GREMLIN Database
YEGD - Uncharacterized chaperone protein YegD
UniProt: P36928 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12200
Length: 450 (401)
Sequences: 838 (596)
Seq/√Len: 29.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
225_L400_P5.3861.00
318_E321_K5.3861.00
117_G120_P5.2291.00
48_E51_Y4.3421.00
117_G121_Q4.2751.00
177_E181_K4.1291.00
173_Q177_E4.0961.00
151_Q187_D4.0401.00
288_A291_I3.6101.00
291_I294_V3.5341.00
391_L395_N3.3591.00
150_T186_R3.1491.00
136_H140_Q3.1381.00
409_S412_S3.0561.00
284_P288_A2.9691.00
281_P284_P2.9231.00
371_Q375_E2.8531.00
288_A294_V2.8391.00
110_K113_L2.7451.00
18_R23_H2.7401.00
288_A292_N2.6661.00
15_A442_A2.6511.00
110_K114_G2.5781.00
281_P285_W2.5260.99
281_P291_I2.5170.99
13_S438_T2.4520.99
138_R142_Q2.4440.99
313_V323_A2.4230.99
344_C369_I2.3540.99
46_V50_L2.3460.99
281_P288_A2.3440.99
48_E52_R2.3050.99
160_F176_L2.2440.99
264_L341_A2.2040.98
355_R368_L2.1770.98
390_Q422_Q2.1620.98
281_P294_V2.1600.98
169_N172_A2.1500.98
202_E238_R2.1490.98
3_I14_V2.1340.98
14_V137_I2.0750.98
267_L367_T2.0610.97
404_Y431_G2.0190.97
47_S51_Y2.0160.97
5_F152_A2.0150.97
385_I415_I1.9610.97
362_S365_L1.9270.96
169_N173_Q1.9130.96
104_W110_K1.8920.96
373_G376_S1.8860.96
285_W288_A1.8820.96
291_I297_Q1.8580.95
39_C103_V1.8560.95
107_K114_G1.8520.95
294_V297_Q1.8510.95
246_S392_A1.8360.95
291_I295_P1.8360.95
208_E231_Q1.8170.95
128_D182_R1.8000.94
266_P269_G1.7990.94
284_P291_I1.7820.94
284_P287_N1.7810.94
281_P287_N1.7530.94
12_C137_I1.7440.93
420_A428_I1.7280.93
225_L396_A1.7260.93
285_W294_V1.7180.93
284_P294_V1.7160.93
154_I180_A1.7040.93
155_G441_L1.6760.92
303_S307_R1.6650.92
166_D169_N1.6070.90
309_L329_W1.5890.90
208_E227_L1.5630.89
287_N291_I1.5460.88
403_I419_L1.5410.88
107_K113_L1.5020.87
195_V226_L1.4960.87
111_S114_G1.4720.86
370_S373_G1.4710.86
275_E280_L1.4630.85
130_V437_V1.4590.85
49_W52_R1.4590.85
287_N294_V1.4480.85
281_P289_V1.4420.85
386_L418_A1.4260.84
6_D9_T1.4230.84
201_Y209_K1.4220.84
267_L365_L1.4050.83
355_R366_A1.4010.83
285_W291_I1.3810.82
159_N166_D1.3780.82
138_R185_F1.3740.82
202_E241_S1.3640.81
192_Y224_S1.3490.80
289_V292_N1.3360.80
158_I334_S1.3210.79
46_V49_W1.3100.78
298_S301_Y1.3100.78
278_I281_P1.3080.78
416_K420_A1.2920.77
142_Q149_I1.2910.77
391_L394_D1.2910.77
166_D170_T1.2820.77
104_W113_L1.2660.76
167_E171_Q1.2650.76
118_L121_Q1.2620.76
109_P113_L1.2580.75
409_S419_L1.2550.75
219_G222_D1.2530.75
289_V294_V1.2500.75
127_E179_A1.2470.75
282_I291_I1.2450.75
4_G251_G1.2440.75
344_C356_A1.2370.74
337_L405_L1.2250.73
