GREMLIN Database
CLCA - H(+)/Cl(-) exchange transporter ClcA
UniProt: P37019 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12331
Length: 473 (404)
Sequences: 5288 (3708)
Seq/√Len: 184.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
396_A428_T4.2681.00
138_T143_M3.5901.00
334_V370_A3.5561.00
271_K275_G3.4691.00
143_M347_C3.4351.00
145_L347_C3.4131.00
144_V344_T3.3621.00
392_A428_T3.2951.00
144_V340_R3.2301.00
155_G181_G2.9341.00
261_I367_L2.9181.00
89_L141_G2.8321.00
49_A158_I2.8031.00
305_L343_T2.6761.00
55_K59_W2.6031.00
95_F99_K2.5611.00
265_F397_L2.4771.00
258_L371_F2.4391.00
255_Y392_A2.4261.00
275_G279_L2.4161.00
90_A94_Y2.3841.00
409_I426_I2.3811.00
337_F370_A2.3801.00
198_L410_I2.3791.00
251_T389_F2.3371.00
39_A43_G2.3281.00
265_F367_L2.2541.00
59_W63_Q2.2461.00
272_W345_L2.2451.00
263_G435_L2.1071.00
399_A429_G2.0831.00
301_L346_L2.0531.00
275_G278_D2.0511.00
138_T145_L2.0431.00
259_G263_G2.0371.00
320_I365_T2.0261.00
306_G313_S2.0141.00
47_G51_V1.9931.00
42_V46_V1.9871.00
138_T352_A1.9841.00
330_M370_A1.9701.00
276_M349_S1.9571.00
128_L157_N1.9351.00
266_G400_A1.9261.00
360_M401_S1.9241.00
86_S90_A1.9181.00
280_L350_S1.9171.00
96_L100_Y1.9111.00
253_W257_I1.9061.00
50_A151_T1.9031.00
264_I268_I1.8921.00
60_L140_G1.8821.00
337_F367_L1.8481.00
163_L174_R1.8451.00
112_I156_G1.8151.00
221_G225_S1.8031.00
56_G136_L1.8011.00
337_F363_L1.7971.00
48_L232_F1.7761.00
220_I224_M1.7701.00
269_F344_T1.7641.00
341_V363_L1.7451.00
403_R437_Q1.7271.00
86_S89_L1.7161.00
161_M165_I1.7061.00
262_F367_L1.6971.00
256_L431_G1.6891.00
91_M94_Y1.6831.00
46_V155_G1.6761.00
323_A366_V1.6461.00
44_T228_M1.6441.00
259_G432_A1.6381.00
298_I350_S1.6341.00
395_G429_G1.6261.00
79_L82_A1.6241.00
319_L362_A1.6191.00
256_L260_I1.6131.00
138_T347_C1.6101.00
304_L308_V1.5891.00
254_L375_A1.5871.00
199_F203_E1.5801.00
249_L253_W1.5721.00
360_M397_L1.5541.00
260_I435_L1.5271.00
337_F366_V1.5231.00
87_A90_A1.5101.00
91_M95_F1.4971.00
279_L283_V1.4811.00
259_G431_G1.4801.00
333_L369_T1.4781.00
51_V232_F1.4771.00
262_F396_A1.4591.00
183_A187_A1.4591.00
93_G97_V1.4521.00
278_D282_R1.4391.00
134_G353_P1.4391.00
95_F100_Y1.4331.00
258_L262_F1.4191.00
413_L422_I1.4191.00
183_A200_I1.4171.00
132_F154_I1.4171.00
255_Y428_T1.4151.00
40_A224_M1.4121.00
371_F375_A1.4061.00
361_L394_M1.4031.00
46_V184_A1.3931.00
184_A221_G1.3891.00
42_V177_L1.3841.00
131_K353_P1.3821.00
262_F397_L1.3611.00
92_F137_G1.3581.00
263_G436_A1.3421.00
329_S332_M1.3351.00
391_I416_T1.3241.00
121_P160_R1.3211.00
160_R174_R1.3161.00
