GREMLIN Database
NORR - Anaerobic nitric oxide reductase transcription regulator NorR
UniProt: P37013 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12108
Length: 504 (438)
Sequences: 12407 (8908)
Seq/√Len: 425.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
334_E339_R4.1811.00
216_E359_R3.7441.00
475_N485_M3.7191.00
260_V270_N3.6151.00
245_A297_A3.2861.00
333_E337_A3.1651.00
276_E310_R3.1271.00
274_K309_Q3.0481.00
249_E294_A2.8801.00
307_D316_C2.8641.00
375_Q408_E2.7881.00
68_F85_V2.7151.00
201_I224_V2.6471.00
308_I319_V2.6191.00
307_D318_R2.5801.00
465_R469_R2.5651.00
475_N482_C2.5651.00
329_R334_E2.5511.00
330_D333_E2.4261.00
467_T471_A2.4121.00
275_F302_V2.3701.00
481_A484_R2.3211.00
203_I419_R2.2941.00
99_D102_I2.2921.00
73_H98_Y2.2911.00
366_I392_R2.2651.00
388_S424_G2.2281.00
387_L411_I2.1991.00
284_F326_A2.1851.00
369_A387_L2.1821.00
474_Q485_M2.1661.00
309_Q316_C2.1581.00
260_V313_D2.1201.00
366_I396_Q2.0981.00
334_E337_A2.0351.00
53_P71_E2.0271.00
72_G75_R2.0231.00
304_Q408_E1.9891.00
234_R320_D1.9861.00
280_N320_D1.9371.00
224_V355_V1.9171.00
400_F410_A1.8981.00
275_F283_L1.8821.00
333_E336_L1.8651.00
46_Y76_L1.8601.00
138_F156_A1.8441.00
398_Y401_P1.8361.00
219_T355_V1.8271.00
362_G366_I1.8211.00
214_S354_S1.8111.00
491_A495_R1.7971.00
391_A395_L1.7901.00
260_V310_R1.7901.00
253_E298_K1.7751.00
303_L323_V1.7681.00
290_E329_R1.7651.00
53_P69_A1.7471.00
464_Q496_L1.7391.00
190_L367_L1.7391.00
325_A348_L1.7131.00
44_L70_L1.7071.00
222_E301_R1.6931.00
471_A475_N1.6761.00
197_L353_L1.6731.00
71_E75_R1.6571.00
461_E499_R1.6561.00
370_G392_R1.6431.00
202_E231_A1.6301.00
302_V308_I1.6231.00
388_S391_A1.6221.00
209_L412_H1.6041.00
214_S352_P1.5991.00
279_D319_V1.5981.00
369_A411_I1.5851.00
390_G425_D1.5761.00
42_A66_R1.5651.00
313_D317_L1.5621.00
74_P96_D1.5581.00
87_R153_A1.5521.00
362_G399_S1.5421.00
362_G365_V1.5381.00
391_A425_D1.5191.00
162_L166_L1.5071.00
191_S363_D1.4891.00
199_K202_E1.4861.00
391_A423_S1.4831.00
392_R396_Q1.4831.00
105_Q135_P1.4741.00
271_R314_D1.4701.00
371_Y375_Q1.4701.00
379_R412_H1.4681.00
354_S360_E1.4671.00
279_D320_D1.4631.00
308_I318_R1.4621.00
394_L425_D1.4611.00
189_G194_M1.4551.00
194_M198_K1.4551.00
252_A295_L1.4501.00
208_D379_R1.4391.00
331_L340_F1.4311.00
387_L392_R1.4261.00
276_E317_L1.4141.00
366_I369_A1.4131.00
368_L372_F1.4131.00
272_S276_E1.4091.00
198_K201_I1.4071.00
471_A486_L1.4041.00
423_S428_I1.3931.00
289_G327_T1.3871.00
386_V422_R1.3771.00
373_C387_L1.3761.00
470_Q474_Q1.3741.00
469_R473_A1.3721.00
245_A290_E1.3711.00
259_H264_F1.3651.00
237_N280_N1.3631.00
481_A485_M1.3631.00
90_A103_P1.3621.00
471_A485_M1.3581.00
189_G198_K1.3581.00
480_A484_R1.3561.00
376_C411_I1.3511.00
424_G427_V1.3501.00
456_L459_A1.3391.00
376_C415_V1.3381.00
