GREMLIN Database
PAGP - Lipid A palmitoyltransferase PagP
UniProt: P37001 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12180
Length: 186 (171)
Sequences: 184 (105)
Seq/√Len: 8.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
90_N114_W3.5740.95
59_A62_A3.5730.95
65_K68_T3.0950.89
95_Y133_T3.0230.88
109_I149_V2.9610.87
49_D83_S2.6840.81
41_T84_R2.6760.80
103_W141_N2.6170.79
60_R73_E2.5030.76
90_N161_V2.4830.75
96_A110_A2.3910.72
48_Y80_F2.3250.70
157_G162_T2.3230.70
165_M178_Y2.3200.70
125_N159_G2.2920.69
86_D107_E2.2660.68
56_T75_P2.1260.63
40_Q44_Q2.0990.61
100_K106_W2.0920.61
135_G149_V2.0630.60
110_A136_V2.0050.58
53_P179_F2.0020.58
51_Y81_G1.9880.57
53_P75_P1.9470.55
78_G168_I1.9400.55
100_K115_E1.8970.53
37_N92_H1.8820.53
130_L154_A1.7560.48
41_T130_L1.7010.45
133_T151_L1.6830.45
65_K69_D1.6690.44
24_F35_R1.6580.44
156_V163_F1.5940.41
87_E153_L1.5280.38
45_P55_I1.4690.36
50_L87_E1.4400.35
103_W121_L1.3960.34
134_A156_V1.3940.33
68_T172_Y1.3920.33
151_L169_P1.3830.33
136_V147_L1.3780.33
86_D92_H1.3570.32
55_I180_A1.3570.32
56_T107_E1.3210.31
54_A142_W1.3150.31
63_Y174_N1.3010.30
18_I21_G1.2970.30
82_L85_W1.2800.29
164_Q181_W1.2780.29
86_D108_P1.2650.29
67_K149_V1.2590.29
33_T80_F1.2570.29
68_T73_E1.2570.29
133_T179_F1.2550.29
71_Y173_N1.2450.28
110_A147_L1.2440.28
71_Y170_G1.2230.28
159_G165_M1.2190.27
108_P137_T1.2170.27
142_W149_V1.1930.27
67_K147_L1.1830.26
60_R167_Y1.1750.26
107_E165_M1.1660.26
165_M180_A1.1550.25
27_A122_A1.1490.25
50_L186_F1.1380.25
118_W164_Q1.1330.25
153_L183_R1.1300.25
64_D173_N1.1280.25
143_N150_L1.1060.24
73_E167_Y1.0950.24
33_T37_N1.0890.23
105_K140_D1.0850.23
115_E155_S1.0840.23
103_W163_F1.0770.23
144_Y181_W1.0730.23
52_I107_E1.0600.23
54_A75_P1.0470.22
158_Y179_F1.0430.22
57_W137_T1.0410.22
15_I18_I1.0390.22
84_R181_W1.0170.21
97_M179_F1.0130.21
15_I20_V1.0120.21
46_E160_P1.0090.21
27_A32_T1.0020.21
69_D147_L0.9820.20
71_Y91_W0.9790.20
49_D81_G0.9770.20
20_V23_V0.9740.20
78_G147_L0.9740.20
133_T173_N0.9730.20
154_A165_M0.9730.20
85_W130_L0.9660.20
42_W73_E0.9620.20
54_A149_V0.9610.20
132_F157_G0.9600.20
117_T135_G0.9580.20
74_R147_L0.9470.19
94_L130_L0.9320.19
64_D172_Y0.9240.19
34_F138_A0.9240.19
59_A85_W0.9140.19
53_P180_A0.9140.19
91_W170_G0.9120.19
167_Y178_Y0.9050.18
99_F108_P0.9030.18
128_L134_A0.9030.18
28_D156_V0.8900.18
125_N138_A0.8860.18
144_Y158_Y0.8840.18
76_W104_N0.8660.17
85_W117_T0.8650.17
104_N171_T0.8620.17
42_W167_Y0.8470.17
41_T136_V0.8460.17
44_Q78_G0.8360.17
96_A127_H0.8260.17
134_A150_L0.8210.16
169_P177_V0.8190.16
86_D132_F0.8010.16
128_L161_V0.8010.16
29_E50_L0.8000.16
89_G128_L0.7970.16
59_A71_Y0.7940.16
135_G179_F0.7930.16
95_Y151_L0.7900.16
15_I52_I0.7840.16
126_F182_M0.7790.15
70_R173_N0.7750.15
158_Y176_N0.7750.15
59_A184_F0.7740.15
57_W71_Y0.7700.15
33_T160_P0.7690.15
135_G147_L0.7650.15
