GREMLIN Database
YADI - Putative phosphotransferase enzyme IIA component YadI
UniProt: P36881 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12322
Length: 146 (130)
Sequences: 2257 (1661)
Seq/√Len: 145.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
21_E26_A3.6101.00
108_T111_E2.9031.00
16_I92_V2.9001.00
11_D14_Q2.8901.00
31_R54_E2.8581.00
39_L47_M2.6491.00
14_Q34_N2.4811.00
15_E18_D2.4771.00
8_C92_V2.3241.00
12_R16_I2.2521.00
99_Q119_L2.1981.00
100_M116_I2.1041.00
31_R51_A2.0261.00
17_L32_A1.8971.00
6_I92_V1.8261.00
17_L30_C1.8081.00
6_I17_L1.7801.00
45_S78_L1.7321.00
17_L21_E1.7201.00
64_L100_M1.6991.00
63_F86_C1.6491.00
35_F44_L1.6461.00
11_D15_E1.6231.00
46_R50_D1.5851.00
8_C13_A1.5831.00
65_T73_Y1.5711.00
48_M76_A1.5651.00
24_H102_A1.5621.00
87_E126_S1.5291.00
87_E110_S1.4691.00
96_L124_V1.4641.00
20_L101_M1.4631.00
19_A94_L1.4401.00
3_G31_R1.4071.00
7_T48_M1.3771.00
13_A34_N1.3761.00
3_G55_A1.3721.00
45_S75_V1.3701.00
30_C101_M1.3571.00
89_I117_V1.3051.00
68_A125_S1.3031.00
49_C82_K1.2681.00
49_C53_H1.2551.00
29_Q57_S1.2351.00
43_M46_R1.2231.00
33_V51_A1.2161.00
114_E129_H1.1991.00
64_L97_I1.1961.00
118_E122_P1.1681.00
93_T124_V1.1240.99
120_G124_V1.1120.99
63_F76_A1.1120.99
8_C12_R1.1090.99
20_L97_I1.1080.99
5_V63_F1.1000.99
76_A88_V1.0680.99
4_W96_L1.0620.99
8_C16_I1.0460.99
50_D54_E1.0430.99
11_D34_N1.0400.99
10_D19_A1.0370.99
73_Y127_L1.0360.99
113_R126_S1.0330.99
49_C83_H1.0270.99
68_A90_S1.0250.99
107_M111_E1.0180.99
21_E27_L1.0150.99
62_I100_M1.0140.99
64_L96_L1.0120.99
77_S127_L1.0060.99
120_G123_E0.9800.98
107_M115_R0.9670.98
62_I109_S0.9560.98
2_L104_R0.9380.98
10_D22_K0.9360.98
6_I97_I0.9270.98
36_W39_L0.9210.98
99_Q103_C0.9160.98
3_G51_A0.9120.97
117_V129_H0.9080.97
96_L120_G0.8980.97
109_S113_R0.8930.97
117_V121_A0.8900.97
5_V51_A0.8830.97
2_L60_G0.8710.97
3_G61_V0.8410.96
8_C34_N0.8370.96
126_S129_H0.8260.96
23_K94_L0.8220.95
55_A58_G0.8200.95
19_A70_A0.8150.95
58_G61_V0.8100.95
4_W100_M0.8050.95
14_Q32_A0.8030.95
78_L82_K0.8020.95
90_S125_S0.8020.95
14_Q18_D0.8000.95
5_V48_M0.7990.95
40_S43_M0.7990.95
43_M47_M0.7960.95
11_D18_D0.7920.94
47_M50_D0.7910.94
64_L92_V0.7900.94
36_W71_P0.7840.94
2_L109_S0.7820.94
72_P76_A0.7820.94
5_V55_A0.7800.94
88_V127_L0.7740.94
41_S71_P0.7740.94
44_L71_P0.7700.93
45_S49_C0.7690.93
96_L123_E0.7680.93
18_D21_E0.7670.93
3_G58_G0.7670.93
4_W101_M0.7600.93
71_P74_R0.7560.93
19_A23_K0.7370.92
33_V40_S0.7370.92
29_Q104_R0.7330.92
92_V97_I0.7300.92
3_G29_Q0.7290.92
79_L82_K0.7280.91
50_D53_H0.7220.91
20_L30_C0.7170.91
22_K37_R0.7100.90
35_F73_Y0.7090.90
64_L93_T0.7020.90
5_V33_V0.7010.90
3_G60_G0.7000.90
55_A61_V0.6980.90
45_S82_K0.6860.89
121_A124_V0.6830.89
27_L104_R0.6790.88
23_K102_A0.6760.88
75_V78_L0.6680.88
24_H98_E0.6670.87
46_R49_C0.6510.86
33_V48_M0.6440.86
2_L59_E0.6430.86
111_E115_R0.6410.85
12_R19_A0.6360.85
60_G109_S0.6360.85
60_G85_R0.6310.84
59_E108_T0.6300.84
35_F72_P0.6220.84
48_M79_L0.6200.83
47_M51_A0.6190.83
51_A54_E0.6160.83
49_C79_L0.6160.83
115_R118_E0.6070.82
125_S130_Q0.6060.82
12_R15_E0.6010.81
87_E113_R0.5990.81
53_H83_H0.5920.80
20_L24_H0.5910.80
48_M75_V0.5790.79
8_C14_Q0.5770.79
119_L122_P0.5730.78
22_K74_R0.5720.78
68_A88_V0.5710.78
87_E128_W0.5690.78
7_T35_F0.5690.78
68_A130_Q0.5670.78
99_Q115_R0.5660.77
41_S44_L0.5650.77
7_T76_A0.5630.77
114_E118_E0.5620.77
12_R94_L0.5580.76
11_D36_W0.5510.76
35_F71_P0.5500.75
117_V124_V0.5490.75
128_W131_Q0.5490.75
5_V61_V0.5470.75
68_A73_Y0.5470.75
48_M63_F0.5450.75
34_N44_L0.5440.75
19_A22_K0.5410.74
119_L123_E0.5400.74
16_I20_L0.5390.74
101_M104_R0.5320.73
2_L112_F0.5290.73
7_T72_P0.5270.72
118_E121_A0.5220.72
22_K99_Q0.5210.72
21_E25_G0.5210.72
89_I120_G0.5210.72
116_I119_L0.5200.71
56_D61_V0.5140.71
35_F75_V0.5140.71
93_T120_G0.5140.71
6_I30_C0.5080.70
68_A95_P0.5060.69
22_K70_A0.5050.69
117_V126_S0.5030.69
83_H86_C0.5000.68
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3iprA 2 0.9178 100 0.221 Contact Map
3mtqA 2 0.911 100 0.232 Contact Map
3lfhA 2 0.9658 100 0.239 Contact Map
1pdoA 2 0.8767 100 0.242 Contact Map
4tkzA 2 0.8699 100 0.245 Contact Map
3bedA 4 0.8836 100 0.246 Contact Map
3gx1A 2 0.8219 100 0.352 Contact Map
3gdwA 2 0.8904 100 0.374 Contact Map
3ct6A 2 0.8493 99.9 0.389 Contact Map
3b48A 2 0.8425 99.9 0.413 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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