GREMLIN Database
YAGA - Uncharacterized protein YagA
UniProt: P37007 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12338
Length: 384 (334)
Sequences: 5010 (4249)
Seq/√Len: 232.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
249_R252_R3.5341.00
237_R243_T3.2911.00
293_A298_R3.0011.00
143_R202_D2.9221.00
177_A193_S2.8751.00
236_S244_Q2.7541.00
226_L231_I2.7301.00
252_R256_A2.6781.00
142_N145_W2.6541.00
145_W194_V2.5381.00
182_E211_P2.4341.00
164_T247_L2.4221.00
293_A301_P2.2711.00
181_D186_T2.2701.00
161_H182_E2.2611.00
168_D246_K2.2561.00
110_F114_H2.2461.00
321_V347_R2.2221.00
164_T251_H2.1891.00
32_S36_R2.1841.00
147_M206_M2.1811.00
112_T115_N2.1061.00
144_L203_R2.1001.00
332_V352_E2.0901.00
97_K101_E2.0631.00
171_R287_H2.0611.00
283_L296_G1.9771.00
54_E58_G1.9681.00
34_C44_G1.9481.00
140_A202_D1.9361.00
150_K255_K1.9221.00
296_G300_Q1.9161.00
170_S298_R1.9041.00
145_W165_L1.8601.00
203_R234_G1.8581.00
323_K347_R1.8531.00
152_H155_F1.8441.00
266_D269_E1.8311.00
80_L83_M1.8291.00
151_G155_F1.8231.00
146_Q245_G1.7681.00
96_I100_L1.7491.00
146_Q168_D1.7461.00
294_V297_S1.7441.00
208_N235_H1.7371.00
173_S250_F1.7151.00
209_G212_W1.7061.00
208_N238_P1.7051.00
226_L233_V1.7021.00
240_H243_T1.6991.00
75_D78_T1.6981.00
139_D143_R1.6931.00
332_V350_L1.6881.00
293_A297_S1.6811.00
206_M233_V1.6731.00
41_P45_Y1.6591.00
174_L177_A1.6151.00
165_L194_V1.5981.00
271_Q275_D1.5931.00
287_H290_L1.5891.00
172_F299_Y1.5851.00
140_A143_R1.5711.00
165_L190_Q1.5681.00
173_S282_N1.5491.00
171_R295_P1.5481.00
74_S77_I1.5401.00
249_R253_S1.5381.00
144_L205_T1.5221.00
183_R186_T1.5161.00
149_F211_P1.5151.00
78_T82_R1.5121.00
80_L84_A1.5081.00
265_A269_E1.5041.00
75_D79_A1.5021.00
257_E285_R1.4961.00
172_F296_G1.4901.00
82_R86_D1.4851.00
109_A112_T1.4681.00
279_T283_L1.4611.00
30_I45_Y1.4541.00
147_M212_W1.4451.00
178_H274_F1.4121.00
43_T47_W1.4071.00
78_T116_L1.3771.00
146_Q244_Q1.3751.00
144_L168_D1.3681.00
188_Q221_A1.3671.00
169_H302_S1.3621.00
331_S336_S1.3521.00
286_P290_L1.3461.00
191_L195_F1.3431.00
97_K100_L1.3411.00
188_Q225_W1.3391.00
205_T243_T1.3351.00
211_P214_D1.3341.00
147_M165_L1.3271.00
109_A115_N1.3251.00
77_I85_H1.3251.00
146_Q247_L1.3221.00
348_V361_V1.3211.00
330_L334_G1.3161.00
179_C189_Q1.3021.00
173_S278_R1.2931.00
213_G235_H1.2891.00
303_A307_S1.2861.00
151_G154_P1.2841.00
175_C278_R1.2831.00
149_F163_L1.2771.00
33_L37_F1.2721.00
99_W102_D1.2601.00
191_L206_M1.2591.00
257_E277_W1.2431.00
81_L84_A1.2401.00
171_R246_K1.2301.00
324_V348_V1.2271.00
111_S115_N1.2201.00
331_S334_G1.2181.00
191_L222_L1.2181.00
32_S35_R1.2031.00
30_I48_L1.2011.00
193_S197_R1.1941.00
179_C190_Q1.1911.00
