GREMLIN Database
RSMB - Ribosomal RNA small subunit methyltransferase B
UniProt: P36929 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12163
Length: 429 (416)
Sequences: 3982 (2927)
Seq/√Len: 143.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
358_D392_R3.9711.00
319_I364_L3.8961.00
145_H168_N3.8331.00
386_I426_L3.8051.00
354_S388_A3.3981.00
59_D82_M3.3651.00
107_I115_K3.2921.00
305_R355_E3.2351.00
251_L316_F2.7901.00
84_G102_T2.7771.00
397_E427_I2.7191.00
189_L209_V2.7021.00
80_L106_A2.6961.00
156_A379_P2.6951.00
152_R380_E2.6811.00
354_S385_Q2.6361.00
202_H208_A2.6281.00
317_D365_K2.5921.00
321_L356_I2.5661.00
124_Q128_Q2.5631.00
369_T427_I2.5491.00
272_Q298_T2.5421.00
43_L93_I2.5151.00
408_G422_F2.4761.00
248_E318_R2.4641.00
124_Q127_R2.4481.00
158_P161_W2.4371.00
361_W396_A2.4341.00
369_T425_K2.3891.00
184_S187_S2.3411.00
399_C427_I2.3211.00
274_V316_F2.3161.00
364_L370_L2.2981.00
188_W228_V2.2821.00
202_H233_A2.2211.00
253_L360_I2.2171.00
269_P297_A2.1981.00
389_F396_A2.1441.00
361_W389_F2.1141.00
358_D393_T2.0791.00
268_A271_A2.0761.00
249_H272_Q2.0721.00
145_H165_V2.0581.00
85_L125_F2.0271.00
399_C425_K1.9701.00
388_A392_R1.9501.00
50_G86_Y1.9491.00
350_A385_Q1.9311.00
150_L165_V1.9251.00
120_G124_Q1.9241.00
277_D283_L1.9091.00
189_L199_G1.8991.00
147_S151_K1.8871.00
200_F212_E1.8531.00
191_L227_W1.8321.00
261_T273_V1.8291.00
371_V425_K1.8171.00
398_L408_G1.8071.00
182_H294_G1.8061.00
183_H188_W1.7961.00
261_T275_A1.7891.00
398_L424_A1.7701.00
283_L301_Q1.7671.00
262_T293_L1.7521.00
106_A118_I1.7511.00
178_I188_W1.7481.00
255_A286_V1.7341.00
100_A104_E1.7261.00
152_R378_L1.7181.00
66_M117_L1.7041.00
283_L299_V1.6951.00
239_M263_H1.6731.00
284_S287_Y1.6621.00
244_P248_E1.6531.00
12_A83_V1.6461.00
54_T57_Q1.6381.00
383_S410_Q1.6321.00
57_Q90_Y1.6241.00
180_R207_D1.6081.00
245_Q248_E1.5981.00
328_T376_S1.5971.00
84_G98_A1.5841.00
160_Q414_G1.5751.00
221_P225_D1.5671.00
154_Q161_W1.5591.00
374_T382_N1.5581.00
364_L428_K1.5551.00
389_F393_T1.5511.00
153_L378_L1.5121.00
328_T378_L1.5081.00
175_W210_R1.4851.00
73_K117_L1.4831.00
242_L264_I1.4721.00
14_A44_L1.4471.00
387_K391_Q1.4471.00
17_Q21_Q1.4411.00
157_Y412_L1.4351.00
47_L83_V1.4281.00
234_S418_G1.4251.00
176_L228_V1.4111.00
153_L165_V1.4111.00
59_D78_H1.4111.00
89_L125_F1.4071.00
160_Q415_A1.4021.00
386_I390_L1.3991.00
65_L125_F1.3941.00
205_Y233_A1.3901.00
80_L102_T1.3851.00
161_W165_V1.3841.00
11_A47_L1.3761.00
14_A32_L1.3631.00
208_A236_Q1.3621.00
229_T262_T1.3601.00
134_A139_S1.3571.00
384_L387_K1.3501.00
274_V300_K1.3231.00
255_A261_T1.3201.00
46_E86_Y1.3201.00
185_R201_P1.3151.00
