GREMLIN Database
RLMA - 23S rRNA (guanine(745)-N(1))-methyltransferase
UniProt: P36999 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12207
Length: 269 (258)
Sequences: 1580 (1257)
Seq/√Len: 78.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
60_A229_A6.0411.00
150_D169_K4.5071.00
90_L149_M4.1471.00
186_E257_Q4.1281.00
163_E166_R3.8271.00
142_L167_V3.8061.00
94_C114_G3.6831.00
144_F149_M3.0611.00
19_Y35_V3.0431.00
92_I164_L2.9791.00
223_R226_E2.7531.00
175_I262_I2.6721.00
70_L260_F2.6711.00
18_S26_Q2.5461.00
175_I264_L2.5151.00
221_R255_D2.4911.00
92_I139_S2.4411.00
182_R217_C2.3811.00
73_A214_A2.3301.00
168_V172_G2.1691.00
69_P218_Y2.1341.00
219_P255_D2.1211.00
142_L163_E2.1171.00
90_L167_V2.0641.00
152_I164_L2.0501.00
215_E259_D1.9741.00
3_F135_C1.9701.00
66_H226_E1.9271.00
218_Y258_T1.9231.00
32_E123_K1.8951.00
146_D163_E1.8891.00
90_L144_F1.8661.00
103_F153_I1.8141.00
68_Q72_D1.8091.00
100_T112_T1.7961.00
73_A77_Q1.7661.00
20_I26_Q1.7471.00
164_L168_V1.7451.00
101_H129_Y1.7371.00
78_L151_A1.7291.00
122_I136_V1.7261.00
7_L39_P1.7171.00
103_F107_L1.7091.00
164_L174_V1.6931.00
182_R257_Q1.6651.00
64_A226_E1.6521.00
173_W264_L1.6331.00
87_T150_D1.6251.00
146_D166_R1.5941.00
115_L137_A1.5851.00
25_H28_D1.5610.99
45_S48_P1.5510.99
29_M35_V1.5500.99
165_A208_F1.5420.99
220_M258_T1.5240.99
54_M156_Y1.5240.99
71_R102_A1.5200.99
10_Q23_Q1.5150.99
14_R29_M1.5000.99
140_H160_K1.4950.99
55_M121_A1.4810.99
88_A149_M1.4660.99
180_G261_N1.4440.99
226_E229_A1.4330.99
94_C125_A1.4220.99
63_D128_R1.4200.99
163_E167_V1.3930.99
10_Q22_P1.3640.99
122_I125_A1.3540.98
61_F66_H1.3480.98
81_R173_W1.3380.98
149_M167_V1.3280.98
180_G259_D1.3200.98
125_A134_F1.3160.98
73_A76_A1.3070.98
149_M152_I1.2950.98
145_S148_S1.2850.98
210_L263_H1.2800.98
186_E256_C1.2720.98
70_L177_A1.2600.98
4_S145_S1.2570.98
241_K245_W1.2550.97
113_F149_M1.2550.97
30_A34_Y1.2430.97
80_E212_Q1.2370.97
54_M183_H1.2370.97
71_R98_Y1.2140.97
184_L230_L1.1860.96
156_Y183_H1.1840.96
246_Q250_A1.1610.96
78_L175_I1.1440.96
99_Y183_H1.1420.96
19_Y29_M1.1370.95
135_C144_F1.1340.95
20_I24_R1.1300.95
66_H222_L1.1250.95
102_A105_D1.1200.95
178_T263_H1.1140.95
154_R164_L1.1090.95
152_I168_V1.1040.95
213_S263_H1.1040.95
217_C259_D1.1020.95
54_M118_S1.0870.94
5_C8_C1.0700.94
74_I175_I1.0630.94
217_C258_T1.0590.93
143_P163_E1.0510.93
142_L166_R1.0500.93
101_H128_R1.0500.93
61_F67_Y1.0490.93
93_G157_A1.0280.92
197_L200_P1.0110.92
13_S16_K1.0110.92
50_D55_M1.0100.92
251_K254_F1.0090.92
168_V174_V1.0070.92
62_L98_Y0.9930.91
158_P179_P0.9880.91
68_Q98_Y0.9830.91
243_E247_T0.9830.91
15_E20_I0.9780.90
231_L245_W0.9780.90
188_K192_Y0.9770.90
27_F30_A0.9770.90
14_R17_N0.9670.90
182_R185_M0.9620.90
13_S22_P0.9610.90
104_A112_T0.9550.89
