GREMLIN Database
PGM - Phosphoglucomutase
UniProt: P36938 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12144
Length: 546 (449)
Sequences: 10896 (6599)
Seq/√Len: 311.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
291_L295_D4.0931.00
379_G382_D4.0841.00
240_G307_Y3.7731.00
232_G297_F3.6021.00
230_T254_N3.4941.00
315_P430_Q3.3751.00
290_L294_R3.3441.00
361_D439_R2.7981.00
66_Q105_N2.7941.00
216_A250_Y2.7911.00
291_L294_R2.6751.00
367_V379_G2.6701.00
230_T256_T2.6571.00
356_D368_E2.6531.00
129_V210_P2.6421.00
80_P108_D2.6191.00
246_R250_Y2.5731.00
344_A365_K2.5701.00
256_T295_D2.5661.00
427_K435_E2.5551.00
95_F111_V2.3921.00
330_N362_L2.3911.00
209_Q213_E2.3441.00
70_E176_R2.3401.00
102_L141_I2.2621.00
303_N415_C2.2441.00
81_C102_L2.2421.00
58_E93_P2.1951.00
289_G293_L2.1901.00
65_A98_V2.1831.00
83_V99_L2.1601.00
103_A202_V2.1551.00
427_K431_E2.1331.00
501_N522_F2.1231.00
84_G123_V2.1101.00
98_V141_I2.1081.00
357_R360_N2.0971.00
74_K176_R2.0871.00
312_I418_A2.0691.00
524_G529_K2.0561.00
69_A102_L1.9961.00
68_I139_D1.9901.00
533_K537_E1.9831.00
85_K95_F1.9601.00
50_S151_E1.9571.00
286_A290_L1.9551.00
85_K91_S1.9151.00
175_D179_A1.9091.00
529_K533_K1.9061.00
333_F364_R1.8971.00
69_A105_N1.8941.00
176_R179_A1.8811.00
92_E96_I1.8771.00
172_V175_D1.8771.00
232_G291_L1.8651.00
330_N334_Q1.8641.00
209_Q246_R1.8391.00
125_N129_V1.8261.00
70_E105_N1.7911.00
108_D203_K1.7911.00
257_I260_D1.7761.00
356_D360_N1.7721.00
89_A267_R1.7641.00
314_T430_Q1.7331.00
461_S465_P1.7131.00
379_G383_G1.7131.00
50_S152_D1.7091.00
212_V247_I1.7021.00
66_Q70_E1.6841.00
301_F415_C1.6791.00
327_V421_I1.6671.00
68_I157_Y1.6341.00
82_Y132_K1.6311.00
428_N431_E1.6121.00
462_K466_E1.6091.00
80_P110_I1.6081.00
330_N435_E1.5821.00
62_L97_S1.5671.00
174_E178_N1.5631.00
530_Q534_E1.5511.00
335_H424_V1.5471.00
493_G496_K1.5381.00
316_A430_Q1.5271.00
266_F269_M1.5191.00
259_N287_M1.5171.00
331_Y424_V1.5051.00
359_V364_R1.5031.00
378_D382_D1.4861.00
213_E250_Y1.4851.00
357_R443_P1.4821.00
315_P428_N1.4781.00
334_Q425_T1.4701.00
519_C532_E1.4671.00
74_K172_V1.4651.00
458_A462_K1.4391.00
290_L293_L1.4371.00
82_Y126_A1.4341.00
245_K249_E1.4281.00
328_A397_F1.4171.00
523_L526_E1.4111.00
269_M274_D1.4081.00
62_L100_E1.4001.00
61_I155_I1.3971.00
80_P138_A1.3921.00
526_E530_Q1.3861.00
102_L107_V1.3841.00
369_V379_G1.3821.00
357_R522_F1.3761.00
347_K366_L1.3711.00
166_D169_V1.3701.00
325_L389_G1.3661.00
376_F388_G1.3521.00
249_E257_I1.3491.00
209_Q250_Y1.3481.00
528_R532_E1.3411.00
165_A173_V1.3371.00
62_L104_A1.3361.00
231_L299_L1.3351.00
87_T117_F1.3321.00
344_A367_V1.3261.00
235_P260_D1.3211.00
418_A429_P1.3201.00
89_A265_T1.3191.00
269_M273_K1.3191.00
230_T295_D1.3151.00
61_I94_A1.3101.00
287_M290_L1.3071.00
125_N214_G1.3041.00
537_E540_S1.3031.00
292_A300_A1.2971.00
215_L413_I1.2961.00