222_G228_V1.3141.00
14_A28_I1.3111.00
243_A318_R1.3081.00
361_W370_L1.3061.00
88_L126_Q1.3011.00
56_S339_W1.3011.00
411_N418_G1.2851.00
240_T267_V1.2811.00
280_E301_Q1.2621.00
244_P250_I1.2611.00
205_Y208_A1.2581.00
13_Q109_I1.2471.00
283_L286_V1.2431.00
242_L318_R1.2421.00
238_C423_Y1.2401.00
199_G209_V1.2331.00
241_W423_Y1.2311.00
101_E104_E1.2261.00
249_H316_F1.2161.00
207_D240_T1.2121.00
354_S392_R1.2021.00
351_Q355_E1.2011.00
249_H274_V1.1981.00
183_H227_W1.1981.00
379_P384_L1.1981.00
58_L86_Y1.1821.00
354_S358_D1.1741.00
323_A356_I1.1591.00
390_L426_L1.1571.00
182_H227_W1.1561.00
103_V119_N1.1540.99
244_P268_A1.1450.99
302_G307_P1.1410.99
232_D332_R1.1370.99
195_A222_G1.1350.99
18_V52_L1.1330.99
120_G127_R1.1230.99
80_L105_G1.1190.99
44_L48_C1.1180.99
93_I98_A1.1170.99
10_M32_L1.1160.99
359_A362_P1.1150.99
250_I271_A1.1110.99
229_T266_E1.1110.99
152_R343_D1.1100.99
364_L396_A1.1080.99
357_L389_F1.1060.99
242_L371_V1.1060.99
190_A193_D1.1040.99
169_N338_K1.1000.99
342_R345_D1.1000.99
304_G356_I1.0950.99
99_L126_Q1.0940.99
175_W233_A1.0820.99
346_I350_A1.0820.99
305_R356_I1.0770.99
234_S411_N1.0770.99
119_N123_R1.0760.99
58_L85_L1.0680.99
185_R189_L1.0620.99
143_Y165_V1.0610.99
185_R209_V1.0610.99
87_Q102_T1.0530.99
43_L91_T1.0510.99
264_I318_R1.0500.99
16_E79_Y1.0490.99
162_Q166_E1.0490.99
362_P393_T1.0450.99
249_H315_Q1.0400.99
137_N147_S1.0380.99
326_S346_I1.0370.99
379_P383_S1.0340.99
290_L297_A1.0320.99
243_A369_T1.0310.99
380_E384_L1.0270.99
370_L389_F1.0190.99
307_P363_H1.0190.99
88_L95_P1.0170.99
19_V22_G1.0140.99
195_A221_P1.0140.99
238_C371_V1.0120.99
88_L98_A1.0060.99
151_K155_K1.0020.99
253_L276_V1.0020.99
180_R266_E1.0010.99
369_T399_C1.0000.99
331_I338_K0.9950.98
341_R345_D0.9910.98
189_L201_P0.9810.98
186_D190_A0.9810.98
352_L355_E0.9790.98
287_Y299_V0.9760.98
24_S27_N0.9750.98
401_T409_K0.9700.98
164_I377_V0.9680.98
305_R352_L0.9670.98
306_Y309_Q0.9670.98
326_S349_L0.9650.98
166_E170_Q0.9620.98
96_H100_A0.9570.98
65_L128_Q0.9560.98
222_G227_W0.9560.98
190_A194_E0.9500.98
318_R369_T0.9500.98
287_Y291_K0.9420.98
129_Q132_L0.9390.98
264_I320_L0.9340.98
12_A79_Y0.9340.98
175_W202_H0.9340.98
19_V55_L0.9310.98
404_P407_P0.9250.98
134_A140_D0.9250.98
200_F210_R0.9240.98
255_A275_A0.9240.98
264_I273_V0.9230.98
204_D233_A0.9230.98
390_L398_L0.9220.98
46_E53_R0.9210.98
154_Q158_P0.9190.97
134_A138_A0.9150.97
63_N78_H0.9140.97
187_S191_L0.9130.97
19_V79_Y0.9120.97
56_S147_S0.9090.97
248_E369_T0.9050.97
202_H205_Y0.9030.97
138_A142_R0.9000.97
359_A363_H0.8990.97
103_V115_K0.8950.97
172_P333_R0.8890.97
9_S109_I0.8880.97
142_R162_Q0.8860.97