113_F144_F0.9530.89
231_L240_A0.9360.88
30_A123_K0.9340.88
88_A169_K0.9260.88
71_R75_V0.9160.87
256_C259_D0.9160.87
4_S11_P0.9050.87
76_A106_A0.9010.86
202_A205_L0.9000.86
18_S35_V0.8990.86
242_P246_Q0.8980.86
104_A131_Q0.8950.86
155_I179_P0.8950.86
11_P14_R0.8900.86
113_F135_C0.8870.85
225_D228_V0.8860.85
213_S261_N0.8790.85
242_P245_W0.8790.85
87_T110_I0.8730.85
91_D115_L0.8650.84
137_A143_P0.8550.83
54_M58_R0.8540.83
36_N136_V0.8510.83
182_R186_E0.8500.83
99_Y156_Y0.8450.83
147_T169_K0.8420.82
129_Y134_F0.8390.82
41_Q46_R0.8380.82
94_C134_F0.8370.82
145_S175_I0.8350.82
27_F37_L0.8320.82
14_R18_S0.8310.82
67_Y99_Y0.8290.81
74_I155_I0.8280.81
100_T114_G0.8250.81
147_T170_P0.8230.81
3_F144_F0.8180.80
117_V136_V0.8150.80
196_H199_A0.8090.80
88_A150_D0.8080.80
143_P166_R0.8070.80
10_Q15_E0.8050.79
40_V48_P0.8040.79
88_A111_T0.8030.79
7_L40_V0.8020.79
62_L156_Y0.8000.79
91_D94_C0.7960.79
17_N29_M0.7960.79
18_S29_M0.7950.79
73_A262_I0.7930.78
112_T129_Y0.7890.78
26_Q29_M0.7860.78
258_T263_H0.7860.78
122_I134_F0.7820.77
58_R118_S0.7800.77
86_A150_D0.7790.77
169_K247_T0.7790.77
11_P145_S0.7780.77
17_N31_K0.7760.77
179_P233_M0.7760.77
182_R259_D0.7740.77
100_T132_V0.7720.77
182_R197_L0.7670.76
13_S255_D0.7660.76
139_S154_R0.7660.76
72_D76_A0.7650.76
100_T153_I0.7610.75
28_D34_Y0.7610.75
8_C157_A0.7600.75
18_S223_R0.7580.75
13_S76_A0.7570.75
14_R35_V0.7540.75
183_H235_P0.7530.75
69_P216_L0.7530.75
93_G154_R0.7530.75
158_P163_E0.7520.75
62_L99_Y0.7490.74
54_M187_L0.7480.74
3_F133_T0.7480.74
116_D156_Y0.7440.74
137_A142_L0.7430.74
254_F257_Q0.7430.74
58_R67_Y0.7420.74
3_F12_L0.7370.73
220_M256_C0.7330.73
91_D117_V0.7250.72
4_S9_H0.7230.72
119_K136_V0.7220.72
58_R156_Y0.7190.71
112_T132_V0.7150.71
165_A171_G0.7150.71
8_C158_P0.7150.71
159_C176_T0.7120.71
61_F222_L0.7110.70
78_L122_I0.7100.70
236_F256_C0.7100.70
60_A68_Q0.7090.70
27_F126_A0.7080.70
91_D97_G0.7040.70
84_D87_T0.7020.69
92_I154_R0.7010.69
245_W248_L0.6990.69
62_L65_G0.6980.69
241_K244_V0.6970.69
50_D156_Y0.6930.68
173_W211_Q0.6920.68
53_E79_R0.6920.68
32_E127_K0.6900.68
247_T251_K0.6870.68
62_L67_Y0.6870.68
194_E238_W0.6870.68
224_G251_K0.6830.67
222_L226_E0.6830.67
55_M91_D0.6820.67
154_R157_A0.6790.67
236_F260_F0.6790.67
58_R233_M0.6780.67
245_W249_A0.6780.67
74_I77_Q0.6780.67
183_H233_M0.6770.67
231_L237_A0.6730.66
59_R124_A0.6730.66
76_A79_R0.6670.66
7_L27_F0.6660.65
147_T162_E0.6620.65
156_Y179_P0.6570.64
10_Q13_S0.6540.64
230_L234_T0.6530.64
9_H14_R0.6500.64
158_P183_H0.6490.63
152_I167_V0.6470.63
227_A253_V0.6460.63
73_A216_L0.6440.63
128_R132_V0.6430.63
8_C179_P0.6410.62
14_R20_I0.6410.62
152_I174_V0.6390.62
134_F236_F0.6380.62
228_V249_A0.6370.62
138_S234_T0.6350.62
50_D183_H0.6330.62
68_Q71_R0.6320.61
36_N117_V0.6310.61