218_I417_L1.2871.00
256_T291_L1.2861.00
51_A90_L1.2851.00
99_L202_V1.2831.00
286_A289_G1.2801.00
464_S491_S1.2721.00
354_M436_L1.2621.00
85_K92_E1.2551.00
69_A107_V1.2531.00
299_L419_A1.2521.00
47_H64_I1.2511.00
329_I345_V1.2431.00
365_K383_G1.2411.00
65_A155_I1.2381.00
229_L298_D1.2231.00
172_V176_R1.2161.00
422_T432_H1.2091.00
420_E424_V1.2081.00
288_A302_A1.2031.00
75_N172_V1.2021.00
230_T296_K1.2001.00
246_R249_E1.1901.00
71_E169_V1.1871.00
118_T122_A1.1841.00
251_Y416_L1.1841.00
99_L103_A1.1801.00
85_K111_V1.1801.00
331_Y335_H1.1791.00
430_Q434_N1.1781.00
248_G255_L1.1751.00
461_S464_S1.1711.00
206_D209_Q1.1671.00
521_S528_R1.1671.00
210_P213_E1.1641.00
536_V540_S1.1631.00
347_K351_S1.1601.00
398_L405_W1.1571.00
299_L422_T1.1551.00
138_A160_P1.1521.00
83_V98_V1.1481.00
296_K315_P1.1401.00
214_G217_D1.1391.00
532_E536_V1.1381.00
129_V214_G1.1361.00
213_E217_D1.1361.00
208_V243_Y1.1331.00
431_E434_N1.1321.00
99_L111_V1.1281.00
326_A354_M1.1251.00
110_I203_K1.1241.00
65_A102_L1.1241.00
301_F312_I1.1201.00
330_N432_H1.1191.00
442_A445_Y1.1121.00
463_L466_E1.1061.00
95_F99_L1.1051.00
102_L109_V1.1001.00
448_L533_K1.1001.00
256_T297_F1.0971.00
427_K432_H1.0961.00
241_I262_V1.0951.00
215_L416_L1.0951.00
446_N529_K1.0951.00
288_A313_V1.0931.00
71_E172_V1.0921.00
212_V250_Y1.0901.00
367_V383_G1.0861.00
71_E176_R1.0841.00
47_H157_Y1.0841.00
81_C139_D1.0821.00
457_K461_S1.0771.00
288_A292_A1.0771.00
327_V433_Y1.0761.00
41_K178_N1.0751.00
351_S355_I1.0731.00
270_H274_D1.0651.00
233_V248_G1.0641.00
108_D201_H1.0641.00
232_G256_T1.0621.00
333_F343_V1.0611.00
220_D420_E1.0611.00
271_L274_D1.0591.00
141_I155_I1.0531.00
462_K465_P1.0521.00
68_I141_I1.0521.00
213_E216_A1.0511.00
240_G303_N1.0441.00
529_K532_E1.0411.00
432_H435_E1.0371.00
525_E530_Q1.0321.00
358_V362_L1.0291.00
79_G138_A1.0291.00
125_N210_P1.0291.00
347_K368_E1.0281.00
289_G318_L1.0261.00
501_N526_E1.0161.00
175_D178_N1.0121.00
66_Q104_A1.0121.00
334_Q362_L1.0091.00
98_V143_I1.0061.00
123_V142_V1.0061.00
112_Q118_T1.0061.00
248_G415_C1.0051.00
258_V291_L1.0041.00
127_I140_G1.0031.00
326_A358_V1.0031.00
458_A461_S1.0011.00
73_A107_V0.9991.00
208_V246_R0.9981.00
98_V102_L0.9921.00
277_I286_A0.9921.00
97_S101_V0.9901.00
67_A177_A0.9891.00
130_H207_L0.9851.00
325_L355_I0.9851.00
123_V140_G0.9831.00
165_A169_V0.9821.00
58_E97_S0.9821.00
333_F362_L0.9801.00
50_S54_H0.9791.00
212_V243_Y0.9791.00
171_K175_D0.9771.00
119_P122_A0.9661.00
233_V240_G0.9641.00
84_G142_V0.9561.00
241_I245_K0.9541.00
356_D366_L0.9491.00
493_G497_V0.9491.00
222_A227_A0.9441.00
171_K174_E0.9441.00
90_L93_P0.9401.00
63_A180_L0.9361.00
159_P169_V0.9351.00
344_A383_G0.9341.00
496_K503_W0.9311.00
491_S495_L0.9311.00
533_K536_V0.9291.00
273_K276_A0.9261.00
196_A199_S0.9231.00
100_E104_A0.9201.00
214_G218_I0.9191.00
359_V366_L0.9191.00
269_M277_I0.9191.00
