GREMLIN Database
FBPC - Fe(3+) ions import ATP-binding protein FbpC
UniProt: P37009 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12340
Length: 348 (282)
Sequences: 27882 (19300)
Seq/√Len: 1149.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
33_Q206_T3.7411.00
36_T204_S3.7391.00
219_G223_D3.6901.00
11_N24_N3.5821.00
20_T23_D3.5011.00
8_E28_T3.3181.00
10_R62_Q3.2751.00
122_A127_E3.1221.00
201_F222_Q2.6701.00
13_T60_E2.6021.00
9_L12_V2.5811.00
114_K118_K2.5781.00
220_S223_D2.5441.00
8_E64_F2.5431.00
14_K51_L2.5111.00
35_V208_L2.5041.00
129_F132_R2.5041.00
15_R20_T2.4611.00
10_R64_F2.4291.00
13_T20_T2.4291.00
30_P33_Q2.4111.00
116_R154_K2.3381.00
109_P112_E2.3301.00
12_V58_P2.3291.00
23_D214_H2.3021.00
79_D156_K2.2661.00
216_M230_S2.2531.00
96_G100_G2.2261.00
13_T24_N2.1671.00
96_G131_D2.0701.00
11_N26_N2.0201.00
182_L188_I2.0031.00
14_K59_S1.9601.00
51_L58_P1.9201.00
125_D174_S1.8721.00
49_L193_V1.8451.00
14_K56_E1.8281.00
96_G118_K1.8001.00
49_L159_L1.7781.00
208_L215_I1.7711.00
96_G114_K1.7511.00
116_R119_E1.7241.00
112_E115_A1.7221.00
7_V157_V1.7051.00
111_A115_A1.6741.00
66_D156_K1.6551.00
121_L130_E1.6241.00
15_R59_S1.6231.00
211_N216_M1.6041.00
29_I35_V1.6031.00
92_H135_D1.5971.00
93_M101_Y1.5971.00
256_G259_L1.5911.00
115_A119_E1.5901.00
22_I51_L1.5781.00
52_V191_L1.5781.00
240_A243_F1.5391.00
94_S97_E1.5371.00
50_R56_E1.5291.00
231_R272_M1.5261.00
9_L27_L1.5211.00
27_L208_L1.5011.00
100_G117_V1.4991.00
208_L218_I1.4791.00
112_E116_R1.4641.00
240_A244_P1.4521.00
120_A152_I1.4521.00
223_D227_Q1.4481.00
13_T23_D1.4291.00
50_R55_L1.4211.00
96_G117_V1.4201.00
124_V148_A1.4031.00
36_T200_A1.3791.00
252_V256_G1.3791.00
222_Q226_R1.3691.00
51_L63_I1.3431.00
206_T217_Q1.3381.00
132_R136_Q1.3331.00
35_V206_T1.2971.00
108_V112_E1.2971.00
58_P63_I1.2931.00
25_I48_I1.2861.00
68_E156_K1.2831.00
9_L52_V1.2831.00
118_K122_A1.2811.00
97_E100_G1.2771.00
231_R235_S1.2741.00
160_F190_S1.2711.00
81_C150_A1.2681.00
257_Y260_P1.2581.00
266_G269_G1.2471.00
10_R26_N1.2461.00
119_E122_A1.2411.00
180_R202_A1.2291.00
180_R203_V1.2141.00
209_V224_L1.2081.00
35_V218_I1.2061.00
22_I25_I1.2041.00
94_S133_F1.1871.00
194_T200_A1.1701.00
133_F136_Q1.1681.00
206_T218_I1.1651.00
9_L48_I1.1561.00
252_V255_Y1.1551.00
93_M98_N1.1451.00
95_L137_I1.1451.00
22_I48_I1.1301.00
81_C155_P1.1291.00
93_M97_E1.1261.00
16_F21_V1.1201.00
119_E123_M1.1171.00
297_V300_M1.1141.00
53_A159_L1.1071.00
192_Y204_S1.1051.00
225_Y228_P1.1041.00
90_F93_M1.0811.00
98_N149_R1.0791.00
100_G113_L1.0701.00
242_L272_M1.0681.00
221_P225_Y1.0651.00
231_R242_L1.0641.00
6_F28_T1.0631.00
241_N244_P1.0601.00
235_S242_L1.0551.00
34_M190_S1.0541.00
6_F31_Q1.0501.00
176_R202_A1.0461.00
108_V113_L1.0421.00
256_G260_P1.0371.00
275_V280_I1.0301.00
253_D256_G1.0211.00
204_S207_V1.0191.00
118_K130_E1.0171.00
261_R265_F1.0111.00
283_S287_E1.0111.00
15_R21_V1.0061.00
31_Q66_D1.0051.00
30_P206_T0.9951.00
29_I189_T0.9941.00
33_Q205_D0.9901.00
127_E130_E0.9891.00
154_K188_I0.9881.00
255_Y259_L0.9751.00
