EAEH - ECOLI - GREMLIN Contacts

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EAEH - Putative attaching and effacing protein homolog

UniProt:	P36943	Sequences: MSHYKTGHKQPRFRYSVLARCVAWANISVQVLFPLAVTFTPVMAARAQHAVQPRLSMGNTTVTADNNVEKNVASFAANAGTFLSSQPDSDATRNFITGMATAKANQEIQEWLGKYGTARVKLNVDKDFSLKDSSLEMLYPIYDTPTNMLFTQGAIHRTDDRTQSNIGFGWRHFSGNDWMAGVNTFIDHDLSRSHTRIGVGAEYWRDYLKLSANGYIRASGWKKSPDIEDYQERPANGWDIRAEGYLPAWPQLGASLMYEQYYGDEVGLFGKDKRQKDPHAISAEVTYTPVPLTQQ	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG12161
Length:	295 (238)
Sequences:	329 (225)
Seq/√Len:	14.6

ECOLI - EAEH YCHO YEEJ

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
290_V	293_T	5.557	1.00
217_R	236_N	5.049	1.00
164_S	190_L	4.850	1.00
265_E	274_R	4.326	1.00
224_S	232_E	4.108	1.00
170_W	182_V	3.858	1.00
66_N	69_E	3.548	0.99
194_H	222_K	3.523	0.99
73_A	80_G	3.218	0.99
173_F	179_M	2.980	0.98
154_A	238_W	2.665	0.95
189_D	234_P	2.601	0.95
227_I	271_K	2.436	0.92
138_L	179_M	2.391	0.92
163_Q	192_R	2.391	0.92
209_K	243_E	2.362	0.91
244_G	254_A	2.299	0.90
121_K	134_S	2.241	0.89
178_W	203_Y	2.216	0.88
56_S	59_N	2.129	0.86
154_A	163_Q	2.031	0.83
288_T	294_Q	1.975	0.81
214_G	217_R	1.946	0.80
163_Q	194_H	1.866	0.77
189_D	192_R	1.852	0.77
161_R	232_E	1.822	0.75
238_W	262_Y	1.804	0.75
192_R	222_K	1.794	0.74
190_L	279_H	1.793	0.74
142_Y	275_Q	1.788	0.74
192_R	225_P	1.700	0.70
136_E	156_H	1.677	0.69
165_N	198_G	1.673	0.69
186_I	195_T	1.621	0.66
56_S	60_T	1.617	0.66
226_D	232_E	1.614	0.66
109_Q	117_T	1.611	0.66
217_R	233_R	1.604	0.65
192_R	207_Y	1.575	0.64
259_E	268_L	1.554	0.63
156_H	192_R	1.550	0.63
122_L	203_Y	1.509	0.60
135_L	155_I	1.497	0.60
146_T	270_G	1.479	0.59
259_E	280_A	1.465	0.58
102_A	219_S	1.465	0.58
197_I	217_R	1.447	0.57
80_G	107_E	1.445	0.57
218_A	233_R	1.443	0.57
267_G	272_D	1.409	0.55
135_L	197_I	1.401	0.55
154_A	188_H	1.393	0.54
103_K	107_E	1.393	0.54
245_Y	287_Y	1.387	0.54
195_T	290_V	1.380	0.53
119_R	134_S	1.380	0.53
230_Y	274_R	1.376	0.53
241_R	257_M	1.363	0.52
161_R	189_D	1.361	0.52
195_T	219_S	1.337	0.51
195_T	203_Y	1.331	0.51
97_T	168_F	1.330	0.51
261_Y	280_A	1.316	0.50
78_N	102_A	1.308	0.49
168_F	262_Y	1.304	0.49
132_D	294_Q	1.303	0.49
148_M	201_A	1.290	0.48
156_H	163_Q	1.289	0.48
254_A	283_A	1.274	0.48
125_D	210_L	1.266	0.47
253_G	261_Y	1.245	0.46
230_Y	250_P	1.233	0.45
204_W	209_K	1.215	0.44
