GREMLIN Database
GATR - Galactitol utilization operon repressor
UniProt: P36930 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12162
Length: 259 (247)
Sequences: 7694 (5640)
Seq/√Len: 358.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
101_M175_L3.2081.00
92_A95_K3.0841.00
114_I212_V3.0411.00
144_T151_T2.6921.00
176_M206_A2.5481.00
15_L30_V2.3571.00
203_V227_L2.2281.00
116_E136_A2.2211.00
215_S238_D2.1871.00
106_D199_S2.1731.00
169_Q201_A2.1321.00
15_L19_Q2.0911.00
210_I234_I2.0831.00
98_H101_M2.0771.00
175_L210_I2.0511.00
11_K14_Q2.0491.00
203_V209_V2.0081.00
91_Q117_G1.9911.00
87_N113_L1.9841.00
104_I173_A1.9641.00
225_Q228_P1.9071.00
166_R169_Q1.8991.00
175_L208_K1.8941.00
99_E122_K1.8591.00
105_L111_T1.8551.00
104_I202_M1.8171.00
241_V246_K1.8131.00
208_K234_I1.7871.00
113_L116_E1.7561.00
246_K250_Q1.7471.00
127_I173_A1.6951.00
228_P231_K1.6651.00
173_A202_M1.6601.00
166_R170_D1.6251.00
93_A212_V1.6111.00
134_A147_V1.5981.00
201_A204_T1.5971.00
93_A177_F1.5961.00
147_V159_M1.5931.00
114_I177_F1.5551.00
82_A216_S1.5371.00
174_D207_N1.5281.00
21_T59_A1.5211.00
148_C167_S1.5051.00
94_V117_G1.5041.00
169_Q204_T1.4961.00
126_V137_L1.4941.00
82_A85_P1.4621.00
189_I232_I1.4571.00
27_L38_I1.4561.00
9_R48_K1.4461.00
247_L251_K1.4431.00
17_N60_K1.4391.00
87_N117_G1.4371.00
33_A38_I1.4371.00
96_M236_I1.4351.00
148_C159_M1.4301.00
19_Q26_D1.4261.00
42_L58_A1.4201.00
90_A117_G1.4161.00
11_K15_L1.4151.00
15_L22_V1.4111.00
164_A198_I1.4041.00
201_A205_A1.3971.00
52_T61_I1.3931.00
211_A232_I1.3911.00
12_I27_L1.3891.00
10_N14_Q1.3821.00
126_V143_I1.3811.00
96_M210_I1.3771.00
107_S158_S1.3751.00
242_S245_D1.3711.00
85_P238_D1.3701.00
97_I118_L1.3611.00
189_I211_A1.3591.00
101_M174_D1.3511.00
152_V159_M1.3471.00
215_S240_A1.3361.00
9_R44_F1.3291.00
13_I50_V1.3261.00
83_S113_L1.3261.00
25_Q35_E1.3241.00
165_E197_S1.3131.00
99_E123_N1.3131.00
183_I218_F1.3071.00
227_L231_K1.3041.00
99_E121_A1.3021.00
148_C164_A1.3011.00
23_L26_D1.3001.00
5_S9_R1.2991.00
100_G123_N1.2851.00
208_K233_D1.2781.00
87_N116_E1.2451.00
16_V51_V1.2401.00
125_T146_V1.2391.00
104_I205_A1.2321.00
86_K109_S1.2311.00
54_F57_G1.2271.00
11_K31_F1.2261.00
92_A96_M1.2221.00
11_K30_V1.2071.00
115_A137_L1.1941.00
16_V60_K1.1931.00
243_E247_L1.1891.00
177_F210_I1.1861.00
83_S87_N1.1811.00
247_L250_Q1.1791.00
218_F241_V1.1621.00
180_A213_L1.1561.00
234_I255_K1.1551.00
43_R47_Q1.1531.00
146_V151_T1.1501.00
85_P215_S1.1491.00
204_T231_K1.1411.00
163_I167_S1.1301.00
36_A40_A1.1231.00
13_I16_V1.1191.00
125_T144_T1.1181.00
52_T59_A1.1131.00
209_V232_I1.1031.00
14_Q18_E1.0991.00
180_A226_V1.0971.00
51_V58_A1.0941.00
184_D187_N1.0931.00