269_M275_G0.9181.00
345_V355_I0.9161.00
108_D200_G0.9161.00
169_V172_V0.9141.00
384_S398_L0.9131.00
361_D440_F0.9131.00
397_F417_L0.9111.00
233_V303_N0.9111.00
323_H433_Y0.9071.00
96_I100_E0.9061.00
375_W378_D0.9061.00
421_I425_T0.9051.00
301_F310_H0.9051.00
445_Y449_Q0.9051.00
380_L385_F0.9041.00
60_H64_I0.9031.00
357_R361_D0.9021.00
287_M291_L0.8981.00
497_V504_F0.8961.00
67_A176_R0.8951.00
266_F271_L0.8931.00
324_Y418_A0.8911.00
345_V359_V0.8911.00
270_H277_I0.8881.00
82_Y112_Q0.8831.00
220_D223_A0.8821.00
95_F143_I0.8811.00
248_G419_A0.8801.00
72_R139_D0.8781.00
200_G203_K0.8751.00
91_S153_G0.8751.00
76_G138_A0.8731.00
207_L210_P0.8731.00
244_W303_N0.8731.00
64_I177_A0.8731.00
310_H414_M0.8711.00
174_E177_A0.8691.00
387_F395_A0.8681.00
495_L531_I0.8651.00
344_A385_F0.8651.00
231_L253_L0.8591.00
168_N172_V0.8561.00
293_L296_K0.8531.00
269_M276_A0.8531.00
230_T298_D0.8531.00
292_A297_F0.8531.00
65_A101_V0.8521.00
216_A251_Y0.8511.00
235_P257_I0.8471.00
463_L506_A0.8461.00
231_L419_A0.8431.00
232_G295_D0.8401.00
266_F273_K0.8331.00
533_K540_S0.8321.00
58_E62_L0.8291.00
292_A313_V0.8281.00
118_T142_V0.8271.00
116_G242_E0.8261.00
343_V364_R0.8251.00
324_Y395_A0.8231.00
170_T173_V0.8201.00
273_K278_R0.8161.00
531_I535_A0.8161.00
377_V396_S0.8161.00
245_K262_V0.8151.00
312_I324_Y0.8141.00
331_Y421_I0.8141.00
274_D277_I0.8111.00
324_Y328_A0.8101.00
244_W412_I0.8091.00
208_V242_E0.8081.00
228_G254_N0.8071.00
358_V361_D0.8071.00
417_L420_E0.8061.00
85_K117_F0.8051.00
243_Y412_I0.8051.00
422_T429_P0.8031.00
459_A462_K0.8031.00
346_G388_G0.8021.00
452_A455_A0.8011.00
117_F239_S0.7991.00
199_S202_V0.7931.00
395_A414_M0.7931.00
220_D424_V0.7921.00
352_S389_G0.7891.00
196_A200_G0.7891.00
325_L345_V0.7881.00
446_N532_E0.7821.00
167_T170_T0.7821.00
229_L422_T0.7821.00
314_T319_M0.7801.00
269_M272_D0.7791.00
237_G269_M0.7781.00
84_G118_T0.7760.99
87_T262_V0.7760.99
460_L463_L0.7750.99
273_K277_I0.7740.99
531_I534_E0.7740.99
223_A424_V0.7730.99
336_R339_W0.7730.99
177_A180_L0.7730.99
271_L277_I0.7730.99
271_L276_A0.7730.99
237_G268_F0.7710.99
167_T375_W0.7710.99
346_G379_G0.7680.99
73_A105_N0.7680.99
127_I139_D0.7660.99
126_A207_L0.7660.99
129_V207_L0.7650.99
87_T239_S0.7570.99
398_L404_P0.7550.99
319_M429_P0.7520.99
316_A434_N0.7500.99
214_G406_S0.7450.99
84_G112_Q0.7450.99
330_N358_V0.7440.99
347_K356_D0.7440.99
301_F419_A0.7440.99
219_V416_L0.7430.99
126_A130_H0.7420.99
245_K260_D0.7410.99
245_K257_I0.7410.99
491_S494_G0.7410.99
122_A208_V0.7410.99
206_D210_P0.7390.99
288_A300_A0.7390.99
330_N436_L0.7370.99
360_N366_L0.7370.99
450_A536_V0.7350.99
360_N365_K0.7340.99
272_D277_I0.7330.99
332_L417_L0.7320.99
269_M278_R0.7320.99
456_Q508_P0.7320.99
170_T174_E0.7290.99
237_G259_N0.7290.99
293_L316_A0.7280.99
212_V246_R0.7280.99
107_V138_A0.7270.99
339_W343_V0.7270.99