335_F339_A1.3151.00
85_C89_L1.3131.00
104_A130_V1.3101.00
50_A188_A1.3061.00
83_F86_S1.3041.00
260_I264_I1.3031.00
333_L370_A1.3011.00
97_V101_A1.2981.00
82_A86_S1.2931.00
400_A432_A1.2781.00
182_A204_M1.2751.00
64_R141_G1.2711.00
169_K173_A1.2711.00
39_A42_V1.2711.00
179_A205_R1.2671.00
433_T437_Q1.2601.00
374_V378_L1.2581.00
398_L408_G1.2531.00
311_A314_G1.2501.00
398_L402_I1.2461.00
309_A339_A1.2451.00
48_L52_A1.2431.00
179_A218_V1.2421.00
365_T390_A1.2381.00
129_P133_F1.2381.00
276_M345_L1.2341.00
180_T221_G1.2201.00
369_T390_A1.2171.00
225_S229_Y1.2171.00
312_T315_G1.2101.00
194_L410_I1.2051.00
333_L366_V1.2001.00
183_A218_V1.1971.00
372_G384_L1.1971.00
217_A222_V1.1851.00
412_V425_M1.1671.00
59_W62_N1.1641.00
226_T230_R1.1631.00
386_A390_A1.1631.00
150_P190_F1.1611.00
384_L389_F1.1591.00
79_L83_F1.1571.00
81_V85_C1.1561.00
334_V338_V1.1501.00
101_A104_A1.1491.00
254_L371_F1.1481.00
428_T432_A1.1481.00
443_P448_I1.1181.00
53_F57_V1.1161.00
291_W294_M1.1151.00
267_P436_A1.1081.00
54_D57_V1.1001.00
274_L447_A1.0991.00
263_G432_A1.0981.00
101_A130_V1.0981.00
403_R436_A1.0941.00
217_A225_S1.0931.00
191_N230_R1.0921.00
164_D174_R1.0861.00
372_G386_A1.0841.00
345_L349_S1.0771.00
302_C343_T1.0721.00
187_A222_V1.0691.00
85_C88_V1.0691.00
251_T255_Y1.0681.00
316_G362_A1.0661.00
230_R235_E1.0641.00
94_Y292_V1.0641.00
421_L425_M1.0601.00
367_L397_L1.0581.00
208_F212_L1.0501.00
395_G412_V1.0491.00
44_T48_L1.0371.00
63_Q67_A1.0361.00
94_Y97_V1.0341.00
279_L282_R1.0331.00
80_T84_L1.0311.00
269_F347_C1.0301.00
35_I39_A1.0291.00
52_A132_F1.0251.00
216_K224_M1.0100.99
312_T343_T1.0100.99
125_W161_M1.0090.99
90_A93_G1.0070.99
321_P325_A1.0060.99
58_A62_N0.9990.99
316_G320_I0.9940.99
53_F135_G0.9940.99
322_I327_N0.9930.99
209_R213_I0.9920.99
88_V91_M0.9870.99
388_T421_L0.9870.99
341_V345_L0.9870.99
97_V100_Y0.9830.99
107_S110_P0.9780.99
267_P439_T0.9730.99
222_V226_T0.9720.99
80_T83_F0.9700.99
389_F393_G0.9680.99
91_M296_G0.9650.99
250_N254_L0.9630.99
94_Y98_R0.9620.99
38_M168_L0.9610.99
218_V222_V0.9570.99
373_M377_E0.9570.99
280_L298_I0.9570.99
51_V55_K0.9560.99
259_G396_A0.9520.99
302_C305_L0.9500.99
302_C347_C0.9460.99
113_E116_L0.9430.99
207_Q213_I0.9410.99
49_A53_F0.9370.99
299_G303_G0.9360.99
110_P113_E0.9320.99
52_A56_G0.9290.99
32_P35_I0.9280.99
310_P313_S0.9270.99
236_V240_D0.9270.99
372_G389_F0.9260.99
106_G131_K0.9260.99
124_W161_M0.9250.99
331_G335_F0.9180.99
189_A203_E0.9130.99
277_Q281_H0.9110.99
290_K293_L0.9070.99
49_A128_L0.9050.99
145_L354_G0.8970.99
89_L95_F0.8960.99
45_L49_A0.8950.99
