69_R73_G0.6900.98
110_M114_M0.6900.98
50_G57_Q0.6810.98
228_R288_D0.6800.98
243_Q246_F0.6790.98
235_I239_K0.6770.98
235_I238_M0.6770.98
146_T150_T0.6740.98
49_E57_Q0.6730.98
348_R351_L0.6720.98
54_V59_R0.6710.98
345_F350_T0.6710.98
377_V380_Q0.6700.98
290_M374_L0.6690.98
22_I25_N0.6680.98
182_M189_Q0.6680.98
231_V235_I0.6670.98
153_A156_L0.6650.98
319_N357_R0.6620.98
291_L374_L0.6590.98
119_S123_H0.6580.98
359_S363_G0.6570.98
25_N29_M0.6560.98
73_G81_P0.6560.98
107_L111_T0.6560.98
101_L104_Y0.6530.98
183_A193_T0.6520.98
18_T22_I0.6520.98
295_L377_V0.6480.98
165_V251_G0.6480.98
60_V64_D0.6480.98
96_G101_L0.6460.98
87_E95_T0.6460.98
13_D17_R0.6460.98
185_L188_L0.6430.98
230_R238_M0.6430.98
35_I39_G0.6420.98
111_T115_M0.6400.97
149_L152_W0.6400.97
184_E193_T0.6400.97
345_F348_R0.6330.97
99_E105_G0.6330.97
307_L311_L0.6330.97
48_H57_Q0.6310.97
105_G109_C0.6280.97
11_A28_V0.6250.97
24_T105_G0.6230.97
188_L193_T0.6220.97
86_G90_G0.6220.97
270_T284_Y0.6220.97
188_L194_T0.6210.97
308_A378_A0.6210.97
182_M186_Q0.6200.97
186_Q193_T0.6190.97
266_T286_Y0.6180.97
347_H353_Y0.6180.97
188_L192_L0.6170.97
317_M323_L0.6160.97
83_R93_G0.6160.97
337_P348_R0.6150.97
182_M192_L0.6140.97
96_G100_N0.6130.97
43_R48_H0.6110.97
183_A187_Q0.6090.97
317_M324_R0.6080.97
80_L84_L0.6070.97
297_S302_W0.6070.97
337_P347_H0.6070.97
369_F373_L0.6060.97
317_M322_L0.6060.97
15_V19_M0.6030.96
325_R328_A0.6020.96
318_D324_R0.6010.96
81_P91_V0.6000.96
314_L361_L0.6000.96
334_N372_R0.6000.96
295_L373_L0.5990.96
33_G91_V0.5980.96
291_L373_L0.5970.96
60_V65_D0.5970.96
255_T259_S0.5970.96
108_V113_E0.5960.96
88_I91_V0.5950.96
80_L109_C0.5930.96
52_L57_Q0.5920.96
227_H230_R0.5910.96
61_V65_D0.5880.96
77_G81_P0.5870.96
364_L375_L0.5850.96
21_I25_N0.5830.96
359_S364_L0.5830.96
25_N37_G0.5820.96
30_D36_I0.5820.96
33_G38_S0.5820.96
127_Q131_L0.5810.96
184_E187_Q0.5810.96
236_T239_K0.5800.96
170_E207_T0.5800.96
310_P364_L0.5780.95
73_G76_Q0.5780.95
347_H352_E0.5780.95
102_R106_E0.5770.95
47_L54_V0.5770.95
166_V210_V0.5760.95
231_V234_L0.5760.95
162_Q216_L0.5760.95
156_L159_D0.5760.95
69_R75_R0.5760.95
29_M35_I0.5750.95
72_H79_N0.5750.95
330_W359_S0.5710.95
25_N28_V0.5700.95
151_E155_R0.5690.95
42_E47_L0.5680.95
185_L192_L0.5670.95
160_L257_P0.5660.95
332_R380_Q0.5660.95
28_V37_G0.5630.95
92_I95_T0.5610.95
135_L139_L0.5600.95
146_T149_L0.5570.94
46_E50_G0.5560.94
292_P295_L0.5550.94
79_N93_G0.5550.94
182_M190_N0.5550.94
59_R64_D0.5540.94
62_D102_R0.5530.94
29_M33_G0.5530.94
59_R62_D0.5520.94
27_N38_S0.5520.94
314_L327_L0.5500.94
187_Q192_L0.5490.94
252_N309_R0.5470.94
335_V352_E0.5460.94
167_A248_V0.5450.94
82_L92_I0.5450.94
26_I94_L0.5440.94
91_V94_L0.5440.94
167_A231_V0.5440.94
137_M203_I0.5420.94
83_R86_G0.5420.94
340_T348_R0.5410.94
70_H74_V0.5410.94
310_P362_T0.5400.94
341_S351_L0.5400.94
299_R302_W0.5390.93
116_L127_Q0.5390.93
69_R79_N0.5390.93
198_N201_V0.5380.93
200_L205_S0.5370.93
235_I248_V0.5370.93
19_M27_N0.5360.93
306_E378_A0.5350.93
150_T154_Q0.5340.93
305_N309_R0.5320.93
327_L375_L0.5310.93
75_R79_N0.5310.93
78_I101_L0.5290.93
163_P255_T0.5270.93
35_I41_R0.5270.93
59_R63_I0.5250.93
74_V80_L0.5250.93
104_Y107_L0.5250.93
300_G304_A0.5250.93
70_H73_G0.5210.92
249_S286_Y0.5200.92
247_R274_G0.5190.92
25_N95_T0.5190.92
257_P260_I0.5190.92
35_I38_S0.5180.92
75_R90_G0.5170.92
185_L191_A0.5170.92
30_D33_G0.5160.92
251_G270_T0.5160.92
289_L292_P0.5150.92
252_N285_F0.5140.92
83_R89_V0.5130.92
167_A214_P0.5130.92
366_L375_L0.5120.92
184_E192_L0.5120.92
317_M361_L0.5100.91
295_L381_L0.5080.91
205_S210_V0.5070.91
311_L327_L0.5050.91
112_A118_Q0.5050.91
15_V22_I0.5050.91
72_H78_I0.5050.91
89_V355_L0.5040.91
116_L123_H0.5040.91
286_Y293_V0.5040.91
305_N308_A0.5030.91
33_G43_R0.5020.91
69_R81_P0.5010.91
247_R281_S0.5000.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3onqA 5 0.6571 100 0.423 Contact Map
2gx5A 2 0.3273 97.9 0.873 Contact Map
4eu0A 1 0.626 96.6 0.897 Contact Map
2w1rA 2 0.2805 96.3 0.9 Contact Map
3ispA 3 0.174 94.7 0.911 Contact Map
3mz1A 2 0 93.9 0.915 Contact Map
1etoA 2 0.2468 93.8 0.915 Contact Map
3hhgA 3 0.1766 93.5 0.916 Contact Map
3qyyA 1 0.374 93.4 0.916 Contact Map
3szpA 3 0.1714 93.3 0.916 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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