213_V330_R1.2240.73
282_I285_W1.2170.73
418_A422_Q1.2110.73
378_L381_P1.2100.72
348_L413_P1.2080.72
382_L414_L1.2030.72
309_L326_Q1.1910.71
357_S366_A1.1900.71
104_W108_S1.1850.71
282_I288_A1.1790.70
3_I149_I1.1790.70
105_F108_S1.1710.70
104_W107_K1.1700.70
287_N292_N1.1680.70
103_V113_L1.1620.69
410_A442_A1.1540.69
406_T436_S1.1530.69
213_V303_S1.1490.68
258_A381_P1.1460.68
109_P114_G1.1440.68
107_K110_K1.1360.68
179_A182_R1.1350.68
26_K29_N1.1270.67
103_V241_S1.1060.65
26_K370_S1.1010.65
167_E170_T1.0980.65
157_P217_G1.0960.65
106_V114_G1.0940.65
154_I188_V1.0940.65
238_R241_S1.0930.65
342_E346_I1.0920.64
260_A338_V1.0910.64
290_A294_V1.0850.64
213_V445_A1.0840.64
47_S50_L1.0830.64
106_V110_K1.0830.64
283_L288_A1.0820.64
378_L409_S1.0760.63
386_L422_Q1.0690.63
110_K115_A1.0640.62
276_K280_L1.0630.62
419_L423_L1.0630.62
263_N373_G1.0600.62
5_F134_M1.0580.62
288_A293_D1.0570.62
103_V110_K1.0550.62
210_R227_L1.0540.62
45_A50_L1.0530.62
294_V298_S1.0500.61
108_S114_G1.0480.61
254_D265_M1.0460.61
289_V295_P1.0430.61
168_A171_Q1.0420.61
308_L311_D1.0390.61
336_R360_F1.0360.60
105_F110_K1.0300.60
165_G168_A1.0300.60
227_L241_S1.0260.60
378_L414_L1.0230.59
403_I423_L1.0200.59
5_F129_L1.0160.59
108_S113_L1.0160.59
353_E368_L0.9960.57
213_V309_L0.9940.57
213_V273_E0.9930.57
281_P292_N0.9890.57
417_K421_E0.9880.57
47_S52_R0.9880.57
14_V149_I0.9850.56
201_Y404_Y0.9830.56
123_V415_I0.9830.56
200_D404_Y0.9760.56
195_V202_E0.9740.56
195_V201_Y0.9660.55
251_G409_S0.9610.55
89_G110_K0.9590.54
168_A172_A0.9540.54
193_E218_G0.9500.54
6_D222_D0.9450.53
142_Q148_A0.9420.53
171_Q175_I0.9390.53
112_F115_A0.9390.53
374_L412_S0.9380.53
106_V109_P0.9330.52
30_D376_S0.9330.52
214_V251_G0.9320.52
4_G126_F0.9320.52
193_E220_T0.9310.52
209_K427_P0.9300.52
26_K144_Q0.9300.52
292_N297_Q0.9290.52
114_G117_G0.9280.52
370_S376_S0.9270.52
216_I358_L0.9250.52
45_A48_E0.9240.52
48_E53_H0.9190.51
201_Y402_V0.9160.51
389_V423_L0.9140.51
410_A433_D0.9140.51
371_Q413_P0.9140.51
378_L412_S0.9110.51
4_G36_S0.9090.50
5_F12_C0.9070.50
288_A297_Q0.9060.50
6_D219_G0.9040.50
230_P435_G0.9040.50
105_F113_L0.9030.50
348_L374_L0.9010.50
257_I261_F0.8990.50
316_A322_V0.8990.50
287_N290_A0.8970.49
328_V361_I0.8960.49
178_R181_K0.8960.49
106_V115_A0.8960.49
325_L328_V0.8960.49
292_N295_P0.8950.49
282_I294_V0.8940.49
216_I301_Y0.8930.49
256_D408_G0.8920.49
193_E217_G0.8920.49
157_P193_E0.8920.49
47_S53_H0.8900.49
286_W290_A0.8890.49
6_D220_T0.8870.49
48_E89_G0.8860.49
107_K111_S0.8850.49
267_L358_L0.8830.48
161_Q249_R0.8820.48
