GREMLIN Database
CRCB - Putative fluoride ion transporter CrcB
UniProt: P37002 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12209
Length: 127 (117)
Sequences: 4198 (3195)
Seq/√Len: 295.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
44_G78_T4.4081.00
43_I77_L4.2511.00
48_I70_T3.2681.00
12_G16_S3.2041.00
9_F13_G3.1761.00
42_L113_M2.6111.00
102_N106_N2.4481.00
11_G68_L2.2691.00
13_G76_G2.1881.00
50_I121_F2.1731.00
18_A73_F2.1481.00
42_L109_G2.0621.00
87_V102_N1.9411.00
22_L40_A1.8851.00
46_F120_L1.8301.00
87_V103_V1.7471.00
45_A110_S1.7371.00
14_T68_L1.7071.00
87_V99_A1.6951.00
51_G69_I1.6891.00
14_T73_F1.6431.00
53_A118_F1.6331.00
40_A77_L1.5901.00
95_R98_W1.5611.00
39_T43_I1.5561.00
48_I114_T1.5471.00
46_F117_A1.5271.00
53_A121_F1.4371.00
13_G17_V1.4351.00
38_L105_V1.4341.00
47_I74_C1.4331.00
26_F36_G1.4061.00
17_V21_L1.3891.00
48_I74_C1.3771.00
20_W24_M1.3441.00
21_L25_R1.3441.00
51_G70_T1.2901.00
18_A77_L1.2591.00
16_S76_G1.2441.00
9_F17_V1.2291.00
53_A57_R1.2291.00
5_L17_V1.2251.00
115_A119_W1.2241.00
23_S40_A1.2161.00
52_F85_A1.2141.00
89_F92_Q1.2021.00
48_I76_G1.1431.00
68_L73_F1.1171.00
37_T86_E1.1151.00
100_L104_F1.0841.00
82_T86_E1.0691.00
117_A121_F1.0581.00
67_V71_T1.0461.00
38_L42_L1.0331.00
91_L99_A1.0271.00
88_V114_T1.0001.00
116_L119_W0.9841.00
46_F113_M0.9811.00
105_V109_G0.9711.00
88_V118_F0.9641.00
91_L96_F0.9501.00
50_I54_W0.9401.00
38_L109_G0.9381.00
96_F100_L0.9211.00
97_G100_L0.9081.00
52_F70_T0.9041.00
33_I38_L0.8981.00
10_I13_G0.8891.00
26_F30_H0.8751.00
21_L24_M0.8651.00
26_F29_L0.8601.00
97_G101_L0.8531.00
8_V67_V0.8511.00
88_V115_A0.8421.00
63_P67_V0.8421.00
105_V108_L0.8331.00
23_S27_N0.8211.00
7_A64_V0.8171.00
36_G40_A0.8151.00
25_R29_L0.8101.00
106_N110_S0.8101.00
86_E89_F0.8021.00
119_W122_S0.7860.99
104_F108_L0.7850.99
34_P90_L0.7850.99
109_G113_M0.7690.99
64_V67_V0.7410.99
84_S114_T0.7380.99
50_I53_A0.7300.99
23_S37_T0.7300.99
24_M28_P0.7220.99
26_F39_T0.7220.99
84_S88_V0.7200.99
23_S86_E0.7100.99
66_K70_T0.7090.99
18_A22_L0.7040.99
8_V11_G0.6980.99
62_D65_W0.6970.99
83_F110_S0.6930.99
40_A43_I0.6890.99
84_S107_L0.6860.98
50_I120_L0.6860.98
35_L39_T0.6860.98
83_F103_V0.6850.98
101_L105_V0.6850.98
118_F122_S0.6730.98
54_W121_F0.6710.98
89_F93_E0.6640.98
49_G114_T0.6610.98
61_I65_W0.6590.98
57_R122_S0.6580.98
38_L106_N0.6550.98
55_F61_I0.6500.98
22_L26_F0.6480.98
18_A21_L0.6470.98
51_G55_F0.6470.98
114_T117_A0.6450.98
113_M116_L0.6430.98
90_L102_N0.6430.98
45_A84_S0.6410.98
16_S74_C0.6400.98
73_F76_G0.6340.97
67_V70_T0.6320.97
80_F84_S0.6300.97
46_F53_A0.6280.97
85_A89_F0.6250.97
73_F77_L0.6250.97
22_L43_I0.6210.97
31_Q98_W0.6190.97
65_W68_L0.6170.97
52_F56_S0.6150.97
49_G53_A0.6140.97
11_G83_F0.6110.97
45_A114_T0.5930.96
33_I90_L0.5920.96
5_L67_V0.5910.96
6_L10_I0.5900.96
76_G83_F0.5880.96
22_L77_L0.5870.96
115_A118_F0.5850.96
112_A115_A0.5770.96
5_L21_L0.5720.95
32_A98_W0.5710.95
103_V107_L0.5710.95
118_F121_F0.5690.95
14_T17_V0.5620.95
19_R72_G0.5610.95
85_A114_T0.5600.95
112_A116_L0.5540.95
22_L36_G0.5540.95
30_H35_L0.5530.94
111_F114_T0.5480.94
7_A68_L0.5480.94
28_P31_Q0.5470.94
76_G80_F0.5460.94
57_R60_N0.5410.94
60_N64_V0.5410.94
10_I68_L0.5410.94
47_I69_I0.5400.94
20_W23_S0.5370.94
63_P66_K0.5360.94
14_T18_A0.5310.93
22_L39_T0.5250.93
49_G117_A0.5210.93
32_A101_L0.5200.93
45_A74_C0.5200.93
108_L112_A0.5190.92
55_F70_T0.5170.92
37_T79_T0.5160.92
57_R121_F0.5130.92
24_M40_A0.5080.92
61_I64_V0.5080.92
116_L120_L0.5060.91
8_V94_G0.5030.91
99_A107_L0.5020.91
31_Q35_L0.5000.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2gfpA 2 0.9291 2.9 0.938 Contact Map
1u7gA 3 0.811 2.7 0.939 Contact Map
4hzuS 1 0.9213 2.5 0.941 Contact Map
3rlbA 1 0.9764 2.4 0.941 Contact Map
3j1zP 8 0.937 2.4 0.941 Contact Map
4dveA 3 0.9921 2.4 0.941 Contact Map
4xnjA 1 0.9528 2.3 0.941 Contact Map
4tkrA 2 0.9764 2.3 0.942 Contact Map
3h90A 3 0.937 2.1 0.943 Contact Map
2j5dA 2 0.3386 2.1 0.943 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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