GREMLIN Database
EAEH - Putative attaching and effacing protein homolog
UniProt: P36943 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12161
Length: 295 (238)
Sequences: 329 (225)
Seq/√Len: 14.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
290_V293_T5.5571.00
217_R236_N5.0491.00
164_S190_L4.8501.00
265_E274_R4.3261.00
224_S232_E4.1081.00
170_W182_V3.8581.00
66_N69_E3.5480.99
194_H222_K3.5230.99
73_A80_G3.2180.99
173_F179_M2.9800.98
154_A238_W2.6650.95
189_D234_P2.6010.95
227_I271_K2.4360.92
138_L179_M2.3910.92
163_Q192_R2.3910.92
209_K243_E2.3620.91
244_G254_A2.2990.90
121_K134_S2.2410.89
178_W203_Y2.2160.88
56_S59_N2.1290.86
154_A163_Q2.0310.83
288_T294_Q1.9750.81
214_G217_R1.9460.80
163_Q194_H1.8660.77
189_D192_R1.8520.77
161_R232_E1.8220.75
238_W262_Y1.8040.75
192_R222_K1.7940.74
190_L279_H1.7930.74
142_Y275_Q1.7880.74
192_R225_P1.7000.70
136_E156_H1.6770.69
165_N198_G1.6730.69
186_I195_T1.6210.66
56_S60_T1.6170.66
226_D232_E1.6140.66
109_Q117_T1.6110.66
217_R233_R1.6040.65
192_R207_Y1.5750.64
259_E268_L1.5540.63
156_H192_R1.5500.63
122_L203_Y1.5090.60
135_L155_I1.4970.60
146_T270_G1.4790.59
259_E280_A1.4650.58
102_A219_S1.4650.58
197_I217_R1.4470.57
80_G107_E1.4450.57
218_A233_R1.4430.57
267_G272_D1.4090.55
135_L197_I1.4010.55
154_A188_H1.3930.54
103_K107_E1.3930.54
245_Y287_Y1.3870.54
195_T290_V1.3800.53
119_R134_S1.3800.53
230_Y274_R1.3760.53
241_R257_M1.3630.52
161_R189_D1.3610.52
195_T219_S1.3370.51
195_T203_Y1.3310.51
97_T168_F1.3300.51
261_Y280_A1.3160.50
78_N102_A1.3080.49
168_F262_Y1.3040.49
132_D294_Q1.3030.49
148_M201_A1.2900.48
156_H163_Q1.2890.48
254_A283_A1.2740.48
125_D210_L1.2660.47
253_G261_Y1.2450.46
230_Y250_P1.2330.45
204_W209_K1.2150.44
111_W139_Y1.2130.44
153_G203_Y1.2110.44
90_D94_N1.1950.43
269_F275_Q1.1920.43
128_F279_H1.1890.43
142_Y234_P1.1830.43
177_D277_D1.1800.42
158_T163_Q1.1780.42
134_S203_Y1.1670.42
253_G259_E1.1610.41
124_V153_G1.1560.41
69_E100_A1.1560.41
235_A263_G1.1530.41
261_Y268_L1.1520.41
163_Q238_W1.1430.40
161_R221_W1.1420.40
81_T210_L1.1410.40
100_A201_A1.1320.40
268_L280_A1.1130.39
124_V149_L1.1030.38
135_L293_T1.0950.38
80_G83_L1.0880.38
80_G89_S1.0830.37
63_T248_A1.0800.37
123_N225_P1.0780.37
180_A203_Y1.0720.37
263_G266_V1.0670.36
69_E73_A1.0460.35
122_L226_D1.0440.35
67_N277_D1.0300.35
188_H195_T1.0160.34
100_A276_K1.0070.33
209_K241_R1.0050.33
221_W224_S1.0040.33
145_P173_F1.0030.33
194_H223_K0.9990.33
107_E135_L0.9900.33
110_E144_T0.9850.32
112_L120_V0.9730.32
226_D270_G0.9720.32
128_F131_K0.9710.32
137_M148_M0.9650.31
157_R162_T0.9600.31
128_F143_D0.9540.31
116_G204_W0.9530.31
122_L269_F0.9510.31