103_V106_V0.8760.48
372_R376_S0.8750.48
287_N293_D0.8740.48
107_K115_A0.8700.47
280_L287_N0.8680.47
5_F14_V0.8660.47
289_V297_Q0.8660.47
260_A265_M0.8640.47
265_M269_G0.8640.47
348_L371_Q0.8630.47
139_Q150_T0.8610.47
13_S168_A0.8580.46
189_V444_W0.8580.46
103_V114_G0.8570.46
297_Q300_F0.8510.46
366_A372_R0.8510.46
225_L392_A0.8510.46
369_I373_G0.8490.46
376_S398_E0.8470.46
372_R375_E0.8460.45
357_S362_S0.8460.45
180_A184_G0.8430.45
159_N169_N0.8430.45
310_N326_Q0.8420.45
106_V113_L0.8420.45
340_S360_F0.8420.45
216_I415_I0.8390.45
25_L144_Q0.8380.45
385_I436_S0.8330.44
103_V107_K0.8330.44
389_V396_A0.8330.44
242_L245_H0.8300.44
320_E383_T0.8280.44
23_H26_K0.8270.44
36_S389_V0.8260.44
131_C373_G0.8250.44
101_E111_S0.8240.44
309_L322_V0.8220.44
337_L384_R0.8220.44
305_N415_I0.8180.43
193_E222_D0.8170.43
105_F112_F0.8140.43
349_S413_P0.8140.43
157_P215_D0.8130.43
3_I442_A0.8080.42
104_W109_P0.8030.42
191_Q202_E0.8000.42
156_R194_P0.7990.42
343_E399_K0.7990.42
53_H355_R0.7970.42
191_Q238_R0.7970.42
190_F437_V0.7970.42
316_A389_V0.7970.42
46_V54_H0.7930.41
411_R415_I0.7890.41
49_W53_H0.7870.41
416_K430_G0.7840.41
180_A238_R0.7830.41
6_D193_E0.7820.40
389_V393_L0.7780.40
167_E236_L0.7760.40
379_S390_Q0.7760.40
405_L416_K0.7730.40
193_E219_G0.7710.40
35_P409_S0.7670.39
392_A410_A0.7660.39
284_P292_N0.7660.39
323_A327_K0.7660.39
172_A256_D0.7650.39
357_S421_E0.7640.39
50_L53_H0.7570.39
411_R433_D0.7570.39
201_Y429_A0.7540.38
215_D407_G0.7530.38
224_S245_H0.7530.38
194_P408_G0.7520.38
194_P256_D0.7520.38
288_A295_P0.7500.38
4_G259_L0.7470.38
404_Y436_S0.7450.38
4_G266_P0.7440.38
371_Q374_L0.7430.38
194_P269_G0.7430.38
280_L285_W0.7410.37
157_P218_G0.7370.37
14_V34_L0.7370.37
351_V370_S0.7350.37
16_V145_L0.7340.37
3_I141_A0.7310.37
204_T396_A0.7280.36
200_D435_G0.7270.36
51_Y89_G0.7270.36
338_V341_A0.7270.36
351_V417_K0.7260.36
392_A396_A0.7260.36
145_L149_I0.7260.36
202_E237_D0.7240.36
13_S444_W0.7170.36
158_I378_L0.7160.36
343_E355_R0.7160.36
274_T280_L0.7140.35
293_D297_Q0.7130.35
160_F172_A0.7110.35
352_A387_E0.7100.35
285_W289_V0.7100.35
327_K331_Q0.7060.35
217_G220_T0.7060.35
157_P220_T0.7060.35
256_D269_G0.7060.35
3_I25_L0.7060.35
160_F195_V0.7050.35
113_L437_V0.7050.35
139_Q352_A0.7040.35
375_E414_L0.7020.35
143_A387_E0.7020.35
283_L291_I0.6980.34
353_E379_S0.6970.34
125_L128_D0.6970.34
212_L224_S0.6960.34
12_C40_A0.6940.34
421_E425_G0.6940.34
318_E376_S0.6900.34
280_L288_A0.6880.34
327_K333_L0.6860.33
179_A245_H0.6840.33
20_G44_E0.6820.33
168_A173_Q0.6790.33
296_A299_D0.6780.33