362_A366_V0.8950.99
304_L307_F0.8940.99
108_G113_E0.8940.99
45_L158_I0.8940.99
107_S111_E0.8920.99
37_F41_V0.8910.99
148_E189_A0.8900.99
83_F307_F0.8890.99
113_E118_D0.8890.99
127_V153_Q0.8870.99
402_I445_Y0.8870.99
405_P408_G0.8820.99
51_V228_M0.8810.99
387_G390_A0.8800.99
260_I431_G0.8790.99
94_Y295_G0.8790.99
272_W341_V0.8750.99
409_I429_G0.8750.99
39_A46_V0.8710.98
114_G449_L0.8690.98
323_A369_T0.8660.98
114_G118_D0.8640.98
45_L162_V0.8610.98
89_L97_V0.8600.98
155_G159_G0.8570.98
108_G149_G0.8550.98
222_V229_Y0.8500.98
216_K220_I0.8500.98
371_F389_F0.8490.98
262_F400_A0.8470.98
267_P271_K0.8450.98
299_G302_C0.8450.98
136_L140_G0.8440.98
336_I366_V0.8410.98
195_A407_T0.8390.98
115_A118_D0.8380.98
380_P383_H0.8370.98
228_M231_I0.8330.98
60_L136_L0.8290.98
259_G427_I0.8270.98
144_V302_C0.8260.98
108_G111_E0.8250.98
357_F415_M0.8240.98
56_G59_W0.8230.98
107_S131_K0.8190.98
264_I435_L0.8190.98
107_S113_E0.8170.98
317_F358_A0.8130.98
255_Y388_T0.8120.98
131_K185_G0.8100.98
369_T386_A0.8090.98
293_L297_A0.8080.97
218_V224_M0.8060.97
257_I371_F0.8060.97
280_L284_H0.8050.97
207_Q212_L0.8020.97
52_A55_K0.8020.97
425_M429_G0.8010.97
34_A173_A0.8010.97
248_P251_T0.7980.97
106_G353_P0.7940.97
130_V134_G0.7930.97
388_T392_A0.7920.97
152_V199_F0.7900.97
298_I343_T0.7900.97
210_Y213_I0.7890.97
116_L204_M0.7880.97
407_T411_L0.7850.97
143_M352_A0.7840.97
224_M227_I0.7830.97
290_K294_M0.7810.97
85_C90_A0.7790.97
217_A220_I0.7790.97
151_T358_A0.7770.97
266_G401_S0.7770.97
268_I341_V0.7770.97
53_F154_I0.7760.97
182_A361_L0.7750.97
402_I415_M0.7740.97
86_S299_G0.7740.97
64_R85_C0.7730.97
300_G305_L0.7700.97
87_A299_G0.7680.97
196_G408_G0.7680.97
87_A296_G0.7670.97
191_N226_T0.7660.97
196_G200_I0.7650.97
89_L137_G0.7650.97
57_V147_R0.7620.96
309_A335_F0.7610.96
109_I152_V0.7560.96
207_Q211_T0.7530.96
295_G299_G0.7510.96
95_F98_R0.7500.96
329_S338_V0.7500.96
276_M280_L0.7500.96
89_L92_F0.7490.96
296_G300_G0.7490.96
145_L348_F0.7460.96
209_R212_L0.7450.96
294_M298_I0.7430.96
268_I272_W0.7430.96
60_L64_R0.7430.96
40_A220_I0.7420.96
273_V276_M0.7410.96
54_D189_A0.7390.96
431_G435_L0.7380.96
250_N253_W0.7360.96
81_V87_A0.7320.96
258_L393_G0.7320.96
219_F406_L0.7230.95
224_M228_M0.7220.95
312_T339_A0.7210.95
402_I405_P0.7210.95
319_L322_I0.7200.95
183_A222_V0.7200.95
168_L173_A0.7200.95
54_D58_A0.7190.95
208_F213_I0.7190.95
203_E348_F0.7190.95
84_L88_V0.7180.95
238_L241_V0.7150.95
356_I444_L0.7130.95
323_A390_A0.7120.95
39_A54_D0.7120.95
192_A357_F0.7110.95
61_Q65_M0.7110.95
82_A89_L0.7100.95
94_Y296_G0.7100.95
