GREMLIN Database
RLMN - Dual-specificity RNA methyltransferase RlmN
UniProt: P36979 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12401
Length: 384 (337)
Sequences: 3178 (1726)
Seq/√Len: 94.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
238_N294_Q4.1491.00
220_D263_R3.6351.00
218_A221_K3.4651.00
185_L225_M3.4561.00
81_E98_A3.0621.00
58_D72_K3.0471.00
239_D255_E3.0261.00
32_F45_V2.9571.00
243_D249_N2.9071.00
27_Q190_P2.9071.00
95_W158_I2.8401.00
130_K319_Y2.6211.00
224_D267_K2.5681.00
296_A337_Y2.5671.00
175_M191_A2.4931.00
37_E70_K2.4071.00
283_D320_G2.4051.00
126_A183_L2.4031.00
258_L298_L2.3911.00
306_I339_F2.3861.00
56_N59_E2.3701.00
224_D263_R2.3521.00
29_R39_P2.3191.00
289_T333_V2.2901.00
262_R302_T2.2591.00
288_G291_H2.2471.00
332_K336_S2.2331.00
30_E34_D2.2161.00
188_V210_L2.2101.00
119_V148_I2.1571.00
193_E225_M2.0741.00
241_I291_H2.0671.00
281_M322_S2.0541.00
69_G73_E2.0481.00
192_M210_L2.0231.00
31_F75_A1.9601.00
293_H333_V1.9531.00
86_Q352_D1.9421.00
47_K62_D1.9171.00
237_P291_H1.9141.00
239_D249_N1.9071.00
88_S350_D1.8731.00
221_K225_M1.8521.00
126_A139_F1.8491.00
289_T326_R1.8361.00
261_V275_V1.8091.00
173_V195_M1.7981.00
33_K39_P1.7861.00
85_E158_I1.7661.00
217_P252_Y1.7631.00
31_F35_L1.7481.00
237_P294_Q1.7451.00
48_W62_D1.7401.00
127_L213_S1.7351.00
283_D323_S1.7221.00
83_V98_A1.7201.00
117_L155_A1.7091.00
238_N241_I1.7001.00
48_W60_M1.6951.00
182_L222_L1.6941.00
47_K51_H1.6291.00
55_D157_K1.5851.00
29_R43_D1.5771.00
175_M188_V1.5531.00
24_N27_Q1.5531.00
205_K227_D1.5301.00
175_M210_L1.5231.00
25_R197_D1.5091.00
243_D250_K1.5001.00
85_E93_I1.4961.00
32_F67_L1.4951.00
43_D199_F1.4681.00
47_K52_Y1.4611.00
183_L215_V1.4591.00
70_K74_V1.4471.00
95_W155_A1.4371.00
239_D243_D1.4300.99
21_L150_G1.4190.99
232_I257_F1.4110.99
259_A263_R1.3960.99
220_D259_A1.3900.99
20_L57_F1.3860.99
352_D361_D1.3730.99
277_I304_C1.3670.99
121_S175_M1.3590.99
98_A103_R1.3480.99
293_H337_Y1.3360.99
121_S188_V1.3320.99
80_P150_G1.3240.99
289_T329_R1.3230.99
204_S207_R1.3170.99
26_Q29_R1.3160.99
328_D331_S1.3120.99
291_H294_Q1.3060.99
25_R29_R1.3020.99
19_N22_D1.2930.99
331_S335_M1.2930.99
253_N256_T1.2820.99
323_S326_R1.2740.99
97_I106_T1.2710.99
137_Q360_G1.2580.99
63_I68_R1.2490.99
145_V187_N1.2360.99
283_D326_R1.2340.98
108_Y115_A1.2310.98
182_L210_L1.2290.98
262_R301_D1.2240.98
238_N291_H1.2220.98
67_L70_K1.2200.98
331_S341_T1.2190.98
97_I154_R1.2180.98
324_N328_D1.2100.98
41_R44_Q1.2010.98
35_L70_K1.1990.98
152_V195_M1.1950.98
69_G72_K1.1740.98
80_P97_I1.1730.98
333_V337_Y1.1670.98
65_K69_G1.1670.98
66_V69_G1.1660.98
281_M327_I1.1580.98
99_V104_V1.1560.98
237_P241_I1.1540.98
54_C59_E1.1510.98