129_L137_I0.6780.33
284_P290_A0.6760.33
188_V310_N0.6760.33
371_Q404_Y0.6750.33
211_V406_T0.6730.33
239_E250_I0.6720.32
242_L443_R0.6720.32
347_A395_N0.6710.32
195_V238_R0.6700.32
198_G228_M0.6690.32
193_E215_D0.6680.32
259_L409_S0.6670.32
191_Q444_W0.6660.32
25_L246_S0.6650.32
28_E35_P0.6650.32
244_G409_S0.6610.32
16_V19_D0.6610.32
235_R354_T0.6600.32
97_I105_F0.6590.32
118_L205_L0.6580.31
221_T389_V0.6580.31
156_R160_F0.6570.31
255_L378_L0.6560.31
352_A421_E0.6520.31
197_A408_G0.6520.31
268_L272_G0.6520.31
407_G440_G0.6520.31
169_N190_F0.6510.31
272_G275_E0.6500.31
194_P406_T0.6490.31
376_S421_E0.6480.31
213_V245_H0.6440.31
307_R311_D0.6430.30
283_L294_V0.6420.30
355_R359_P0.6420.30
13_S39_C0.6420.30
36_S134_M0.6420.30
12_C121_Q0.6400.30
328_V333_L0.6380.30
166_D369_I0.6380.30
160_F194_P0.6350.30
218_G222_D0.6330.30
26_K30_D0.6330.30
352_A370_S0.6320.30
155_G190_F0.6310.30
285_W290_A0.6300.30
357_S363_N0.6300.30
199_L263_N0.6290.30
130_V134_M0.6280.29
358_L362_S0.6270.29
327_K360_F0.6270.29
295_P298_S0.6270.29
147_E390_Q0.6270.29
106_V112_F0.6260.29
267_L321_K0.6250.29
436_S441_L0.6230.29
165_G169_N0.6200.29
139_Q231_Q0.6200.29
304_A386_L0.6190.29
34_L392_A0.6190.29
285_W292_N0.6180.29
210_R241_S0.6170.29
414_L443_R0.6170.29
132_A359_P0.6160.29
19_D357_S0.6150.29
279_A290_A0.6140.29
281_P295_P0.6130.28
208_E221_T0.6130.28
390_Q394_D0.6120.28
409_S418_A0.6080.28
98_D357_S0.6080.28
358_L361_I0.6070.28
244_G335_Y0.6070.28
191_Q208_E0.6060.28
156_R190_F0.6040.28
364_E395_N0.6030.28
368_L379_S0.6030.28
340_S343_E0.6030.28
6_D218_G0.6020.28
176_L183_A0.6020.28
192_Y216_I0.6020.28
187_D231_Q0.6010.28
5_F180_A0.5980.28
173_Q185_F0.5980.28
353_E364_E0.5970.27
261_F377_A0.5960.27
376_S393_L0.5950.27
305_N329_W0.5950.27
251_G254_D0.5950.27
127_E178_R0.5940.27
26_K31_S0.5930.27
251_G435_G0.5920.27
263_N367_T0.5910.27
180_A228_M0.5900.27
39_C241_S0.5890.27
177_E228_M0.5880.27
194_P197_A0.5880.27
97_I177_E0.5880.27
283_L290_A0.5870.27
378_L419_L0.5860.27
217_G407_G0.5850.27
157_P407_G0.5850.27
9_T219_G0.5850.27
108_S111_S0.5820.27
162_G249_R0.5800.26
15_A178_R0.5770.26
352_A373_G0.5760.26
172_A184_G0.5760.26
180_A183_A0.5760.26
6_D11_N0.5760.26
209_K445_A0.5760.26
49_W54_H0.5760.26
254_D342_E0.5750.26
197_A256_D0.5750.26
180_A185_F0.5740.26
379_S414_L0.5740.26
103_V109_P0.5740.26
343_E347_A0.5720.26
131_C182_R0.5720.26
213_V386_L0.5710.26
6_D157_P0.5710.26
6_D217_G0.5710.26
213_V264_L0.5710.26
8_G215_D0.5710.26
191_Q195_V0.5710.26
4_G348_L0.5710.26
200_D409_S0.5700.26
217_G222_D0.5690.26