370_P375_W0.7260.99
232_G258_V0.7260.99
233_V257_I0.7260.99
315_P431_E0.7260.99
97_S100_E0.7250.99
195_E199_S0.7250.99
229_L423_A0.7220.99
65_A69_A0.7190.99
457_K460_L0.7190.99
386_G404_P0.7190.99
419_A422_T0.7170.99
45_S348_T0.7150.99
173_V177_A0.7140.99
534_E537_E0.7140.99
355_I389_G0.7140.99
394_G409_K0.7130.99
327_V432_H0.7130.99
89_A266_F0.7130.99
248_G252_N0.7120.99
528_R531_I0.7110.99
232_G300_A0.7110.99
229_L299_L0.7100.99
82_Y130_H0.7090.99
110_I205_Q0.7090.99
517_I536_V0.7080.99
214_G405_W0.7070.99
317_G430_Q0.7050.99
326_A352_S0.7040.99
270_H273_K0.7030.99
229_L419_A0.7020.99
212_V216_A0.7010.99
165_A170_T0.7010.99
459_A463_L0.6990.99
59_P63_A0.6990.99
330_N439_R0.6980.99
313_V318_L0.6970.99
303_N411_G0.6950.99
233_V244_W0.6930.99
65_A141_I0.6930.99
44_T510_G0.6930.99
259_N268_F0.6920.99
220_D224_I0.6910.99
445_Y448_L0.6890.99
242_E246_R0.6890.99
103_A199_S0.6890.99
289_G313_V0.6890.99
91_S95_F0.6890.99
311_G318_L0.6880.99
89_A264_Q0.6870.99
112_Q122_A0.6850.99
338_Q343_V0.6850.99
519_C528_R0.6820.99
343_V386_G0.6810.99
52_A55_S0.6810.99
336_R386_G0.6810.99
209_Q212_V0.6800.99
447_R452_A0.6800.99
310_H415_C0.6780.99
353_A520_E0.6760.99
234_D288_A0.6740.99
425_T432_H0.6730.99
300_A313_V0.6730.99
219_V222_A0.6730.99
166_D170_T0.6720.99
118_T208_V0.6720.99
219_V223_A0.6720.99
502_G521_S0.6710.99
521_S526_E0.6710.99
70_E73_A0.6690.98
333_F359_V0.6680.98
490_A494_G0.6680.98
342_D365_K0.6670.98
205_Q209_Q0.6670.98
248_G253_L0.6650.98
299_L312_I0.6650.98
433_Y436_L0.6640.98
349_L505_A0.6630.98
52_A93_P0.6620.98
70_E74_K0.6600.98
61_I97_S0.6590.98
460_L508_P0.6590.98
272_D275_G0.6580.98
178_N181_L0.6580.98
79_G107_V0.6580.98
191_I196_A0.6570.98
267_R273_K0.6570.98
448_L536_V0.6570.98
328_A421_I0.6560.98
325_L387_F0.6520.98
443_P522_F0.6510.98
270_H275_G0.6490.98
63_A177_A0.6470.98
194_D197_M0.6470.98
272_D278_R0.6420.98
70_E179_A0.6410.98
68_I72_R0.6380.98
78_T138_A0.6370.98
164_P170_T0.6360.98
112_Q123_V0.6350.98
147_H156_K0.6330.98
43_G46_G0.6320.98
310_H411_G0.6320.98
191_I194_D0.6320.98
266_F274_D0.6320.98
532_E535_A0.6310.98
99_L109_V0.6300.98
504_F535_A0.6280.98
499_T502_G0.6260.98
422_T425_T0.6260.98
355_I366_L0.6240.98
45_S447_R0.6240.98
75_N169_V0.6210.98
259_N262_V0.6200.98
329_I387_F0.6180.97
328_A417_L0.6180.97
266_F272_D0.6150.97
525_E529_K0.6150.97
52_A57_N0.6150.97
163_G381_F0.6140.97
270_H276_A0.6130.97
100_E103_A0.6130.97
291_L297_F0.6120.97
496_K505_A0.6120.97
71_E75_N0.6110.97
124_S407_T0.6100.97
319_M327_V0.6100.97
492_I495_L0.6090.97
326_A436_L0.6090.97
244_W415_C0.6070.97
70_E180_L0.6070.97
148_N511_T0.6060.97
64_I157_Y0.6040.97
337_P343_V0.6020.97
208_V212_V0.5990.97
298_D315_P0.5980.97
435_E438_K0.5980.97
218_I413_I0.5980.97
367_V385_F0.5970.97
526_E531_I0.5960.97
130_H210_P0.5950.97
434_N438_K0.5940.97
50_S55_S0.5920.97