134_T178_M1.1490.98
236_A241_I1.1480.98
37_E67_L1.1450.98
220_D224_D1.1430.98
196_L205_K1.1390.97
23_L31_F1.1360.97
254_I298_L1.1360.97
215_V218_A1.1320.97
108_Y155_A1.1240.97
24_N190_P1.1230.97
79_A150_G1.1230.97
277_I302_T1.1220.97
32_F42_A1.1220.97
37_E41_R1.1170.97
216_V260_A1.1150.97
196_L208_V1.1120.97
87_R93_I1.1120.97
18_I75_A1.1100.97
277_I299_L1.1070.97
239_D253_N1.1060.97
196_L227_D1.1030.97
102_Q140_N1.1020.97
193_E226_I1.1020.97
223_G263_R1.1020.97
50_Y201_F1.1000.97
189_V225_M1.0970.97
106_T155_A1.0950.97
299_L306_I1.0940.97
185_L189_V1.0660.96
99_V123_V1.0640.96
40_F44_Q1.0600.96
243_D246_V1.0600.96
57_F76_E1.0590.96
258_L302_T1.0530.96
284_H326_R1.0510.96
185_L221_K1.0500.96
117_L170_I1.0470.96
53_C156_A1.0450.96
25_R43_D1.0330.95
45_V63_I1.0310.95
196_L204_S1.0300.95
82_V85_E1.0250.95
20_L75_A1.0250.95
289_T293_H1.0250.95
24_N193_E1.0250.95
145_V190_P1.0220.95
25_R42_A1.0200.95
240_E244_E1.0190.95
327_I343_V1.0170.95
328_D343_V1.0160.95
321_R349_D1.0080.95
101_D141_R1.0060.95
148_I191_A1.0060.95
263_R267_K1.0050.95
26_Q193_E1.0030.95
292_A333_V0.9970.94
29_R33_K0.9900.94
229_A273_G0.9890.94
256_T259_A0.9860.94
209_T231_A0.9840.94
43_D62_D0.9770.94
139_F183_L0.9760.94
61_T68_R0.9730.94
249_N253_N0.9700.94
116_T172_N0.9700.94
139_F142_N0.9680.94
37_E66_V0.9650.93
156_A201_F0.9620.93
299_L339_F0.9610.93
265_L303_P0.9600.93
31_F34_D0.9570.93
61_T64_N0.9560.93
258_L261_V0.9530.93
255_E298_L0.9520.93
57_F60_M0.9500.93
136_Q316_G0.9490.93
258_L262_R0.9430.93
175_M192_M0.9370.92
282_L285_V0.9360.92
22_D146_S0.9330.92
334_L341_T0.9320.92
292_A330_F0.9320.92
329_R332_K0.9300.92
149_I194_I0.9250.92
222_L228_V0.9230.92
188_V192_M0.9220.92
296_A339_F0.9190.92
66_V70_K0.9120.91
325_S329_R0.9100.91
313_P349_D0.9080.91
127_L183_L0.9060.91
83_V103_R0.9040.91
33_K38_K0.9010.91
57_F77_I0.8990.91
133_S352_D0.8970.91
280_V311_W0.8920.90
43_D47_K0.8920.90
219_L232_I0.8890.90
56_N72_K0.8880.90
241_I294_Q0.8880.90
114_R347_R0.8880.90
30_E33_K0.8800.90
175_M195_M0.8740.90
80_P106_T0.8730.90
215_V248_I0.8730.90
232_I261_V0.8720.89
84_E362_V0.8700.89
287_D322_S0.8670.89
93_I158_I0.8660.89
97_I155_A0.8660.89
18_I23_L0.8640.89
106_T117_L0.8620.89
189_V222_L0.8550.89
48_W52_Y0.8550.89
80_P154_R0.8470.88
186_N221_K0.8470.88
89_S350_D0.8460.88
137_Q359_A0.8430.88
332_K335_M0.8420.88
254_I258_L0.8360.87
282_L311_W0.8360.87
133_S314_F0.8330.87
113_D172_N0.8260.87
254_I259_A0.8230.87
311_W317_A0.8220.87
322_S327_I0.8220.87
52_Y62_D0.8210.86
21_L50_Y0.8160.86
79_A157_K0.8160.86
153_W201_F0.8140.86
213_S246_V0.8140.86
294_Q297_E0.8130.86
32_F35_L0.8040.85
198_D202_G0.8040.85
96_A359_A0.7970.85
26_Q30_E0.7960.85
241_I244_E0.7960.85
