GREMLIN Database
YADG - Uncharacterized ABC transporter ATP-binding protein YadG
UniProt: P36879 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12320
Length: 308 (236)
Sequences: 92042 (54519)
Seq/√Len: 3548.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
32_D205_N3.5771.00
19_Q22_R3.0561.00
79_Q156_K3.0191.00
6_E27_Q2.9941.00
34_Y207_G2.9551.00
205_N217_N2.8611.00
9_Q23_G2.7901.00
8_Q61_R2.7791.00
13_T19_Q2.7051.00
29_E32_D2.5831.00
35_A203_C2.5691.00
61_R68_D2.5391.00
6_E63_S2.5131.00
11_K59_S2.4301.00
129_K132_E2.3141.00
11_K19_Q2.3031.00
219_S222_A2.2981.00
12_K50_I2.2451.00
218_T222_A2.2081.00
8_Q63_S2.1971.00
22_R213_E2.1841.00
65_F156_K2.1251.00
11_K23_G2.0891.00
207_G214_L2.0571.00
207_G217_N2.0311.00
109_E112_E1.9331.00
7_L10_L1.9041.00
118_E130_R1.8471.00
118_E126_L1.8321.00
30_A156_K1.8271.00
72_D75_N1.7831.00
96_Q130_R1.7081.00
96_Q100_V1.7081.00
48_I192_T1.6841.00
95_V137_L1.6671.00
154_E187_T1.6421.00
48_I159_I1.6391.00
14_Y46_T1.6281.00
116_R154_E1.6131.00
14_Y20_A1.6101.00
180_K201_M1.6101.00
132_E136_M1.5981.00
181_D185_K1.5811.00
200_E221_K1.5781.00
118_E122_K1.5631.00
119_K123_Q1.5621.00
116_R119_K1.5361.00
96_Q131_N1.5031.00
12_K55_V1.4961.00
65_F79_Q1.4761.00
9_Q25_D1.4561.00
218_T223_L1.4541.00
26_L207_G1.4541.00
100_V113_A1.4461.00
193_T199_A1.4441.00
11_K22_R1.4341.00
103_A106_Y1.4221.00
12_K58_T1.4211.00
114_Y118_E1.4011.00
32_D204_R1.3691.00
7_L26_L1.3681.00
10_L57_K1.3661.00
28_V34_Y1.3541.00
13_T58_T1.3371.00
4_A65_F1.3231.00
227_L231_T1.3171.00
121_L130_R1.3041.00
123_Q185_K1.3001.00
34_Y217_N1.2911.00
26_L47_T1.2691.00
222_A226_K1.2641.00
29_E205_N1.2631.00
63_S68_D1.2601.00
68_D71_K1.2581.00
94_T97_Q1.2511.00
122_K127_W1.2401.00
33_F183_N1.2301.00
53_S56_N1.2281.00
35_A199_A1.2241.00
210_Q215_V1.2241.00
7_L51_I1.2241.00
34_Y205_N1.2161.00
120_Y152_M1.2051.00
229_S232_F1.2041.00
24_I47_T1.2031.00
230_E233_I1.1531.00
92_F97_Q1.1521.00
160_L189_I1.1491.00
216_E226_K1.1491.00
93_E97_Q1.1461.00
231_T235_D1.1411.00
100_V117_S1.1391.00
99_V121_L1.1321.00
8_Q27_Q1.1201.00
36_L47_T1.1181.00
52_S82_L1.1151.00
33_F203_C1.1041.00
123_Q181_D1.1011.00
109_E113_A1.1001.00
110_R114_Y1.0961.00
100_V114_Y1.0941.00
220_M230_E1.0911.00
67_Y75_N1.0851.00
173_R177_G1.0751.00
30_A65_F1.0681.00
176_W198_E1.0611.00
183_N189_I1.0581.00
73_V77_K1.0571.00
111_K115_I1.0511.00
115_I119_K1.0511.00
33_F189_I1.0411.00
94_T131_N1.0391.00
33_F191_L1.0361.00
97_Q100_V1.0251.00
112_E115_I1.0181.00
96_Q114_Y1.0161.00
50_I57_K1.0121.00
8_Q25_D1.0111.00
73_V76_A1.0071.00