56_S144_L0.8860.97
56_S141_A0.8860.97
288_D291_K0.8850.97
46_E171_R0.8820.97
145_H150_L0.8790.97
246_N270_E0.8760.97
160_Q163_S0.8760.97
10_M36_V0.8760.97
16_E20_E0.8750.97
145_H169_N0.8740.97
403_T406_Q0.8730.97
206_P240_T0.8700.96
263_H267_V0.8680.96
168_N377_V0.8640.96
17_Q28_I0.8600.96
45_Q49_F0.8570.96
238_C263_H0.8550.96
43_L47_L0.8540.96
262_T289_N0.8530.96
79_Y82_M0.8490.96
276_V302_G0.8490.96
403_T407_P0.8490.96
264_I271_A0.8480.96
265_L295_M0.8480.96
66_M73_K0.8470.96
181_T295_M0.8450.96
12_A16_E0.8440.96
390_L396_A0.8430.96
176_L211_L0.8420.96
216_P219_A0.8380.96
331_I337_I0.8360.96
262_T290_L0.8340.96
188_W222_G0.8330.96
345_D348_E0.8330.96
223_F228_V0.8320.95
266_E295_M0.8310.95
330_V334_H0.8310.95
347_P380_E0.8280.95
250_I268_A0.8260.95
61_L125_F0.8260.95
348_E351_Q0.8250.95
172_P332_R0.8250.95
208_A233_A0.8250.95
150_L161_W0.8230.95
58_L90_Y0.8210.95
251_L276_V0.8170.95
321_L360_I0.8130.95
112_P116_G0.8130.95
243_A267_V0.8130.95
350_A354_S0.8120.95
232_D333_R0.8100.95
185_R208_A0.8090.95
276_V300_K0.8090.95
319_I370_L0.8070.95
12_A105_G0.8050.95
244_P264_I0.8030.95
164_I414_G0.8030.95
77_V106_A0.8010.94
128_Q131_E0.8000.94
163_S166_E0.7970.94
241_W401_T0.7970.94
193_D199_G0.7970.94
270_E297_A0.7950.94
94_P97_A0.7930.94
408_G424_A0.7890.94
38_D42_A0.7870.94
88_L99_L0.7840.94
28_I32_L0.7830.94
18_V48_C0.7830.94
284_S288_D0.7830.94
14_A48_C0.7800.94
358_D388_A0.7790.94
281_Q284_S0.7760.93
377_V410_Q0.7740.93
134_A137_N0.7730.93
233_A418_G0.7730.93
370_L396_A0.7710.93
396_A426_L0.7690.93
350_A378_L0.7680.93
22_G28_I0.7680.93
136_F139_S0.7670.93
74_Q114_L0.7670.93
244_P267_V0.7650.93
253_L304_G0.7650.93
43_L87_Q0.7640.93
11_A48_C0.7640.93
160_Q164_I0.7630.93
9_S108_A0.7620.93
357_L370_L0.7620.93
80_L118_I0.7620.93
80_L84_G0.7610.93
87_Q98_A0.7590.93
143_Y150_L0.7570.93
87_Q93_I0.7540.92
149_L378_L0.7530.92
307_P359_A0.7520.92
179_N182_H0.7520.92
176_L209_V0.7520.92
15_V48_C0.7500.92
136_F154_Q0.7500.92
413_P420_G0.7490.92
61_L89_L0.7480.92
58_L82_M0.7450.92
181_T269_P0.7450.92
97_A101_E0.7410.92
403_T408_G0.7410.92
268_A273_V0.7400.92
27_N285_R0.7370.92
189_L193_D0.7340.91
178_I185_R0.7340.91
104_E107_I0.7330.91
111_R114_L0.7330.91
205_Y240_T0.7310.91
366_T428_K0.7290.91
183_H187_S0.7290.91
346_I378_L0.7270.91
385_Q388_A0.7250.91
107_I112_P0.7240.91
243_A248_E0.7230.91
183_H191_L0.7220.91
412_L415_A0.7190.91
126_Q129_Q0.7190.91
55_L82_M0.7190.91
51_V82_M0.7180.91
76_T111_R0.7180.91
153_L377_V0.7180.91
151_K343_D0.7170.90
62_I66_M0.7170.90
246_N268_A0.7160.90
56_S140_D0.7150.90
149_L328_T0.7150.90
188_W191_L0.7120.90
12_A76_T0.7110.90