127_L248_I0.7950.85
261_V277_I0.7920.84
113_D134_T0.7900.84
110_P168_R0.7900.84
195_M201_F0.7840.84
173_V208_V0.7770.83
54_C60_M0.7760.83
57_F71_L0.7760.83
141_R147_E0.7720.83
322_S326_R0.7710.83
185_L193_E0.7700.83
50_Y153_W0.7690.83
346_T349_D0.7670.82
220_D260_A0.7660.82
108_Y159_V0.7650.82
154_R157_K0.7620.82
243_D253_N0.7620.82
80_P99_V0.7600.82
110_P115_A0.7600.82
313_P320_G0.7590.82
48_W54_C0.7580.82
22_D144_R0.7560.82
182_L218_A0.7510.81
85_E95_W0.7490.81
31_F74_V0.7480.81
35_L74_V0.7480.81
49_M77_I0.7440.81
149_I195_M0.7410.80
173_V203_L0.7380.80
156_A160_G0.7360.80
296_A334_L0.7330.80
210_L228_V0.7330.80
63_I67_L0.7320.79
18_I31_F0.7310.79
189_V193_E0.7300.79
149_I153_W0.7280.79
45_V57_F0.7280.79
46_M194_I0.7280.79
310_P346_T0.7220.79
300_K337_Y0.7220.79
38_K64_N0.7200.78
130_K136_Q0.7190.78
38_K41_R0.7180.78
335_M341_T0.7180.78
41_R64_N0.7150.78
134_T175_M0.7140.78
254_I257_F0.7130.78
328_D332_K0.7130.78
86_Q361_D0.7120.78
305_K342_I0.7120.78
326_R329_R0.7120.78
236_A239_D0.7110.77
209_T276_T0.7090.77
57_F75_A0.7090.77
221_K224_D0.7070.77
136_Q314_F0.7060.77
114_R134_T0.7060.77
114_R172_N0.7050.77
137_Q178_M0.6970.76
220_D256_T0.6960.76
46_M50_Y0.6950.76
134_T137_Q0.6920.76
296_A333_V0.6920.76
111_E114_R0.6890.75
235_H342_I0.6860.75
193_E197_D0.6860.75
213_S248_I0.6850.75
39_P42_A0.6830.75
80_P104_V0.6810.74
321_R327_I0.6800.74
189_V228_V0.6770.74
55_D59_E0.6730.74
219_L260_A0.6730.74
126_A138_G0.6700.73
297_E337_Y0.6680.73
27_Q30_E0.6670.73
65_K68_R0.6650.73
265_L269_N0.6640.73
133_S315_P0.6620.72
287_D326_R0.6590.72
196_L203_L0.6570.72
248_I252_Y0.6560.72
325_S328_D0.6550.72
253_N257_F0.6550.72
235_H246_V0.6500.71
136_Q317_A0.6500.71
244_E285_V0.6470.71
156_A170_I0.6450.70
191_A195_M0.6430.70
311_W314_F0.6430.70
37_E64_N0.6430.70
20_L49_M0.6420.70
329_R333_V0.6410.70
290_E294_Q0.6400.70
127_L215_V0.6400.70
216_V256_T0.6380.70
115_A168_R0.6370.69
116_T171_T0.6360.69
133_S359_A0.6350.69
40_F43_D0.6350.69
92_T109_I0.6350.69
136_Q139_F0.6350.69
310_P343_V0.6320.69
70_K73_E0.6310.69
290_E293_H0.6300.69
135_A317_A0.6300.69
60_M63_I0.6300.69
332_K343_V0.6280.68
181_P188_V0.6280.68
190_P194_I0.6280.68
251_K256_T0.6280.68
128_E135_A0.6270.68
150_G154_R0.6270.68
110_P347_R0.6270.68
255_E259_A0.6260.68
68_R72_K0.6260.68
223_G260_A0.6250.68
241_I285_V0.6250.68
41_R67_L0.6250.68
134_T172_N0.6250.68
316_G359_A0.6230.68
82_V97_I0.6220.68
20_L28_M0.6190.67
297_E300_K0.6160.67
49_M53_C0.6150.67
229_A305_K0.6120.66
216_V252_Y0.6110.66
134_T191_A0.6110.66
236_A294_Q0.6090.66
237_P279_Y0.6080.66
293_H297_E0.6060.66
279_Y354_A0.6060.66
76_E100_G0.6030.65
25_R199_F0.6020.65
236_A292_A0.6000.65
310_P321_R0.6000.65