111_W	139_Y	1.213	0.44
153_G	203_Y	1.211	0.44
90_D	94_N	1.195	0.43
269_F	275_Q	1.192	0.43
128_F	279_H	1.189	0.43
142_Y	234_P	1.183	0.43
177_D	277_D	1.180	0.42
158_T	163_Q	1.178	0.42
134_S	203_Y	1.167	0.42
253_G	259_E	1.161	0.41
124_V	153_G	1.156	0.41
69_E	100_A	1.156	0.41
235_A	263_G	1.153	0.41
261_Y	268_L	1.152	0.41
163_Q	238_W	1.143	0.40
161_R	221_W	1.142	0.40
81_T	210_L	1.141	0.40
100_A	201_A	1.132	0.40
268_L	280_A	1.113	0.39
124_V	149_L	1.103	0.38
135_L	293_T	1.095	0.38
80_G	83_L	1.088	0.38
80_G	89_S	1.083	0.37
63_T	248_A	1.080	0.37
123_N	225_P	1.078	0.37
180_A	203_Y	1.072	0.37
263_G	266_V	1.067	0.36
69_E	73_A	1.046	0.35
122_L	226_D	1.044	0.35
67_N	277_D	1.030	0.35
188_H	195_T	1.016	0.34
100_A	276_K	1.007	0.33
209_K	241_R	1.005	0.33
221_W	224_S	1.004	0.33
145_P	173_F	1.003	0.33
194_H	223_K	0.999	0.33
107_E	135_L	0.990	0.33
110_E	144_T	0.985	0.32
112_L	120_V	0.973	0.32
226_D	270_G	0.972	0.32
128_F	131_K	0.971	0.32
137_M	148_M	0.965	0.31
157_R	162_T	0.960	0.31
128_F	143_D	0.954	0.31
116_G	204_W	0.953	0.31
122_L	269_F	0.951	0.31
92_T	266_V	0.949	0.31
211_S	267_G	0.947	0.31
199_V	216_I	0.937	0.30
257_M	290_V	0.933	0.30
118_A	246_L	0.931	0.30
214_G	236_N	0.930	0.30
191_S	194_H	0.926	0.30
192_R	226_D	0.911	0.29
267_G	282_S	0.908	0.29
281_I	285_V	0.908	0.29
56_S	61_T	0.906	0.29
130_L	233_R	0.905	0.29
267_G	271_K	0.904	0.29
109_Q	137_M	0.902	0.28
113_G	277_D	0.901	0.28
112_L	116_G	0.900	0.28
243_E	249_W	0.894	0.28
109_Q	243_E	0.894	0.28
229_D	236_N	0.892	0.28
92_T	97_T	0.891	0.28
93_R	210_L	0.890	0.28
86_Q	273_K	0.877	0.27
58_G	240_I	0.865	0.27
124_V	212_A	0.859	0.27
69_E	72_V	0.852	0.26
63_T	66_N	0.846	0.26
106_Q	285_V	0.846	0.26
221_W	263_G	0.845	0.26
193_S	285_V	0.843	0.26
65_D	198_G	0.839	0.26
179_M	214_G	0.839	0.26
219_S	222_K	0.839	0.26
273_K	280_A	0.838	0.26
173_F	217_R	0.837	0.26
103_K	254_A	0.833	0.25
145_P	243_E	0.833	0.25
134_S	186_I	0.832	0.25
116_G	268_L	0.830	0.25
243_E	255_S	0.830	0.25
188_H	219_S	0.829	0.25
107_E	123_N	0.824	0.25
170_W	227_I	0.824	0.25
111_W	217_R	0.817	0.25
154_A	157_R	0.817	0.25
107_E	273_K	0.816	0.25
108_I	293_T	0.816	0.25
107_E	209_K	0.815	0.25
69_E	184_T	0.814	0.25
159_D	285_V	0.812	0.25
205_R	222_K	0.812	0.25
156_H	161_R	0.809	0.24
242_A	245_Y	0.800	0.24
231_Q	238_W	0.798	0.24
221_W	235_A	0.796	0.24
134_S	281_I	0.792	0.24
89_S	180_A	0.791	0.24