398_Y406_E1.3121.00
489_D492_N1.3111.00
385_V421_T1.3101.00
306_G318_R1.2961.00
204_V351_F1.2851.00
460_T463_F1.2821.00
197_L355_V1.2811.00
81_R110_V1.2791.00
373_C415_V1.2751.00
290_E328_N1.2731.00
212_L325_A1.2611.00
187_M223_L1.2611.00
196_Q199_K1.2581.00
209_L380_Q1.2551.00
310_R313_D1.2551.00
57_D69_A1.2531.00
47_D53_P1.2521.00
336_L342_A1.2511.00
491_A494_H1.2501.00
393_N397_H1.2481.00
216_E357_P1.2431.00
188_I371_Y1.2431.00
111_H114_V1.2401.00
117_P152_L1.2391.00
197_L224_V1.2341.00
94_L98_Y1.2341.00
492_N496_L1.2321.00
478_N481_A1.2251.00
418_A427_V1.2241.00
263_A311_V1.2181.00
467_T486_L1.2151.00
261_K269_S1.2121.00
489_D495_R1.2101.00
471_A482_C1.2071.00
332_R336_L1.2051.00
459_A463_F1.2051.00
57_D61_K1.2031.00
377_R385_V1.2031.00
213_I324_L1.1981.00
495_R499_R1.1971.00
208_D234_R1.1971.00
429_L432_Q1.1951.00
42_A68_F1.1891.00
261_K268_I1.1841.00
372_F408_E1.1831.00
206_A233_P1.1821.00
468_I493_L1.1761.00
478_N490_V1.1751.00
80_A107_S1.1751.00
68_F79_I1.1671.00
239_L281_G1.1661.00
482_C485_M1.1651.00
463_F467_T1.1641.00
70_L79_I1.1621.00
200_E417_L1.1531.00
213_I224_V1.1511.00
254_S259_H1.1471.00
372_F411_I1.1461.00
77_E106_E1.1441.00
226_K241_Y1.1411.00
243_N290_E1.1401.00
387_L423_S1.1401.00
88_F107_S1.1381.00
479_W494_H1.1221.00
187_M224_V1.1191.00
209_L350_V1.1171.00
254_S264_F1.1131.00
249_E292_S1.1091.00
63_V150_A1.1091.00
372_F376_C1.1071.00
275_F321_V1.1061.00
90_A118_L1.1061.00
106_E109_K1.1021.00
259_H263_A1.0991.00
365_V369_A1.0931.00
350_V409_H1.0921.00
227_A231_A1.0891.00
79_I85_V1.0881.00
472_L482_C1.0871.00
104_G116_L1.0841.00
73_H103_P1.0821.00
480_A490_V1.0811.00
388_S422_R1.0811.00
283_L323_V1.0771.00
362_G396_Q1.0701.00
363_D396_Q1.0611.00
414_A418_A1.0611.00
201_I227_A1.0591.00
259_H311_V1.0581.00
279_D321_V1.0581.00
89_P153_A1.0581.00
252_A291_L1.0541.00
377_R383_S1.0541.00
410_A414_A1.0521.00
289_G331_L1.0521.00
479_W497_A1.0501.00
201_I353_L1.0491.00
214_S332_R1.0481.00
252_A256_L1.0481.00
73_H94_L1.0471.00
189_G367_L1.0471.00
276_E308_I1.0431.00
194_M197_L1.0431.00
455_N458_E1.0381.00
414_A423_S1.0311.00
186_Q230_E1.0311.00
125_I130_L1.0301.00
187_M198_K1.0261.00
413_R417_L1.0261.00
370_G374_E1.0241.00
310_R317_L1.0221.00
385_V415_V1.0221.00
277_M314_D1.0221.00
131_D135_P1.0171.00
456_L460_T1.0131.00
162_L165_Q1.0101.00
70_L76_L1.0091.00
390_G424_G1.0071.00
255_E271_R1.0041.00
283_L302_V1.0031.00
222_E241_Y1.0021.00
47_D94_L1.0001.00
332_R431_A0.9911.00
323_V348_L0.9881.00
198_K224_V0.9871.00
106_E110_V0.9871.00
208_D233_P0.9851.00
264_F267_A0.9801.00
77_E98_Y0.9781.00
190_L195_T0.9781.00
469_R502_L0.9771.00
209_L416_V0.9731.00
274_K277_M0.9721.00
472_L479_W0.9701.00
466_E470_Q0.9691.00
479_W491_A0.9681.00
197_L201_I0.9661.00
374_E378_L0.9621.00
127_A140_V0.9611.00