221_K225_A1.0001.00
67_Y72_D0.9991.00
49_G55_V0.9981.00
119_K122_K0.9961.00
21_L50_I0.9941.00
120_Y148_A0.9891.00
98_I149_R0.9831.00
206_I220_M0.9791.00
178_F181_D0.9761.00
7_L47_T0.9731.00
167_V175_M0.9621.00
222_A225_A0.9621.00
47_T209_I0.9611.00
116_R120_Y0.9611.00
216_E227_L0.9521.00
104_G113_A0.9521.00
81_G155_P0.9481.00
99_V152_M0.9461.00
110_R113_A0.9381.00
4_A30_A0.9361.00
172_R195_Y0.9341.00
39_P210_Q0.9321.00
85_Q139_G0.9301.00
180_K183_N0.9231.00
117_S120_Y0.9211.00
36_L190_I0.9201.00
137_L145_L0.9161.00
215_V229_S0.9151.00
172_R198_E0.9151.00
158_L187_T0.9071.00
81_G150_A0.8971.00
134_A145_L0.8961.00
36_L207_G0.8961.00
230_E234_L0.8831.00
83_V160_L0.8801.00
9_Q59_S0.8711.00
96_Q117_S0.8701.00
162_E194_H0.8601.00
108_V112_E0.8601.00
67_Y79_Q0.8571.00
12_K46_T0.8541.00
13_T17_G0.8511.00
103_A152_M0.8481.00
158_L189_I0.8471.00
51_I190_I0.8461.00
95_V145_L0.8441.00
33_F180_K0.8421.00
106_Y153_H0.8411.00
124_L148_A0.8381.00
176_W201_M0.8351.00
56_N70_E0.8321.00
7_L62_V0.8321.00
103_A113_A0.8271.00
113_A117_S0.8261.00
83_V147_I0.8241.00
5_L51_I0.8231.00
83_V150_A0.8201.00
55_V58_T0.8181.00
96_Q118_E0.8171.00
133_R136_M0.8171.00
42_A209_I0.8141.00
30_A186_G0.8121.00
125_D174_S0.8111.00
127_W130_R0.8111.00
94_T133_R0.8101.00
160_L179_L0.8071.00
4_A27_Q0.8051.00
103_A107_G0.8011.00
177_G180_K0.8001.00
216_E228_K0.7981.00
13_T22_R0.7981.00
120_Y124_L0.7971.00
183_N204_R0.7911.00
92_F135_R0.7881.00
179_L189_I0.7871.00
52_S159_I0.7831.00
89_F142_K0.7821.00
109_E118_E0.7811.00
113_A118_E0.7791.00
50_I55_V0.7771.00
210_Q234_L0.7761.00
72_D76_A0.7761.00
10_L50_I0.7701.00
102_Q149_R0.7661.00
220_M224_L0.7641.00
75_N78_R0.7631.00
233_I237_A0.7621.00
23_G213_E0.7611.00
120_Y123_Q0.7591.00
114_Y130_R0.7571.00
21_L24_I0.7531.00
112_E126_L0.7501.00
13_T20_A0.7501.00
112_E116_R0.7501.00
174_S177_G0.7501.00
49_G54_L0.7491.00
156_K187_T0.7481.00
159_I190_I0.7441.00
23_G59_S0.7441.00
93_E98_I0.7401.00
191_L203_C0.7331.00
57_K70_E0.7321.00
100_V104_G0.7311.00
182_L187_T0.7271.00
214_L217_N0.7271.00
53_S73_V0.7251.00
137_L141_M0.7241.00
50_I62_V0.7241.00
28_V188_T0.7231.00
24_I214_L0.7221.00
28_V190_I0.7221.00
98_I134_A0.7201.00
232_F235_D0.7151.00
37_L199_A0.7121.00
200_E224_L0.7051.00
29_E188_T0.7051.00
4_A29_E0.6991.00
200_E220_M0.6991.00
93_E101_N0.6991.00
229_S233_I0.6971.00
125_D181_D0.6951.00
94_T98_I0.6931.00
232_F236_L0.6881.00
180_K202_L0.6821.00
34_Y190_I0.6781.00
177_G181_D0.6781.00
114_Y117_S0.6781.00
216_E223_L0.6701.00
33_F202_L0.6691.00
75_N79_Q0.6661.00