197_I219_F0.7080.95
44_T224_M0.7070.95
90_A299_G0.7060.95
39_A220_I0.7000.94
33_L37_F0.6990.94
319_L366_V0.6990.94
196_G199_F0.6990.94
392_A396_A0.6990.94
444_L448_I0.6980.94
174_R178_L0.6970.94
300_G304_L0.6970.94
57_V139_L0.6950.94
316_G340_R0.6950.94
311_A336_I0.6920.94
114_G119_Q0.6920.94
90_A295_G0.6920.94
353_P356_I0.6910.94
114_G117_E0.6900.94
266_G399_A0.6900.94
217_A349_S0.6880.94
293_L296_G0.6870.94
277_Q353_P0.6860.94
195_A404_A0.6860.94
265_F268_I0.6850.94
171_D175_H0.6830.94
78_L88_V0.6820.93
255_Y258_L0.6810.93
295_G298_I0.6750.93
263_G400_A0.6750.93
122_V164_D0.6750.93
362_A365_T0.6730.93
131_K150_P0.6730.93
99_K102_P0.6720.93
115_A160_R0.6700.93
87_A300_G0.6690.93
280_L294_M0.6680.93
239_I323_A0.6660.93
430_L434_L0.6650.93
266_G397_L0.6650.93
195_A356_I0.6640.93
90_A269_F0.6630.93
83_F304_L0.6620.92
294_M302_C0.6620.92
144_V347_C0.6620.92
175_H178_L0.6610.92
375_A379_F0.6610.92
412_V421_L0.6600.92
112_I115_A0.6590.92
31_T34_A0.6570.92
92_F95_F0.6570.92
97_V102_P0.6560.92
78_L81_V0.6550.92
66_G374_V0.6530.92
106_G110_P0.6520.92
178_L211_T0.6440.91
335_F338_V0.6430.91
410_I413_L0.6420.91
246_D249_L0.6390.91
111_E114_G0.6390.91
220_I225_S0.6390.91
125_W164_D0.6370.91
131_K149_G0.6360.91
397_L401_S0.6360.91
131_K134_G0.6360.91
163_L181_G0.6330.91
104_A131_K0.6320.91
269_F445_Y0.6320.91
227_I231_I0.6300.91
151_T407_T0.6290.90
364_G393_G0.6280.90
138_T353_P0.6260.90
36_L43_G0.6240.90
60_L67_A0.6230.90
139_L150_P0.6220.90
187_A229_Y0.6220.90
92_F96_L0.6220.90
262_F401_S0.6200.90
442_K447_A0.6190.90
311_A322_I0.6170.90
222_V225_S0.6160.90
195_A410_I0.6160.90
115_A120_R0.6150.89
383_H389_F0.6150.89
269_F363_L0.6150.89
316_G361_L0.6130.89
344_T363_L0.6130.89
63_Q66_G0.6120.89
144_V343_T0.6120.89
266_G270_N0.6100.89
185_G263_G0.6090.89
149_G414_E0.6060.89
327_N331_G0.6060.89
87_A303_G0.6030.89
197_I201_I0.6020.88
226_T229_Y0.6000.88
281_H285_G0.6000.88
96_L130_V0.5990.88
330_M373_M0.5950.88
149_G353_P0.5950.88
253_W256_L0.5940.88
330_M374_V0.5910.88
51_V233_N0.5910.88
186_L421_L0.5870.87
218_V227_I0.5860.87
111_E116_L0.5860.87
255_Y259_G0.5850.87
266_G345_L0.5850.87
262_F428_T0.5830.87
338_V374_V0.5830.87
100_Y130_V0.5820.87
147_R153_Q0.5810.87
100_Y103_E0.5800.87
78_L82_A0.5800.87
152_V357_F0.5800.87
385_E390_A0.5790.86
324_T387_G0.5790.86
235_E238_L0.5770.86
88_V92_F0.5760.86
340_R351_G0.5760.86
187_A419_Y0.5740.86
96_L307_F0.5730.86
309_A343_T0.5720.86
53_F147_R0.5720.86
99_K104_A0.5700.86
369_T372_G0.5680.85
53_F132_F0.5670.85
38_M166_F0.5650.85
51_V188_A0.5650.85
139_L356_I0.5650.85