472_L497_A0.9591.00
59_L146_L0.9591.00
429_L433_H0.9531.00
210_N306_G0.9531.00
73_H77_E0.9501.00
468_I486_L0.9401.00
259_H270_N0.9371.00
192_P196_Q0.9351.00
210_N325_A0.9291.00
189_G224_V0.9271.00
226_K230_E0.9261.00
275_F319_V0.9201.00
43_L65_G0.9161.00
493_L496_L0.9141.00
468_I496_L0.9121.00
104_G118_L0.9121.00
211_V228_I0.9091.00
87_R157_L0.9081.00
277_M313_D0.9061.00
272_S277_M0.9031.00
466_E469_R0.9021.00
42_A85_V0.8991.00
93_E122_Q0.8971.00
272_S314_D0.8951.00
65_G154_A0.8841.00
459_A462_A0.8841.00
382_L385_V0.8841.00
240_V277_M0.8841.00
89_P149_I0.8821.00
460_T467_T0.8821.00
47_D52_I0.8791.00
241_Y301_R0.8791.00
289_G328_N0.8741.00
377_R384_R0.8731.00
259_H271_R0.8721.00
68_F83_G0.8711.00
492_N495_R0.8691.00
408_E412_H0.8651.00
78_A82_A0.8651.00
486_L496_L0.8631.00
248_P311_V0.8631.00
240_V278_A0.8621.00
349_S352_P0.8621.00
193_G196_Q0.8611.00
72_G96_D0.8611.00
455_N487_E0.8601.00
216_E219_T0.8601.00
369_A414_A0.8581.00
45_R67_R0.8531.00
63_V154_A0.8521.00
101_L132_G0.8501.00
154_A158_S0.8501.00
187_M194_M0.8501.00
90_A94_L0.8481.00
490_V494_H0.8471.00
349_S413_R0.8471.00
308_I317_L0.8461.00
282_T324_L0.8451.00
473_A477_H0.8441.00
184_Q227_A0.8431.00
160_A164_E0.8421.00
98_Y102_I0.8411.00
382_L415_V0.8391.00
243_N291_L0.8381.00
131_D134_Q0.8361.00
494_H498_K0.8351.00
42_A83_G0.8351.00
365_V395_L0.8321.00
259_H267_A0.8321.00
468_I497_A0.8311.00
259_H268_I0.8251.00
393_N396_Q0.8231.00
270_N310_R0.8231.00
376_C408_E0.8221.00
357_P360_E0.8211.00
78_A81_R0.8181.00
92_S127_A0.8181.00
88_F114_V0.8161.00
470_Q473_A0.8151.00
89_P117_P0.8151.00
370_G386_V0.8141.00
225_A239_L0.8131.00
301_R305_Y0.8121.00
195_T199_K0.8111.00
193_G360_E0.8111.00
204_V211_V0.8091.00
203_I427_V0.8081.00
201_I228_I0.8071.00
387_L391_A0.8021.00
475_N481_A0.7981.00
242_L283_L0.7981.00
234_R237_N0.7971.00
376_C412_H0.7931.00
291_L295_L0.7931.00
462_A466_E0.7911.00
369_A392_R0.7891.00
213_I355_V0.7891.00
489_D494_H0.7831.00
194_M224_V0.7831.00
189_G201_I0.7821.00
493_L497_A0.7811.00
92_S118_L0.7801.00
70_L73_H0.7771.00
195_T198_K0.7751.00
376_C380_Q0.7741.00
366_I370_G0.7731.00
90_A116_L0.7731.00
209_L351_F0.7711.00
479_W486_L0.7701.00
490_V495_R0.7681.00
158_S163_I0.7661.00
158_S161_L0.7661.00
260_V317_L0.7601.00
158_S162_L0.7591.00
332_R342_A0.7571.00
270_N313_D0.7561.00
247_L256_L0.7511.00
141_F144_E0.7501.00
75_R79_I0.7481.00
188_I367_L0.7471.00
222_E305_Y0.7471.00
46_Y103_P0.7451.00
398_Y432_Q0.7451.00
349_S409_H0.7421.00
488_T493_L0.7421.00
102_I105_Q0.7391.00
459_A467_T0.7391.00
332_R345_F0.7371.00
74_P78_A0.7351.00
345_F349_S0.7351.00
496_L500_L0.7341.00
406_E431_A0.7331.00
189_G227_A0.7331.00
105_Q131_D0.7281.00
488_T492_N0.7281.00
271_R274_K0.7261.00
151_A155_G0.7251.00
456_L463_F0.7241.00
205_A232_S0.7221.00
465_R500_L0.7201.00