361_W364_L0.7110.90
85_L89_L0.7090.90
371_V423_Y0.7060.90
390_L393_T0.7060.90
404_P408_G0.7040.90
87_Q91_T0.7040.90
383_S387_K0.7030.90
308_S359_A0.6940.89
393_T396_A0.6930.89
229_T293_L0.6920.89
320_L373_A0.6910.89
320_L371_V0.6910.89
407_P422_F0.6910.89
411_N415_A0.6880.89
251_L319_I0.6870.89
10_M44_L0.6860.88
305_R359_A0.6830.88
253_L321_L0.6820.88
152_R156_A0.6810.88
239_M264_I0.6800.88
181_T268_A0.6800.88
353_Q372_Y0.6800.88
12_A109_I0.6780.88
221_P224_E0.6780.88
25_L337_I0.6770.88
55_L339_W0.6750.88
46_E91_T0.6720.87
226_G292_R0.6710.87
103_V123_R0.6710.87
233_A237_G0.6710.87
178_I209_V0.6700.87
17_Q23_Q0.6700.87
86_Y90_Y0.6690.87
261_T290_L0.6650.87
244_P369_T0.6640.87
55_L79_Y0.6630.87
229_T289_N0.6630.87
104_E115_K0.6630.87
290_L299_V0.6620.87
95_P126_Q0.6610.87
280_E287_Y0.6610.87
78_H82_M0.6580.86
160_Q412_L0.6570.86
179_N266_E0.6570.86
55_L58_L0.6550.86
54_T144_L0.6540.86
131_E135_E0.6530.86
253_L319_I0.6520.86
84_G122_L0.6520.86
195_A220_L0.6510.86
251_L274_V0.6510.86
177_R266_E0.6510.86
93_I97_A0.6500.86
62_I81_I0.6500.86
238_C373_A0.6500.86
15_V51_V0.6490.86
179_N229_T0.6490.86
384_L388_A0.6480.85
175_W208_A0.6480.85
123_R127_R0.6460.85
194_E209_V0.6410.85
19_V82_M0.6390.85
268_A297_A0.6360.84
396_A428_K0.6350.84
265_L273_V0.6350.84
79_Y83_V0.6350.84
20_E75_R0.6350.84
62_I125_F0.6330.84
332_R419_D0.6310.84
414_G418_G0.6290.84
14_A29_L0.6290.84
273_V295_M0.6280.84
13_Q32_L0.6270.84
185_R188_W0.6270.84
42_A46_E0.6270.84
185_R205_Y0.6260.83
276_V304_G0.6250.83
203_A233_A0.6230.83
274_V298_T0.6230.83
18_V25_L0.6230.83
361_W428_K0.6230.83
207_D267_V0.6220.83
398_L422_F0.6200.83
309_Q359_A0.6190.83
66_M121_V0.6180.83
103_V116_G0.6170.83
17_Q32_L0.6160.83
276_V307_P0.6150.82
40_D91_T0.6150.82
46_E50_G0.6150.82
16_E76_T0.6140.82
385_Q392_R0.6140.82
278_I301_Q0.6130.82
373_A423_Y0.6130.82
235_A421_F0.6120.82
87_Q97_A0.6120.82
54_T90_Y0.6110.82
112_P115_K0.6110.82
319_I360_I0.6110.82
77_V118_I0.6100.82
112_P117_L0.6090.82
84_G88_L0.6090.82
247_G270_E0.6080.82
401_T425_K0.6070.82
289_N292_R0.6050.81
77_V114_L0.6050.81
207_D263_H0.6020.81
334_H340_L0.6000.81
118_I121_V0.5990.81
26_S334_H0.5990.81
74_Q111_R0.5990.81
277_D286_V0.5980.81
382_N410_Q0.5980.81
15_V79_Y0.5980.81
269_P295_M0.5960.80
253_L356_I0.5960.80
66_M70_M0.5950.80
116_G119_N0.5940.80
286_V299_V0.5940.80
9_S13_Q0.5930.80
43_L92_R0.5920.80
57_Q142_R0.5910.80
163_S414_G0.5910.80
313_E362_P0.5900.80
281_Q285_R0.5900.80
409_K423_Y0.5890.80
153_L161_W0.5890.80
62_I85_L0.5890.80
239_M267_V0.5880.80
87_Q94_P0.5860.79
250_I318_R0.5860.79
322_D375_C0.5860.79
223_F226_G0.5850.79