157_L188_T0.6641.00
122_K128_G0.6631.00
164_T175_M0.6551.00
53_S76_A0.6551.00
210_Q229_S0.6531.00
61_R70_E0.6491.00
80_L157_L0.6491.00
108_V113_A0.6491.00
21_L47_T0.6411.00
12_K21_L0.6411.00
27_Q217_N0.6391.00
65_F157_L0.6381.00
19_Q23_G0.6341.00
70_E73_V0.6341.00
115_I118_E0.6321.00
5_L64_V0.6301.00
37_L196_L0.6271.00
208_I223_L0.6271.00
96_Q127_W0.6261.00
210_Q213_E0.6241.00
139_G144_R0.6231.00
63_S66_G0.6221.00
28_V157_L0.6221.00
203_C206_I0.6211.00
234_L238_P0.6211.00
102_Q153_H0.6191.00
227_L230_E0.6141.00
99_V117_S0.6131.00
5_L157_L0.6121.00
196_L224_L0.6121.00
234_L237_A0.6091.00
19_Q59_S0.6091.00
20_A46_T0.6081.00
9_Q12_K0.6061.00
81_G153_H0.6051.00
37_L208_I0.6041.00
112_E121_L0.6041.00
193_T198_E0.6021.00
171_L174_S0.6021.00
198_E202_L0.6011.00
177_G201_M0.5911.00
223_L232_F0.5911.00
14_Y55_V0.5871.00
13_T59_S0.5841.00
13_T18_V0.5821.00
224_L227_L0.5801.00
52_S80_L0.5761.00
121_L126_L0.5741.00
76_A80_L0.5701.00
164_T198_E0.5681.00
40_N171_L0.5661.00
191_L202_L0.5631.00
51_I62_V0.5611.00
104_G110_R0.5611.00
118_E128_G0.5571.00
125_D128_G0.5501.00
199_A203_C0.5501.00
4_A157_L0.5491.00
32_D217_N0.5491.00
87_F142_K0.5471.00
205_N219_S0.5451.00
65_F69_L0.5441.00
33_F204_R0.5441.00
64_V79_Q0.5421.00
50_I58_T0.5421.00
91_P135_R0.5401.00
4_A188_T0.5401.00
119_K154_E0.5391.00
103_A108_V0.5391.00
138_S141_M0.5381.00
99_V112_E0.5371.00
86_E142_K0.5371.00
83_V146_M0.5361.00
91_P142_K0.5361.00
157_L190_I0.5341.00
45_S49_G0.5341.00
120_Y151_L0.5311.00
197_E201_M0.5281.00
203_C220_M0.5271.00
227_L232_F0.5241.00
4_A64_V0.5241.00
226_K229_S0.5221.00
222_A228_K0.5221.00
18_V211_H0.5221.00
231_T234_L0.5211.00
147_I175_M0.5211.00
108_V116_R0.5201.00
40_N162_E0.5171.00
208_I227_L0.5171.00
87_F146_M0.5171.00
129_K141_M0.5151.00
233_I236_L0.5141.00
199_A220_M0.5111.00
31_G188_T0.5101.00
227_L235_D0.5091.00
151_L187_T0.5071.00
215_V230_E0.5061.00
154_E185_K0.5061.00
51_I159_I0.5031.00
6_E25_D0.5031.00
216_E231_T0.5021.00
22_R211_H0.5021.00
64_V157_L0.5011.00
30_A188_T0.5001.00
90_N98_I0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4yerA 2 0.9058 100 0.119 Contact Map
3tuiC 2 0.9935 100 0.184 Contact Map
4u00A 1 0.7727 100 0.199 Contact Map
4rvcA 4 0.7792 100 0.204 Contact Map
2oljA 2 0.7727 100 0.204 Contact Map
4mkiB 2 0.8864 100 0.206 Contact Map
4huqB 1 0.8799 100 0.213 Contact Map
1b0uA 2 0.7857 100 0.214 Contact Map
3fvqA 2 0.987 100 0.215 Contact Map
1vplA 2 0.7727 100 0.215 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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