95_Y126_F0.7620.15
51_Y57_W0.7580.15
89_G119_R0.7540.15
111_G129_G0.7490.15
173_N183_R0.7470.15
37_N149_V0.7460.15
15_I19_S0.7420.15
92_H114_W0.7360.15
32_T61_F0.7360.15
161_V184_F0.7340.15
98_A136_V0.7320.14
99_F176_N0.7320.14
21_G159_G0.7320.14
97_M164_Q0.7310.14
41_T181_W0.7230.14
165_M177_V0.7230.14
17_L20_V0.7200.14
114_W130_L0.7130.14
59_A176_N0.7130.14
127_H157_G0.7080.14
49_D119_R0.7070.14
73_E170_G0.6990.14
145_I174_N0.6960.14
54_A110_A0.6920.14
116_S127_H0.6900.14
121_L141_N0.6890.14
88_K132_F0.6850.14
61_F154_A0.6840.14
50_L78_G0.6820.14
71_Y176_N0.6820.14
76_W91_W0.6820.14
117_T165_M0.6790.13
170_G176_N0.6790.13
63_Y76_W0.6730.13
18_I186_F0.6700.13
114_W160_P0.6700.13
33_T117_T0.6640.13
89_G143_N0.6540.13
88_K121_L0.6480.13
64_D68_T0.6460.13
57_W168_I0.6450.13
120_P155_S0.6390.13
68_T93_G0.6390.13
36_E98_A0.6380.13
20_V65_K0.6330.13
151_L183_R0.6330.13
42_W170_G0.6320.13
114_W165_M0.6280.13
135_G150_L0.6270.12
107_E136_V0.6260.12
74_R107_E0.6230.12
52_I182_M0.6230.12
71_Y185_Q0.6180.12
153_L181_W0.6120.12
117_T121_L0.6120.12
33_T132_F0.6120.12
40_Q80_F0.6100.12
57_W166_T0.6070.12
103_W142_W0.6060.12
34_F38_I0.6010.12
78_G115_E0.5980.12
69_D128_L0.5930.12
97_M153_L0.5920.12
30_W150_L0.5910.12
37_N132_F0.5900.12
151_L177_V0.5880.12
107_E168_I0.5870.12
20_V29_E0.5850.12
104_N113_G0.5840.12
104_N153_L0.5810.12
40_Q93_G0.5810.12
53_P158_Y0.5800.12
36_E94_L0.5790.12
22_K65_K0.5780.12
150_L184_F0.5740.12
30_W161_V0.5730.12
71_Y164_Q0.5720.12
166_T184_F0.5700.12
38_I143_N0.5670.11
127_H154_A0.5660.11
49_D92_H0.5650.11
94_L137_T0.5640.11
17_L21_G0.5630.11
93_G154_A0.5600.11
38_I64_D0.5600.11
18_I32_T0.5570.11
54_A182_M0.5560.11
78_G154_A0.5560.11
24_F37_N0.5560.11
138_A144_Y0.5550.11
90_N165_M0.5510.11
53_P167_Y0.5500.11
27_A44_Q0.5470.11
68_T167_Y0.5460.11
85_W159_G0.5460.11
21_G32_T0.5440.11
145_I173_N0.5400.11
67_K140_D0.5380.11
35_R149_V0.5370.11
54_A103_W0.5330.11
24_F66_E0.5310.11
91_W158_Y0.5300.11
92_H107_E0.5260.11
60_R170_G0.5260.11
132_F150_L0.5240.11
91_W137_T0.5240.11
75_P171_T0.5220.11
59_A73_E0.5220.11
109_I135_G0.5200.11
103_W178_Y0.5160.11
18_I23_V0.5150.11
62_A67_K0.5140.11
64_D71_Y0.5090.11
83_S117_T0.5070.10
171_T177_V0.5060.10
107_E121_L0.5060.10
158_Y170_G0.5030.10
61_F184_F0.5030.10
63_Y167_Y0.5030.10
16_Q147_L0.5020.10
113_G180_A0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3gp6A 1 0.828 100 0.097 Contact Map
3nb3A 2 0.6183 21.7 0.965 Contact Map
4u6dA 2 0.7419 5.2 0.973 Contact Map
3uqsA 4 0.3226 4.4 0.974 Contact Map
2kncB 1 0.3495 3.7 0.975 Contact Map
3hkiC 1 0.0806 3.7 0.975 Contact Map
4txvB 1 0.414 2.8 0.977 Contact Map
4onlB 1 0.2796 2.6 0.977 Contact Map
1t8sA 3 0.3226 2.4 0.978 Contact Map
4um9B 2 0 2.1 0.978 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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