92_T266_V0.9490.31
211_S267_G0.9470.31
199_V216_I0.9370.30
257_M290_V0.9330.30
118_A246_L0.9310.30
214_G236_N0.9300.30
191_S194_H0.9260.30
192_R226_D0.9110.29
267_G282_S0.9080.29
281_I285_V0.9080.29
56_S61_T0.9060.29
130_L233_R0.9050.29
267_G271_K0.9040.29
109_Q137_M0.9020.28
113_G277_D0.9010.28
112_L116_G0.9000.28
243_E249_W0.8940.28
109_Q243_E0.8940.28
229_D236_N0.8920.28
92_T97_T0.8910.28
93_R210_L0.8900.28
86_Q273_K0.8770.27
58_G240_I0.8650.27
124_V212_A0.8590.27
69_E72_V0.8520.26
63_T66_N0.8460.26
106_Q285_V0.8460.26
221_W263_G0.8450.26
193_S285_V0.8430.26
65_D198_G0.8390.26
179_M214_G0.8390.26
219_S222_K0.8390.26
273_K280_A0.8380.26
173_F217_R0.8370.26
103_K254_A0.8330.25
145_P243_E0.8330.25
134_S186_I0.8320.25
116_G268_L0.8300.25
243_E255_S0.8300.25
188_H219_S0.8290.25
107_E123_N0.8240.25
170_W227_I0.8240.25
111_W217_R0.8170.25
154_A157_R0.8170.25
107_E273_K0.8160.25
108_I293_T0.8160.25
107_E209_K0.8150.25
69_E184_T0.8140.25
159_D285_V0.8120.25
205_R222_K0.8120.25
156_H161_R0.8090.24
242_A245_Y0.8000.24
231_Q238_W0.7980.24
221_W235_A0.7960.24
134_S281_I0.7920.24
89_S180_A0.7910.24
201_A256_L0.7900.24
133_S159_D0.7890.24
178_W208_L0.7830.23
123_N132_D0.7810.23
72_V147_N0.7800.23
64_A285_V0.7790.23
274_R282_S0.7770.23
178_W259_E0.7770.23
206_D270_G0.7760.23
151_T256_L0.7750.23
178_W261_Y0.7730.23
112_L245_Y0.7730.23
161_R224_S0.7720.23
264_D276_K0.7720.23
80_G128_F0.7710.23
150_F253_G0.7710.23
99_M120_V0.7690.23
96_I118_A0.7640.23
249_W285_V0.7580.22
114_K285_V0.7580.22
170_W267_G0.7580.22
119_R243_E0.7560.22
134_S205_R0.7550.22
150_F206_D0.7540.22
175_G240_I0.7510.22
185_F221_W0.7510.22
76_A240_I0.7460.22
59_N62_V0.7440.22
197_I238_W0.7420.22
57_M60_T0.7340.22
194_H232_E0.7270.21
286_T294_Q0.7260.21
130_L209_K0.7220.21
285_V293_T0.7190.21
191_S222_K0.7180.21
103_K293_T0.7160.21
223_K231_Q0.7160.21
163_Q191_S0.7150.21
194_H234_P0.7130.21
76_A102_A0.7110.21
62_V166_I0.7100.21
79_A83_L0.7070.21
150_F169_G0.7030.20
91_A96_I0.7020.20
219_S267_G0.7010.20
247_P259_E0.6970.20
63_T285_V0.6960.20
207_Y261_Y0.6950.20
69_E290_V0.6920.20
230_Y253_G0.6890.20
241_R250_P0.6890.20
64_A179_M0.6860.20
69_E80_G0.6860.20
90_D242_A0.6820.20
147_N170_W0.6740.19
81_T151_T0.6730.19
177_D193_S0.6730.19
58_G62_V0.6680.19
270_G275_Q0.6680.19
233_R270_G0.6670.19
155_I162_T0.6670.19
270_G279_H0.6640.19
270_G276_K0.6630.19
166_I293_T0.6630.19
161_R234_P0.6620.19
269_F284_E0.6580.19
287_Y290_V0.6570.19
168_F283_A0.6550.19
61_T101_T0.6520.19
159_D280_A0.6520.19
104_A199_V0.6500.19
180_A243_E0.6490.18
263_G289_P0.6460.18
177_D184_T0.6450.18
87_P137_M0.6440.18
198_G262_Y0.6430.18