130_K244_E0.5990.65
263_R266_E0.5970.64
301_D304_C0.5970.64
45_V67_L0.5940.64
212_T230_L0.5930.64
130_K245_I0.5900.64
116_T276_T0.5880.63
152_V170_I0.5870.63
321_R346_T0.5860.63
123_V140_N0.5840.63
113_D191_A0.5840.63
254_I277_I0.5830.63
329_R336_S0.5830.63
23_L27_Q0.5820.62
29_R32_F0.5810.62
32_F37_E0.5810.62
152_V156_A0.5800.62
257_F261_V0.5770.62
293_H336_S0.5770.62
299_L304_C0.5760.62
276_T305_K0.5750.62
119_V152_V0.5740.61
274_R305_K0.5720.61
122_Q142_N0.5710.61
278_E307_N0.5700.61
50_Y149_I0.5690.61
82_V154_R0.5680.61
311_W319_Y0.5680.61
152_V203_L0.5650.60
262_R298_L0.5640.60
46_M197_D0.5600.60
194_I200_G0.5590.59
331_S343_V0.5560.59
44_Q48_W0.5540.59
38_K44_Q0.5540.59
31_F57_F0.5540.59
305_K340_T0.5520.58
40_F62_D0.5520.58
229_A269_N0.5520.58
116_T174_V0.5500.58
114_R178_M0.5490.58
44_Q68_R0.5490.58
288_G326_R0.5490.58
135_A178_M0.5490.58
156_A169_P0.5490.58
134_T359_A0.5490.58
288_G292_A0.5480.58
315_P361_D0.5480.58
106_T119_V0.5480.58
330_F353_A0.5470.58
114_R191_A0.5460.58
310_P327_I0.5450.57
95_W106_T0.5440.57
95_W108_Y0.5440.57
50_Y78_R0.5410.57
281_M343_V0.5400.57
91_G110_P0.5390.57
60_M68_R0.5390.57
44_Q206_R0.5390.57
262_R266_E0.5380.57
159_V170_I0.5370.56
49_M57_F0.5370.56
282_L322_S0.5360.56
53_C157_K0.5350.56
46_M200_G0.5350.56
92_T351_I0.5350.56
26_Q31_F0.5340.56
133_S235_H0.5330.56
25_R46_M0.5330.56
187_N191_A0.5320.56
119_V175_M0.5310.56
239_D254_I0.5310.56
204_S227_D0.5310.56
108_Y170_I0.5310.56
111_E305_K0.5300.55
44_Q62_D0.5300.55
99_V102_Q0.5290.55
21_L49_M0.5270.55
58_D65_K0.5270.55
223_G265_L0.5240.55
218_A257_F0.5230.54
235_H280_V0.5220.54
137_Q353_A0.5220.54
187_N190_P0.5210.54
83_V329_R0.5210.54
48_W276_T0.5200.54
109_I116_T0.5200.54
237_P298_L0.5190.54
20_L77_I0.5170.54
130_K246_V0.5160.53
114_R231_A0.5160.53
250_K253_N0.5150.53
133_S136_Q0.5110.53
323_S328_D0.5100.53
240_E294_Q0.5090.52
116_T175_M0.5090.52
159_V168_R0.5080.52
111_E347_R0.5070.52
235_H322_S0.5070.52
175_M178_M0.5060.52
189_V226_I0.5060.52
58_D68_R0.5050.52
18_I33_K0.5040.52
28_M50_Y0.5040.52
258_L299_L0.5030.52
29_R63_I0.5010.51
78_R150_G0.5010.51
266_E269_N0.5000.51
306_I341_T0.5000.51
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3rfaA 1 0.9349 100 0.394 Contact Map
2yx0A 1 0.7656 100 0.727 Contact Map
2z2uA 1 0.6667 100 0.728 Contact Map
2a5hA 4 0.875 100 0.79 Contact Map
4r33A 2 0.8229 100 0.819 Contact Map
3c8fA 1 0.5781 99.9 0.827 Contact Map
4wcxA 1 0.849 99.9 0.828 Contact Map
4rtbA 2 0.7943 99.9 0.836 Contact Map
3iixA 1 0.763 99.9 0.846 Contact Map
3t7vA 1 0.7552 99.9 0.848 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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