446_N449_Q0.5890.97
274_D278_R0.5880.97
267_R274_D0.5870.97
429_P433_Y0.5860.97
460_L464_S0.5860.97
494_G497_V0.5860.97
89_A150_P0.5850.97
329_I355_I0.5840.96
157_Y173_V0.5820.96
150_P265_T0.5800.96
110_I204_E0.5790.96
323_H438_K0.5780.96
111_V202_V0.5780.96
237_G271_L0.5760.96
194_D200_G0.5760.96
235_P258_V0.5750.96
111_V204_E0.5750.96
285_C288_A0.5740.96
62_L101_V0.5740.96
267_R271_L0.5740.96
347_K353_A0.5720.96
247_I250_Y0.5700.96
530_Q533_K0.5700.96
263_D269_M0.5680.96
248_G303_N0.5670.96
350_V371_V0.5650.96
63_A66_Q0.5640.96
63_A181_L0.5630.96
353_A357_R0.5630.96
244_W248_G0.5620.96
93_P97_S0.5620.96
68_I81_C0.5620.96
271_L275_G0.5620.96
285_C289_G0.5600.96
285_C300_A0.5600.96
57_N60_H0.5600.96
270_H278_R0.5600.96
380_L398_L0.5600.96
285_C313_V0.5590.96
346_G369_V0.5590.96
43_G510_G0.5590.96
45_S164_P0.5570.95
249_E255_L0.5570.95
535_A538_I0.5570.95
161_N381_F0.5570.95
228_G423_A0.5570.95
81_C107_V0.5560.95
421_I424_V0.5540.95
328_A414_M0.5530.95
257_I262_V0.5520.95
387_F397_F0.5520.95
434_N437_A0.5520.95
80_P132_K0.5500.95
56_F61_I0.5500.95
425_T428_N0.5490.95
534_E538_I0.5470.95
58_E100_E0.5460.95
227_A298_D0.5420.95
231_L255_L0.5410.95
328_A418_A0.5410.95
271_L278_R0.5410.95
492_I496_K0.5390.95
358_V440_F0.5370.94
195_E198_A0.5370.94
103_A109_V0.5370.94
272_D276_A0.5360.94
333_F337_P0.5350.94
78_T139_D0.5350.94
302_A313_V0.5340.94
211_F410_D0.5340.94
453_T456_Q0.5340.94
92_E116_G0.5320.94
61_I65_A0.5320.94
230_T297_F0.5320.94
444_S447_R0.5310.94
145_P148_N0.5300.94
332_L337_P0.5280.94
373_F409_K0.5260.94
490_A498_M0.5260.94
322_N445_Y0.5250.94
62_L66_Q0.5250.94
42_F64_I0.5240.94
346_G376_F0.5230.94
122_A243_Y0.5220.94
405_W408_D0.5220.94
347_K355_I0.5220.94
78_T108_D0.5220.94
80_P130_H0.5210.94
63_A178_N0.5200.93
49_G55_S0.5200.93
326_A330_N0.5190.93
247_I412_I0.5190.93
196_A201_H0.5190.93
425_T435_E0.5180.93
324_Y393_A0.5180.93
73_A79_G0.5180.93
192_S195_E0.5180.93
234_D302_A0.5160.93
176_R180_L0.5150.93
98_V155_I0.5140.93
253_L423_A0.5140.93
266_F276_A0.5130.93
285_C318_L0.5130.93
339_W342_D0.5120.93
503_W520_E0.5120.93
508_P515_Y0.5110.93
48_R147_H0.5110.93
129_V213_E0.5100.93
253_L419_A0.5100.93
192_S196_A0.5090.93
396_S406_S0.5090.93
196_A202_V0.5070.93
146_S156_K0.5050.92
275_G278_R0.5030.92
316_A428_N0.5020.92
522_F526_E0.5020.92
197_M203_K0.5000.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3na5A 2 0.9872 100 0.176 Contact Map
2z0fA 2 0.8883 100 0.2 Contact Map
1wqaA 3 0.8297 100 0.207 Contact Map
2f7lA 4 0.8242 100 0.215 Contact Map
1tuoA 1 0.7912 100 0.217 Contact Map
3uw2A 1 0.815 100 0.238 Contact Map
1p5dX 1 0.8223 100 0.244 Contact Map
3pdkA 2 0.8095 100 0.244 Contact Map
4qg5A 1 0.8681 100 0.255 Contact Map
3i3wA 2 0.7949 100 0.259 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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