104_A127_V0.5630.85
86_S94_Y0.5630.85
179_A200_I0.5620.85
336_I362_A0.5610.85
390_A393_G0.5600.85
127_V131_K0.5590.84
436_A441_G0.5570.84
370_A373_M0.5560.84
274_L278_D0.5560.84
90_A96_L0.5550.84
42_V159_G0.5540.84
135_G402_I0.5530.84
196_G263_G0.5530.84
165_I374_V0.5510.84
54_D147_R0.5510.84
203_E404_A0.5510.84
139_L151_T0.5510.84
162_V166_F0.5500.84
115_A119_Q0.5500.84
187_A225_S0.5500.84
153_Q353_P0.5490.83
435_L439_T0.5490.83
93_G137_G0.5490.83
113_E446_S0.5480.83
94_Y100_Y0.5470.83
189_A348_F0.5470.83
326_G329_S0.5470.83
103_E124_W0.5460.83
173_A176_T0.5460.83
124_W127_V0.5450.83
182_A186_L0.5450.83
402_I411_L0.5450.83
40_A228_M0.5450.83
302_C306_G0.5440.83
78_L430_L0.5440.83
85_C93_G0.5420.83
35_I177_L0.5420.83
261_I285_G0.5420.83
53_F149_G0.5400.82
92_F377_E0.5400.82
145_L358_A0.5390.82
247_A251_T0.5380.82
344_T347_C0.5370.82
110_P117_E0.5350.82
77_L81_V0.5350.82
98_R101_A0.5340.82
68_L403_R0.5330.82
96_L99_K0.5330.82
139_L408_G0.5320.81
199_F445_Y0.5310.81
338_V342_I0.5300.81
185_G404_A0.5300.81
372_G400_A0.5300.81
217_A224_M0.5290.81
185_G259_G0.5280.81
219_F223_I0.5280.81
90_A97_V0.5270.81
180_T218_V0.5270.81
55_K232_F0.5260.81
38_M162_V0.5260.81
93_G104_A0.5250.81
383_H386_A0.5230.80
342_I374_V0.5230.80
104_A107_S0.5230.80
377_E380_P0.5220.80
332_M335_F0.5210.80
306_G310_P0.5210.80
224_M231_I0.5200.80
419_Y422_I0.5190.80
110_P152_V0.5190.80
191_N234_H0.5180.80
47_G228_M0.5170.80
229_Y411_L0.5170.80
404_A407_T0.5160.80
361_L397_L0.5150.79
113_E117_E0.5150.79
161_M164_D0.5150.79
361_L398_L0.5140.79
258_L389_F0.5140.79
292_V295_G0.5130.79
328_F333_L0.5130.79
374_V377_E0.5120.79
43_G54_D0.5120.79
191_N207_Q0.5110.79
46_V54_D0.5110.79
108_G116_L0.5100.79
154_I425_M0.5090.79
221_G224_M0.5090.79
265_F374_V0.5090.79
46_V357_F0.5090.79
149_G190_F0.5090.79
186_L357_F0.5060.78
87_A91_M0.5060.78
189_A263_G0.5060.78
318_N322_I0.5050.78
75_Y264_I0.5040.78
236_V239_I0.5040.78
45_L165_I0.5040.78
280_L283_V0.5040.78
50_A54_D0.5030.78
168_L174_R0.5030.78
373_M386_A0.5000.77
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3nd0A 2 0.8985 100 0.182 Contact Map
4eneA 2 0.9387 100 0.191 Contact Map
3orgA 2 0.8732 100 0.253 Contact Map
1jcnA 6 0.2051 98.9 0.885 Contact Map
4j05A 3 0.8224 83.2 0.954 Contact Map
3usbA 4 0.1987 81 0.955 Contact Map
2cfqA 1 0.4693 52.5 0.963 Contact Map
1pw4A 1 0.852 44.4 0.965 Contact Map
4zw9A 1 0.8499 42.1 0.965 Contact Map
2kogA 1 0.1142 22.7 0.97 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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