84_A87_N1.0931.00
96_M234_I1.0741.00
98_H175_L1.0731.00
182_G190_T1.0721.00
94_V97_I1.0681.00
165_E198_I1.0681.00
183_I213_L1.0601.00
218_F235_I1.0591.00
93_A114_I1.0551.00
44_F48_K1.0541.00
90_A94_V1.0541.00
19_Q30_V1.0511.00
75_F109_S1.0501.00
127_I171_I1.0471.00
210_I236_I1.0331.00
245_D248_A1.0161.00
148_C168_L1.0141.00
105_L114_I1.0141.00
97_I177_F1.0111.00
7_E11_K1.0021.00
85_P89_I1.0021.00
165_E201_A1.0011.00
15_L18_E0.9921.00
151_T194_E0.9911.00
94_V114_I0.9901.00
24_V42_L0.9881.00
28_A35_E0.9831.00
108_G111_T0.9801.00
114_I117_G0.9791.00
115_A136_A0.9501.00
163_I171_I0.9491.00
145_L152_V0.9441.00
176_M202_M0.9411.00
5_S44_F0.9401.00
87_N91_Q0.9381.00
181_D191_T0.9361.00
82_A214_D0.9341.00
180_A211_A0.9331.00
230_E252_T0.9311.00
26_D30_V0.9261.00
132_P157_R0.9261.00
22_V27_L0.9191.00
43_R46_E0.9141.00
184_D221_R0.9141.00
111_T133_A0.9111.00
22_V58_A0.9051.00
163_I170_D0.9051.00
28_A38_I0.8991.00
170_D200_G0.8991.00
44_F47_Q0.8931.00
13_I17_N0.8861.00
138_S157_R0.8851.00
89_I110_T0.8821.00
156_T181_D0.8811.00
246_K256_L0.8771.00
111_T114_I0.8731.00
110_T214_D0.8721.00
93_A236_I0.8661.00
177_F212_V0.8631.00
90_A114_I0.8591.00
119_M140_N0.8561.00
119_M136_A0.8541.00
168_L201_A0.8531.00
248_A251_K0.8521.00
115_A133_A0.8511.00
86_K217_K0.8481.00
172_N187_N0.8431.00
86_K110_T0.8431.00
45_L50_V0.8421.00
90_A113_L0.8381.00
130_S133_A0.8371.00
172_N207_N0.8351.00
88_R91_Q0.8301.00
7_E10_N0.8261.00
172_N225_Q0.8261.00
207_N221_R0.8261.00
105_L115_A0.8241.00
209_V233_D0.8151.00
14_Q17_N0.8121.00
185_A188_G0.8121.00
172_N221_R0.8021.00
187_N221_R0.8011.00
189_I226_V0.8001.00
110_T217_K0.7991.00
168_L202_M0.7951.00
112_M136_A0.7821.00
172_N205_A0.7761.00
135_F157_R0.7761.00
104_I168_L0.7711.00
7_E21_T0.7691.00
111_T212_V0.7681.00
123_N142_D0.7661.00
20_G60_K0.7641.00
203_V226_V0.7631.00
43_R53_R0.7531.00
121_A124_I0.7521.00
84_A88_R0.7501.00
190_T221_R0.7491.00
185_A248_A0.7471.00
173_A206_A0.7451.00
180_A189_I0.7421.00
105_L126_V0.7421.00
78_R181_D0.7421.00
241_V245_D0.7401.00
153_R160_H0.7361.00
119_M122_K0.7351.00
26_D29_G0.7351.00
82_A215_S0.7321.00
89_I212_V0.7271.00
170_D225_Q0.7261.00
9_R13_I0.7190.99
74_G77_E0.7150.99
213_L235_I0.7020.99
176_M209_V0.7010.99
200_G204_T0.7010.99
149_G167_S0.7000.99
88_R92_A0.6990.99
136_A139_E0.6980.99
248_A252_T0.6980.99
113_L117_G0.6970.99
13_I45_L0.6970.99
140_N143_I0.6970.99
241_V256_L0.6950.99
109_S217_K0.6950.99
79_F112_M0.6950.99
54_F59_A0.6920.99
46_E51_V0.6910.99
183_I229_I0.6900.99
134_A159_M0.6900.99
42_L53_R0.6890.99
134_A152_V0.6840.99
107_S156_T0.6840.99
191_T196_Y0.6790.99
161_G164_A0.6790.99
244_V248_A0.6780.99
243_E246_K0.6770.99
210_I233_D0.6750.99
