GREMLIN Database
CSPB - Cold shock-like protein CspB
UniProt: P36995 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12203
Length: 71 (64)
Sequences: 4121 (1718)
Seq/√Len: 214.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
32_V67_V3.5281.00
56_E65_A3.3081.00
54_S66_N2.6591.00
49_Q69_I2.4071.00
14_A46_F2.1771.00
52_T68_I2.0641.00
24_V50_K2.0131.00
8_L50_K1.9481.00
6_T52_T1.8931.00
38_Q68_I1.8531.00
6_T50_K1.8051.00
5_M23_P1.7781.00
36_A65_A1.6601.00
23_P28_K1.5981.00
46_F49_Q1.5151.00
38_Q66_N1.4971.00
14_A42_Y1.4911.00
57_S62_P1.4801.00
58_G63_A1.4181.00
39_N69_I1.4031.00
32_V45_L1.3631.00
14_A44_T1.2621.00
58_G62_P1.2431.00
23_P26_G1.2161.00
23_P53_F1.2101.00
30_V55_I1.1421.00
28_K62_P1.1301.00
8_L22_S1.1071.00
36_A56_E1.0761.00
55_I62_P1.0051.00
6_T24_V1.0041.00
34_F43_R1.0041.00
37_I42_Y0.9871.00
21_I53_F0.9801.00
10_K29_D0.9761.00
7_G21_I0.9581.00
5_M25_D0.9160.99
37_I43_R0.9000.99
7_G64_A0.8630.99
58_G61_G0.8480.99
10_K16_K0.8340.99
45_L51_V0.8330.99
12_F34_F0.8280.99
37_I40_D0.8110.99
36_A66_N0.8080.98
11_W16_K0.8010.98
21_I51_V0.7600.98
56_E63_A0.7600.98
34_F37_I0.7540.98
23_P55_I0.7490.98
53_F64_A0.7410.97
5_M55_I0.7310.97
5_M54_S0.7090.97
46_F69_I0.6980.96
12_F16_K0.6830.96
13_N31_F0.6820.96
9_V45_L0.6680.95
8_L24_V0.6560.95
11_W29_D0.6520.95
54_S65_A0.6490.94
21_I64_A0.6480.94
34_F60_K0.6400.94
12_F17_G0.6360.94
39_N43_R0.6320.94
30_V56_E0.6300.93
5_M53_F0.6270.93
19_G32_V0.6230.93
21_I32_V0.6180.93
47_E63_A0.6090.92
16_K29_D0.6050.92
28_K57_S0.5900.91
15_D49_Q0.5890.91
18_F30_V0.5820.90
52_T69_I0.5800.90
43_R51_V0.5760.90
30_V36_A0.5740.90
15_D46_F0.5710.90
22_S30_V0.5700.90
15_D63_A0.5690.89
20_F33_H0.5690.89
5_M68_I0.5580.89
17_G37_I0.5550.88
42_Y46_F0.5520.88
37_I67_V0.5460.87
39_N44_T0.5430.87
40_D69_I0.5410.87
17_G29_D0.5400.87
59_A62_P0.5310.86
39_N42_Y0.5300.86
11_W17_G0.5280.86
16_K41_N0.5230.85
22_S48_G0.5140.84
13_N41_N0.5040.83
18_F33_H0.5040.83
18_F29_D0.5010.83
10_K17_G0.5000.83
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2lssA 1 0.9859 99.8 0.152 Contact Map
3i2zB 2 0.9859 99.7 0.171 Contact Map
1h95A 1 1 99.7 0.174 Contact Map
2mqhA 1 0.9577 99.7 0.194 Contact Map
3camA 2 0.9437 99.7 0.195 Contact Map
1wfqA 1 0.9577 99.7 0.197 Contact Map
1g6pA 1 0.9296 99.7 0.198 Contact Map
2ytyA 1 0.9577 99.7 0.199 Contact Map
1x65A 1 0.9437 99.7 0.211 Contact Map
2kcmA 1 0.9296 99.7 0.212 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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