157_P222_D0.5690.26
191_Q199_L0.5690.26
138_R141_A0.5670.26
35_P107_K0.5670.26
36_S348_L0.5660.26
231_Q421_E0.5660.26
317_R321_K0.5650.25
201_Y406_T0.5630.25
157_P219_G0.5620.25
379_S383_T0.5610.25
211_V439_A0.5600.25
135_L139_Q0.5590.25
416_K428_I0.5590.25
352_A391_L0.5590.25
274_T279_A0.5590.25
25_L268_L0.5590.25
300_F303_S0.5580.25
15_A42_T0.5580.25
251_G264_L0.5580.25
438_T444_W0.5570.25
436_S440_G0.5570.25
126_F437_V0.5560.25
203_A443_R0.5550.25
38_L245_H0.5550.25
198_G201_Y0.5550.25
308_L314_R0.5550.25
147_E394_D0.5550.25
40_A133_M0.5540.25
361_I365_L0.5530.25
311_D314_R0.5520.25
281_P297_Q0.5520.25
211_V410_A0.5510.25
325_L334_S0.5460.24
180_A237_D0.5460.24
410_A435_G0.5440.24
262_K377_A0.5440.24
156_R256_D0.5430.24
272_G321_K0.5420.24
286_W292_N0.5420.24
295_P332_R0.5420.24
183_A359_P0.5420.24
51_Y54_H0.5410.24
314_R368_L0.5400.24
195_V224_S0.5400.24
188_V306_G0.5400.24
245_H409_S0.5390.24
155_G269_G0.5370.24
283_L287_N0.5370.24
104_W115_A0.5350.24
257_I318_E0.5350.24
411_R442_A0.5340.24
186_R320_E0.5330.24
13_S435_G0.5330.24
251_G436_S0.5320.24
109_P115_A0.5320.24
274_T277_G0.5310.24
315_D403_I0.5300.23
281_P290_A0.5300.23
192_Y221_T0.5290.23
149_I410_A0.5290.23
363_N394_D0.5290.23
389_V392_A0.5280.23
30_D347_A0.5280.23
405_L430_G0.5280.23
352_A371_Q0.5260.23
140_Q262_K0.5250.23
36_S371_Q0.5240.23
45_A233_R0.5230.23
31_S134_M0.5210.23
103_V108_S0.5210.23
147_E372_R0.5200.23
98_D331_Q0.5200.23
199_L389_V0.5200.23
19_D23_H0.5190.23
264_L344_C0.5180.23
301_Y335_Y0.5170.23
163_L337_L0.5170.23
132_A347_A0.5160.23
156_R269_G0.5160.23
286_W294_V0.5130.22
199_L381_P0.5120.22
5_F214_V0.5120.22
156_R441_L0.5120.22
221_T396_A0.5110.22
269_G408_G0.5110.22
386_L421_E0.5110.22
125_L403_I0.5100.22
175_I216_I0.5100.22
375_E417_K0.5090.22
5_F159_N0.5080.22
195_V241_S0.5080.22
215_D220_T0.5080.22
156_R408_G0.5080.22
349_S406_T0.5080.22
181_K350_S0.5070.22
16_V385_I0.5070.22
395_N417_K0.5050.22
247_G252_G0.5050.22
422_Q425_G0.5050.22
429_A435_G0.5050.22
4_G442_A0.5020.22
133_M223_C0.5000.22
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4fl9A 1 0.82 100 0.48 Contact Map
4jneA 2 0.8222 100 0.481 Contact Map
3d2fA 1 0.8222 100 0.486 Contact Map
3i33A 1 0.8178 100 0.503 Contact Map
2v7yA 1 0.7578 100 0.507 Contact Map
4kboA 1 0.8111 100 0.515 Contact Map
4rtfD 1 0.7533 100 0.522 Contact Map
4j8fA 2 0.82 100 0.527 Contact Map
4gniA 2 0.8111 100 0.561 Contact Map
3qfuA 1 0.8178 100 0.569 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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