260_V276_E0.7201.00
394_L428_I0.7191.00
207_S416_V0.7191.00
362_G367_L0.7191.00
365_V396_Q0.7191.00
486_L492_N0.7181.00
107_S116_L0.7161.00
73_H96_D0.7141.00
270_N315_R0.7111.00
72_G94_L0.7101.00
289_G329_R0.7091.00
196_Q200_E0.7061.00
79_I82_A0.7061.00
389_A392_R0.7031.00
335_V345_F0.7021.00
250_S253_E0.6991.00
234_R321_V0.6991.00
477_H497_A0.6981.00
213_I225_A0.6971.00
70_L75_R0.6961.00
288_I348_L0.6951.00
275_F308_I0.6951.00
350_V412_H0.6941.00
75_R78_A0.6941.00
203_I382_L0.6931.00
472_L477_H0.6881.00
187_M227_A0.6881.00
414_A428_I0.6881.00
263_A267_A0.6881.00
103_P107_S0.6851.00
190_L363_D0.6831.00
457_R471_A0.6831.00
50_Q53_P0.6811.00
461_E465_R0.6781.00
458_E466_E0.6771.00
413_R416_V0.6771.00
458_E462_A0.6771.00
77_E103_P0.6761.00
289_G340_F0.6721.00
86_V160_A0.6711.00
280_N321_V0.6691.00
351_F416_V0.6691.00
79_I83_G0.6681.00
146_L150_A0.6661.00
332_R335_V0.6641.00
200_E351_F0.6630.99
494_H497_A0.6620.99
291_L299_L0.6600.99
261_K270_N0.6590.99
265_T326_A0.6580.99
306_G321_V0.6560.99
46_Y88_F0.6550.99
192_P195_T0.6550.99
151_A162_L0.6550.99
461_E500_L0.6540.99
377_R382_L0.6540.99
377_R415_V0.6520.99
199_K419_R0.6510.99
457_R496_L0.6500.99
130_L134_Q0.6500.99
198_K227_A0.6500.99
201_I231_A0.6480.99
197_L200_E0.6480.99
206_A232_S0.6480.99
468_I500_L0.6480.99
65_G150_A0.6470.99
223_L227_A0.6460.99
289_G326_A0.6440.99
375_Q379_R0.6410.99
468_I471_A0.6400.99
389_A393_N0.6390.99
48_S143_D0.6380.99
89_P119_F0.6380.99
87_R115_G0.6380.99
261_K267_A0.6360.99
274_K314_D0.6350.99
302_V305_Y0.6300.99
203_I417_L0.6290.99
120_A143_D0.6270.99
388_S425_D0.6260.99
91_D94_L0.6240.99
140_V143_D0.6240.99
119_F122_Q0.6240.99
105_Q109_K0.6230.99
208_D320_D0.6210.99
265_T328_N0.6210.99
45_R57_D0.6210.99
497_A502_L0.6210.99
351_F417_L0.6210.99
242_L274_K0.6190.99
486_L493_L0.6190.99
376_C379_R0.6170.99
243_N246_A0.6160.99
274_K316_C0.6160.99
44_L85_V0.6160.99
329_R339_R0.6160.99
184_Q198_K0.6150.99
248_P251_V0.6150.99
271_R277_M0.6140.99
380_Q415_V0.6130.99
91_D143_D0.6120.99
340_F344_L0.6110.99
279_D317_L0.6100.99
344_L348_L0.6090.99
140_V148_L0.6080.99
479_W493_L0.6070.99
373_C411_I0.6070.99
284_F324_L0.6070.99
76_L103_P0.6060.99
479_W490_V0.6050.99
313_D316_C0.6040.99
479_W488_T0.6040.99
248_P253_E0.6040.99
270_N317_L0.6030.99
354_S357_P0.6020.99
193_G197_L0.6010.99
491_A498_K0.6010.99
208_D380_Q0.6000.99
251_V265_T0.5990.99
464_Q468_I0.5980.99
200_E203_I0.5980.99
369_A373_C0.5970.99
43_L60_A0.5960.99
108_L115_G0.5960.99
414_A427_V0.5960.99
227_A230_E0.5960.99
199_K203_I0.5940.99
394_L397_H0.5940.99
410_A428_I0.5940.99
98_Y106_E0.5930.99
272_S308_I0.5900.99
217_T290_E0.5900.99
55_A59_L0.5870.99
45_R56_I0.5860.99
192_P363_D0.5850.99
260_V311_V0.5840.99
145_E148_L0.5840.99
126_G131_D0.5810.99
363_D366_I0.5780.99