201_A	256_L	0.790	0.24
133_S	159_D	0.789	0.24
178_W	208_L	0.783	0.23
123_N	132_D	0.781	0.23
72_V	147_N	0.780	0.23
64_A	285_V	0.779	0.23
274_R	282_S	0.777	0.23
178_W	259_E	0.777	0.23
206_D	270_G	0.776	0.23
151_T	256_L	0.775	0.23
178_W	261_Y	0.773	0.23
112_L	245_Y	0.773	0.23
161_R	224_S	0.772	0.23
264_D	276_K	0.772	0.23
80_G	128_F	0.771	0.23
150_F	253_G	0.771	0.23
99_M	120_V	0.769	0.23
96_I	118_A	0.764	0.23
249_W	285_V	0.758	0.22
114_K	285_V	0.758	0.22
170_W	267_G	0.758	0.22
119_R	243_E	0.756	0.22
134_S	205_R	0.755	0.22
150_F	206_D	0.754	0.22
175_G	240_I	0.751	0.22
185_F	221_W	0.751	0.22
76_A	240_I	0.746	0.22
59_N	62_V	0.744	0.22
197_I	238_W	0.742	0.22
57_M	60_T	0.734	0.22
194_H	232_E	0.727	0.21
286_T	294_Q	0.726	0.21
130_L	209_K	0.722	0.21
285_V	293_T	0.719	0.21
191_S	222_K	0.718	0.21
103_K	293_T	0.716	0.21
223_K	231_Q	0.716	0.21
163_Q	191_S	0.715	0.21
194_H	234_P	0.713	0.21
76_A	102_A	0.711	0.21
62_V	166_I	0.710	0.21
79_A	83_L	0.707	0.21
150_F	169_G	0.703	0.20
91_A	96_I	0.702	0.20
219_S	267_G	0.701	0.20
247_P	259_E	0.697	0.20
63_T	285_V	0.696	0.20
207_Y	261_Y	0.695	0.20
69_E	290_V	0.692	0.20
230_Y	253_G	0.689	0.20
241_R	250_P	0.689	0.20
64_A	179_M	0.686	0.20
69_E	80_G	0.686	0.20
90_D	242_A	0.682	0.20
147_N	170_W	0.674	0.19
81_T	151_T	0.673	0.19
177_D	193_S	0.673	0.19
58_G	62_V	0.668	0.19
270_G	275_Q	0.668	0.19
233_R	270_G	0.667	0.19
155_I	162_T	0.667	0.19
270_G	279_H	0.664	0.19
270_G	276_K	0.663	0.19
166_I	293_T	0.663	0.19
161_R	234_P	0.662	0.19
269_F	284_E	0.658	0.19
287_Y	290_V	0.657	0.19
168_F	283_A	0.655	0.19
61_T	101_T	0.652	0.19
159_D	280_A	0.652	0.19
104_A	199_V	0.650	0.19
180_A	243_E	0.649	0.18
263_G	289_P	0.646	0.18
177_D	184_T	0.645	0.18
87_P	137_M	0.644	0.18
198_G	262_Y	0.643	0.18
186_I	220_G	0.637	0.18
224_S	231_Q	0.633	0.18
126_K	281_I	0.632	0.18
106_Q	290_V	0.631	0.18
241_R	244_G	0.631	0.18
204_W	294_Q	0.631	0.18
194_H	270_G	0.629	0.18
234_P	250_P	0.628	0.18
153_G	178_W	0.628	0.18
117_T	151_T	0.627	0.18
210_L	242_A	0.626	0.18
165_N	259_E	0.625	0.18
133_S	265_E	0.624	0.18
68_V	87_P	0.624	0.18
112_L	252_L	0.620	0.18
89_S	96_I	0.619	0.18
247_P	261_Y	0.619	0.18
94_N	98_G	0.617	0.17
192_R	238_W	0.617	0.17
57_M	62_V	0.616	0.17
224_S	227_I	0.614	0.17
140_P	169_G	0.613	0.17
149_L	220_G	0.605	0.17
263_G	278_P	0.605	0.17
95_F	245_Y	0.600	0.17
96_I	252_L	0.599	0.17
134_S	207_Y	0.597	0.17