42_A49_Q1.1891.00
178_H271_Q1.1831.00
269_E272_R1.1771.00
80_L85_H1.1741.00
113_V117_M1.1731.00
29_N32_S1.1651.00
149_F179_C1.1641.00
166_L250_F1.1641.00
350_L359_Y1.1601.00
187_V222_L1.1541.00
99_W103_Q1.1531.00
45_Y49_Q1.1511.00
287_H291_D1.1481.00
31_R41_P1.1471.00
267_S271_Q1.1461.00
116_L119_R1.1431.00
174_L193_S1.1431.00
154_P157_G1.1411.00
100_L104_G1.1401.00
28_A36_R1.1371.00
256_A260_Q1.1361.00
153_F156_G1.1361.00
206_M235_H1.1341.00
149_F182_E1.1341.00
192_V196_E1.1271.00
321_V349_G1.1231.00
81_L85_H1.1221.00
163_L190_Q1.1201.00
330_L350_L1.1141.00
93_A96_I1.1091.00
236_S239_Y1.1071.00
128_P131_P1.1051.00
170_S302_S1.1021.00
77_I86_D1.0871.00
160_C270_L1.0861.00
146_Q246_K1.0861.00
150_K251_H1.0771.00
172_F282_N1.0711.00
42_A45_Y1.0681.00
275_D279_T1.0681.00
91_W95_K1.0631.00
108_P112_T1.0581.00
278_R282_N1.0531.00
164_T250_F1.0531.00
111_S114_H1.0521.00
236_S243_T1.0511.00
31_R35_R1.0481.00
94_R98_R1.0371.00
97_K113_V1.0351.00
205_T244_Q1.0271.00
171_R290_L1.0121.00
322_R350_L1.0111.00
28_A32_S1.0101.00
57_A60_Q1.0091.00
166_L247_L1.0091.00
39_I44_G1.0001.00
174_L197_R0.9971.00
149_F161_H0.9941.00
332_V359_Y0.9931.00
203_R232_R0.9911.00
49_Q53_Q0.9891.00
93_A117_M0.9891.00
81_L116_L0.9871.00
81_L96_I0.9851.00
237_R240_H0.9841.00
163_L187_V0.9831.00
65_I69_S0.9801.00
224_L228_R0.9781.00
152_H156_G0.9771.00
247_L251_H0.9761.00
191_L204_M0.9751.00
253_S281_Y0.9691.00
244_Q247_L0.9661.00
184_R188_Q0.9601.00
100_L113_V0.9591.00
162_P178_H0.9561.00
319_V349_G0.9551.00
114_H118_A0.9551.00
343_F346_E0.9551.00
61_D64_R0.9531.00
93_A114_H0.9531.00
92_G100_L0.9521.00
205_T234_G0.9511.00
250_F254_L0.9501.00
290_L298_R0.9481.00
258_V277_W0.9441.00
58_G61_D0.9441.00
149_F187_V0.9361.00
179_C186_T0.9321.00
194_V198_Y0.9321.00
302_S306_Y0.9321.00
324_V330_L0.9321.00
184_R221_A0.9311.00
77_I80_L0.9291.00
63_P66_P0.9291.00
88_H91_W0.9291.00
21_L25_Q0.9281.00
200_L229_L0.9261.00
249_R256_A0.9231.00
174_L194_V0.9231.00
82_R85_H0.9231.00
70_P73_S0.9211.00
220_T224_L0.9191.00
187_V212_W0.9171.00
95_K98_R0.9161.00
334_G337_L0.9111.00
220_T223_E0.9091.00
93_A97_K0.9091.00
273_A276_H0.9071.00
141_P169_H0.9020.99
141_P170_S0.9020.99
138_H144_L0.9020.99
30_I34_C0.9000.99
124_P127_S0.9000.99
290_L295_P0.8950.99
117_M120_H0.8850.99
189_Q193_S0.8820.99
310_T314_E0.8770.99
114_H117_M0.8750.99
26_D29_N0.8730.99
325_D328_G0.8710.99
242_Q245_G0.8650.99
200_L231_I0.8640.99
79_A83_M0.8640.99
163_L212_W0.8620.99
204_M231_I0.8610.99
33_L36_R0.8600.99
81_L113_V0.8570.99
96_I113_V0.8500.99
333_K337_L0.8480.99
222_L226_L0.8480.99
40_S43_T0.8470.99
258_V274_F0.8420.99
324_V328_G0.8420.99
94_R97_K0.8360.99
142_N299_Y0.8310.99