215_I218_I0.9751.00
31_Q156_K0.9701.00
100_G104_K0.9651.00
270_E274_G0.9611.00
164_L179_I0.9601.00
251_Y255_Y0.9591.00
15_R60_E0.9571.00
43_C210_M0.9551.00
9_L63_I0.9441.00
15_R18_S0.9401.00
118_K127_E0.9401.00
240_A274_G0.9401.00
12_V51_L0.9311.00
134_V145_V0.9311.00
296_H299_Y0.9291.00
255_Y258_H0.9251.00
110_R114_K0.9251.00
11_N60_E0.9221.00
209_V228_P0.9091.00
97_E104_K0.9061.00
233_M237_M0.9021.00
283_S286_G0.8961.00
48_I210_M0.8911.00
223_D226_R0.8841.00
99_V121_L0.8841.00
14_K47_T0.8831.00
262_P265_F0.8831.00
253_D257_Y0.8831.00
89_L98_N0.8821.00
120_A148_A0.8811.00
284_D287_E0.8791.00
173_R177_D0.8761.00
246_T270_E0.8751.00
221_P224_L0.8721.00
98_N134_V0.8711.00
254_I257_Y0.8691.00
64_F67_G0.8681.00
91_P135_D0.8671.00
219_G224_L0.8611.00
252_V259_L0.8601.00
83_V150_A0.8571.00
222_Q299_Y0.8561.00
253_D258_H0.8551.00
40_P43_C0.8541.00
119_E154_K0.8541.00
55_L84_F0.8471.00
90_F102_G0.8381.00
120_A151_L0.8361.00
226_R299_Y0.8331.00
276_R280_I0.8311.00
101_Y105_M0.8301.00
99_V102_G0.8281.00
99_V152_I0.8221.00
172_R196_D0.8211.00
32_G187_D0.8201.00
255_Y260_P0.8191.00
96_G130_E0.8191.00
113_L117_V0.8191.00
6_F30_P0.8161.00
32_G189_T0.8151.00
211_N214_H0.8141.00
198_S202_A0.8131.00
15_R19_N0.8111.00
51_L59_S0.8071.00
277_P280_I0.8061.00
120_A124_V0.8021.00
8_E67_G0.8011.00
111_A114_K0.7991.00
265_F269_G0.7931.00
177_D181_E0.7921.00
234_A238_G0.7911.00
105_M110_R0.7891.00
253_D260_P0.7851.00
89_L134_V0.7831.00
53_A82_M0.7801.00
65_I78_R0.7791.00
10_R28_T0.7791.00
267_T270_E0.7781.00
274_G277_P0.7781.00
289_S293_V0.7781.00
275_V279_A0.7781.00
6_F66_D0.7721.00
121_L126_L0.7641.00
273_V276_R0.7631.00
37_L210_M0.7601.00
224_L228_P0.7541.00
120_A123_M0.7541.00
46_T50_R0.7521.00
147_L160_F0.7521.00
178_K181_E0.7501.00
294_I297_V0.7461.00
277_P281_T0.7431.00
156_K188_I0.7411.00
227_Q231_R0.7391.00
268_Q271_G0.7361.00
38_L209_V0.7361.00
245_A271_G0.7351.00
24_N60_E0.7351.00
249_D252_V0.7331.00
92_H133_F0.7311.00
179_I190_S0.7301.00
274_G278_E0.7301.00
293_V296_H0.7281.00
159_L191_L0.7271.00
118_K126_L0.7271.00
137_I145_V0.7271.00
269_G273_V0.7251.00
34_M203_V0.7211.00
101_Y104_K0.7211.00
254_I259_L0.7211.00
225_Y229_A0.7201.00
270_E277_P0.7181.00
16_F56_E0.7181.00
157_V189_T0.7171.00
264_H267_T0.7171.00
94_S98_N0.7171.00
282_L286_G0.7161.00
292_C295_R0.7161.00
271_G274_G0.7151.00
102_G153_L0.7131.00
51_L56_E0.7081.00
269_G277_P0.7071.00
99_V148_A0.7061.00
106_L153_L0.7051.00
12_V63_I0.7041.00
80_I157_V0.7021.00
286_G289_S0.7021.00
158_L188_I0.6991.00
164_L192_Y0.6981.00
87_Y166_N0.6971.00
110_R113_L0.6951.00
162_E195_H0.6911.00
253_D259_L0.6911.00
7_V65_I0.6881.00
258_H262_P0.6861.00
265_F268_Q0.6841.00
244_P272_M0.6811.00
240_A245_A0.6791.00
272_M275_V0.6711.00
102_G149_R0.6701.00
81_C153_L0.6701.00
252_V257_Y0.6621.00
228_P233_M0.6621.00
232_F235_S0.6601.00
35_V191_L0.6601.00
169_A173_R0.6601.00
260_P263_L0.6591.00
104_K110_R0.6581.00
37_L48_I0.6541.00
246_T250_G0.6531.00
250_G253_D0.6511.00
174_S178_K0.6511.00
269_G276_R0.6511.00