134_S	155_I	0.596	0.17
82_F	277_D	0.595	0.17
226_D	271_K	0.595	0.17
268_L	275_Q	0.593	0.17
57_M	79_A	0.593	0.17
159_D	248_A	0.592	0.17
92_T	203_Y	0.592	0.17
71_N	86_Q	0.592	0.17
66_N	285_V	0.590	0.17
132_D	149_L	0.590	0.17
65_D	102_A	0.589	0.17
163_Q	232_E	0.586	0.16
254_A	259_E	0.586	0.16
141_I	168_F	0.585	0.16
154_A	178_W	0.585	0.16
106_Q	211_S	0.584	0.16
160_D	180_A	0.583	0.16
87_P	106_Q	0.581	0.16
156_H	194_H	0.580	0.16
158_T	255_S	0.578	0.16
105_N	108_I	0.577	0.16
98_G	225_P	0.576	0.16
91_A	290_V	0.575	0.16
161_R	191_S	0.573	0.16
112_L	248_A	0.571	0.16
211_S	238_W	0.569	0.16
135_L	162_T	0.564	0.16
63_T	67_N	0.563	0.16
106_Q	214_G	0.559	0.16
206_D	253_G	0.559	0.16
86_Q	109_Q	0.558	0.16
270_G	282_S	0.556	0.16
236_N	262_Y	0.556	0.16
138_L	216_I	0.556	0.16
261_Y	288_T	0.555	0.16
114_K	236_N	0.554	0.16
192_R	270_G	0.554	0.16
65_D	285_V	0.553	0.15
103_K	110_E	0.551	0.15
137_M	249_W	0.551	0.15
141_I	148_M	0.548	0.15
138_L	173_F	0.546	0.15
154_A	192_R	0.545	0.15
163_Q	223_K	0.542	0.15
81_T	164_S	0.542	0.15
85_S	245_Y	0.539	0.15
216_I	222_K	0.538	0.15
111_W	116_G	0.538	0.15
147_N	172_H	0.537	0.15
64_A	277_D	0.537	0.15
104_A	274_R	0.536	0.15
102_A	146_T	0.533	0.15
111_W	173_F	0.532	0.15
106_Q	146_T	0.531	0.15
73_A	90_D	0.525	0.15
204_W	212_A	0.522	0.15
132_D	238_W	0.515	0.14
268_L	288_T	0.513	0.14
251_Q	280_A	0.513	0.14
197_I	272_D	0.513	0.14
155_I	190_L	0.511	0.14
100_A	290_V	0.511	0.14
163_Q	203_Y	0.509	0.14
151_T	174_S	0.507	0.14
100_A	258_Y	0.506	0.14
247_P	280_A	0.506	0.14
131_K	238_W	0.506	0.14
171_R	215_Y	0.504	0.14
171_R	202_E	0.504	0.14
171_R	187_D	0.504	0.14
202_E	215_Y	0.504	0.14
187_D	215_Y	0.504	0.14
181_G	187_D	0.504	0.14
181_G	202_E	0.504	0.14
181_G	215_Y	0.504	0.14
171_R	181_G	0.504	0.14
187_D	202_E	0.504	0.14
192_R	223_K	0.503	0.14
91_A	121_K	0.500	0.14

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4e1tA	1	0.6203	100	0.394	Contact Map
4e1sA	1	0.6102	100	0.406	Contact Map
3qraA	1	0.4678	67.7	0.962	Contact Map
1i78A	2	0.7898	64.7	0.962	Contact Map
1ormA	1	0.4508	62.9	0.963	Contact Map
2jmmA	1	0.4339	55.3	0.965	Contact Map
2k0lA	1	0.5966	43.3	0.967	Contact Map
2x27X	1	0.5763	22.4	0.972	Contact Map
3nb3A	2	0.4102	20.1	0.972	Contact Map
4rlcA	1	0.4034	15.6	0.974	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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