225_W229_L0.8290.99
313_P317_E0.8290.99
210_S214_D0.8260.99
245_G251_H0.8260.99
272_R276_H0.8240.99
166_L246_K0.8220.99
307_S310_T0.8200.99
138_H143_R0.8140.99
255_K259_L0.8130.99
76_D79_A0.8130.99
205_T236_S0.8080.99
181_D211_P0.8040.99
281_Y287_H0.8040.99
180_T267_S0.8030.99
190_Q193_S0.8010.99
178_H270_L0.7990.99
48_L52_A0.7990.99
120_H123_L0.7990.99
303_A309_N0.7980.99
97_K110_F0.7970.99
330_L337_L0.7950.99
274_F278_R0.7900.99
95_K99_W0.7860.99
92_G97_K0.7850.99
319_V351_K0.7850.99
121_G125_G0.7830.99
147_M150_K0.7800.99
351_K362_W0.7790.99
169_H298_R0.7790.99
286_P289_A0.7780.99
139_D144_L0.7740.98
43_T46_K0.7720.98
106_T112_T0.7710.98
320_M332_V0.7700.98
168_D245_G0.7690.98
149_F190_Q0.7580.98
37_F44_G0.7580.98
145_W201_P0.7580.98
112_T116_L0.7580.98
346_E363_W0.7560.98
22_F25_Q0.7550.98
208_N213_G0.7540.98
258_V273_A0.7490.98
174_L278_R0.7480.98
318_G321_V0.7470.98
163_L179_C0.7460.98
327_S336_S0.7450.98
214_D220_T0.7420.98
194_V197_R0.7360.98
160_C178_H0.7350.98
42_A46_K0.7350.98
303_A306_Y0.7350.98
154_P158_G0.7340.98
135_R144_L0.7340.98
151_G157_G0.7330.98
205_T235_H0.7290.98
162_P274_F0.7290.98
177_A189_Q0.7290.98
162_P251_H0.7280.98
57_A61_D0.7220.98
209_G214_D0.7180.97
77_I81_L0.7140.97
348_V363_W0.7130.97
155_F158_G0.7110.97
105_H108_P0.7110.97
247_L250_F0.7090.97
297_S300_Q0.7070.97
303_A310_T0.7060.97
221_A225_W0.7060.97
115_N118_A0.7050.97
193_S196_E0.7040.97
90_R97_K0.7020.97
110_F113_V0.7010.97
91_W96_I0.7000.97
214_D222_L0.6970.97
191_L225_W0.6970.97
138_H168_D0.6920.97
143_R203_R0.6920.97
165_L191_L0.6920.97
270_L274_F0.6910.97
109_A113_V0.6900.97
175_C193_S0.6860.97
94_R110_F0.6810.97
140_A169_H0.6800.97
295_P299_Y0.6790.96
322_R348_V0.6780.96
269_E273_A0.6780.96
201_P231_I0.6770.96
76_D81_L0.6770.96
357_G361_V0.6770.96
175_C254_L0.6750.96
277_W280_V0.6740.96
51_W55_G0.6720.96
253_S282_N0.6700.96
81_L100_L0.6690.96
224_L227_M0.6680.96
160_C267_S0.6660.96
49_Q52_A0.6650.96
322_R330_L0.6640.96
77_I84_A0.6610.96
92_G95_K0.6600.96
141_P302_S0.6600.96
313_P316_D0.6590.96
59_L63_P0.6590.96
197_R279_T0.6590.96
93_A100_L0.6520.96
310_T315_Y0.6480.95
96_I99_W0.6440.95
250_F281_Y0.6420.95
108_P113_V0.6410.95
146_Q205_T0.6380.95
27_G32_S0.6360.95
76_D80_L0.6350.95
351_K360_E0.6330.95
92_G96_I0.6320.95
79_A82_R0.6320.95
302_S305_Q0.6310.95
95_K257_E0.6310.95
130_I133_T0.6290.95
171_R289_A0.6290.95
79_A86_D0.6280.95
349_G362_W0.6270.95
78_T120_H0.6270.95
342_A346_E0.6250.94
161_H211_P0.6240.94
187_V209_G0.6220.94
306_Y310_T0.6220.94
300_Q304_R0.6220.94
341_K344_R0.6190.94
184_R187_V0.6190.94
50_R53_Q0.6170.94
277_W282_N0.6120.94
363_W366_T0.6110.94
172_F283_L0.6080.94