58_R183_H0.6290.61
3_F261_N0.6290.61
26_Q35_V0.6290.61
158_P233_M0.6290.61
94_C122_I0.6240.60
71_R99_Y0.6240.60
114_G134_F0.6230.60
66_H220_M0.6220.60
17_N106_A0.6200.60
62_L183_H0.6180.60
139_S157_A0.6110.59
96_E234_T0.6090.59
89_V112_T0.6070.58
15_E76_A0.6060.58
50_D54_M0.6050.58
52_A81_R0.6040.58
253_V256_C0.6030.58
231_L236_F0.6030.58
156_Y235_P0.6030.58
81_R212_Q0.6030.58
53_E56_Q0.6020.58
115_L135_C0.6010.58
224_G227_A0.6010.58
40_V138_S0.5990.57
17_N20_I0.5990.57
147_T209_T0.5980.57
177_A262_I0.5980.57
60_A225_D0.5970.57
101_H105_D0.5960.57
13_S88_A0.5950.57
143_P184_L0.5940.57
179_P184_L0.5940.57
55_M183_H0.5890.56
144_F167_V0.5880.56
14_R22_P0.5860.56
250_A255_D0.5820.55
51_S55_M0.5810.55
39_P48_P0.5810.55
21_C25_H0.5810.55
217_C257_Q0.5780.55
58_R99_Y0.5770.55
40_V49_G0.5760.54
96_E157_A0.5760.54
41_Q45_S0.5760.54
129_Y157_A0.5750.54
7_L10_Q0.5740.54
8_C21_C0.5720.54
50_D184_L0.5720.54
41_Q117_V0.5710.54
179_P235_P0.5700.54
220_M254_F0.5700.54
33_G37_L0.5680.53
76_A214_A0.5680.53
24_R31_K0.5650.53
147_T171_G0.5610.52
41_Q49_G0.5600.52
74_I177_A0.5600.52
30_A37_L0.5590.52
9_H23_Q0.5590.52
15_E18_S0.5590.52
25_H58_R0.5570.52
28_D31_K0.5570.52
91_D191_I0.5560.52
179_P183_H0.5560.52
232_Q245_W0.5540.52
134_F157_A0.5540.52
94_C201_H0.5510.51
200_P205_L0.5510.51
118_S121_A0.5490.51
227_A254_F0.5480.51
50_D58_R0.5440.50
180_G215_E0.5430.50
81_R108_P0.5420.50
244_V247_T0.5390.50
8_C178_T0.5380.50
164_L178_T0.5380.50
38_L117_V0.5360.49
10_Q16_K0.5360.49
68_Q204_Q0.5350.49
121_A156_Y0.5350.49
143_P167_V0.5340.49
58_R177_A0.5340.49
77_Q207_G0.5340.49
78_L103_F0.5320.49
34_Y37_L0.5320.49
241_K246_Q0.5310.49
16_K255_D0.5290.48
61_F235_P0.5280.48
107_L110_I0.5280.48
61_F226_E0.5280.48
25_H33_G0.5280.48
187_L258_T0.5250.48
92_I100_T0.5240.48
186_E219_P0.5210.47
232_Q237_A0.5210.47
216_L262_I0.5200.47
198_H201_H0.5200.47
4_S7_L0.5180.47
180_G217_C0.5150.47
261_N264_L0.5150.47
89_V261_N0.5140.46
157_A200_P0.5140.46
214_A223_R0.5130.46
10_Q14_R0.5120.46
105_D131_Q0.5070.46
38_L192_Y0.5070.46
25_H30_A0.5070.46
15_E72_D0.5070.46
18_S255_D0.5060.45
11_P86_A0.5060.45
60_A118_S0.5060.45
94_C118_S0.5060.45
221_R250_A0.5050.45
15_E147_T0.5050.45
77_Q264_L0.5010.45
38_L45_S0.5000.45
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1p91A 2 0.9963 100 0.326 Contact Map
2yqzA 1 0.7955 99.9 0.608 Contact Map
3ccfA 1 0.7435 99.9 0.618 Contact Map
2p35A 2 0.7695 99.9 0.636 Contact Map
3ujcA 1 0.8439 99.9 0.641 Contact Map
4kriA 1 0.9703 99.9 0.643 Contact Map
4xrpC 1 0.8476 99.9 0.644 Contact Map
4rv9A 1 0.9182 99.9 0.646 Contact Map
4obxA 2 0.6431 99.9 0.647 Contact Map
3mggA 2 0.7546 99.9 0.649 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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