25_Q29_G0.6680.99
91_Q95_K0.6680.99
102_T127_I0.6680.99
97_I114_I0.6670.99
16_V22_V0.6660.99
197_S200_G0.6660.99
162_S166_R0.6660.99
129_N202_M0.6640.99
131_L159_M0.6620.99
169_Q205_A0.6620.99
46_E53_R0.6590.99
103_V126_V0.6570.99
122_K142_D0.6560.99
139_E157_R0.6540.99
149_G164_A0.6520.99
191_T226_V0.6480.99
72_E78_R0.6430.99
215_S241_V0.6430.99
103_V175_L0.6430.99
183_I189_I0.6400.99
27_L42_L0.6380.99
162_S197_S0.6370.99
181_D222_G0.6360.99
33_A36_A0.6330.99
24_V38_I0.6330.99
131_L147_V0.6290.99
153_R195_G0.6250.99
171_I224_N0.6250.99
164_A167_S0.6230.99
123_N144_T0.6230.99
127_I146_V0.6220.98
6_F9_R0.6210.98
112_M132_P0.6210.98
132_P135_F0.6210.98
8_R41_D0.6190.98
245_D249_L0.6110.98
214_D217_K0.6100.98
178_V203_V0.6100.98
196_Y224_N0.6070.98
206_A209_V0.6030.98
127_I223_F0.6030.98
163_I166_R0.6030.98
162_S165_E0.6020.98
131_L135_F0.6010.98
178_V206_A0.5930.98
102_T223_F0.5910.98
31_F38_I0.5890.98
165_E169_Q0.5860.98
128_T134_A0.5820.98
208_K255_K0.5810.98
182_G222_G0.5790.98
198_I201_A0.5760.98
88_R239_D0.5740.97
76_K79_F0.5740.97
189_I227_L0.5710.97
227_L232_I0.5710.97
181_D192_F0.5700.97
240_A246_K0.5690.97
178_V209_V0.5690.97
153_R193_N0.5690.97
105_L133_A0.5680.97
103_V177_F0.5670.97
218_F237_T0.5660.97
106_D111_T0.5660.97
178_V226_V0.5640.97
104_I176_M0.5620.97
36_A181_D0.5570.97
108_G179_G0.5560.97
85_P240_A0.5540.97
36_A130_S0.5530.97
85_P88_R0.5450.97
24_V28_A0.5440.97
250_Q255_K0.5420.96
105_L118_L0.5410.96
79_F113_L0.5410.96
209_V231_K0.5400.96
192_F222_G0.5390.96
75_F157_R0.5380.96
182_G220_R0.5380.96
159_M167_S0.5360.96
104_I127_I0.5360.96
219_N245_D0.5350.96
72_E153_R0.5350.96
121_A142_D0.5330.96
78_R106_D0.5330.96
215_S239_D0.5330.96
218_F245_D0.5310.96
146_V163_I0.5310.96
12_I31_F0.5290.96
40_A183_I0.5270.96
134_A145_L0.5240.96
184_D190_T0.5240.96
117_G120_T0.5210.96
199_S226_V0.5180.95
46_E52_T0.5170.95
103_V114_I0.5160.95
185_A245_D0.5140.95
166_R200_G0.5130.95
243_E250_Q0.5120.95
28_A34_S0.5120.95
42_L46_E0.5110.95
138_S152_V0.5080.95
181_D199_S0.5080.95
9_R31_F0.5050.95
29_G32_A0.5040.95
24_V55_H0.5040.95
179_G191_T0.5010.95
246_K249_L0.5010.95
144_T154_H0.5000.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1stzA 3 0.9421 100 0.513 Contact Map
3rrlB 1 0.6486 100 0.534 Contact Map
2w48A 3 0.9035 100 0.573 Contact Map
3l7oA 2 0.583 100 0.609 Contact Map
1o8bA 2 0.5714 100 0.612 Contact Map
2o0mA 1 0.6834 100 0.617 Contact Map
1m0sA 2 0.5946 100 0.62 Contact Map
1lk5A 4 0.5907 100 0.621 Contact Map
1uj6A 2 0.5907 100 0.623 Contact Map
3uw1A 2 0.6023 100 0.625 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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