186_I220_G0.6370.18
224_S231_Q0.6330.18
126_K281_I0.6320.18
106_Q290_V0.6310.18
241_R244_G0.6310.18
204_W294_Q0.6310.18
194_H270_G0.6290.18
234_P250_P0.6280.18
153_G178_W0.6280.18
117_T151_T0.6270.18
210_L242_A0.6260.18
165_N259_E0.6250.18
133_S265_E0.6240.18
68_V87_P0.6240.18
112_L252_L0.6200.18
89_S96_I0.6190.18
247_P261_Y0.6190.18
94_N98_G0.6170.17
192_R238_W0.6170.17
57_M62_V0.6160.17
224_S227_I0.6140.17
140_P169_G0.6130.17
149_L220_G0.6050.17
263_G278_P0.6050.17
95_F245_Y0.6000.17
96_I252_L0.5990.17
134_S207_Y0.5970.17
134_S155_I0.5960.17
82_F277_D0.5950.17
226_D271_K0.5950.17
268_L275_Q0.5930.17
57_M79_A0.5930.17
159_D248_A0.5920.17
92_T203_Y0.5920.17
71_N86_Q0.5920.17
66_N285_V0.5900.17
132_D149_L0.5900.17
65_D102_A0.5890.17
163_Q232_E0.5860.16
254_A259_E0.5860.16
141_I168_F0.5850.16
154_A178_W0.5850.16
106_Q211_S0.5840.16
160_D180_A0.5830.16
87_P106_Q0.5810.16
156_H194_H0.5800.16
158_T255_S0.5780.16
105_N108_I0.5770.16
98_G225_P0.5760.16
91_A290_V0.5750.16
161_R191_S0.5730.16
112_L248_A0.5710.16
211_S238_W0.5690.16
135_L162_T0.5640.16
63_T67_N0.5630.16
106_Q214_G0.5590.16
206_D253_G0.5590.16
86_Q109_Q0.5580.16
270_G282_S0.5560.16
236_N262_Y0.5560.16
138_L216_I0.5560.16
261_Y288_T0.5550.16
114_K236_N0.5540.16
192_R270_G0.5540.16
65_D285_V0.5530.15
103_K110_E0.5510.15
137_M249_W0.5510.15
141_I148_M0.5480.15
138_L173_F0.5460.15
154_A192_R0.5450.15
163_Q223_K0.5420.15
81_T164_S0.5420.15
85_S245_Y0.5390.15
216_I222_K0.5380.15
111_W116_G0.5380.15
147_N172_H0.5370.15
64_A277_D0.5370.15
104_A274_R0.5360.15
102_A146_T0.5330.15
111_W173_F0.5320.15
106_Q146_T0.5310.15
73_A90_D0.5250.15
204_W212_A0.5220.15
132_D238_W0.5150.14
268_L288_T0.5130.14
251_Q280_A0.5130.14
197_I272_D0.5130.14
155_I190_L0.5110.14
100_A290_V0.5110.14
163_Q203_Y0.5090.14
151_T174_S0.5070.14
100_A258_Y0.5060.14
247_P280_A0.5060.14
131_K238_W0.5060.14
171_R215_Y0.5040.14
171_R202_E0.5040.14
171_R187_D0.5040.14
202_E215_Y0.5040.14
187_D215_Y0.5040.14
181_G187_D0.5040.14
181_G202_E0.5040.14
181_G215_Y0.5040.14
171_R181_G0.5040.14
187_D202_E0.5040.14
192_R223_K0.5030.14
91_A121_K0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4e1tA 1 0.6203 100 0.394 Contact Map
4e1sA 1 0.6102 100 0.406 Contact Map
3qraA 1 0.4678 67.7 0.962 Contact Map
1i78A 2 0.7898 64.7 0.962 Contact Map
1ormA 1 0.4508 62.9 0.963 Contact Map
2jmmA 1 0.4339 55.3 0.965 Contact Map
2k0lA 1 0.5966 43.3 0.967 Contact Map
2x27X 1 0.5763 22.4 0.972 Contact Map
3nb3A 2 0.4102 20.1 0.972 Contact Map
4rlcA 1 0.4034 15.6 0.974 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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