96_G99_V0.6481.00
198_S300_M0.6371.00
270_E273_V0.6371.00
271_G275_V0.6331.00
288_E291_R0.6311.00
166_N171_L0.6301.00
109_P113_L0.6271.00
263_L266_G0.6271.00
252_V260_P0.6261.00
235_S239_D0.6231.00
276_R284_D0.6221.00
242_L246_T0.6201.00
27_L218_I0.6191.00
177_D296_H0.6161.00
182_L190_S0.6161.00
272_M276_R0.6141.00
269_G272_M0.6121.00
116_R120_A0.6111.00
241_N245_A0.6071.00
244_P270_E0.6071.00
173_R198_S0.6041.00
294_I299_Y0.6041.00
250_G255_Y0.6041.00
90_F98_N0.6031.00
237_M241_N0.6011.00
261_R264_H0.6011.00
15_R23_D0.5991.00
108_V116_R0.5981.00
106_L110_R0.5971.00
37_L208_L0.5961.00
276_R282_L0.5941.00
155_P158_L0.5931.00
211_N232_F0.5931.00
105_M109_P0.5931.00
98_N101_Y0.5921.00
244_P247_F0.5921.00
175_M178_K0.5921.00
170_N235_S0.5901.00
103_L106_L0.5821.00
31_Q187_D0.5801.00
260_P265_F0.5781.00
158_L190_S0.5771.00
13_T22_I0.5761.00
276_R283_S0.5751.00
79_D153_L0.5751.00
277_P284_D0.5721.00
289_S292_C0.5721.00
52_V159_L0.5721.00
221_P232_F0.5711.00
94_S131_D0.5711.00
16_F47_T0.5701.00
121_L124_V0.5661.00
243_F249_D0.5661.00
65_I80_I0.5651.00
238_G241_N0.5631.00
83_V143_Q0.5631.00
114_K117_V0.5631.00
23_D212_K0.5611.00
84_F87_Y0.5611.00
34_M192_Y0.5611.00
117_V120_A0.5591.00
287_E291_R0.5571.00
102_G106_L0.5571.00
277_P283_S0.5571.00
17_G20_T0.5571.00
24_N214_H0.5561.00
266_G270_E0.5551.00
210_M215_I0.5531.00
263_L267_T0.5521.00
207_V221_P0.5521.00
103_L152_I0.5521.00
275_V282_L0.5481.00
104_K113_L0.5471.00
248_S253_D0.5451.00
193_V196_D0.5451.00
102_G105_M0.5451.00
294_I300_M0.5441.00
37_L191_L0.5431.00
200_A204_S0.5431.00
56_E59_S0.5401.00
259_L262_P0.5361.00
121_L127_E0.5361.00
83_V147_L0.5341.00
66_D78_R0.5341.00
192_Y203_V0.5331.00
126_L129_F0.5321.00
209_V233_M0.5321.00
267_T271_G0.5321.00
256_G261_R0.5311.00
95_L98_N0.5291.00
180_R299_Y0.5291.00
249_D253_D0.5271.00
237_M240_A0.5261.00
275_V278_E0.5261.00
54_G65_I0.5251.00
157_V191_L0.5251.00
123_M181_E0.5211.00
125_D128_G0.5201.00
54_G57_K0.5191.00
6_F189_T0.5181.00
14_K22_I0.5181.00
29_I191_L0.5181.00
278_E282_L0.5181.00
281_T285_R0.5161.00
50_R82_M0.5141.00
234_A237_M0.5141.00
282_L285_R0.5141.00
177_D180_R0.5131.00
261_R268_Q0.5131.00
160_F192_Y0.5131.00
251_Y254_I0.5101.00
262_P266_G0.5101.00
245_A249_D0.5081.00
290_Q293_V0.5081.00
125_D178_K0.5081.00
11_N14_K0.5071.00
95_L145_V0.5071.00
177_D202_A0.5061.00
232_F236_F0.5061.00
268_Q272_M0.5051.00
100_G114_K0.5041.00
169_A176_R0.5041.00
167_L175_M0.5041.00
259_L263_L0.5021.00
27_L48_I0.5021.00
113_L116_R0.5011.00
14_K21_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2it1A 1 0.9885 100 0.164 Contact Map
1v43A 2 0.9598 100 0.165 Contact Map
1oxxK 1 0.9741 100 0.169 Contact Map
2yyzA 1 0.9856 100 0.176 Contact Map
3rlfA 2 0.9885 100 0.176 Contact Map
1g291 4 0.9885 100 0.176 Contact Map
3fvqA 2 0.9856 100 0.181 Contact Map
1z47A 2 0.9828 100 0.186 Contact Map
3d31A 2 0.9626 100 0.192 Contact Map
4tquS 2 0.9885 100 0.213 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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