407_P410_Q0.5840.79
140_D147_S0.5830.79
244_P318_R0.5830.79
144_L165_V0.5820.79
387_K408_G0.5810.79
358_D385_Q0.5800.79
114_L117_L0.5800.79
257_P282_R0.5790.78
350_A380_E0.5790.78
18_V22_G0.5780.78
105_G109_I0.5760.78
20_E79_Y0.5760.78
343_D347_P0.5760.78
95_P129_Q0.5740.78
257_P286_V0.5740.78
299_V302_G0.5740.78
406_Q410_Q0.5730.78
143_Y162_Q0.5720.78
177_R229_T0.5710.78
141_A144_L0.5710.78
55_L59_D0.5710.78
161_W164_I0.5700.77
260_K322_D0.5680.77
383_S422_F0.5640.77
47_L98_A0.5620.76
153_L164_I0.5620.76
187_S190_A0.5610.76
403_T410_Q0.5600.76
361_W393_T0.5590.76
38_D41_K0.5580.76
57_Q144_L0.5570.76
144_L339_W0.5570.76
26_S30_P0.5560.76
23_Q28_I0.5540.75
309_Q363_H0.5530.75
347_P350_A0.5530.75
176_L230_V0.5520.75
164_I412_L0.5510.75
75_R79_Y0.5500.75
8_R11_A0.5500.75
40_D43_L0.5470.74
91_T94_P0.5470.74
177_R231_Q0.5470.74
245_Q318_R0.5460.74
98_A102_T0.5440.74
62_I82_M0.5430.74
386_I424_A0.5430.74
102_T105_G0.5420.74
99_L119_N0.5420.74
232_D419_D0.5410.74
54_T169_N0.5410.74
193_D196_G0.5400.74
29_L44_L0.5400.74
364_L368_G0.5390.73
383_S408_G0.5380.73
162_Q165_V0.5380.73
144_L169_N0.5380.73
344_R348_E0.5370.73
99_L103_V0.5370.73
135_E138_A0.5360.73
367_G428_K0.5340.73
307_P362_P0.5340.73
248_E268_A0.5340.73
142_R166_E0.5330.73
51_V55_L0.5320.72
139_S162_Q0.5300.72
177_R263_H0.5270.72
122_L125_F0.5260.72
59_D62_I0.5260.72
57_Q61_L0.5260.72
16_E19_V0.5260.72
319_I362_P0.5240.71
149_L331_I0.5240.71
273_V290_L0.5230.71
385_Q389_F0.5230.71
285_R288_D0.5220.71
83_V105_G0.5220.71
61_L85_L0.5220.71
191_L194_E0.5210.71
348_E352_L0.5210.71
398_L401_T0.5210.71
129_Q133_L0.5200.71
10_M13_Q0.5200.71
328_T331_I0.5170.70
386_I398_L0.5160.70
75_R78_H0.5160.70
333_R419_D0.5150.70
120_G125_F0.5150.70
314_Q428_K0.5130.70
338_K421_F0.5120.70
145_H338_K0.5100.69
151_K154_Q0.5100.69
74_Q113_Q0.5100.69
50_G58_L0.5090.69
130_E133_L0.5080.69
176_L222_G0.5080.69
260_K375_C0.5070.69
327_A337_I0.5070.69
102_T118_I0.5060.69
148_W343_D0.5050.69
328_T346_I0.5040.68
47_L93_I0.5030.68
210_R417_E0.5020.68
411_N423_Y0.5020.68
135_E140_D0.5010.68
15_V83_V0.5000.68
25_L336_D0.5000.68
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1sqgA 1 0.9883 100 0.243 Contact Map
2yxlA 1 0.9883 100 0.263 Contact Map
2frxA 1 0.648 100 0.441 Contact Map
1ixkA 1 0.669 100 0.453 Contact Map
3m6wA 2 0.6573 100 0.459 Contact Map
3m4xA 1 0.6434 100 0.462 Contact Map
2b9eA 1 0.5641 100 0.49 Contact Map
3ajdA 1 0.5548 100 0.549 Contact Map
4fzvA 1 0.6737 100 0.58 Contact Map
2vdvE 2 0.4359 99.9 0.803 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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