90_A104_G0.5770.99
479_W495_R0.5770.99
123_N129_T0.5770.99
478_N495_R0.5740.99
42_A86_V0.5730.99
464_Q500_L0.5730.99
60_A153_A0.5730.99
219_T223_L0.5710.99
155_G158_S0.5700.98
205_A231_A0.5700.98
102_I106_E0.5700.98
186_Q227_A0.5690.98
275_F323_V0.5690.98
201_I206_A0.5690.98
478_N494_H0.5680.98
489_D496_L0.5680.98
214_S330_D0.5680.98
49_R52_I0.5670.98
477_H502_L0.5670.98
193_G363_D0.5660.98
204_V232_S0.5660.98
380_Q416_V0.5640.98
306_G319_V0.5630.98
362_G397_H0.5630.98
456_L467_T0.5630.98
478_N482_C0.5600.98
367_L370_G0.5600.98
59_L150_A0.5600.98
495_R498_K0.5590.98
212_L327_T0.5580.98
292_S295_L0.5580.98
198_K202_E0.5560.98
458_E463_F0.5560.98
480_A483_A0.5540.98
125_I129_T0.5540.98
214_S327_T0.5530.98
247_L252_A0.5510.98
462_A465_R0.5500.98
134_Q139_D0.5490.98
394_L398_Y0.5490.98
197_L204_V0.5490.98
140_V144_E0.5460.98
332_R352_P0.5430.98
293_L297_A0.5410.98
56_I119_F0.5400.98
467_T482_C0.5390.98
80_A114_V0.5390.98
457_R460_T0.5380.98
488_T496_L0.5380.98
460_T496_L0.5370.98
226_K305_Y0.5360.98
292_S297_A0.5340.98
279_D308_I0.5330.98
479_W482_C0.5320.98
308_I316_C0.5310.98
120_A123_N0.5310.98
263_A270_N0.5300.98
371_Y374_E0.5300.98
80_A88_F0.5300.98
94_L100_G0.5290.98
419_R427_V0.5290.98
48_S91_D0.5280.98
461_E464_Q0.5270.98
244_C400_F0.5250.97
420_A424_G0.5250.97
48_S120_A0.5250.97
242_L256_L0.5250.97
373_C377_R0.5240.97
262_G267_A0.5240.97
223_L404_V0.5240.97
95_P98_Y0.5230.97
212_L289_G0.5230.97
272_S310_R0.5220.97
244_C409_H0.5220.97
395_L410_A0.5220.97
456_L486_L0.5210.97
391_A414_A0.5200.97
48_S121_G0.5200.97
163_I166_L0.5180.97
467_T489_D0.5180.97
115_G159_N0.5180.97
152_L156_A0.5150.97
252_A298_K0.5150.97
90_A107_S0.5150.97
295_L298_K0.5150.97
411_I414_A0.5140.97
415_V418_A0.5130.97
343_D347_R0.5120.97
237_N279_D0.5120.97
56_I149_I0.5110.97
184_Q202_E0.5110.97
454_Q457_R0.5110.97
279_D318_R0.5110.97
468_I482_C0.5090.97
384_R415_V0.5080.97
260_V263_A0.5080.97
463_F486_L0.5070.97
471_A489_D0.5070.97
52_I494_H0.5070.97
210_N350_V0.5070.97
487_E490_V0.5060.97
490_V493_L0.5060.97
467_T470_Q0.5050.97
123_N142_S0.5050.97
138_F152_L0.5050.97
255_E274_K0.5040.97
251_V254_S0.5040.97
155_G162_L0.5020.97
460_T486_L0.5020.97
50_Q54_L0.5020.97
46_Y94_L0.5010.97
115_G163_I0.5010.97
76_L88_F0.5010.97
70_L85_V0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4l4uA 2 0.7679 100 0.164 Contact Map
3dzdA 2 0.7282 100 0.343 Contact Map
1ojlA 3 0.5972 100 0.444 Contact Map
4fwgA 3 0.6091 100 0.623 Contact Map
4qhsA 3 0.4841 100 0.659 Contact Map
4qosA 1 0.4762 100 0.663 Contact Map
1r6bX 1 0.8492 100 0.68 Contact Map
1qvrA 3 0.8413 100 0.691 Contact Map
3pxiA 3 0.7897 100 0.698 Contact Map
4ciuA 1 0.8194 100 0.7 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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