139_D142_N0.6080.94
186_T189_Q0.6070.94
102_D280_V0.6060.94
335_V339_A0.6050.93
302_S308_G0.6040.93
314_E317_E0.6040.93
254_L258_V0.6030.93
73_S77_I0.6030.93
182_E212_W0.6020.93
82_R120_H0.6020.93
111_S118_A0.6010.93
29_N35_R0.6010.93
64_R67_H0.5980.93
185_E221_A0.5960.93
304_R307_S0.5960.93
138_H169_H0.5950.93
31_R42_A0.5940.93
251_H255_K0.5930.93
306_Y309_N0.5930.93
287_H295_P0.5920.93
188_Q222_L0.5920.93
358_S362_W0.5910.93
192_V225_W0.5900.93
40_S46_K0.5890.93
186_T211_P0.5860.92
163_L177_A0.5840.92
142_N150_K0.5830.92
147_M204_M0.5820.92
172_F279_T0.5810.92
174_L198_Y0.5780.92
22_F26_D0.5780.92
54_E57_A0.5770.92
254_L274_F0.5770.92
68_H73_S0.5760.92
276_H280_V0.5750.92
242_Q251_H0.5740.92
330_L361_V0.5740.92
268_G271_Q0.5730.92
170_S299_Y0.5720.91
153_F157_G0.5720.91
24_S48_L0.5720.91
123_L126_A0.5720.91
162_P175_C0.5700.91
66_P71_N0.5690.91
147_M191_L0.5670.91
353_M359_Y0.5670.91
285_R288_E0.5640.91
120_H124_P0.5630.91
125_G129_G0.5600.91
146_Q236_S0.5600.91
286_P291_D0.5580.90
206_M212_W0.5570.90
301_P304_R0.5530.90
198_Y299_Y0.5510.90
171_R253_S0.5510.90
148_D248_E0.5500.90
311_T314_E0.5480.90
339_A361_V0.5470.90
307_S311_T0.5460.89
253_S257_E0.5450.89
175_C274_F0.5450.89
299_Y304_R0.5430.89
152_H157_G0.5430.89
101_E107_M0.5430.89
24_S28_A0.5420.89
305_Q309_N0.5370.89
142_N199_G0.5370.89
184_R211_P0.5350.89
54_E62_R0.5340.88
123_L127_S0.5340.88
82_R116_L0.5340.88
145_W299_Y0.5320.88
310_T313_P0.5320.88
350_L361_V0.5320.88
289_A293_A0.5320.88
76_D82_R0.5310.88
66_P69_S0.5310.88
113_V116_L0.5300.88
343_F363_W0.5290.88
347_R366_T0.5280.88
165_L206_M0.5260.88
136_F246_K0.5250.88
303_A311_T0.5240.87
297_S303_A0.5240.87
320_M352_E0.5230.87
172_F197_R0.5200.87
239_Y244_Q0.5190.87
62_R65_I0.5190.87
253_S277_W0.5180.87
195_F204_M0.5180.87
98_R257_E0.5180.87
324_V339_A0.5170.87
28_A33_L0.5160.87
195_F201_P0.5110.86
182_E186_T0.5100.86
96_I117_M0.5070.86
27_G33_L0.5060.86
29_N33_L0.5040.85
236_S240_H0.5040.85
234_G243_T0.5030.85
60_Q63_P0.5030.85
333_K352_E0.5030.85
149_F209_G0.5030.85
110_F118_A0.5030.85
149_F212_W0.5020.85
94_R101_E0.5020.85
357_G366_T0.5010.85
73_S78_T0.5000.85
69_S73_S0.5000.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4fcyA 4 0.9271 100 0.358 Contact Map
1bcoA 1 0.612 100 0.52 Contact Map
3oymA 3 0.8724 100 0.538 Contact Map
3f9kA 5 0.5391 100 0.595 Contact Map
4fw2A 2 0.5312 100 0.595 Contact Map
3hphA 3 0.5365 100 0.597 Contact Map
1k6yA 4 0.5052 100 0.598 Contact Map
2x78A 2 0.4792 100 0.609 Contact Map
4fw1A 2 0.5521 100 0.636 Contact Map
4u7bA 2 0.7266 100 0.637 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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